Brief Information of the Cell Line and Protein
Cell Line ID: CL000026 , CHO-K1
Synonyms
CHO K1
CHOK1
CHO cell clone K1
GM15452
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0214
Protein ID: PT01028 , Ephrin type-B receptor 4
Gene Name EPHB4
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P54760
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000026  Protein ID: PT01028
 
Compound ID Compound Name Compound Formula
CP0233572
2-N-(2,6-dimorpholin-4-ylpyridin-4-yl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamine
   Show/Hide
C25H29N9O2
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0135851
(3-(isopropyl(2-(3-(methylsulfonyl)-5-morpholinophenylamino)pyrimidin-4-yl)amino)-4-methylphenyl)methanol
   Show/Hide
C26H33N5O4S
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0219293
(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-5-methoxyphenyl)methanol
   Show/Hide
C27H34N6O4
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0252925
(3-((2-(2,6-dimorpholinopyridin-4-ylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanol
   Show/Hide
C26H33N7O3
 1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0116958
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamine
   Show/Hide
C26H30N8O2
 1
1
IC50 = 9 nM
   TI
   LI
   LO
   TS
CP0135850
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(3-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine
   Show/Hide
C26H32N6O3
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0207621
(4-methyl-3-(methyl(2-(3-(methylsulfonyl)-5-morpholinophenylamino)pyrimidin-4-yl)amino)phenyl)methanol
   Show/Hide
C24H29N5O4S
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0313104
(4-methyl-3-(methyl(2-(3-morpholino-5-(piperidin-1-yl)phenylamino)pyrimidin-4-yl)amino)phenyl)methanol
   Show/Hide
C28H36N6O2
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0049382
(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanol
   Show/Hide
C27H34N6O3
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0252926
(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(2-methoxyethyl)amino)-4-methylphenyl)methanol
   Show/Hide
C29H38N6O4
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0300435
4-N-(3-chlorophenyl)-2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-methylpyrimidine-2,4-diamine
   Show/Hide
C25H29ClN6O2
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0036684
(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(isopropyl)amino)-4-methylphenyl)methanol
   Show/Hide
C29H38N6O3
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0207638
(2-chloro-5-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)phenyl)methanol
   Show/Hide
C26H31ClN6O3
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0127575
4-N-(5-chloro-1,3-benzodioxol-4-yl)-2-N-(3,5-dimorpholin-4-ylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C25H27ClN6O4
 2
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
2
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0207620
(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(ethyl)amino)-4-methylphenyl)methanol
   Show/Hide
C28H36N6O3
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0253439
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(5-methoxy-2-methylphenyl)-4-N-methylpyrimidine-2,4-diamine
   Show/Hide
C27H34N6O3
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0135843
(4-methyl-3-(methyl(2-(3-morpholino-5-(tetrahydro-2H-pyran-4-yloxy)phenylamino)pyrimidin-4-yl)amino)phenyl)methanol
   Show/Hide
C28H35N5O4
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0116959
2-N-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamine
   Show/Hide
C24H28N10O2
 1
1
IC50 = 24 nM
   TI
   LI
   LO
   TS
CP0252942
(4-methyl-3-(methyl(2-(3-morpholino-5-(morpholinomethyl)phenylamino)pyrimidin-4-yl)amino)phenyl)methanol
   Show/Hide
C28H36N6O3
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0271323
(4-methyl-3-(methyl(2-(3-morpholino-5-(pyrrolidin-1-yl)phenylamino)pyrimidin-4-yl)amino)phenyl)methanol
   Show/Hide
C27H34N6O2
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0102613
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-methyl-4-N-(3-methylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C26H32N6O2
 1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
CP0164812
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-methyl-4-N-(2-methylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C26H32N6O2
 1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
CP0255598
(4-methyl-3-(methyl(2-(3-morpholino-5-(1,4-oxazepan-4-yl)phenylamino)pyrimidin-4-yl)amino)phenyl)methanol
   Show/Hide
C28H36N6O3
 1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
CP0294196
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(6-methoxypyridin-2-yl)-4-N-methylpyrimidine-2,4-diamine
   Show/Hide
C25H31N7O3
 1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
CP0253191
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(5-methoxypyridin-3-yl)-4-N-methylpyrimidine-2,4-diamine
   Show/Hide
C25H31N7O3
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0352321
4-N-(5-chloro-1,3-benzodioxol-4-yl)-2-N-(3-methylsulfonyl-5-morpholin-4-ylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C22H22ClN5O5S
 1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0171140
(3-((2-(3-methoxy-5-morpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanol
   Show/Hide
C24H29N5O3
 1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0253757
(4-methyl-3-(methyl(2-(3-(4-methylpiperazin-1-yl)-5-morpholinophenylamino)pyrimidin-4-yl)amino)phenyl)methanol
   Show/Hide
C28H37N7O2
 1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0300465
(3-((2-(3-(2-methoxyethoxy)-5-morpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanol
   Show/Hide
C26H33N5O4
 1
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0135844
4-N-(2,5-dimethylphenyl)-2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-methylpyrimidine-2,4-diamine
   Show/Hide
C27H34N6O2
 1
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
CP0256544
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(4-methoxypyridin-2-yl)-4-N-methylpyrimidine-2,4-diamine
   Show/Hide
C25H31N7O3
 1
1
IC50 = 41 nM
   TI
   LI
   LO
   TS
CP0225226
4-N-(5-chloro-1,3-benzodioxol-4-yl)-4-N-methyl-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C19H17ClN4O4S
 1
1
IC50 = 42 nM
   TI
   LI
   LO
   TS
CP0271322
4-(3-(4-((5-(hydroxymethyl)-2-methylphenyl)(methyl)amino)pyrimidin-2-ylamino)-5-morpholinophenyl)piperazin-1-ol
   Show/Hide
C27H35N7O3
 1
1
IC50 = 45 nM
   TI
   LI
   LO
   TS
CP0317073
4-N-(1H-indazol-4-yl)-4-N-methyl-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C19H18N6O2S
 1
1
IC50 = 51 nM
   TI
   LI
   LO
   TS
CP0292022
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-methyl-4-N-phenylpyrimidine-2,4-diamine
   Show/Hide
C25H30N6O2
 1
1
IC50 = 84 nM
   TI
   LI
   LO
   TS
CP0315192
(3-((2-(2,6-dimorpholinopyrimidin-4-ylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanol
   Show/Hide
C25H32N8O3
 1
1
IC50 = 106 nM
   TI
   LI
   LO
   TS
CP0222563
(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)phenyl)methanol
   Show/Hide
C26H32N6O3
 1
1
IC50 = 114 nM
   TI
   LI
   LO
   TS
CP0352322
N-[3-[[4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-morpholin-4-ylphenyl]methanesulfonamide
   Show/Hide
C22H23ClN6O5S
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0185785
2,4-Pyrimidine derivative, 25
   Show/Hide
C17H14ClN5O4S
 1
1
IC50 = 172 nM
   TI
   LI
   LO
   TS
CP0218553
1-(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)ethanol
   Show/Hide
C28H36N6O3
 1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0116956
4-N-(1,3-benzodioxol-4-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C18H16N4O4S
 1
1
IC50 = 186 nM
   TI
   LI
   LO
   TS
CP0091881
2,4-Pyrimidine derivative, 28
   Show/Hide
C18H15ClN4O4S
 2
1
IC50 = 187 nM
   TI
   LI
   LO
   TS
2
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0127580
2-((5-chlorobenzo[d][1,3]dioxol-4-yl)(2-(3-(methylsulfonyl)phenylamino)pyrimidin-4-yl)amino)ethanol
   Show/Hide
C20H19ClN4O5S
 1
1
IC50 = 187 nM
   TI
   LI
   LO
   TS
CP0258761
2-((5-chlorobenzo[d][1,3]dioxol-4-yl)(2-(3-(methylsulfonyl)phenylamino)pyrimidin-4-yl)amino)acetonitrile
   Show/Hide
C20H16ClN5O4S
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0554479
2-N-[3,5-bis(methylsulfonyl)phenyl]-4-N-(5-chloro-1,3-benzodioxol-4-yl)pyrimidine-2,4-diamine
   Show/Hide
C19H17ClN4O6S2
 1
1
IC50 = 209 nM
   TI
   LI
   LO
   TS
CP0317074
4-N-(3-chloro-2H-indazol-4-yl)-2-N-(3,5-dimorpholin-4-ylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C25H27ClN8O2
 1
1
IC50 = 227 nM
   TI
   LI
   LO
   TS
CP0315164
(3-(4-((1H-indazol-4-yl)(methyl)amino)pyrimidin-2-ylamino)phenyl)methanol
   Show/Hide
C19H18N6O
 1
1
IC50 = 232 nM
   TI
   LI
   LO
   TS
CP0315162
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(1H-indazol-4-yl)pyrimidine-2,4-diamine
   Show/Hide
C25H28N8O2
 1
1
IC50 = 302 nM
   TI
   LI
   LO
   TS
CP0342840
4-N-(5-chloro-1,3-benzodioxol-4-yl)-4-N-(2-methoxyethyl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C21H21ClN4O5S
 1
1
IC50 = 378 nM
   TI
   LI
   LO
   TS
CP0258762
3-(4-((1H-indazol-4-yl)(methyl)amino)pyrimidin-2-ylamino)-N,N-dimethylbenzamide
   Show/Hide
C21H21N7O
 1
1
IC50 = 453 nM
   TI
   LI
   LO
   TS
CP0256543
(3-(4-((5-(hydroxymethyl)-2-methylphenyl)(methyl)amino)pyrimidin-2-ylamino)-5-morpholinophenyl)(morpholino)methanone
   Show/Hide
C28H34N6O4
 1
1
IC50 = 459 nM
   TI
   LI
   LO
   TS
CP0127578
4-N-(1-benzofuran-7-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C19H16N4O3S
 1
1
IC50 = 460 nM
   TI
   LI
   LO
   TS
CP0258763
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(3-methyl-2H-indazol-4-yl)pyrimidine-2,4-diamine
   Show/Hide
C26H30N8O2
 1
1
IC50 = 513 nM
   TI
   LI
   LO
   TS
CP0086942
N-[3-[[4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]phenyl]methanesulfonamide
   Show/Hide
C18H16ClN5O4S
 1
1
IC50 = 741 nM
   TI
   LI
   LO
   TS
CP0369740
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(1H-indol-4-yl)pyrimidine-2,4-diamine
   Show/Hide
C26H29N7O2
 1
1
IC50 = 856 nM
   TI
   LI
   LO
   TS
CP0336576
3-(4-(5-chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)-5-morpholinobenzamide
   Show/Hide
C22H21ClN6O4
 1
1
IC50 = 887 nM
   TI
   LI
   LO
   TS
CP0369739
4-N-(6-chloro-1-benzofuran-7-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C19H15ClN4O3S
 1
1
IC50 = 897 nM
   TI
   LI
   LO
   TS
CP0090272
3-(4-(5-chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)benzamide
   Show/Hide
C18H14ClN5O3
 1
1
IC50 = 900 nM
   TI
   LI
   LO
   TS
CP0317733
4-N-(1,3-benzoxazol-7-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C18H15N5O3S
 1
1
IC50 = 1350 nM
   TI
   LI
   LO
   TS
CP0127579
4-N-(2,3-dihydro-1-benzofuran-7-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C19H18N4O3S
 1
1
IC50 = 1720 nM
   TI
   LI
   LO
   TS
CP0317072
4-N-(1,3-benzoxazol-4-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C18H15N5O3S
 1
1
IC50 = 1760 nM
   TI
   LI
   LO
   TS
CP0197707
N-[3-[[4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-methylsulfonylphenyl]methanesulfonamide
   Show/Hide
C19H18ClN5O6S2
 1
1
IC50 = 2054 nM
   TI
   LI
   LO
   TS
CP0258760
4-N-(1H-indazol-4-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C18H16N6O2S
 1
1
IC50 = 2530 nM
   TI
   LI
   LO
   TS
CP0116957
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(1H-indazol-7-yl)pyrimidine-2,4-diamine
   Show/Hide
C25H28N8O2
 1
1
IC50 = 3500 nM
   TI
   LI
   LO
   TS
CP0315163
(3-(4-(1H-indazol-4-ylamino)pyrimidin-2-ylamino)phenyl)methanol
   Show/Hide
C18H16N6O
 1
1
IC50 = 4400 nM
   TI
   LI
   LO
   TS
CP0511559
N-[3-[[4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-(methanesulfonamido)phenyl]methanesulfonamide
   Show/Hide
C19H19ClN6O6S2
 1
1
IC50 = 7175 nM
   TI
   LI
   LO
   TS
CP0342841
N-[3-[[4-(1H-indazol-4-ylamino)pyrimidin-2-yl]amino]phenyl]methanesulfonamide
   Show/Hide
C18H17N7O2S
 1
1
IC50 = 8420 nM
   TI
   LI
   LO
   TS
CP0105791
4-N-(2H-benzotriazol-4-yl)-2-N-(3,5-dimorpholin-4-ylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C24H27N9O2
 1
1
IC50 = 8600 nM
   TI
   LI
   LO
   TS
CP0233571
3-(4-(1H-indazol-4-ylamino)pyrimidin-2-ylamino)-N,N-dimethylbenzamide
   Show/Hide
C20H19N7O
 1
1
IC50 = 10400 nM
   TI
   LI
   LO
   TS
CP0342842
2-N-(4,6-dimorpholin-4-ylpyrimidin-2-yl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamine
   Show/Hide
C24H28N10O2
 1
1
IC50 = 12000 nM
   TI
   LI
   LO
   TS
CP0554480
3-(4-(5-chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)-5-(methylsulfonamido)benzenesulfonamide
   Show/Hide
C18H17ClN6O6S2
 1
1
IC50 = 14117 nM
   TI
   LI
   LO
   TS
CP0206903
3-(4-(5-chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)-5-(methylsulfonyl)benzamide
   Show/Hide
C19H16ClN5O5S
 1
1
IC50 = 22200 nM
   TI
   LI
   LO
   TS
CP0197708
5-(4-(5-chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)isophthalamide
   Show/Hide
C19H15ClN6O4
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0344908
3-(4-(5-chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)-5-(methylsulfonamido)benzamide
   Show/Hide
C19H17ClN6O5S
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS