Brief Information of the Cell Line and Protein
Cell Line ID: CL000026 , CHO-K1
Synonyms
CHO K1
CHOK1
CHO cell clone K1
GM15452
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0214
Protein ID: PT01132 , Orexin receptor type 2
Gene Name HCRTR2
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID O43614
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000026  Protein ID: PT01132
 
Compound ID Compound Name Compound Formula
CP0391199
(2S)-1-[2-[(6-methyl-1H-benzimidazol-2-yl)sulfanyl]acetyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C25H25N5O2S
 1
1
Activity = 2 nM
   TI
   LI
   LO
   TS
CP0436316
(2S)-1-[2-(1-methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C25H25N5O2S
 1
1
Activity = 2 nM
   TI
   LI
   LO
   TS
CP0405058
(2S)-1-[3-(1-methylbenzimidazol-2-yl)propanoyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C26H27N5O2
 1
1
Activity = 3 nM
   TI
   LI
   LO
   TS
CP0059177
(2S)-1-[2-(1-methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C27H26N4O2S
 1
1
Activity = 4 nM
   TI
   LI
   LO
   TS
CP0382195
(2S)-1-[3-(1H-benzimidazol-2-yl)propanoyl]-N-[2-(2-fluorophenyl)phenyl]pyrrolidine-2-carboxamide
   Show/Hide
C27H25FN4O2
 1
1
Activity = 4 nM
   TI
   LI
   LO
   TS
CP0394568
(2S)-1-[3-(1H-benzimidazol-2-yl)propanoyl]-N-[2-(2-methoxyphenyl)phenyl]pyrrolidine-2-carboxamide
   Show/Hide
C28H28N4O3
 1
1
Activity = 5 nM
   TI
   LI
   LO
   TS
CP0394570
(2S)-1-[3-(1-methylbenzimidazol-2-yl)propanoyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C28H28N4O2
 1
1
Activity = 5 nM
   TI
   LI
   LO
   TS
CP0433114
(S)-1-(2-(1H-benzo[d]imidazol-2-ylthio)acetyl)-N-(2-(1H-pyrrol-1-yl)phenyl)pyrrolidine-2-carboxamide
   Show/Hide
C24H23N5O2S
 1
1
Activity = 6 nM
   TI
   LI
   LO
   TS
CP0382196
(2S)-1-[2-(1H-benzimidazol-2-ylsulfanyl)acetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C26H24N4O2S
 1
1
Activity = 7 nM
   TI
   LI
   LO
   TS
CP0422093
(2S)-1-[2-(1,5-dimethylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C26H27N5O2S
 1
1
Activity = 8 nM
   TI
   LI
   LO
   TS
CP0515983
(2S)-1-[2-(1,6-dimethylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C26H27N5O2S
 1
1
Activity = 8 nM
   TI
   LI
   LO
   TS
CP0433116
(2S)-1-[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C24H22N4O2S2
 1
1
Activity = 11 nM
   TI
   LI
   LO
   TS
CP0382194
(2S)-1-[2-(1H-benzimidazol-2-ylsulfanyl)acetyl]-N-(2-phenoxyphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C26H24N4O3S
 1
1
Activity = 16 nM
   TI
   LI
   LO
   TS
CP0382190
(2S)-1-[3-(1H-benzimidazol-2-yl)propanoyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C27H26N4O2
 1
1
Activity = 20 nM
   TI
   LI
   LO
   TS
CP0382191
(2S)-1-[2-(1,3-benzoxazol-2-ylsulfanyl)acetyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C24H22N4O3S
 1
1
Activity = 28 nM
   TI
   LI
   LO
   TS
CP0382193
(2S)-1-[3-(1H-benzimidazol-2-yl)propanoyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C25H25N5O2
 1
1
Activity = 36 nM
   TI
   LI
   LO
   TS
CP0433115
(2S)-1-[2-(1H-benzimidazol-2-ylsulfanyl)acetyl]-N-(4-phenylphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C26H24N4O2S
 1
1
Activity = 143 nM
   TI
   LI
   LO
   TS
CP0501979
(2S)-1-[2-(1H-benzimidazol-2-ylsulfanyl)acetyl]-N-(3-phenylphenyl)pyrrolidine-2-carboxamide
   Show/Hide
C26H24N4O2S
 1
1
Activity = 2640 nM
   TI
   LI
   LO
   TS
CP0462533
(2S)-1-[2-(1H-benzimidazol-2-ylsulfanyl)acetyl]-N-phenylpyrrolidine-2-carboxamide
   Show/Hide
C20H20N4O2S
 1
1
Activity = 4050 nM
   TI
   LI
   LO
   TS
CP0969650
Orexin A
   Show/Hide
C152H246N46O45S4
 1
1
EC50 = 0.18 nM
   TI
   LI
   LO
   TS
CP0544123
(2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((cis-4- phenylcyclohexyl)oxy)methyl)- piperidine-1-carboxamide
   Show/Hide
C22H35N3O4S
 1
1
EC50 = 0.29 nM
   TI
   LI
   LO
   TS
CP0544498
US10287305, Example 5
   Show/Hide
C21H32N2O5S
 1
1
EC50 = 5.5 nM
   TI
   LI
   LO
   TS
CP0528725
N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl)-1- propionylpiperidin-3- yl)methanesulfonamide
   Show/Hide
C22H34N2O4S
 1
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
CP0380127
N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-3-methylbenzamide
   Show/Hide
C32H34N4O5S
 1
1
EC50 = 23 nM
   TI
   LI
   LO
   TS
CP0528726
US10287305, Example 303
   Show/Hide
C22H34N2O5S
 1
1
EC50 = 27 nM
   TI
   LI
   LO
   TS
CP0385734
2-(dimethylamino)-N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]benzamide
   Show/Hide
C33H37N5O5S
 1
1
EC50 = 28 nM
   TI
   LI
