| Compound ID |
Compound Name |
Compound Formula |
|
CP0465228
|
(4S)-3-[2-[[(1S)-1-[5-(2-tert-butylpyridin-4-yl)pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
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|
C26H32N6O2
|
1
|
| 1 |
IC50 < 2 nM
|
|
|
|
CP0076796
|
5-[[(1S)-1-[6-chloro-2-oxo-7-[(1R)-1-pyridin-2-ylethoxy]-1H-quinolin-3-yl]ethyl]amino]-1-methyl-6-oxopyridine-2-carbonitrile
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|
C25H22ClN5O3
|
1
|
| 1 |
IC50 < 2 nM
|
|
|
|
CP0179575
|
5-[[(1S)-1-[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1H-quinolin-3-yl]ethyl]amino]-1-methyl-6-oxopyridine-2-carbonitrile
Show/Hide
|
C24H20ClN5O3
|
2
|
| 1 |
IC50 < 2 nM
|
|
|
| 2 |
IC50 = 6 nM
|
|
|
|
CP0188595
|
5-[[(1S)-1-[6-chloro-7-(cyclopropylmethoxy)-2-oxo-1H-quinolin-3-yl]ethyl]amino]-1-methyl-6-oxopyridine-2-carbonitrile
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|
C22H21ClN4O3
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 17 nM
|
|
|
|
CP0196436
|
US10112931, Example 388
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|
C20H20ClFN6O2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0326564
|
5-[[(1S)-1-(6-chloro-7-methoxy-2-oxo-1H-quinolin-3-yl)ethyl]amino]-1-methyl-6-oxopyridine-2-carbonitrile
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|
C19H17ClN4O3
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 14 nM
|
|
|
|
CP0762758
|
(S)-2-(1-(6-chloro-7-isopropoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethylamino)-4-methoxypyrimidine-5-carbonitrile
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|
C20H20ClN5O3
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 104 nM
|
|
|
|
CP0660547
|
(S)-4-(1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethylamino)-2-methoxybenzonitrile
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|
C19H16ClN3O2
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
IC50 = 213 nM
|
|
|
|
CP0669565
|
(S)-2-(1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethylamino)-4-methoxypyrimidine-5-carbonitrile
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|
C18H16ClN5O3
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 40 nM
|
|
|
|
CP0465227
|
(4S)-3-[2-[[(1S)-1-[6-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
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|
C24H25F3N6O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0552283
|
(4S)-3-[2-[[(1S)-1-[1-(4-chlorophenyl)imidazol-4-yl]ethyl]amino]-5-fluoropyrimidin-4-yl]-4-ethyl-1,3-oxazolidin-2-one
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|
C20H20ClFN6O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0217390
|
(4S)-3-[2-[[(1S)-1-[4-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
Show/Hide
|
C24H25F3N6O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0240938
|
(4S)-3-[2-[[(1S)-1-[5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
Show/Hide
|
C23H25FN6O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0322219
|
US10112931, Example 456
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|
C21H21F3N6O2
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0476664
|
(4S)-3-[2-[[(1S)-1-[1-(4-chlorophenyl)imidazol-4-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
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|
C21H23ClN6O2
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0117201
|
Ft-2102
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|
C18H15ClN4O2
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
IC50 = 94 nM
|
|
|
|
CP0362178
|
US10112931, Example 450
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|
C20H19ClF2N6O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0147089
|
5-[[(1S)-1-(6-chloro-7-fluoro-2-oxo-1H-quinolin-3-yl)ethyl]amino]-1-methyl-6-oxopyridine-2-carbonitrile
Show/Hide
|
C18H14ClFN4O2
|
2
|
| 1 |
IC50 = 22 nM
|
|
|
| 2 |
IC50 = 104 nM
|
|
|
|
CP0839866
|
(S)-2-(1-(6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl)ethylamino)-4-methoxypyrimidine-5-carbonitrile
Show/Hide
|
C23H19ClN6O3
|
2
|
| 1 |
IC50 = 22 nM
|
|
|
| 2 |
IC50 = 36 nM
|
|
|
|
CP0107120
|
US10112931, Example 466
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|
C23H22F4N6O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0189882
|
US10112931, Example 429
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|
C19H17ClF2N6O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0714072
|
(S)-2-(1-(6-chloro-7-cyclopropyl-2-oxo-1,2-dihydroquinolin-3-yl)ethylamino)-4-methoxypyrimidine-5-carbonitrile
