General Information of the Compound
| Compound ID |
CP0120365
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| Compound Name |
5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine
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| Synonyms |
ADX-88178
MGluR4 PAM modulators (oral, Parkinson's disease/anxiety)
MGluR4 PAM modulators (oral, Parkinson's disease/anxiety), Addex/Merck & Co
MGluR4 positive modulators, Addex/Merck
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| Structure |
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| Formula |
C12H12N6S
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| Molecular Weight |
272.337
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| Canonical SMILES |
Cc1sc(Nc2nccc(C)n2)nc1-c1cn[nH]c1
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| InChI |
InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)
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| InChIKey |
MIQNXKWDQRNHAU-UHFFFAOYSA-N
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02199, Metabotropic glutamate receptor 4
Protein ID: PT03457, Metabotropic glutamate receptor 7
Protein ID: PT04980, Metabotropic glutamate receptor 8
Clinical Information about the Compound