Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT02199 , Metabotropic glutamate receptor 4
Gene Name GRM4
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q14833
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT02199
 
Compound ID Compound Name Compound Formula
CP0110742
N-[3-chloro-4-[(2-chlorophenyl)sulfamoyl]phenyl]pyridine-2-carboxamide
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C18H13Cl2N3O3S
 1
1
EC50 = 19.8 nM
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CP0072398
N-(3-cyclopropyl-1-methylindazol-6-yl)-2H-pyrazolo[3,4-b]pyrazin-3-amine
   Show/Hide
C16H15N7
 1
1
EC50 = 19.8 nM
   TI
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CP0435941
N-[1-methyl-3-(1-methylcyclopropyl)indazol-6-yl]-2H-pyrazolo[3,4-b]pyrazin-3-amine
   Show/Hide
C17H17N7
 1
1
EC50 = 24.9 nM
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CP0140546
N-[4-[(2-chlorophenyl)sulfamoyl]phenyl]pyridine-2-carboxamide
   Show/Hide
C18H14ClN3O3S
 1
1
EC50 = 27 nM
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CP0895990
N-[3-cyclopropyl-1-(2,2,2-trideuterioethyl)indazol-6-yl]-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C18H18N6
 1
1
EC50 = 36.2 nM
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CP0459220
N-(3-ethyl-1-methylindazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C16H16N6
 1
1
EC50 = 37.9 nM
   TI
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CP0081221
N-[3-chloranyl-4-[4-chloranyl-1,3-bis(oxidanylidene)isoindol-2-yl]phenyl]pyridine-2-carboxamide
   Show/Hide
C20H11Cl2N3O3
 1
1
EC50 = 41.9 nM
   TI
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CP0230804
N-(3-cyclopropyl-1-methylindazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C17H16N6
 1
1
EC50 = 43 nM
   TI
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CP0554352
N-(3-cyclopropyl-1-methylindazol-6-yl)-2H-pyrazolo[3,4-b]pyridin-3-amine
   Show/Hide
C17H16N6
 1
1
EC50 = 43.2 nM
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CP0462236
N-[1-methyl-3-(oxan-4-yloxy)indazol-6-yl]-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C19H20N6O2
 1
1
EC50 = 45.4 nM
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CP0471901
N-[1-(cyclobutylmethyl)-3-methylindazol-5-yl]-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C19H20N6
 1
1
EC50 = 46.8 nM
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CP0120365
5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine
   Show/Hide
C12H12N6S
 1
1
EC50 = 52 nM
   TI
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CP0131596
N-(3-chloro-4-phthalimido-phenyl)picolinamide
   Show/Hide
C20H12ClN3O3
 1
1
EC50 = 59.4 nM
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CP0408248
N-[1-methyl-3-(1-methylcyclopropyl)indazol-6-yl]-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C18H18N6
 1
1
EC50 = 67.9 nM
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CP0399100
US9163015, 2
   Show/Hide
C12H8ClFN4
 1
1
EC50 = 68 nM
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CP0504479
N-[4-[(2-chlorophenyl)sulfamoyl]phenyl]-1,3-thiazole-2-carboxamide
   Show/Hide
C16H12ClN3O3S2
 1
1
EC50 = 77.4 nM
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CP0230562
N-(1,3-dimethylindazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C15H14N6
 1
1
EC50 = 78.1 nM
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CP0408249
N-[1-methyl-3-(oxan-2-ylmethoxy)indazol-6-yl]-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C20H22N6O2
 1
1
EC50 = 85.6 nM
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CP0389118
N-(1-ethyl-3-methylindazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C16H16N6
 1
1
EC50 = 95.1 nM
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CP0487131
N-[1-methyl-3-(2,2,2-trifluoroethyl)indazol-6-yl]-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C16H13F3N6
 1
1
EC50 = 95.5 nM
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CP0047496
N-[4-[(2-chlorobenzoyl)amino]-3-methoxy-phenyl]picolinamide
   Show/Hide
C20H16ClN3O3
 1
1
EC50 = 99.5 nM
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CP0071217
N-[4-(1,1,3,3-tetraoxo-1lambda6,3lambda6,2-benzodithiazol-2-yl)phenyl]-1,3-thiazole-4-carboxamide
   Show/Hide
C16H11N3O5S3
 1
1
EC50 = 104 nM
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CP0490185
N-[1-methyl-3-[(3-methyl-1,2-oxazol-5-yl)methoxy]indazol-6-yl]-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C19H17N7O2
 1
1
EC50 = 104 nM
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CP0392926
N-[3-chloro-4-(5-chloropyridin-2-yl)oxyphenyl]pyridine-2-carboxamide
   Show/Hide
C17H11Cl2N3O2
 1
1
EC50 = 108 nM
   TI
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CP0091077
N-[3-chloro-4-[(2-chloro-4-fluorobenzoyl)amino]phenyl]pyridine-2-carboxamide
   Show/Hide
C19H12Cl2FN3O2
 1
1
EC50 = 114 nM
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CP0487146
N-(3,3-difluorocyclobutyl)-1-methyl-6-(1H-pyrazolo[4,3-b]pyridin-3-ylamino)indazole-3-carboxamide
   Show/Hide
C19H17F2N7O
 1
1
EC50 = 116 nM
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CP0444514
N-[1-(2,5-dichloropyridin-4-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C19H17Cl2N5O
 1
1
EC50 = 116 nM
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CP0487144
N-[1-methyl-3-(trifluoromethyl)indazol-6-yl]-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C15H11F3N6
 1
1
EC50 = 119 nM
   TI
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CP0501968
N-[4-[(2-chlorophenyl)sulfamoyl]phenyl]-6-fluoropyridine-2-carboxamide
   Show/Hide
C18H13ClFN3O3S
 1
1
EC50 = 122 nM
   TI
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CP0438787
N-[1-methyl-3-(1-methylcyclopropyl)indazol-6-yl]-2H-pyrazolo[3,4-b]pyridin-3-amine
   Show/Hide
C18H18N6
 1
1
EC50 = 129 nM
   TI
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CP0501971
N-[3-methoxy-4-[(2-methoxyphenyl)sulfamoyl]phenyl]pyridine-2-carboxamide
   Show/Hide
C20H19N3O5S
 1
1
EC50 = 132 nM
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CP0131602
N-[4-(1,1,3,3-tetraoxo-1lambda6,3lambda6,2-benzodithiazol-2-yl)phenyl]pyridine-2-carboxamide
   Show/Hide
C18H13N3O5S2
 1
1
EC50 = 136 nM
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CP0042891
N-[3-chloro-4-(1,3-diketo-2-azaspiro[4.5]decan-2-yl)phenyl]picolinamide
   Show/Hide
C21H20ClN3O3
 1
1
EC50 = 158 nM
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CP0504481
N-[4-[(2,4,6-trimethylphenyl)sulfamoyl]phenyl]pyridine-2-carboxamide
   Show/Hide
C21H21N3O3S
 1
1
EC50 = 159 nM
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CP0911802
N-[3-cyclopropyl-1-(2,2,2-trideuterioethyl)indazol-6-yl]-1H-pyrazolo[3,4-b]pyridin-3-amine
   Show/Hide
C18H18N6
 1
1
EC50 = 160 nM
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CP0487100
N-[4-(phenylsulfamoyl)phenyl]pyridine-2-carboxamide
   Show/Hide
C18H15N3O3S
 1
1
EC50 = 177 nM
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CP0042895
N-[4-(1,1,3,3-tetraoxo-1lambda6,3lambda6,2-benzodithiazol-2-yl)phenyl]pyrimidine-4-carboxamide
   Show/Hide
C17H12N4O5S2
 1
1
EC50 = 179 nM
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CP0523787
N-[4-[(2-fluorophenyl)sulfamoyl]phenyl]pyridine-2-carboxamide
   Show/Hide
C18H14FN3O3S
 1
1
EC50 = 206 nM
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CP0456232
N-[4-(1,1,3,3-tetraoxo-1lambda6,3lambda6,2-benzodithiazol-2-yl)phenyl]furan-2-carboxamide
   Show/Hide
C17H12N2O6S2
 1
1
EC50 = 226 nM
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CP0438788
N-[1-methyl-3-(2-methylpropoxy)indazol-6-yl]-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C18H20N6O
 1
1
EC50 = 231 nM
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CP0226110
N-[4-[(2-chlorophenyl)methylsulfonyl]phenyl]pyridine-2-carboxamide
   Show/Hide
C19H15ClN2O3S
 1
1
EC50 = 237 nM
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CP0174848
N-(4-chloro-3-methoxyphenyl)pyridine-2-carboxamide
   Show/Hide
C13H11ClN2O2
 1
1
EC50 = 240 nM
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CP0389120
N-(1-methylindazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C14H12N6
 1
1
EC50 = 257 nM
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CP0482942
N-(1-cyclopentyl-3-methylindazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C19H20N6
 1
1
EC50 = 265 nM
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CP0504482
N-[4-[(2-chlorophenyl)sulfamoyl]phenyl]thiophene-3-carboxamide
   Show/Hide
C17H13ClN2O3S2
 1
1
EC50 = 269 nM
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CP0734168
SID99309090
   Show/Hide
C22H18ClN3O3
 1
1
EC50 = 287 nM
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CP0389122