Show/Hide
|
C20H18ClN5O2
|
2
|
| 1 |
IC50 = 24 nM
|
|
|
| 2 |
IC50 = 195 nM
|
|
|
|
CP0326922
|
US10112931, Example 404
Show/Hide
|
C19H18ClFN6O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0315190
|
(4R)-4-(fluoromethyl)-3-[2-[[(1S)-1-[1-[4-(trifluoromethyl)phenyl]imidazol-4-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C20H18F4N6O2
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0482623
|
(4S)-4-propan-2-yl-3-[2-[[(1S)-1-[5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C23H23F3N6O2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0080002
|
(4S)-4-ethyl-3-[2-[[(1S)-1-[4-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C23H23F3N6O2
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0714073
|
(S)-2-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-4-methoxypyrimidine-5-carbonitrile
Show/Hide
|
C17H14ClN5O2
|
2
|
| 1 |
IC50 = 45 nM
|
|
|
| 2 |
IC50 = 233 nM
|
|
|
|
CP0517962
|
(4S)-3-[2-[[(1S)-1-[5-(4-fluoro-3-methylphenyl)pyrazin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
Show/Hide
|
C23H25FN6O2
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0513619
|
(4S)-3-[2-[[(1S)-1-[1-(4-chlorophenyl)imidazol-4-yl]ethyl]amino]-5-fluoropyrimidin-4-yl]-4-methyl-1,3-oxazolidin-2-one
Show/Hide
|
C19H18ClFN6O2
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0745638
|
(S)-2-(1-(6-chloro-7-(cyclopropylmethoxy)-2-oxo-1,2-dihydroquinolin-3-yl)ethylamino)-4-methoxypyrimidine-5-carbonitrile
Show/Hide
|
C21H20ClN5O3
|
2
|
| 1 |
IC50 = 49 nM
|
|
|
| 2 |
IC50 = 54 nM
|
|
|
|
CP0660534
|
(S)-6-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-4-methoxynicotinonitrile
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|
C18H15ClN4O2
|
2
|
| 1 |
IC50 = 51 nM
|
|
|
| 2 |
IC50 = 411 nM
|
|
|
|
CP0269572
|
(4S)-3-[2-[[(1S)-1-[3-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
Show/Hide
|
C24H25F3N6O2
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0393056
|
(4R)-4-(fluoromethyl)-3-[2-[[(1S)-1-[4-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H20F4N6O2
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0762754
|
(S)-6-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-2-methoxynicotinonitrile
Show/Hide
|
C18H15ClN4O2
|
2
|
| 1 |
IC50 = 92 nM
|
|
|
| 2 |
IC50 = 152 nM
|
|
|
|
CP0412482
|
US10112931, Example 59
Show/Hide
|
C23H23F3N6O3
|
1
|
| 1 |
IC50 = 102 nM
|
|
|
|
CP0117942
|
(4S)-3-[2-[[(1S)-1-[5-(2-methylpyridin-4-yl)pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
Show/Hide
|
C23H26N6O2
|
1
|
| 1 |
IC50 = 145 nM
|
|
|
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CP0762757
|
(S)-2-(1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethylamino)-4-methoxypyrimidine-5-carbonitrile
Show/Hide
|
C17H13ClFN5O2
|
2
|
| 1 |
IC50 = 172 nM
|
|
|
| 2 |
IC50 = 259 nM
|
|
|
|
CP0660539
|
(S)-5-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-6-methoxypicolinonitrile
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|
C18H15ClN4O2
|
2
|
| 1 |
IC50 = 185.1 nM
|
|
|
| 2 |
IC50 = 338 nM
|
|
|
|
CP0165474
|
6-{[(6-chloro-2-oxo-1,2-
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|
C17H13ClN4O
|
2
|
| 1 |
IC50 = 219 nM
|
|
|
| 2 |
IC50 = 3210 nM
|
|
|
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CP0750884
|
(S)-6-(1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethylamino)-2-methylnicotinonitrile
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|
C18H15ClN4O
|
2
|
| 1 |
IC50 = 234 nM
|
|
|
| 2 |
IC50 = 269 nM
|
|
|
|
CP0514107
|
US10112931, Example 399
Show/Hide
|
C20H19ClF2N6O2
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0412483
|
(4S)-4-methyl-3-[2-[[(1S)-1-[4-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H21F3N6O2
|
1
|
| 1 |
IC50 = 258 nM
|
|
|
|
CP0225556
|
4-{[(6-chloro-2-oxo-1,2-
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|
C18H14ClN3O2
|
2
|
| 1 |
IC50 = 266 nM
|
|
|
| 2 |
IC50 = 1920 nM
|
|
|
|
CP0714071
|
(S)-2-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-4-methylpyrimidine-5-carbonitrile
Show/Hide
|
C17H14ClN5O
|
1
|
| 1 |
IC50 = 293 nM
|
|
|
|
CP0465226
|
(4R)-4-[(1R)-1-fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C23H22F4N6O2
|
1
|
| 1 |
IC50 = 316 nM
|
|
|
|
CP0556648
|
3-[2-[[(1S)-1-[1-(4-chlorophenyl)imidazol-4-yl]ethyl]amino]-5-fluoropyrimidin-4-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C18H16ClFN6O2
|
1
|
| 1 |
IC50 = 560 nM
|
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|