   LO
   TS
CP0385733
2-chloro-N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]benzamide
   Show/Hide
C31H31ClN4O5S
 1
1
EC50 = 31 nM
   TI
   LI
   LO
   TS
CP0385732
3-[4-methoxy-3-[[3-[2-[(3-methoxybenzoyl)amino]ethylamino]phenyl]sulfamoyl]phenyl]-N,N-dimethylbenzamide
   Show/Hide
C32H34N4O6S
 1
1
EC50 = 33 nM
   TI
   LI
   LO
   TS
CP0380343
N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-2-methoxybenzamide
   Show/Hide
C32H34N4O6S
 1
1
EC50 = 50 nM
   TI
   LI
   LO
   TS
CP0380341
3-[3-[[3-[2-[(3-chlorobenzoyl)amino]ethylamino]phenyl]sulfamoyl]-4-methoxyphenyl]-N,N-dimethylbenzamide
   Show/Hide
C31H31ClN4O5S
 1
1
EC50 = 94 nM
   TI
   LI
   LO
   TS
CP0478623
2-methoxy-N-[2-[3-[[2-methoxy-5-[3-(methylcarbamoyl)phenyl]phenyl]sulfonylamino]anilino]ethyl]benzamide
   Show/Hide
C31H32N4O6S
 1
1
EC50 = 182 nM
   TI
   LI
   LO
   TS
CP0428579
N-[2-[3-[[5-[3-(azetidine-1-carbonyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-2-methoxybenzamide
   Show/Hide
C33H34N4O6S
 1
1
EC50 = 235 nM
   TI
   LI
   LO
   TS
CP0381416
2-methoxy-N-[2-[3-[(2-methoxy-5-pyridin-3-ylphenyl)sulfonylamino]anilino]ethyl]benzamide
   Show/Hide
C28H28N4O5S
 1
1
EC50 = 268 nM
   TI
   LI
   LO
   TS
CP0528724
N-((2R,3S)-1-acetyl-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)- piperidin-3-yl)ethanesulfonamide
   Show/Hide
C19H36N2O4S
 1
1
EC50 = 270 nM
   TI
   LI
   LO
   TS
CP0577855
N-((2R,3S)-1-acetyl-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)- piperidin-3-yl)methanesulfonamide
   Show/Hide
C18H34N2O4S
 1
1
EC50 = 330 nM
   TI
   LI
   LO
   TS
CP0528729
N-[1-acetyl-2-[(4-propan-2-ylcyclohexyl)oxymethyl]piperidin-3-yl]ethanesulfonamide
   Show/Hide
C19H36N2O4S
 1
1
EC50 = 570 nM
   TI
   LI
   LO
   TS
CP0411515
N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-2-methylbenzamide
   Show/Hide
C32H34N4O5S
 1
1
EC50 = 800 nM
   TI
   LI
   LO
   TS
CP0428577
2-methoxy-N-[2-[3-[[2-methoxy-5-(3-methoxyphenyl)phenyl]sulfonylamino]anilino]ethyl]benzamide
   Show/Hide
C30H31N3O6S
 1
1
EC50 = 800 nM
   TI
   LI
   LO
   TS
CP0542690
N-(cis-1-acetyl-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)- piperidin-3-yl)propane-2-sulfonamide
   Show/Hide
C20H38N2O4S
 1
1
EC50 = 940 nM
   TI
   LI
   LO
   TS
CP0428684
3-[4-methoxy-3-[[3-[2-[(4-methoxybenzoyl)amino]ethylamino]phenyl]sulfamoyl]phenyl]-N,N-dimethylbenzamide
   Show/Hide
C32H34N4O6S
 1
1
EC50 = 1047 nM
   TI
   LI
   LO
   TS
CP0528728
N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl)- piperidin-3-yl)methanesulfonamide
   Show/Hide
C19H30N2O3S
 1
1
EC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0573347
N-(cis-1-acetyl-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)- piperidin-3-yl)propane-1-sulfonamide
   Show/Hide
C20H38N2O4S
 1
1
EC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0579679
N-(cis-1-acetyl-2-(((cis-4- methylcyclohexyl)oxy)methyl)- piperidin-3-yl)methanesulfonamide
   Show/Hide
C16H30N2O4S
 1
1
EC50 = 3700 nM
   TI
   LI
   LO
   TS
CP0380340
N-[2-[3-[[5-(3-fluorophenyl)-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-2-methoxybenzamide
   Show/Hide
C29H28FN3O5S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0380344
3-[3-[[3-(2-benzamidoethylamino)phenyl]sulfamoyl]-4-methoxyphenyl]-N,N-dimethylbenzamide
   Show/Hide
C31H32N4O5S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0385731
methyl 3-[4-methoxy-3-[[3-[2-[(2-methoxybenzoyl)amino]ethylamino]phenyl]sulfamoyl]phenyl]benzoate
   Show/Hide
C31H31N3O7S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0491310
2-methoxy-N-[2-[3-[(2-methoxy-5-phenylphenyl)sulfonylamino]anilino]ethyl]benzamide
   Show/Hide
C29H29N3O5S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0542691
N-[(2R,3S)-1-acetyl-2-[(4-propan-2-ylcyclohexyl)oxymethyl]piperidin-3-yl]-N-methylmethanesulfonamide
   Show/Hide
C19H36N2O4S
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0568990
N-[(2R,3S)-1-acetyl-2-[(4-propan-2-ylcyclohexyl)oxymethyl]piperidin-3-yl]ethanesulfonamide
   Show/Hide
C19H36N2O4S
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0573592
N-[(2R,3R)-1-acetyl-2-[(4-propan-2-ylcyclohexyl)oxymethyl]piperidin-3-yl]ethanesulfonamide
   Show/Hide
C19H36N2O4S
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0578033
CHEMBL5073349
   Show/Hide
C19H36N2O4S
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0578323
[(2R,3S)-1-acetyl-2-[(4-propan-2-ylcyclohexyl)oxymethyl]piperidin-3-yl]carbamic acid
   Show/Hide
C18H32N2O4
