2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-5-chlorobenzoic acid

2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-4-chlorobenzoic acid

2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-5-bromobenzoic acid

N-(5-((3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-1H-imidazole-4-sulfonamide

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(3-(phenylsulfonyl)pyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine

2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-4-methoxybenzoic acid

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(isopropylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine

2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-4-bromobenzoic acid

2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-3-bromobenzoic acid

N-[5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]ethanesulfonamide

N-[5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-2,2,2-trifluoroethanesulfonamide

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine

N-[5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]propanamide

N-[5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]cyclopropanecarboxamide

(2R,3S,5R)-5-(1-(cyclopropylsulfonyl)pyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-amine

(2R,3S,5R)-5-(2-(cyclopropylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-amine

(2R,3S,5R)-5-(2-(cyclopentylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-amine

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(3-(isopropylsulfonyl)pyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(3-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine

2-[[4-[(3R)-3-aminopiperidin-1-yl]-3-but-2-ynyl-2,6-dioxopyrimidin-1-yl]methyl]-6-fluorobenzoic acid

N-[5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-1-pyridin-4-ylmethanesulfonamide

N-[5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]cyclopropanesulfonamide

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(ethylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(1-methylimidazol-4-yl)sulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]oxan-3-amine

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-[3-(trifluoromethyl)phenyl]sulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]oxan-3-amine

(2S,3R)-9-methoxy-8-methylsulfonyl-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-benzo[f]chromen-2-amine

2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]benzoic acid

(2S,3R)-8,9-dimethoxy-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-benzo[f]chromen-2-amine

MK-3102

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(phenylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(trifluoromethylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine

2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-5-fluorobenzoic acid

2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-4-cyanobenzoic acid

2-[[4-[(3R)-3-aminopiperidin-1-yl]-3-but-2-ynyl-2,6-dioxopyrimidin-1-yl]methyl]-4-bromobenzoic acid

US8592371, 3

2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile

methyl 2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]benzoate

N-[5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]methanesulfonamide

2-[[4-[(3R)-3-aminopiperidin-1-yl]-3-but-2-ynyl-2,6-dioxopyrimidin-1-yl]methyl]-4-cyanobenzoic acid

N-[5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]pyridine-4-carboxamide

2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-3-chlorobenzoic acid

2-[[4-[(3R)-3-aminopiperidin-1-yl]-3-but-2-ynyl-2,6-dioxopyrimidin-1-yl]methyl]-5-chlorobenzoic acid

(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)butanamide trifluoroacetate

2-[[4-[(3R)-3-aminopiperidin-1-yl]-3-but-2-ynyl-2,6-dioxopyrimidin-1-yl]methyl]-4-methoxybenzoic acid

N-[5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-1,3-thiazole-2-carboxamide

2-[[4-[(3R)-3-aminopiperidin-1-yl]-3-but-2-ynyl-2,6-dioxopyrimidin-1-yl]methyl]-5-bromobenzoic acid

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(1-(1-methyl-1H-imidazol-4-ylsulfonyl)pyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine

methyl 2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-6-fluorobenzoate

(2S,3R)-8-bromo-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-benzo[f]chromen-2-amine

methyl 2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-4-chlorobenzoate

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(propylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine

2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-3-methoxybenzoic acid

N-[(2S,3R)-2-amino-9-methoxy-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-benzo[f]chromen-8-yl]methanesulfonamide

(1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorobenzyl)propylamine

2-[[4-[(3R)-3-aminopiperidin-1-yl]-3-but-2-ynyl-2,6-dioxopyrimidin-1-yl]methyl]benzoic acid

2-[[4-[(3R)-3-aminopiperidin-1-yl]-3-but-2-ynyl-2,6-dioxopyrimidin-1-yl]methyl]-5-fluorobenzoic acid

(2R,3S)-2-amino-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-benzo[f]chromene-8-carbonitrile

2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-6-fluorobenzoic acid

Trifluoro-acetate(1S,2S)-2-dimethylcarbamoyl-2-(4'-fluoro-biphenyl-4-yl)-1-((S)-3-fluoro-pyrrolidine-1-carbonyl)-ethyl-ammonium

(2R,3S)-9-(3-methylsulfonylphenyl)-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-benzo[f]chromen-2-amine

(2S,3S)-1-((S)-3-fluoropyrrolidin-1-yl)-3-(4-(N-methylacetamido)cyclohexyl)-1-oxobutan-2-aminium chloride

(2S,3R)-2-amino-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-benzo[f]chromene-8-carboxylic acid

(2S,3R)-8-methoxy-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-benzo[f]chromen-2-amine

methyl 2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-5-chlorobenzoate

(2S,3S)-1-((S)-3-fluoropyrrolidin-1-yl)-3-(4-(N-methylcyclopropanecarboxamido)cyclohexyl)-1-oxobutan-2-aminium chloride

(2S,3S)-3-(4-(3-fluoro-N-methylbenzamido)cyclohexyl)-1-((S)-3-fluoropyrrolidin-1-yl)-1-oxobutan-2-aminium chloride

methyl 2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-5-bromobenzoate

(2S,3S)-4-(dimethylamino)-3-(4-(3-fluoro-N-methylbenzamido)cyclohexyl)-1-((S)-3-fluoropyrrolidin-1-yl)-1,4-dioxobutan-2-aminium chloride

trifluoro-acetate(1S,2S)-2-dimethylcarbamoyl-1-((S)-3-fluoro-pyrrolidine-1-carbonyl)-2-{4-[methyl-(4-methyl-benzoyl)-amino]-phenyl}-ethyl-ammonium

(2S,3S)-1-((S)-3-fluoropyrrolidin-1-yl)-3-(4-(4-methoxy-N-methylbenzamido)cyclohexyl)-1-oxobutan-2-aminium chloride

trifluoro-acetate(1S,2S)-2-dimethylcarbamoyl-2-{4-[(4-fluoro-benzoyl)-methyl-amino]-phenyl}-1-((S)-3-fluoro-pyrrolidine-1-carbonyl)-ethyl-ammonium

(2S,3S)-4-(dimethylamino)-1-((S)-3-fluoropyrrolidin-1-yl)-3-(4-(N-methylacetamido)cyclohexyl)-1,4-dioxobutan-2-aminium chloride

(2S,3R)-3-(2,5-difluorophenyl)-9-methoxy-2,3-dihydro-1H-benzo[f]chromen-2-amine

(2R,3S)-8-bromo-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-benzo[f]chromen-2-amine

(S)-1-(4-(2,4-difluorophenylsulfonamido)cyclohexyl)-2-((S)-3-fluoropyrrolidin-1-yl)-2-oxoethanaminium chloride

methyl 2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-3-chlorobenzoate

methyl 2-[2-[[4-[(3R)-3-aminopiperidin-1-yl]-3-but-2-ynyl-2,6-dioxopyrimidin-1-yl]methyl]phenyl]acetate

Trifluoro-acetate(1S,2S)-2-(4'-fluoro-biphenyl-4-yl)-1-((S)-3-fluoro-pyrrolidine-1-carbonyl)-propyl-ammonium

(2S,3R)-8-morpholin-4-yl-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-benzo[f]chromen-2-amine

(2S,3S)-1-((S)-3-fluoropyrrolidin-1-yl)-3-(4-(4-methoxybenzamido)cyclohexyl)-1-oxobutan-2-aminium chloride

ethyl 2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-5-chlorobenzoate

methyl 2-[[4-[(3R)-3-aminopiperidin-1-yl]-3-but-2-ynyl-2,6-dioxopyrimidin-1-yl]methyl]benzoate

(2S,3R)-3-(2,4-difluorophenyl)-9-methoxy-2,3-dihydro-1H-benzo[f]chromen-2-amine

ethyl 2-[[8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-1-yl]methyl]-5-bromobenzoate

2-[2-[[4-[(3R)-3-aminopiperidin-1-yl]-3-but-2-ynyl-2,6-dioxopyrimidin-1-yl]methyl]phenyl]acetic acid

methyl 2-[[4-[(3R)-3-aminopiperidin-1-yl]-3-but-2-ynyl-2,6-dioxopyrimidin-1-yl]methyl]-6-fluorobenzoate

(2R,3S)-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-benzo[f]chromen-2-amine

(2S,3R)-3-(3-fluorophenyl)-9-methoxy-2,3-dihydro-1H-benzo[f]chromen-2-amine

trifluoro-acetate(1S,2S)-2-[4-(acetyl-methyl-amino)-phenyl]-2-dimethylcarbamoyl-1-((S)-3-fluoro-pyrrolidine-1-carbonyl)-ethyl-ammonium

trifluoro-acetate(1S,2S)-2-(4-acetylamino-phenyl)-2-dimethylcarbamoyl-1-((S)-3-fluoro-pyrrolidine-1-carbonyl)-ethyl-ammonium

(8R,9S)-9-amino-4-methyl-8-(2,4,5-trifluorophenyl)-9,10-dihydro-8H-pyrano[2,3-h]chromen-2-one

(2R,3S)-2-amino-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-benzo[f]chromene-9-carbonitrile

trifluoro-acetate(1S,2S)-2-[4-(acetyl-methyl-amino)-phenyl]-1-((S)-3-fluoro-pyrrolidine-1-carbonyl)-propyl-ammonium

(2R,3S)-9-bromo-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-benzo[f]chromen-2-amine

trifluoro-acetate(1S,2S)-2-{4-[(4-fluoro-benzoyl)-methyl-amino]-phenyl}-1-((S)-3-fluoro-pyrrolidine-1-carbonyl)-propyl-ammonium

(2S,3S)-3-(4-(2,4-difluorophenylsulfonamido)cyclohexyl)-4-(dimethylamino)-1-((S)-3-fluoropyrrolidin-1-yl)-1,4-dioxobutan-2-aminium chloride

(2S,3R)-3-(2-chlorophenyl)-9-methoxy-2,3-dihydro-1H-benzo[f]chromen-2-amine

(2S,3S)-4-(dimethylamino)-1-((S)-3-fluoropyrrolidin-1-yl)-1,4-dioxo-3-(4-(4-(trifluoromethoxy)phenylsulfonamido)cyclohexyl)butan-2-aminium chloride

methyl 2-[[4-[(3R)-3-aminopiperidin-1-yl]-3-but-2-ynyl-2,6-dioxopyrimidin-1-yl]methyl]-4-bromobenzoate

trifluoro-acetate(1S,2S)-2-dimethylcarbamoyl-1-((S)-3-fluoro-pyrrolidine-1-carbonyl)-2-{4-[methyl-(toluene-4-sulfonyl)-amino]-phenyl}-ethyl-ammonium

(2S,3S)-1-((S)-3-fluoropyrrolidin-1-yl)-1-oxo-3-(4-(4-(trifluoromethoxy)phenylsulfonamido)cyclohexyl)butan-2-aminium chloride

(2S,3S)-3-(4-(2,4-difluorophenylsulfonamido)cyclohexyl)-1-((S)-3-fluoropyrrolidin-1-yl)-1-oxobutan-2-aminium chloride

(2S,3R)-3-(2-fluorophenyl)-9-methoxy-2,3-dihydro-1H-benzo[f]chromen-2-amine

trifluoro-acetate(1S,2S)-2-(4-acetylamino-phenyl)-1-((S)-3-fluoro-pyrrolidine-1-carbonyl)-propyl-ammonium

trifluoro-acetate(1S,2S)-2-(4-benzenesulfonylamino-phenyl)-2-dimethylcarbamoyl-1-((S)-3-fluoro-pyrrolidine-1-carbonyl)-ethyl-ammonium

(2R,3S)-9-methoxy-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-benzo[f]chromen-2-amine