General Information of the Protein
Protein ID
PT00989
Protein Name
Dipeptidyl peptidase 2
Secondarily
Protein Name
Dipeptidyl aminopeptidase II
Dipeptidyl peptidase 7
Dipeptidyl peptidase II
Quiescent cell proline dipeptidase
Gene Name
DPP7
Secondarily
Gene Name
DPP2
QPP
Sequence
MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Serine protease
>
Serine protease SC clan
>
Serine protease S28 family
Function
Plays an important role in the degradation of some oligopeptides.
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Uniprot ID
Primary ID:
Q9UHL4

Secondarily ID:
A8K7U7
Q5VSF1
Q969X4
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Ensembl ID
ENSG00000176978
HGNC ID
HGNC:14892
Subcellular Location
Lysosome
Cytoplasmic vesicle
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000023 , BTI-Tn-5B1-4
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0280292
 Compound Info 
2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1-yl-butan-1-one
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C16H24ClN3O
  1
1
IC50 = 5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0417860
 Compound Info 
(2R)-1-{(2S, 4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl}pyrrolidine-2-boronic Acid
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C19H24BN3O5
  1
1
IC50 = 400 nM
 Bioactivity Info 
   TI
   LI
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CP0377209
 Compound Info 
(S)-1-((S)-2-amino-5-(1-oxoisoindolin-2-yl)pentanoyl)pyrrolidine-2-carbonitrile
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C18H22N4O2
  1
1
IC50 = 2600 nM
 Bioactivity Info 
   TI
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CP0048107
 Compound Info 
(2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}pyrrolidine-2-carbonitrile
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C17H25N3O2
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0007316
 Compound Info 
(1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorobenzyl)propylamine
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C16H15F6N5O
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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   LO
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CP0067540
 Compound Info 
(R)-1-(2-(1-naphthamido)acetyl)pyrrolidin-2-ylboronic acid
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C17H19BN2O4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0077736
 Compound Info 
(2S)-1-[(2S)-2-amino-4-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-4-oxobutanoyl]pyrrolidine-2-carbonitrile
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C26H29F2N5O2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0089998
 Compound Info 
(2S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4,4-difluoropyrrolidine-2-carbonitrile
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C20H20F2N4O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0117955
 Compound Info 
(S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-1-naphthamide
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C18H17N3O2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0138655
 Compound Info 
(2S,3R)-2-amino-1-(isoindolin-2-yl)-3-methylpentan-1-one
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C14H20N2O
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0172402
 Compound Info 
(R)-1-(2-(1-oxoisoindolin-2-yl)acetyl)pyrrolidin-2-ylboronic acid
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C14H17BN2O4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0365775
 Compound Info 
(2S,4S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4-fluoropyrrolidine-2-carbonitrile
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C20H21FN4O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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   LO
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CP0377210
 Compound Info 
(S)-1-((2S,4R)-4-(2-(isoindolin-2-yl)-2-oxoethyl)-5-oxopyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
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C20H22N4O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0377211
 Compound Info 
(2S)-1-[{(2S,4S)-5-Oxo-4-(2-oxo-2-(piperidin-1-yl)ethyl)pyrrolidine-2-yl}carbonyl]pyrrolidine-2-carbonitrile
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C17H24N4O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0377217
 Compound Info 
(2S)-1-{(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl}pyrrolidine-2-carboxylic Acid tert-Butylamide
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C24H32N4O4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0377219
 Compound Info 
(2S)-1-({(2S,4S)-4-[2-[4-(Pyridine-4-yl)-piperazin-1-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
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C21H26N6O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0386927
 Compound Info 
(2S)-1-{(2S,4S)-4-[2-(5-Fluoro-1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl}pyrrolidine-2-carbonitrile
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C20H21FN4O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0386928
 Compound Info 
(2S)-1-({(2S,4S)-4-[2-[4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2H)-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
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C23H25ClN4O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0398656
 Compound Info 
(2S)-1-({(2S,4S)-4-[2-(5-Chloro-1,3-dihydro-2H-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
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C20H21ClN4O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0398665
 Compound Info 
(2S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoquinol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
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C21H24N4O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0405590
 Compound Info 
(3S,5S)-3-[2-(1,3-Dihydro-2H-isoindol-2-yl)-2-oxoethyl]-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-2-one
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C18H21N3O3S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0405591
 Compound Info 
(3S,5S)-3-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-(pyrrolidine-1-carbonyl)pyrrolidin-2-one
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C19H23N3O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0405592
 Compound Info 
(2S)-1-({(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl}pyrrolidine-2-carboxylic Acid Amide
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C20H24N4O4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0405593
 Compound Info 
(2S)-1-{(2S, 4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl}pyrrolidine-2-carbonitrile
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C20H22N4O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0416406
 Compound Info 
(2S)-1-({(2S,4S)-5-Oxo-4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]pyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
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C16H22N4O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0416420
 Compound Info 
2S)-1-({(2S,4S)-5-oxo-4-[2-Oxo-[2-(trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]ethyl]pyrrolidin-2-yl}carbonyl)-pyrrolidine-2-carbonitrile
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C19H21F3N6O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0417856
 Compound Info 
(2S)-1-({(2S,4S)-5-Oxo-4-[2-oxo-2-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]ethyl]pyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
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C18H20F3N7O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0417859
 Compound Info 
(2S,4S)-1-{(2S,4S)-4-[2-(5-Chloro-1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl}-4-fluoropyrrolidine-2-carbonitrile
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C20H20ClFN4O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0469898
 Compound Info 
2-[(3S,5S)-5-{[(2S)-2-Cyanopyrrolidin-1-yl]carbonyl}-2-oxopyrrolidin-3-yl]-N-phenylacetamide
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C18H20N4O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0473229
 Compound Info 
2S)-1-({(2S,4S)-4-[2-(6,7-Dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
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C19H22N4O3S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0477589
 Compound Info 
(2S)-1-({(2S,4S)-4-[2-(5-Trifluoromethyl-1,3-dihydro-2H-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
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C21H21F3N4O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0507612
 Compound Info 
(2S)-1-({(2S,4S)-4-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
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C22H26FN5O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0903652
 Compound Info 
(2S)-1-((2S)-4-(2-(isoindolin-2-yl)-2-oxoethyl)-5-oxopyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
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C20H22N4O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0280292
 Compound Info 
2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1-yl-butan-1-one
   Show/Hide
C16H24ClN3O
  1
1 IC50 = 0.23 nM
CP0648753
 Compound Info 
Trifluoro-acetate(1S,2S)-2-(4'-fluoro-biphenyl-4-yl)-1-((S)-3-fluoro-pyrrolidine-1-carbonyl)-propyl-ammonium
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C22H23F5N2O3
  1
1 IC50 = 2700 nM
CP0138655
 Compound Info 
(2S,3R)-2-amino-1-(isoindolin-2-yl)-3-methylpentan-1-one
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C14H20N2O
  2
1 IC50 = 28700 nM
2 IC50 = 29000 nM
CP0059208
 Compound Info 
(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
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C16H18F2N4O
  1
1 IC50 = 34000 nM
CP0660053
 Compound Info 
Trifluoro-acetate(1S,2S)-2-dimethylcarbamoyl-2-(4'-fluoro-biphenyl-4-yl)-1-((S)-3-fluoro-pyrrolidine-1-carbonyl)-ethyl-ammonium
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C24H26F5N3O4
  1
1 IC50 = 45000 nM
CP0007316
 Compound Info 
(1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorobenzyl)propylamine
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C16H15F6N5O
  3
1 IC50 = 59830 nM
2 IC50 > 20000 nM
3 IC50 > 100000 nM
CP0048107
 Compound Info 
(2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}pyrrolidine-2-carbonitrile
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C17H25N3O2
  3
1 IC50 > 20000 nM
2 IC50 > 50000 nM
3 IC50 > 100000 nM
CP0064961
 Compound Info 
MK-3102
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C17H20F2N4O3S
  1
1 IC50 > 67000 nM
CP0077736
 Compound Info 
(2S)-1-[(2S)-2-amino-4-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-4-oxobutanoyl]pyrrolidine-2-carbonitrile
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C26H29F2N5O2
  1
1 IC50 > 100000 nM
CP0645535
 Compound Info 
(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)butanamide trifluoroacetate
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C24H26F4N6O4
  1
1 IC50 > 100000 nM
CP0117955
 Compound Info 
(S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-1-naphthamide
   Show/Hide
C18H17N3O2
  1
1 IC50 > 100000 nM
CP0089998
 Compound Info 
(2S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4,4-difluoropyrrolidine-2-carbonitrile
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C20H20F2N4O3
  1
1 IC50 > 100000 nM
Clinical Information about the Protein
Target 1 ( Dipeptidyl-peptidase 7 (DPP7) )
Target Type Patented-recorded Target