General Information of the Compound
Compound ID
CP0170545
Compound Name
N-[5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]propanamide
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Structure
Formula
C19H23F2N5O2
Molecular Weight
391.422
Canonical SMILES
CCC(=O)Nc1n[nH]c2CN(Cc12)[C@H]1CO[C@@H]([C@@H](N)C1)c1cc(F)ccc1F
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InChI
InChI=1S/C19H23F2N5O2/c1-2-17(27)23-19-13-7-26(8-16(13)24-25-19)11-6-15(22)18(28-9-11)12-5-10(20)3-4-14(12)21/h3-5,11,15,18H,2,6-9,22H2,1H3,(H2,23,24,25,27)/t11-,15+,18-/m1/s1
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InChIKey
QALWBJBQCBFJMD-DJCROIMJSA-N
Physicochemical Property
logP
2.2095
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
96.27
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127035376
ChEMBL ID
CHEMBL3736135
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00989, Dipeptidyl peptidase 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00907, Dipeptidyl peptidase 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 1.4 nM
   TI
   LI
   LO
   TS
Protein ID: PT00975, Dipeptidyl peptidase 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000053 COS-7 Chlorocebus aethiops (Green monkey)  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS