| Compound ID |
Compound Name |
Compound Formula |
|
CP0001158
|
US9284315, BEZ-235
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|
C30H23N5O
|
1
|
| 1 |
IC50 = 5.3 nM
|
|
|
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CP0579027
|
(4S,5S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-5-(hydroxymethyl)-4-methyl-1,3-oxazolidin-2-one
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|
C18H20F3N7O4
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
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CP0576748
|
(4S,5R)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-(hydroxymethyl)-5-methyl-1,3-oxazolidin-2-one
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|
C18H20F3N7O4
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
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CP0576744
|
(4S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-methyl-1,3-oxazolidin-2-one
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|
C17H18F3N7O3
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
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CP0007893
|
4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine
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|
C23H27N7O3S2
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
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CP0125999
|
2-amino-5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-1H-pyrimidin-6-one
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|
C16H21N7O3
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
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CP0545315
|
(4S,5R)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-5-(hydroxymethyl)-4-methyl-1,3-oxazolidin-2-one
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|
C18H20F3N7O4
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
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CP0548467
|
(4S,5S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-(hydroxymethyl)-5-methyl-1,3-oxazolidin-2-one
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|
C18H20F3N7O4
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
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CP0577684
|
5-[6-(7-methoxy-2,3-dihydro-1,4-benzoxazin-4-yl)-2-morpholin-4-ylpyrimidin-4-yl]pyrimidin-2-amine
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|
C21H23N7O3
|
1
|
| 1 |
IC50 = 108 nM
|
|
|
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CP0573794
|
(4S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-[(1S)-1-hydroxyethyl]-1,3-oxazolidin-2-one
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|
C18H20F3N7O4
|
1
|
| 1 |
IC50 = 109 nM
|
|
|
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CP0545313
|
(4S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-(hydroxymethyl)-1,3-oxazolidin-2-one
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|
C17H18F3N7O4
|
1
|
| 1 |
IC50 = 116 nM
|
|
|
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CP0001930
|
5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine
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|
C18H21F3N6O2
|
1
|
| 1 |
IC50 = 117 nM
|
|
|
|
CP0188346
|
5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyrimidin-2-amine
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|
C17H20F3N7O2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
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CP0545312
|
(4S)-3-[4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-methyl-1,3-oxazolidin-2-one
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|
C18H19F3N6O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
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CP0543347
|
(4S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-(hydroxymethyl)-5,5-dimethyl-1,3-oxazolidin-2-one
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|
C19H22F3N7O4
|
1
|
| 1 |
IC50 = 134 nM
|
|
|
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CP0576745
|
(5R)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
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|
C17H18F3N7O4
|
1
|
| 1 |
IC50 = 158 nM
|
|
|
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CP0577015
|
(3aS,6aS)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]oxazol-2-one
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|
C18H18F3N7O4
|
1
|
| 1 |
IC50 = 214 nM
|
|
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CP0568134
|
(4S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-(hydroxymethyl)-4-methyl-1,3-oxazolidin-2-one
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|
C18H20F3N7O4
|
1
|
| 1 |
IC50 = 215 nM
|
|
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CP0574438
|
1-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]-1,3-dimethylurea
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|
C17H20F3N7O2
|
1
|
| 1 |
IC50 = 249 nM
|
|
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CP0543348
|
(4R)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-(hydroxymethyl)-1,3-oxazolidin-2-one
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|
C17H18F3N7O4
|
1
|
| 1 |
IC50 = 256 nM
|
|
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CP0576740
|
3-[6-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-2-morpholin-4-ylpyrimidin-4-yl]-1,3-oxazolidin-2-one
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|
C16H16F3N7O3
|
1
|
| 1 |
IC50 = 256 nM
|
|
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CP0546964
|
1-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]pyrrolidin-2-one
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|
C18H19F3N6O2
|
1
|
| 1 |
IC50 = 258 nM
|
|
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CP0579376
|
3-[6-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-2-morpholin-4-ylpyrimidin-4-yl]-1,3-oxazinan-2-one
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|
C17H18F3N7O3
|
1
|
| 1 |
IC50 = 264 nM
|
|
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CP0576741
|
(5S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
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|
C17H18F3N7O4
|
1
|
| 1 |
IC50 = 277 nM
|
|
|
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CP0552713
|
1-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]piperidin-2-one
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|
C19H21F3N6O2
|
1
|
| 1 |
IC50 = 369 nM
|
|
|
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CP0548095
|
2-[(4S,5R)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-5-methyl-2-oxo-1,3-oxazolidin-4-yl]acetonitrile
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|
C19H19F3N8O3
|
1
|
| 1 |
IC50 = 376 nM
|
|
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CP0576738
|
2-amino-5-[6-[2-(2-hydroxyethyl)morpholin-4-yl]-2-morpholin-4-ylpyrimidin-4-yl]pyridine-4-carbonitrile
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|
C20H25N7O3
|
1
|
| 1 |
IC50 = 476 nM
|
|
|
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CP0577685
|
3-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]-1,3-oxazolidin-2-one
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|
C17H17F3N6O3
|
1
|
| 1 |
IC50 = 484 nM
|
|
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CP0568135
|
1-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]imidazolidin-2-one
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|
C17H18F3N7O2
|
1
|
| 1 |
IC50 = 558 nM
|
|
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CP0579116
|
[(3R)-4-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]morpholin-3-yl]methanol
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|
C19H23F3N6O3
|
1
|
| 1 |
IC50 = 601 nM
|
|
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CP0579375
|
1-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]-3-phenylimidazolidin-2-one
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|
C23H22F3N7O2
|
1
|
| 1 |
IC50 = 606 nM
|
|
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CP0576737
|
5-(2,6-dimorpholin-4-ylpyridin-4-yl)-4-(trifluoromethyl)pyridin-2-amine
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|
C19H22F3N5O2
|
1
|
| 1 |
IC50 = 739 nM
|
|
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CP0574436
|
5-[2-morpholin-4-yl-6-(2-phenylmorpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine
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|
C24H25F3N6O2
|
1
|
| 1 |
IC50 = 1247 nM
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CP0552712
|
5-[6-(1,1-dioxo-1,4-thiazinan-4-yl)-2-morpholin-4-ylpyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine
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|
C18H21F3N6O3S
|
1
|
| 1 |
IC50 = 1770 nM
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CP0568133
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1-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]-1-(2-hydroxyethyl)-3-methylurea
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|
C18H22F3N7O3
|
1
|
| 1 |
IC50 = 3060 nM
|
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CP0545314
|
(4S,5R)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-5-methyl-4-[(1-oxo-1,4-thiazinan-4-yl)methyl]-1,3-oxazolidin-2-one
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|
C22H27F3N8O4S
|
1
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| 1 |
IC50 = 4600 nM
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CP0574440
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2-[[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]amino]-3-phenylpropan-1-ol
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|
C23H25F3N6O2
|
1
|
| 1 |
IC50 = 6185 nM
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