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0546793
N-[2-[3-[[5-(3-aminophenyl)-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-2-methoxybenzamide
   Show/Hide
C29H30N4O5S
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0555909
methyl (2R,3S,5R)-3-(fluoromethylsulfamoylamino)-2-[[4-(3-fluorophenyl)cyclohexyl]oxymethyl]-5-methylpyrrolidine-1-carboxylate
   Show/Hide
C21H31F2N3O5S
 1
1
IC50 = 0.23 nM
   TI
   LI
   LO
   TS
CP0565444
US11098029, Example 67
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C22H34FN3O5S
 1
1
IC50 = 0.23 nM
   TI
   LI
   LO
   TS
CP0555908
US11098029, Example 25
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C21H32FN3O5S
 1
1
IC50 = 0.27 nM
   TI
   LI
   LO
   TS
CP0943811
methyl (2R,3S,5R)-2-[[(1S,3R,4R)-3,4-dideuterio-4-(3-fluorophenyl)cyclohexoxy]methyl]-3-(dimethylsulfamoylamino)-5-methyl-pyrrolidine-1-carboxylate
   Show/Hide
C22H34FN3O5S
 1
1
IC50 = 0.46 nM
   TI
   LI
   LO
   TS
CP0425737
methyl (2R,3S,5R)-2-[[4-(2,5-difluorophenyl)cyclohexyl]oxymethyl]-5-methyl-3-(methylsulfamoylamino)pyrrolidine-1-carboxylate
   Show/Hide
C21H31F2N3O5S
 1
1
IC50 = 0.47 nM
   TI
   LI
   LO
   TS
CP0478979
US11098029, Example 18
   Show/Hide
C21H33N3O5S
 1
1
IC50 = 0.5 nM
   TI
   LI
   LO
   TS
CP0240486
[(2S)-2-[[4-(4-fluorophenyl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C24H23FN6O2
 1
1
IC50 = 0.784 nM
   TI
   LI
   LO
   TS
CP0567781
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C23H22FN7O2
 1
1
IC50 = 1.27 nM
   TI
   LI
   LO
   TS
CP0329822
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]piperidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C24H24FN7O
 1
1
IC50 = 1.64 nM
   TI
   LI
   LO
   TS
CP0479636
[(2S)-2-[[4-(5-fluoropyridin-2-yl)triazol-2-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C22H21FN8O2
 1
1
IC50 = 1.88 nM
   TI
   LI
   LO
   TS
CP0240488
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[5-fluoro-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C22H19F2N7O2
 1
1
IC50 = 1.96 nM
   TI
   LI
   LO
   TS
CP0520900
[(2S)-2-[[1-(5-fluoropyridin-2-yl)pyrazol-4-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C23H22FN7O2
 1
1
IC50 = 2.03 nM
   TI
   LI
   LO
   TS
CP0520897
[(2S)-2-[[4-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C23H22FN7O2
 1
1
IC50 = 2.21 nM
   TI
   LI
   LO
   TS
CP0437404
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C22H20FN7O2
 1
1
IC50 = 2.62 nM
   TI
   LI
   LO
   TS
CP0403779
N-ethyl-N-[2-[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]ethyl]-5-methyl-2-(triazol-2-yl)benzamide
   Show/Hide
C22H22FN7O
 1
1
IC50 = 2.81 nM
   TI
   LI
   LO
   TS
CP0338972
[(2S)-2-[[4-(5-fluoropyridin-2-yl)triazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C22H21FN8O2
 1
1
IC50 = 3.07 nM
   TI
   LI
   LO
   TS
CP0322680
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C23H22FN7O
 1
1
IC50 = 3.15 nM
   TI
   LI
   LO
   TS
CP0322682
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-(5-methyl-2-pyrimidin-2-ylphenyl)methanone
   Show/Hide
C25H23FN6O2
 1
1
IC50 = 3.18 nM
   TI
   LI
   LO
   TS
CP0225046
[(4S)-4-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C23H22FN7O2
 1
1
IC50 = 3.41 nM
   TI
   LI
   LO
   TS
CP0162718
[(2S)-2-[[5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C22H20FN7O3
 1
1
IC50 = 3.6 nM
   TI
   LI
   LO
   TS
CP0479637
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-(5-fluoro-2-pyrimidin-2-ylphenyl)methanone
   Show/Hide
C24H20F2N6O2
 1
1
IC50 = 4.58 nM
   TI
   LI
   LO
   TS
CP0477767
4-(5-fluoropyridin-2-yl)-2-[[(2S)-3-[5-methyl-2-(triazol-2-yl)benzoyl]-1,3-oxazinan-2-yl]methyl]-1,2,4-triazol-3-one
   Show/Hide
C22H21FN8O3
 1
1
IC50 = 5.4 nM
   TI
   LI
   LO
   TS
CP0279489
2-({(3r,6r)-1-[(2- ethoxyphenyl)carbonyl]-6- methylpiperidin-3-yl}oxy)-3- methylpyridine-4-carbonitrile
   Show/Hide
C22H25N3O3
 2
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
2
Ki = 0.7 nM
   TI
   LI
   LO
   TS
CP0398066
[(2R,5R)-2-methyl-5-(4-methylsulfanylpyridin-2-yl)oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C21H23N5O2S
 2
1
IC50 = 6.7 nM
   TI
   LI
   LO
   TS
2
Ki = 0.2 nM
   TI
   LI
   LO
   TS
CP0398072
[(2R,5R)-5-(4-iodopyridin-2-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C20H20IN5O2
 2
1
IC50 = 7.2 nM
   TI
   LI
   LO
   TS
2
Ki = 0.4 nM
   TI
   LI
   LO
   TS
CP0410158
3-methyl-2-{[(3r,6r)-6- methyl-1-{[2-(2h-tetrazol-2- yl)phenyl]carbonyl}piperidin- 3-yl]oxy}pyridine-4- carbonitrile
   Show/Hide
C21H21N7O2
 2
1
IC50 = 7.7 nM
   TI
   LI
   LO
   TS
2
Ki = 1.6 nM
   TI
   LI
   LO
   TS
CP0441197
US9546152, example 1
   Show/Hide
C22H22N6O2
 2
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
2
Ki = 0.4 nM
   TI
   LI
   LO
   TS
CP0441643
[(2R,5R)-2-methyl-5-(5-methylpyridin-2-yl)oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C21H23N5O2
 2
1
IC50 = 9 nM
   TI
   LI
   LO
   TS
2
Ki = 2.6 nM
   TI
   LI
   LO
   TS
CP0064820
Orexin receptor antagonist 1
   Show/Hide
C21H20N6O2
 3
1
IC50 = 9 nM
   TI
   LI
   LO
   TS
2
IC50 = 13 nM
   TI
   LI
   LO
   TS
3
Ki = 1.6 nM
   TI
   LI
   LO
   TS
CP0535977
2-({(3r,6r)-1-[(2- cyclopropylphenyl)carbonyl]- 6-methylpiperidin-3-yl}oxy)-3- methylpyridine-4-carbonitrile
   Show/Hide
C23H25N3O2
 2
1
IC50 = 9 nM
   TI
   LI
   LO
   TS
2
Ki = 0.7 nM
   TI
   LI
   LO
   TS
CP0415395
[(2R,5R)-5-(4-bromopyridin-2-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C20H20BrN5O2
 2
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
2
Ki = 1.8 nM
   TI
   LI
   LO
   TS
CP0415396
[(2R,5R)-5-(4-ethynylpyridin-2-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C22H21N5O2
 2
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
2
Ki = 0.6 nM
   TI
   LI
   LO
   TS
CP0414622
[(2R,5R)-5-(4-chloropyridin-2-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C20H20ClN5O2
 2
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
2
Ki = 1.4 nM
   TI
   LI
   LO
   TS
CP0486988
[(2R,5R)-5-(4-ethylpyridin-2-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C22H25N5O2
 2
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
2
Ki = 0.6 nM
   TI
   LI
   LO
   TS
CP0560368
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazolidin-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C22H20FN7O2
 1
1
IC50 = 12.1 nM
   TI
   LI
   LO
   TS
CP0448293
[(2R,5R)-5-(4-methoxypyridin-2-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C21H23N5O3
 2
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
2
Ki = 1.3 nM
   TI
   LI
   LO
   TS
CP0088519
2-{[(3r,6r)-1-{[4-methoxy-2- (2h-1,2,3-triazol-2- yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]oxy}-3- methylpyridine-4-carbonitrile
   Show/Hide
C23H24N6O3
 2
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
2
Ki = 1.3 nM
   TI
   LI
   LO
   TS
CP0441215
2-{[(3R,6R)-6-methyl-1-{[2-(2H- 1,2,3-triazol-2- yl)phenyl]carbonyl}piperidin-3- yl]sulfanyl}pyridine-4-carbonitrile
   Show/Hide
C21H20N6OS
 2
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
2
Ki = 1.7 nM
   TI
   LI
   LO
   TS
CP0520899
[(4R)-4-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-thiazolidin-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C22H20FN7OS
 1
1
IC50 = 13.1 nM
   TI
   LI
   LO
   TS
CP0240487
[(3R)-3-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]morpholin-4-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C23H22FN7O2
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0441636
[(2R,5R)-2-methyl-5-(4-methylsulfonylpyridin-2-yl)oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C21H23N5O4S
 2
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
2
Ki = 0.9 nM
   TI
   LI
   LO
   TS
CP0441642
[(2R,5R)-2-methyl-5-(4-methylpyridin-2-yl)oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C21H23N5O2
 2
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
2
Ki = 2.6 nM
   TI
   LI
   LO
   TS
CP0391757
3-methyl-2-{[(3r,6r)-6- methyl-1-{[2- (trifluoromethoxy)phenyl] carbonyl}piperidin-3- yl]oxy}pyridine-4-carbonitrile
   Show/Hide
C21H20F3N3O3
 2
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
2
Ki = 0.8 nM
   TI
   LI
   LO
   TS
CP0445513
[(2R,5R)-2-methyl-5-[4-(trifluoromethyl)pyridin-2-yl]oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C21H20F3N5O2
 2
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
2
Ki = 0.2 nM
   TI
   LI
   LO
   TS
CP0417070
US9586950, 1
   Show/Hide
C23H22N6O4
 2
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
2
Ki = 0.5 nM
   TI
   LI
   LO
   TS
CP0447275
US9556190, Example 1
   Show/Hide
C24H25N5O4
 2
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
2
Ki = 2.2 nM
   TI
   LI
   LO
   TS
CP0459404
ethyl 2-[(2R,5R)-5-(4-cyanopyridin-2-yl)oxy-2-methylpiperidine-1-carbonyl]benzoate
   Show/Hide
C22H23N3O4
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0459405
methyl 2-[(2R,5R)-5-(4-cyanopyridin-2-yl)oxy-2-methylpiperidine-1-carbonyl]benzoate
   Show/Hide
C21H21N3O4
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0283227
US9546152, example 2
   Show/Hide
C22H23N7O3
 2
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
2
Ki = 3 nM
   TI
   LI
   LO
   TS
CP0410157
3-methyl-2-{[(3r,6r)-6- methyl-1-{[2- (trifluoromethyl)phenyl]carbonyl} piperidin-3- yl]oxy}pyridine-4-carbonitrile
   Show/Hide
C21H20F3N3O2
 2
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
2
Ki = 3.1 nM
   TI
   LI
   LO
   TS
CP0398071
methyl 2-[(3R,6R)-6-methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]oxypyridine-4-carboxylate
   Show/Hide
C22H23N5O4
 2
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
2
Ki = 3.9 nM
   TI
   LI
   LO
   TS
CP0436506
US9546152, example 84
   Show/Hide
C21H24N4O3S
 2
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
2
Ki = 2 nM
   TI
   LI
   LO
   TS
CP0417073
methyl 2-[(3R,6R)-6-methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]sulfanylpyridine-3-carboxylate
   Show/Hide
C22H23N5O3S
 2
1
IC50 = 24 nM
   TI
   LI
   LO
   TS
2
Ki = 0.8 nM
   TI
   LI
   LO
   TS
CP0086965
Orexin receptor antagonist 3
   Show/Hide
C22H21N5O3
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0447277
3-methyl-2-({(3r,6r)-6- methyl-1-[(2-phenylpyridin-3- yl)carbonyl]piperidin-3- yl}oxy)pyridine-4-carbonitrile
   Show/Hide
C25H24N4O2
 2
1
IC50 = 26 nM
   TI
   LI
   LO
   TS
2
Ki = 2.6 nM
   TI
   LI
   LO
   TS
CP0074339
Orexin receptor antagonist 2
   Show/Hide
C23H21N5O2
 2
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
2
Ki = 1.3 nM
   TI
   LI
   LO
   TS
CP0391725
US9546152, example 89
   Show/Hide
C21H20BrN7O2
 2
1
IC50 = 29 nM
   TI
   LI
   LO
   TS
2
Ki = 5.1 nM
   TI
   LI
   LO
   TS
CP0397863
3-methyl-2-({(3r,6r)-6- methyl-1-[(2-pyrrolidin-1- ylphenyl)carbonyl]piperidin-3- yl}oxy)pyridine-4-carbonitrile
   Show/Hide
C24H28N4O2
 2
1
IC50 = 29 nM
   TI
   LI
   LO
   TS
2
Ki = 3.4 nM
   TI
   LI
   LO
   TS
CP0410159
2-(((3R,6R)-1-(2-(2H-1,2,3-Triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile
   Show/Hide
C21H21N7O
 2
1
IC50 = 29 nM
   TI
   LI
   LO
   TS
2
Ki = 0.9 nM
   TI
   LI
   LO
   TS
CP0555072
2-[(3R,6R)-6-methyl-1-[2-(2,2,2-trifluoroethyl)benzoyl]piperidin-3-yl]oxypyridine-4-carbonitrile
   Show/Hide
C21H20F3N3O2
 1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0397828
2-({(3r,6r)-1-[(2-cyclopropyl- 6-methoxypyridin-3- yl)carbonyl]-6- methylpiperidin-3-yl}oxy)-3- methylpyridine-4-carbonitrile
   Show/Hide
C23H26N4O3
 2
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
2
Ki = 1.7 nM
   TI
   LI
   LO
   TS
CP0398070
[(2R,5R)-2-methyl-5-(6-methylpyridin-2-yl)oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C21H23N5O2
 2
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
2
Ki = 7.6 nM
   TI
   LI
   LO
   TS
CP0441640
[(2R,5R)-5-(4-fluoropyridin-2-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C20H20FN5O2
 2
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
2
Ki = 3.9 nM
   TI
   LI
   LO
   TS
CP0454454
methyl 2-[(3R,6R)-6-methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]oxypyridine-3-carboxylate
   Show/Hide
C22H23N5O4
 2
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
2
Ki = 2.5 nM
   TI
   LI
   LO
   TS
CP0448331
2-[(3R,6R)-1-[2-(difluoromethoxy)benzoyl]-6-methylpiperidin-3-yl]oxypyridine-4-carbonitrile
   Show/Hide
C20H19F2N3O3
 1
1
IC50 = 37 nM
   TI
   LI
   LO
   TS
CP0441635
propan-2-yl 2-[(2R,5R)-5-(4-cyanopyridin-2-yl)oxy-2-methylpiperidine-1-carbonyl]benzoate
   Show/Hide
C23H25N3O4
 1
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
CP0391755
N-[6-[(2R,5R)-5-(4-cyano-3-methylpyridin-2-yl)oxy-2-methylpiperidine-1-carbonyl]-5-phenylpyridin-2-yl]acetamide
   Show/Hide
C27H27N5O3
 2
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
2
Ki = 0.6 nM
   TI
   LI
   LO
   TS
CP0397830
N-[4-[(2R,5R)-5-(4-cyano-3-methylpyridin-2-yl)oxy-2-methylpiperidine-1-carbonyl]-5-phenylpyridin-2-yl]acetamide
   Show/Hide
C27H27N5O3
 2
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
2
Ki = 0.7 nM
   TI
   LI
   LO
   TS
CP0441196
methyl 2-[[(3R,6R)-6-methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]amino]pyridine-3-carboxylate
   Show/Hide
C22H24N6O3
 2
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
2
Ki = 0.4 nM
   TI
   LI
   LO
   TS
CP0133670
N-ethyl-N-[2-[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]ethyl]-2-(triazol-2-yl)benzamide
   Show/Hide
C21H20FN7O
 1
1
IC50 = 38.7 nM
   TI
   LI
   LO
   TS
CP0530447
[(2R,5R)-2-methyl-5-(4-phenylpyridin-2-yl)oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C26H25N5O2
 2
1
IC50 = 45 nM
   TI
   LI
   LO
   TS
2
Ki = 3.8 nM
   TI
   LI
   LO
   TS
CP0520898
[(2R)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]piperidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C24H24FN7O
 1
1
IC50 = 52.4 nM
   TI
   LI
   LO
   TS
CP0417071
2-({(3r,6r)-1-[(6-methoxy- 2,4'-bipyridin-3-yl)carbonyl]- 6-methylpiperidin-3-yl}oxy)-3- methylpyridine-4-carbonitrile
   Show/Hide
C25H25N5O3
 2
1
IC50 = 65 nM
   TI
   LI
   LO
   TS
2
Ki = 8.9 nM
   TI
   LI
   LO
   TS
CP0441195
3-methyl-2-({(3r,6r)-6- methyl-1-[(3-phenylpyridin-4- yl)carbonyl]piperidin-3- yl}oxy)pyridine-4-carbonitrile
   Show/Hide
C25H24N4O2
 2
1
IC50 = 69 nM
   TI
   LI
   LO
   TS
2
Ki = 16.6 nM
   TI
   LI
   LO
   TS
CP0441641
N,N-dimethyl-2-[(3R,6R)-6-methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]oxypyridine-4-carboxamide
   Show/Hide
C23H26N6O3
 2
1
IC50 = 95 nM
   TI
   LI
   LO
   TS
2
Ki = 6.5 nM
   TI
   LI
   LO
   TS
CP0448330
[(2R,5R)-5-[4-(dimethylamino)pyridin-2-yl]oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C22H26N6O2
 2
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
2
Ki = 4.5 nM
   TI
   LI
   LO
   TS
CP0322681
[(4R)-4-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazolidin-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C22H20FN7O2
 1
1
IC50 = 133 nM
   TI
   LI
   LO
   TS
CP0244025
[(2R)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C23H22FN7O2
 1
1
IC50 = 274 nM
   TI
   LI
   LO
   TS
CP0338971
[(2R)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C23H22FN7O
 1
1
IC50 = 313 nM
   TI
   LI
   LO
   TS
CP0162716
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-thiazolidin-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C22H20FN7OS
 1
1
IC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0484907
[(2R)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazolidin-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C22H20FN7O2
 1
1
IC50 = 2320 nM
   TI
   LI
   LO
   TS
CP0381084
(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(benzenesulfonyl)-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C31H32N2O7S
 2
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
2
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0429699
(E)-N-[(4R,4aS,7S,7aR,12bS)-3-(benzenesulfonyl)-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C31H32N2O7S
 2
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
2
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0489021
(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(benzenesulfonyl)-4a-hydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C30H30N2O6S
 1
1
IC50 >= 10000 nM
   TI
   LI
   LO
   TS
CP0521759
(E)-N-[(1R,9R,10S,13R)-17-(benzenesulfonyl)-10-hydroxy-4-methoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C31H34N2O6S
 2
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
2
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0542988
4-methoxy-N-[3-[(1R,3S,4R,7R,9S)-9-[3-[(4-methoxybenzoyl)amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C36H35N3O7
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0550047
4-methoxy-N-[3-[(1S,3R,4S,7S,9R)-9-[3-[(4-methoxybenzoyl)amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C36H35N3O7
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0551691
4-(dimethylamino)-N-[3-[(1S,3S,4S,7S,9S)-9-[3-[[4-(dimethylamino)benzoyl]amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C38H41N5O5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0551695
2-(dimethylamino)-N-[3-[(1S,3R,4S,7S,9R)-9-[3-[[2-(dimethylamino)benzoyl]amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C38H41N5O5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0551696
N-[3-[(1S,3R,4S,7S,9R)-3,9-dimethyl-9-[3-(pyridine-4-carbonylamino)phenyl]-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]pyridine-4-carboxamide
   Show/Hide
C32H29N5O5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0551698
3-(dimethylamino)-N-[3-[(1S,3R,4S,7S,9R)-9-[3-[[3-(dimethylamino)benzoyl]amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C38H41N5O5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0551699
4-methoxy-N-[3-[9-[3-[(4-methoxybenzoyl)amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C36H35N3O7
 2
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
2
Ki = 16.7 nM
   TI
   LI
   LO
   TS
CP0568637
4-(dimethylamino)-N-[3-[(1S,3R,4S,7S,9R)-9-[3-[[4-(dimethylamino)benzoyl]amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C38H41N5O5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0568638
N-[3-[(1S,3R,4S,7S,9R)-9-(3-benzamidophenyl)-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C34H31N3O5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0569988
N-[3-[(1S,3R,4S,7S,9R)-3,9-dimethyl-9-[3-(pyridine-2-carbonylamino)phenyl]-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]pyridine-2-carboxamide
   Show/Hide
C32H29N5O5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0570847
3-methoxy-N-[3-[(1S,3R,4S,7S,9R)-9-[3-[(3-methoxybenzoyl)amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C36H35N3O7
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0575201
3-(dimethylamino)-N-[3-[(1S,3S,4S,7S,9S)-9-[3-[[3-(dimethylamino)benzoyl]amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C38H41N5O5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0576137
2-(dimethylamino)-N-[3-[(1S,3S,4S,7S,9S)-9-[3-[[2-(dimethylamino)benzoyl]amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C38H41N5O5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0579158
N-[3-[(1S,3R,4S,7S,9R)-3,9-dimethyl-9-[3-(pyridine-3-carbonylamino)phenyl]-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]pyridine-3-carboxamide
   Show/Hide
C32H29N5O5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0064578
1-(2,4-dibromophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea
   Show/Hide
C19H20Br2N2O3
 1
1
Ki = 5.012 nM
   TI
   LI
   LO
   TS
CP0575202
N-[3-[(1S,3S,4S,7S,9S)-9-(3-benzamidophenyl)-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]-3-methoxybenzamide
   Show/Hide
C35H33N3O6
 1
1
Ki = 5.38 nM
   TI
   LI
   LO
   TS
CP0569609
4-methoxy-N-[3-[(1S,3S,4S,7S,9S)-9-[3-[(4-methoxybenzoyl)amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C36H35N3O7
 1
1
Ki = 6.01 nM
   TI
   LI
   LO
   TS
CP0571097
N-[3-[(1S,3S,4S,7S,9S)-9-(3-benzamidophenyl)-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C34H31N3O5
 1
1
Ki = 15.1 nM
   TI
   LI
   LO
   TS
CP0580119
4-methoxy-N-[3-[(1R,3R,4R,7R,9R)-9-[3-[(4-methoxybenzoyl)amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C36H35N3O7
 1
1
Ki = 26.6 nM
   TI
   LI
   LO
   TS
CP0551697
N-[3-[(1S,3S,4S,7S,9S)-9-(3-benzamidophenyl)-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]-2-methoxybenzamide
   Show/Hide
C35H33N3O6
 1
1
Ki = 56 nM
   TI
   LI
   LO
   TS
CP0570848
N-[3-[(1S,3S,4S,7S,9S)-3,9-dimethyl-9-[3-(pyridine-2-carbonylamino)phenyl]-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]pyridine-2-carboxamide
   Show/Hide
C32H29N5O5
 1
1
Ki = 69.6 nM
   TI
   LI
   LO
   TS
CP0468868
(E)-N-[(1S,9R,10R,13S)-17-(benzenesulfonyl)-4-methoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C31H34N2O5S
 1
1
Ki = 79.9 nM
   TI
   LI
   LO
   TS
CP0526040
(E)-N-[(1R,9R,10S,13S)-17-(benzenesulfonyl)-10-hydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadec-2(7)-en-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C30H36N2O5S
 1
1
Ki = 91.9 nM
   TI
   LI
   LO
   TS
CP0530719
(E)-N-[(4R,7S,7aR,12bS)-3-(benzenesulfonyl)-9-methoxy-2,4,6,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C31H30N2O6S
 1
1
Ki = 123 nM
   TI
   LI
   LO
   TS
CP0474022
(E)-N-[(1R,9R,10S,13S)-17-(benzenesulfonyl)-10-hydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C30H32N2O5S
 1
1
Ki = 173 nM
   TI
   LI
   LO
   TS
CP0544810
N-[3-[(1S,3S,4S,7S,9S)-3,9-dimethyl-9-[3-(pyridine-4-carbonylamino)phenyl]-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]pyridine-4-carboxamide
   Show/Hide
C32H29N5O5
 1
1
Ki = 179 nM
   TI
   LI
   LO
   TS
CP0572986
tert-butyl N-[3-[(1S,3S,4S,6S,7S)-3,6-dimethyl-6-[3-[(2-methylpropan-2-yl)oxycarbonylamino]phenyl]-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]carbamate
   Show/Hide
C30H39N3O7
 1
1
Ki = 180 nM
   TI
   LI
   LO
   TS
CP0576136
N-[4-[(1S,3R,4S,7S,9S)-9-[3-(benzenesulfonamido)phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzenesulfonamide
   Show/Hide
C32H31N3O7S2
 1
1
Ki = 222 nM
   TI
   LI
   LO
   TS
CP0562830
N-[3-[(1S,3S,4S,7S,9S)-3,9-dimethyl-9-[3-(pyridine-3-carbonylamino)phenyl]-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]pyridine-3-carboxamide
   Show/Hide
C32H29N5O5
 1
1
Ki = 261 nM
   TI
   LI
   LO
   TS
CP0474023
(E)-N-[(1R,9R,10S,13S)-17-(benzenesulfonyl)-10-hydroxy-4-methoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C31H34N2O6S
 1
1
Ki = 294 nM
   TI
   LI
   LO
   TS
CP0415397
[(2R,5R)-2-methyl-5-(3-methylpyridin-2-yl)oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C21H23N5O2
 1
1
Ki = 621 nM
   TI
   LI
   LO
   TS
CP0550046
3-[(1S,3S,4S,7S,9S)-9-[3-(dimethylamino)phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]-N,N-dimethylaniline
   Show/Hide
C24H31N3O3
 1
1
Ki = 655 nM
   TI
   LI
   LO
   TS
CP0551690
2-methoxy-N-[3-[(1S,3R,4S,7S,9R)-9-[3-[(3-methoxybenzoyl)amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
   Show/Hide
C36H35N3O7
 1
1
Ki = 722 nM
   TI
   LI
   LO
   TS
CP0539028
(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-(4-methylbenzoyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C33H34N2O6
 1
1
Ki = 725 nM
   TI
   LI
   LO
   TS
CP0863976
1-(6,8-Difluoro-2-methylquinolin-4-yl)-3-[4-(dimethylamino)phenyl]urea Dihydrochloride
   Show/Hide
C19H20Cl2F2N4O
 1
1
Ki = 2070 nM
   TI
   LI
   LO
   TS
CP0414351
[(2R,5R)-2-methyl-5-pyridin-2-yloxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
   Show/Hide
C20H21N5O2
 1
1
Ki = 2400 nM
   TI
   LI
   LO
   TS
CP0469646
(E)-N-[(4R,4aR,7R,7aR,12bS)-3-(benzenesulfonyl)-9-methoxy-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C31H32N2O6S
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0532155
(E)-N-[(4R,7R,7aR,12bS)-3-(benzenesulfonyl)-9-methoxy-2,4,6,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C31H30N2O6S
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0557356
(E)-N-[(4R,4aR,7S,7aR,12bS)-3-(benzenesulfonyl)-9-methoxy-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C31H32N2O6S
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0416647
(E)-N-[(1R,9R,13S)-17-(benzenesulfonyl)-4-methoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,10-tetraen-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C31H32N2O5S
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0416648
(E)-N-[(1R,9R,10S,13R)-17-(benzenesulfonyl)-10-hydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadec-2(7)-en-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C30H36N2O5S
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0416649
(E)-N-[(1R,9R,10S,13R)-17-(benzenesulfonyl)-10-hydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C30H32N2O5S
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0474021
(E)-N-[(1R,9R,13R)-17-(benzenesulfonyl)-4-methoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,10-tetraen-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C31H32N2O5S
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0526039
(E)-N-[(1S,9R,10R,13R)-17-(benzenesulfonyl)-4-methoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C31H34N2O5S
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0384267
(E)-N-[(1R,2S,5S,6R,14S)-6-[benzenesulfonyl(cyclopropylmethyl)amino]-5-hydroxy-11-methoxy-15-oxatetracyclo[10.2.1.05,14.08,13]pentadeca-8(13),9,11-trien-2-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C33H36N2O7S
 1
1
Ki > 10 nM
   TI
   LI
   LO
   TS
CP0413999
(E)-N-[(1R,2R,5R,6R,14S)-6-[benzenesulfonyl(cyclopropylmethyl)amino]-11-methoxy-15-oxatetracyclo[10.2.1.05,14.08,13]pentadeca-8(13),9,11-trien-2-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C33H36N2O6S
 1
1
Ki > 10 nM
   TI
   LI
   LO
   TS
CP0416552
(E)-N-[(3S,4aR,10R,10aS)-10-[benzenesulfonyl(cyclopropylmethyl)amino]-10a-hydroxy-6-methoxy-2,3,4,4a,9,10-hexahydro-1H-phenanthren-3-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C33H38N2O6S
 1
1
Ki > 10 nM
   TI
   LI
   LO
   TS
CP0520808
(E)-N-[(3R,4aS,10R,10aR)-10-[benzenesulfonyl(cyclopropylmethyl)amino]-6-methoxy-1,2,3,4,4a,9,10,10a-octahydrophenanthren-3-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C33H38N2O5S
 1
1
Ki > 10 nM
   TI
   LI
   LO
   TS
CP0530089
(E)-N-[(3S,4aS,10R,10aR)-10-[benzenesulfonyl(cyclopropylmethyl)amino]-6-methoxy-1,2,3,4,4a,9,10,10a-octahydrophenanthren-3-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C33H38N2O5S
 1
1
Ki > 10 nM
   TI
   LI
   LO
   TS
CP0530090
(E)-N-[(3R,4aR,10R,10aS)-10-[benzenesulfonyl(cyclopropylmethyl)amino]-10a-hydroxy-6-methoxy-2,3,4,4a,9,10-hexahydro-1H-phenanthren-3-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C33H38N2O6S
 1
1
Ki > 10 nM
   TI
   LI
   LO
   TS
CP0535214
(E)-N-[(1R,2S,5R,6R,14S)-6-[benzenesulfonyl(cyclopropylmethyl)amino]-11-methoxy-15-oxatetracyclo[10.2.1.05,14.08,13]pentadeca-8(13),9,11-trien-2-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C33H36N2O6S
 1
1
Ki > 10 nM
   TI
   LI
   LO
   TS
CP0554291
(E)-N-[(1R,2R,5S,6R,14S)-6-[benzenesulfonyl(cyclopropylmethyl)amino]-5-hydroxy-11-methoxy-15-oxatetracyclo[10.2.1.05,14.08,13]pentadeca-8(13),9,11-trien-2-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
   Show/Hide
C33H36N2O7S
 1
1
Ki > 10 nM
   TI
   LI
   LO
   TS