(3,3-difluoropyrrolidin-1-yl)-[1-methyl-6-(1H-pyrazolo[4,3-b]pyridin-3-ylamino)indazol-3-yl]methanone
   Show/Hide
C19H17F2N7O
 1
1
EC50 = 289 nM
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CP0650411
Pyridine-2-carboxylic acid [3-chloro-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-phenyl]-amide
   Show/Hide
C21H16ClN3O3
 1
1
EC50 = 291 nM
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CP0420630
N-[1-(3-chloro-5-cyanopyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C20H17ClN6O
 1
1
EC50 = 304 nM
   TI
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CP0402456
N-[4-[(2,5-difluorophenyl)sulfamoyl]phenyl]pyridine-2-carboxamide
   Show/Hide
C18H13F2N3O3S
 1
1
EC50 = 325 nM
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CP0040676
N-[3-(difluoromethoxy)phenyl]pyridine-2-carboxamide
   Show/Hide
C13H10F2N2O2
 1
1
EC50 = 340 nM
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CP0471900
N-(1,3-dimethylindazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C15H14N6
 1
1
EC50 = 345 nM
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CP0146381
N-[4-(1,1,3,3-tetraoxo-1lambda6,3lambda6,2-benzodithiazol-2-yl)phenyl]-1,3-thiazole-2-carboxamide
   Show/Hide
C16H11N3O5S3
 1
1
EC50 = 353 nM
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CP0500469
N-(4-benzamido-3-chlorophenyl)pyridine-2-carboxamide
   Show/Hide
C19H14ClN3O2
 1
1
EC50 = 361 nM
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CP0650414
cis-N-(3-Chloro-4-((3aR,7aS)-1,3-dioxohexahydro-1H-isoindol-2(3H)-yl)phenyl)picolinamide
   Show/Hide
C20H18ClN3O3
 1
1
EC50 = 370 nM
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CP0386464
N-[4-(4-methylpiperidin-1-yl)sulfonylphenyl]pyridine-2-carboxamide
   Show/Hide
C18H21N3O3S
 1
1
EC50 = 372 nM
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CP0469467
N-[1-(5-chloro-2-methoxypyridin-4-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C20H20ClN5O2
 1
1
EC50 = 373 nM
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CP0525087
N-[4-(1,1,3,3-tetraoxo-1lambda6,3lambda6,2-benzodithiazol-2-yl)phenyl]benzamide
   Show/Hide
C19H14N2O5S2
 1
1
EC50 = 402 nM
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CP0047495
N-[2-chloro-4-(pyridine-2-carbonylamino)phenyl]-1,3-thiazole-2-carboxamide
   Show/Hide
C16H11ClN4O2S
 1
1
EC50 = 403 nM
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CP0435942
N-(1-methyl-3-propan-2-yloxyindazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C17H18N6O
 1
1
EC50 = 413 nM
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CP0381483
N-[3-chloro-4-(cyclohexanecarbonylamino)phenyl]pyridine-2-carboxamide
   Show/Hide
C19H20ClN3O2
 1
1
EC50 = 426 nM
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CP0734167
SID99309091
   Show/Hide
C19H16ClN3O3
 1
1
EC50 = 435 nM
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CP0230563
N-(3-cyclopropyl-2H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C16H14N6
 1
1
EC50 = 452 nM
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CP0420634
N-[1-(3-chloro-5-fluoropyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C19H17ClFN5O
 1
1
EC50 = 464 nM
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CP0438783
3-cyclopropyl-1-methyl-N-(1H-pyrazolo[4,3-b]pyridin-3-yl)pyrazolo[4,3-b]pyridin-6-amine
   Show/Hide
C16H15N7
 1
1
EC50 = 468 nM
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CP0516135
N-[4-[(2-chlorophenyl)sulfamoyl]phenyl]pyrimidine-4-carboxamide
   Show/Hide
C17H13ClN4O3S
 1
1
EC50 = 478 nM
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CP0438792
(4,4-difluoropiperidin-1-yl)-[1-methyl-6-(1H-pyrazolo[4,3-b]pyridin-3-ylamino)indazol-3-yl]methanone
   Show/Hide
C20H19F2N7O
 1
1
EC50 = 498 nM
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CP0112401
N-[3-chloranyl-4-[(2-chlorophenyl)carbonylamino]phenyl]pyridine-2-carboxamide
   Show/Hide
C19H13Cl2N3O2
 1
1
EC50 = 517 nM
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CP0057653
N-[4-[(2-chlorobenzoyl)amino]-3-fluoro-phenyl]picolinamide
   Show/Hide
C19H13ClFN3O2
 1
1
EC50 = 556 nM
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CP0438608
N-(3-methoxy-4-methylphenyl)pyridine-2-carboxamide
   Show/Hide
C14H14N2O2
 1
1
EC50 = 560 nM
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CP0225124
