General Information of the Protein
Protein ID
PT02199
Protein Name
Metabotropic glutamate receptor 4
Gene Name
GRM4
Secondarily
Gene Name
GPRC1D
MGLUR4
Sequence
MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
    Show/Hide
Uniprot ID
Primary ID:
Q14833

Secondarily ID:
B3KVL9
B7Z1T9
B7Z1U6
F5GXM5
Q5SZ84
Q6ZMQ2
    Show/Hide
Ensembl ID
ENSG00000124493
HGNC ID
HGNC:4596
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000094 , 1321N1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0170781
 Compound Info 
9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C19H18N4OS
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000051 , BHK-21
 Cell Line Info 
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Cell Line ID: CL000460 , Flp-In-T-REx-293
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000125 , MCB3901
 Cell Line Info 
Cell Line ID: CL000309 , NCTC clone 929
 Cell Line Info 
Cell Line ID: CL000058 , T-REx-293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0120365
 Compound Info 
5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine
   Show/Hide
C12H12N6S
  1
1 EC50 = 4 nM
CP0233089
 Compound Info 
N-pyrimidin-2-yl-5-thia-3,11,12-triazatricyclo[8.3.0.02,6]trideca-1(10),2(6),3,12-tetraen-4-amine
   Show/Hide
C13H12N6S
  1
1 EC50 = 9 nM
CP0110742
 Compound Info 
N-[3-chloro-4-[(2-chlorophenyl)sulfamoyl]phenyl]pyridine-2-carboxamide
   Show/Hide
C18H13Cl2N3O3S
  2
1 EC50 = 19.8 nM
2 EC50 = 20 nM
CP0140546
 Compound Info 
N-[4-[(2-chlorophenyl)sulfamoyl]phenyl]pyridine-2-carboxamide
   Show/Hide
C18H14ClN3O3S
  1
1 EC50 = 162 nM
CP0063510
 Compound Info 
(S)-2-Amino-4-phosphono-butyric acid
   Show/Hide
C4H10NO5P
  2
1 EC50 = 200 nM
2 Ki = 470 nM
CP0226110
 Compound Info 
N-[4-[(2-chlorophenyl)methylsulfonyl]phenyl]pyridine-2-carboxamide
   Show/Hide
C19H15ClN2O3S
  1
1 EC50 = 237 nM
CP0040676
 Compound Info 
N-[3-(difluoromethoxy)phenyl]pyridine-2-carboxamide
   Show/Hide
C13H10F2N2O2
  1
1 EC50 = 340 nM
CP0164536
 Compound Info 
N-(3-chlorophenyl)pyridine-2-carboxamide
   Show/Hide
C12H9ClN2O
  1
1 EC50 = 1196 nM
CP0120363
 Compound Info 
(1aS,7E,7aS)-7-hydroxyimino-N-phenyl-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide
   Show/Hide
C17H14N2O3
  1
1 EC50 = 1400 nM
CP0638863
 Compound Info 
(2S)-2-amino-4-(hydroxy(hydroxy(4-hydroxy-3-methoxy-5-nitrophenyl)methyl)phosphoryl)butanoic acid
   Show/Hide
C12H17N2O9P
  2
1 EC50 = 1500 nM
2 IC50 = 8600 nM
CP0002355
 Compound Info 
(2S)-2-aminopentanedioic acid
   Show/Hide
C5H9NO4
  3
1 EC50 = 9800 nM
2 EC50 = 20000 nM
3 Ki = 1600 nM
CP0069484
 Compound Info 
(+/-)-trans-ACPD
   Show/Hide
C7H11NO4
  1
1 EC50 = 50000 nM
CP0060391
 Compound Info 
3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
   Show/Hide
C16H12F5N3O
  1
1 EC50 > 10000 nM
CP0159291
 Compound Info 
3-(2,6-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
   Show/Hide
C16H12F5N3O
  1
1 EC50 > 10000 nM
CP0289599
 Compound Info 
(1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-phenyl-cyclopropanecarboxylic acid
   Show/Hide
C12H13NO4
  1
1 Ki = 50000 nM
Clinical Information about the Protein
Target 1 ( Metabotropic glutamate receptor 4 (mGluR4) )
Target Type Literature-reported Target
Disease 2 Target-related Diseases  2
1 Anxiety disorder [ICD-11: 6B00-6B0Z]
2 Parkinson disease [ICD-11: 8A00.0]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 DT-1687
 Drug Info 
Phase 2
Parkinson disease
Investigative Drug(s) 1 Investigative Drug  1
1 ADX-88178
 Drug Info 
Investigative
Anxiety disorder
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02446 Metabotropic glutamate receptor 4 Rattus norvegicus, Rat
 Protein Info