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]-1,3-thiazole-2-carboxamide
   Show/Hide
C18H14ClN3O3S
 1
1
EC50 = 627 nM
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CP0420635
N-[1-(5-chloro-3-fluoropyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C19H17ClFN5O
 1
1
EC50 = 648 nM
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CP0438791
N-cyclobutyl-1-methyl-6-(1H-pyrazolo[4,3-b]pyridin-3-ylamino)indazole-3-carboxamide
   Show/Hide
C19H19N7O
 1
1
EC50 = 653 nM
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CP0444512
N-[1-(6-fluoropyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C19H18FN5O
 1
1
EC50 = 668 nM
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CP0666723
SID99309094
   Show/Hide
C22H16ClN3O3
 1
1
EC50 = 674 nM
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CP0427469
N-[4-[(2-chlorophenyl)-methylsulfamoyl]phenyl]-1,3-thiazole-2-carboxamide
   Show/Hide
C17H14ClN3O3S2
 1
1
EC50 = 686 nM
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CP0402455
N-[4-chloro-3-[(2-chlorophenyl)sulfamoyl]phenyl]pyridine-2-carboxamide
   Show/Hide
C18H13Cl2N3O3S
 1
1
EC50 = 731 nM
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CP0535700
N-[1-(3,4-difluorophenyl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C20H18F2N4O
 1
1
EC50 = 737 nM
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CP0470046
(1R,2S)-2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylic acid
   Show/Hide
C14H15Cl2NO3
 1
1
EC50 = 740 nM
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CP0514498
[(3S)-3-fluoropyrrolidin-1-yl]-[1-methyl-6-(1H-pyrazolo[4,3-b]pyridin-3-ylamino)indazol-3-yl]methanone
   Show/Hide
C19H18FN7O
 1
1
EC50 = 764 nM
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CP0393617
N-[4-(1,1,3,3-tetraoxo-1lambda6,3lambda6,2-benzodithiazol-2-yl)phenyl]cyclohexanecarboxamide
   Show/Hide
C19H20N2O5S2
 1
1
EC50 = 765 nM
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CP0272877
N-[3-chloranyl-4-[3-methyl-2,5-bis(oxidanylidene)-3-phenyl-pyrrolidin-1-yl]phenyl]pyridine-2-carboxamide
   Show/Hide
C23H18ClN3O3
 1
1
EC50 = 771 nM
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   LI
   LO
   TS
CP0182003
N-(4-fluoro-3-methoxyphenyl)pyridine-2-carboxamide
   Show/Hide
C13H11FN2O2
 1
1
EC50 = 780 nM
   TI
   LI
   LO
   TS
CP0487145
N-(3-fluorocyclobutyl)-1-methyl-6-(1H-pyrazolo[4,3-b]pyridin-3-ylamino)indazole-3-carboxamide
   Show/Hide
C19H18FN7O
 1
1
EC50 = 794 nM
   TI
   LI
   LO
   TS
CP0389121
N-(3-chloro-1-ethylindazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C15H13ClN6
 1
1
EC50 = 815 nM
   TI
   LI
   LO
   TS
CP0471902
[1-methyl-6-(1H-pyrazolo[4,3-b]pyridin-3-ylamino)indazol-3-yl]-pyrrolidin-1-ylmethanone
   Show/Hide
C19H19N7O
 1
1
EC50 = 827 nM
   TI
   LI
   LO
   TS
CP0469181
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]-1,3-thiazole-4-carboxamide
   Show/Hide
C18H14ClN3O3S
 1
1
EC50 = 845 nM
   TI
   LI
   LO
   TS
CP0471899
N-(1-methylindazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C14H12N6
 1
1
EC50 = 870 nM
   TI
   LI
   LO
   TS
CP0438790
[(3R)-3-fluoropyrrolidin-1-yl]-[1-methyl-6-(1H-pyrazolo[4,3-b]pyridin-3-ylamino)indazol-3-yl]methanone
   Show/Hide
C19H18FN7O
 1
1
EC50 = 907 nM
   TI
   LI
   LO
   TS
CP0373941
(1S,2R)-N1-(3,5-dichlorophenyl)cyclohexane-1,2-dicarboxamide
   Show/Hide
C14H16Cl2N2O2
 1
1
EC50 = 950 nM
   TI
   LI
   LO
   TS
CP0444511
N-[1-(3-chloropyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C19H18ClN5O
 1
1
EC50 = 952 nM
   TI
   LI
   LO
   TS
CP0047498
N-[3-chloro-4-[(2-methylbenzoyl)amino]phenyl]pyridine-2-carboxamide
   Show/Hide
C20H16ClN3O2
 1
1
EC50 = 958 nM
   TI
   LI
   LO
   TS
CP0047288
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]furan-2-carboxamide
   Show/Hide
C19H15ClN2O4
 1
1
EC50 = 977 nM
   TI
   LI
   LO
   TS
CP0427471
N-[4-[(2-chlorophenyl)-methylsulfamoyl]phenyl]pyrimidine-4-carboxamide
   Show/Hide
C18H15ClN4O3S
 1
1
EC50 = 990 nM
   TI
   LI
   LO
   TS
CP0500087
N-[4-(cyclohexylsulfamoyl)phenyl]pyridine-2-carboxamide
   Show/Hide
C18H21N3O3S
 1
1
EC50 = 1030 nM
   TI
   LI
   LO
   TS
CP0534159
N-[1-(5-cyanopyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C20H18N6O
 1
1
EC50 = 1031 nM
   TI
   LI
   LO
   TS
CP0377238
N-[3-chloro-4-(thiophene-2-carbonylamino)phenyl]pyridine-2-carboxamide
   Show/Hide
C17H12ClN3O2S
 1
1
EC50 = 1040 nM
   TI
   LI
   LO
   TS
CP0164536
N-(3-chlorophenyl)pyridine-2-carboxamide
   Show/Hide
C12H9ClN2O
 1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0455264
N-(3-chloro-4-methoxyphenyl)pyridine-2-carboxamide
   Show/Hide
C13H11ClN2O2
 1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0375295
N-[2-fluoro-4-(1,1,3,3-tetraoxo-1lambda6,3lambda6,2-benzodithiazol-2-yl)phenyl]pyridine-2-carboxamide
   Show/Hide
C18H12FN3O5S2
 1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0381482
2-chloro-N-(4-(cyclohexanecarboxamido)-2-methoxyphenyl)benzamide
   Show/Hide
C21H23ClN2O3
 1
1
EC50 = 1120 nM
   TI
   LI
   LO
   TS
CP0653640
N-(4-(2-chlorobenzamido)-3-methoxyphenyl)thiophene-2-carboxamide
   Show/Hide
C19H15ClN2O3S
 1
1
EC50 = 1170 nM
   TI
   LI
   LO
   TS
CP0438784
N-(3-cyclopropyl-1-ethylindazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C18H18N6
 1
1
EC50 = 1210 nM
   TI
   LI
   LO
   TS
CP0538520
N-[1-(3-fluoropyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C19H18FN5O
 1
1
EC50 = 1216 nM
   TI
   LI
   LO
   TS
CP0520203
N-[1-(5-chloropyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C19H18ClN5O
 1
1
EC50 = 1269 nM
   TI
   LI
   LO
   TS
CP0910822
SID99309088
   Show/Hide
C20H16ClN3O4
 1
1
EC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0420632
N-[1-(6-chloropyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C19H18ClN5O
 1
1
EC50 = 1320 nM
   TI
   LI
   LO
   TS
CP0409522
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]pyrimidine-4-carboxamide
   Show/Hide
C19H15ClN4O3
 1
1
EC50 = 1330 nM
   TI
   LI
   LO
   TS
CP0535753
N-[1-(3-chloro-5-cyclopropylpyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C22H22ClN5O
 1
1
EC50 = 1388 nM
   TI
   LI
   LO
   TS
CP0386789
N-(3,4-dichlorophenyl)pyridine-2-carboxamide
   Show/Hide
C12H8Cl2N2O
 1
1
EC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0287892
2-(2-bromophenoxy)-1-(2,4-dihydroxyphenyl)ethanone
   Show/Hide
C14H11BrO4
 1
1
EC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0428303
N-[3-chloranyl-4-[3,3-dimethyl-2,5-bis(oxidanylidene)pyrrolidin-1-yl]phenyl]pyridine-2-carboxamide
   Show/Hide
C18H16ClN3O3
 1
1
EC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0261580
N-[1-(2-methoxybenzoyl)indol-5-yl]pyridine-2-carboxamide
   Show/Hide
C22H17N3O3
 1
1
EC50 = 1410 nM
   TI
   LI
   LO
   TS
CP0377240
N-[1-(2-chloro-4-fluorobenzoyl)indol-5-yl]pyridine-2-carboxamide
   Show/Hide
C21H13ClFN3O2
 1
1
EC50 = 1420 nM
   TI
   LI
   LO
   TS
CP0462235
3-methyl-N-(1H-pyrazolo[4,3-b]pyridin-3-yl)benzotriazol-5-amine
   Show/Hide
C13H11N7
 1
1
EC50 = 1430 nM
   TI
   LI
   LO
   TS
CP0152699
5-bromo-N-(4-(2-chlorobenzamido)-3-methoxyphenyl)furan-2-carboxamide
   Show/Hide
C19H14BrClN2O4
 1
1
EC50 = 1440 nM
   TI
   LI
   LO
   TS
CP0538521
N-[1-[6-(difluoromethoxy)pyridin-3-yl]azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C20H19F2N5O2
 1
1
EC50 = 1460 nM
   TI
   LI
   LO
   TS
CP0443481
N-[4-fluoro-3-(trifluoromethyl)phenyl]pyridine-2-carboxamide
   Show/Hide
C13H8F4N2O
 1
1
EC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0377236
N-[4-[(2-chlorobenzoyl)amino]phenyl]pyridine-2-carboxamide
   Show/Hide
C19H14ClN3O2
 1
1
EC50 = 1605 nM
   TI
   LI
   LO
   TS
CP0735921
4-((2-(3-methylquinoxalin-2-yl)hydrazono)methyl)phenol
   Show/Hide
C16H14N4O
 1
1
EC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0465473
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]pyrazine-2-carboxamide
   Show/Hide
C19H15ClN4O3
 1
1
EC50 = 1780 nM
   TI
   LI
   LO
   TS
CP0456233
N-(pyridin-2-ylmethyl)-4-(1,1,3,3-tetraoxo-1lambda6,3lambda6,2-benzodithiazol-2-yl)aniline
   Show/Hide
C18H15N3O4S2
 1
1
EC50 = 1800 nM
   TI
   LI
   LO
   TS
CP0525088
6-fluoro-N-[4-(1,1,3,3-tetraoxo-1lambda6,3lambda6,2-benzodithiazol-2-yl)phenyl]pyridine-2-carboxamide
   Show/Hide
C18H12FN3O5S2
 1
1
EC50 = 1800 nM
   TI
   LI
   LO
   TS
CP0438789
N-[1-methyl-3-(1-methylpiperidin-4-yl)oxyindazol-6-yl]-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C20H23N7O
 1
1
EC50 = 1880 nM
   TI
   LI
   LO
   TS
CP0388394
(1R,2S)-2-(3-chloro-5-fluorophenylcarbamoyl)cyclohexanecarboxylic acid
   Show/Hide
C14H15ClFNO3
 1
1
EC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0473768
(1S,2R)-2-cyano-N-(3,5-dichlorophenyl)cyclohexanecarboxamide
   Show/Hide
C14H14Cl2N2O
 1
1
EC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0377235
N-[4-[(2-chlorobenzoyl)amino]-3-(trifluoromethyl)phenyl]pyridine-2-carboxamide
   Show/Hide
C20H13ClF3N3O2
 1
1
EC50 = 2090 nM
   TI
   LI
   LO
   TS
CP0377653
N-[4-chloro-3-(trifluoromethyl)phenyl]pyridine-2-carboxamide
   Show/Hide
C13H8ClF3N2O
 1
1
EC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0501864
N-[3-chloro-4-[(3,5-dichlorobenzoyl)amino]phenyl]pyridine-2-carboxamide
   Show/Hide
C19H12Cl3N3O2
 1
1
EC50 = 2150 nM
   TI
   LI
   LO
   TS
CP0415814
N-[4-[(2-chlorophenyl)sulfonylmethyl]phenyl]pyridine-2-carboxamide
   Show/Hide
C19H15ClN2O3S
 1
1
EC50 = 2170 nM
   TI
   LI
   LO
   TS
CP0381487
N-[2-chloro-4-(pyridine-2-carbonylamino)phenyl]-1,3-thiazole-5-carboxamide
   Show/Hide
C16H11ClN4O2S
 1
1
EC50 = 2180 nM
   TI
   LI
   LO
   TS
CP0377237
N-[3-chloro-4-[(2-fluorobenzoyl)amino]phenyl]pyridine-2-carboxamide
   Show/Hide
C19H13ClFN3O2
 1
1
EC50 = 2380 nM
   TI
   LI
   LO
   TS
CP0883031
3-((2-(3-methylquinoxalin-2-yl)hydrazono)methyl)phenol
   Show/Hide
C16H14N4O
 1
1
EC50 = 2400 nM
   TI
   LI
   LO
   TS
CP0535752
N-[1-(5-cyclopropylpyrazin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C21H22N6O
 1
1
EC50 = 2509 nM
   TI
   LI
   LO
   TS
CP0444513
N-[1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
   Show/Hide
C20H17ClF3N5O
 1
1
EC50 = 2631 nM
   TI
   LI
   LO
   TS
CP0514397
(1R,6S)-6-(3,5-dichlorophenylcarbamoyl)cyclohex-3-enecarboxylic acid
   Show/Hide
C14H13Cl2NO3
 1
1
EC50 = 2700 nM
   TI
   LI
   LO
   TS
CP0407657
N-(3,4-dichlorophenyl)pyrimidine-4-carboxamide
   Show/Hide
C11H7Cl2N3O
 1
1
EC50 = 2800 nM
   TI
   LI
   LO
   TS
CP0441374
2-(1-phenylethyl)-3-p-tolyl-2,3-dihydroquinazolin-4(1H)-one
   Show/Hide
C23H22N2O
 1
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0461156
(1S,2R)-N1-(3,5-dichlorophenyl)cyclohex-4-ene-1,2-dicarboxamide
   Show/Hide
C14H14Cl2N2O2
 1
1
EC50 = 3100 nM
   TI
   LI
   LO
   TS
CP0288101
methyl 4-[3-[2-(4-acetamidophenyl)sulfanylacetyl]-2,5-dimethylpyrrol-1-yl]benzoate
   Show/Hide
C24H24N2O4S
 1
1
EC50 = 3200 nM
   TI
   LI
   LO
   TS
CP0485572
3,4-dimethyl-N-[1-(5-propan-2-yloxypyrimidin-2-yl)azetidin-3-yl]cinnoline-6-carboxamide
   Show/Hide
C21H24N6O2
 1
1
EC50 = 3204 nM
   TI
   LI
   LO
   TS
CP0920414
(3aR)-2-(3,5-dichlorophenyl)hexahydro-1H-isoindole-1,3(2H)-dione
   Show/Hide
C14H13Cl2NO2
 1
1
EC50 = 3300 nM
   TI
   LI
   LO
   TS
CP0420631
3,4-dimethyl-N-[1-[6-(trifluoromethyl)pyridin-2-yl]azetidin-3-yl]cinnoline-6-carboxamide
   Show/Hide
C20H18F3N5O
 1
1
EC50 = 3363 nM
   TI
   LI
   LO
   TS
CP0554351
N-(1-methylindol-5-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C15H13N5
 1
1
EC50 = 3590 nM
   TI
   LI
   LO
   TS
CP0870504
2-((2-(3-methylquinoxalin-2-yl)hydrazono)methyl)phenol
   Show/Hide
C16H14N4O
 1
1
EC50 = 4100 nM
   TI
   LI
   LO
   TS
CP0506441
5-bromo-N-(3,4-dichlorophenyl)furan-2-carboxamide
   Show/Hide
C11H6BrCl2NO2
 1
1
EC50 = 4100 nM
   TI
   LI
   LO
   TS
CP0381484
N-[3-chloro-4-(2-methylpropanoylamino)phenyl]pyridine-2-carboxamide
   Show/Hide
C16H16ClN3O2
 1
1
EC50 = 4270 nM
   TI
   LI
   LO
   TS
CP0910867
2-(2-benzylidenehydrazinyl)-3-methylquinoxaline
   Show/Hide
C16H14N4
 1
1
EC50 = 4400 nM
   TI
   LI
   LO
   TS
CP0431343
2-(2-bromophenoxy)-1-pyridin-2-ylethanone
   Show/Hide
C13H10BrNO2
 1
1
EC50 = 4600 nM
   TI
   LI
   LO
   TS
CP0381485
N-[2-chloro-4-(pyridine-2-carbonylamino)phenyl]-1-methylindole-2-carboxamide
   Show/Hide
C22H17ClN4O2
 1
1
EC50 = 4720 nM
   TI
   LI
   LO
   TS
CP0120363
(1aS,7E,7aS)-7-hydroxyimino-N-phenyl-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide
   Show/Hide
C17H14N2O3
 2
1
EC50 = 4740 nM
   TI
   LI
   LO
   TS
2
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0501970
N-[4-[(2,4,6-trimethylphenyl)sulfamoyl]phenyl]furan-2-carboxamide
   Show/Hide
C20H20N2O4S
 1
1
EC50 = 5960 nM
   TI
   LI
   LO
   TS
CP0905155
SID99309084
   Show/Hide
C16H12ClN3O3
 1
1
EC50 = 6200 nM
   TI
   LI
   LO
   TS
CP0393619
N-(1-pyridin-2-ylcyclopropyl)-4-(1,1,3,3-tetraoxo-1lambda6,3lambda6,2-benzodithiazol-2-yl)aniline
   Show/Hide
C20H17N3O4S2
 1
1
EC50 = 6400 nM
   TI
   LI
   LO
   TS
CP0381114
(1S,2R)-N1-(3,5-dichlorophenyl)-N2-propylcyclohexane-1,2-dicarboxamide
   Show/Hide
C17H22Cl2N2O2
 1
1
EC50 = 9600 nM
   TI
   LI
   LO
   TS
CP0482940
N-(3-methyl-1-propan-2-ylindazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
   Show/Hide
C17H18N6
 1
1
EC50 = 9890 nM
   TI
   LI
   LO
   TS
CP0441375
methyl 4-[4-oxo-2-(1-phenylethyl)-1,2-dihydroquinazolin-3-yl]benzoate
   Show/Hide
C24H22N2O3
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0441376
3-(3-fluorophenyl)-2-(1-phenylethyl)-2,3-dihydroquinazolin-4(1H)-one
   Show/Hide
C22H19FN2O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0381115
(1R,2S)-N1-(cyclopropylmethyl)-N2-(3,5-dichlorophenyl)cyclohexane-1,2-dicarboxamide
   Show/Hide
C18H22Cl2N2O2
 1
1
EC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0455228
(1S,2R)-N-(3,5-dichlorophenyl)-2-(1H-tetrazol-5-yl)cyclohexanecarboxamide
   Show/Hide
C14H15Cl2N5O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0473490
(1S,2R)-N1-(3,5-dichlorophenyl)-N2-methylcyclohexane-1,2-dicarboxamide
   Show/Hide
C15H18Cl2N2O2
 1
1
EC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0497008
(1R,2S)-2-(phenylcarbamoyl)cyclohexanecarboxylic acid
   Show/Hide
C14H17NO3
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0374432
N-[4-cyano-3-(trifluoromethyl)phenyl]pyridine-2-carboxamide
   Show/Hide
C14H8F3N3O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0375755
N-(1,3-benzodioxol-5-yl)pyridine-2-carboxamide
   Show/Hide
C13H10N2O3
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0381977
N-(3,4-dichlorophenyl)thiophene-3-carboxamide
   Show/Hide
C11H7Cl2NOS
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0407491
N-(6-methoxypyrimidin-4-yl)pyridine-2-carboxamide
   Show/Hide
C11H10N4O2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0407658
N-[6-(trifluoromethyl)pyridin-2-yl]pyridine-2-carboxamide
   Show/Hide
C12H8F3N3O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0431439
N-(3,4-dichlorophenyl)-1-methylpyrrole-2-carboxamide
   Show/Hide
C12H10Cl2N2O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0439609
N-(3,4-dichlorophenyl)pyrazine-2-carboxamide
   Show/Hide
C11H7Cl2N3O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0496598
N-(3,4-dichlorophenyl)-1-benzofuran-2-carboxamide
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C15H9Cl2NO2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0498459
N-(3,4-dichlorophenyl)cyclohexanecarboxamide
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C13H15Cl2NO
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0506015
N-(3,4-dichlorophenyl)-1,2-oxazole-5-carboxamide
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C10H6Cl2N2O2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0535526
N-(3,4-dichlorophenyl)-5-phenylfuran-2-carboxamide
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C17H11Cl2NO2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0538032
N-(3,4-dichlorophenyl)benzamide
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C13H9Cl2NO
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0504480
N-[4-(2-methoxyethylsulfamoyl)phenyl]pyridine-2-carboxamide
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C15H17N3O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0504483
N-[4-(cyclopropylsulfamoyl)phenyl]pyridine-2-carboxamide
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C15H15N3O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0060391
3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
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C16H12F5N3O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0159291
3-(2,6-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
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C16H12F5N3O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0482641
3-(4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
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C16H14F3N3O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0396071
N-(3-methylbenzimidazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine
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C14H12N6
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0421337
3-ethyl-N-(2H-pyrazolo[3,4-b]pyridin-3-yl)-1,2-benzoxazol-5-amine
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C15H13N5O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0438461
3,4-dimethyl-N-[1-[5-(trifluoromethyl)pyrimidin-2-yl]azetidin-3-yl]cinnoline-6-carboxamide
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C19H17F3N6O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0479107
(S)-1-(2-amino-2-carboxyethyl)-1H-1,2,3-triazole-4-carboxylic acid
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C6H8N4O4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0479108
(S)-2-amino-3-(1-(carboxymethyl)-1H-1,2,3-triazol-4-yl)propanoic acid
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C7H10N4O4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0501683
(S)-2-amino-3-(1-(carboxymethyl)-1H-1,2,3-triazol-5-yl)propanoic acid
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C7H10N4O4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0502129
(S)-2-amino-3-(1-((S)-1-carboxy-2-phenylethyl)-1H-1,2,3-triazol-4-yl)propanoic acid
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C14H16N4O4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0502130
(S)-2-amino-3-(1-((S)-1-carboxy-2-phenylethyl)-1H-1,2,3-triazol-5-yl)propanoic acid
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C14H16N4O4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0868559
2-(2-(4-fluorobenzylidene)hydrazinyl)-3-methylquinoxaline
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C16H13FN4
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0285238
N-(3,4-dimethoxyphenyl)pyridine-2-carboxamide
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C14H14N2O3
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0375756
N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide
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C13H9F3N2O
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0375757
N-[3-(trifluoromethoxy)phenyl]pyridine-2-carboxamide
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C13H9F3N2O2
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0377654
N-(5-chloro-6-methoxypyridin-2-yl)pyridine-2-carboxamide
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C12H10ClN3O2
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0407656
N-(3,4-dichlorophenyl)furan-2-carboxamide
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C11H7Cl2NO2
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0431440
N-(3-chlorophenyl)furan-2-carboxamide
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C11H8ClNO2
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0506124
N-(4-bromo-3-methylphenyl)furan-2-carboxamide
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C12H10BrNO2
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0372619
N-[4-(cyclopropylmethylsulfamoyl)phenyl]pyridine-2-carboxamide
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C16H17N3O3S
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0473087
N-[4-(cyclobutylsulfamoyl)phenyl]pyridine-2-carboxamide
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C16H17N3O3S
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0488407
1-(6-chloropyridin-3-yl)-2-[4-(trifluoromethyl)phenoxy]ethanone
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C14H9ClF3NO2
 1
1
IC50 = 4700 nM
   TI
   LI
   LO
   TS
CP0401189
2-(3-bromophenoxy)-1-(6-chloropyridin-3-yl)ethanone
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C13H9BrClNO2
 1
1
IC50 = 7700 nM
   TI
   LI
   LO
   TS
CP0391774
1-(6-chloropyridin-3-yl)-2-(2-pyridin-2-ylphenoxy)ethanone
   Show/Hide
C18H13ClN2O2
 1
1
IC50 = 8000 nM
   TI
   LI
   LO
   TS
CP0484880
2-(2-bromophenoxy)-1-(6-chloropyridin-3-yl)ethanone
   Show/Hide
C13H9BrClNO2
 1
1
IC50 = 8200 nM
   TI
   LI
   LO
   TS
CP0391777
1-(6-chloropyridin-3-yl)-2-(2-pyrimidin-5-ylphenoxy)ethanone
   Show/Hide
C17H12ClN3O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0392005
2-(2-bromophenoxy)-1-[6-(2-pyridin-3-ylethylamino)pyridin-3-yl]ethanone
   Show/Hide
C20H18BrN3O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0428238
1-(6-chloropyridin-3-yl)-2-(2-phenylphenoxy)ethanone
   Show/Hide
C19H14ClNO2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0431144
1-(6-chloropyridin-3-yl)-2-[2-(1-methylpyrazol-4-yl)phenoxy]ethanone
   Show/Hide
C17H14ClN3O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0389571
6-(2,4-dimethylphenyl)-2-ethyl-6,7-dihydro-5H-1,3-benzoxazol-4-one
   Show/Hide
C17H19NO2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS