General Information of the Protein
Protein ID
PT02446
Protein Name
Metabotropic glutamate receptor 4
Gene Name
GRM4
Secondarily
Gene Name
Gprc1d
Mglur4
Sequence
MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALATKQTYVTYTNHAI
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
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Uniprot ID
P31423
Ensembl ID
ENSG00000124493
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0420635
 Compound Info 
N-[1-(5-chloro-3-fluoropyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
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C19H17ClFN5O
  1
1
EC50 = 82 nM
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CP0047496
 Compound Info 
N-[4-[(2-chlorobenzoyl)amino]-3-methoxy-phenyl]picolinamide
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C20H16ClN3O3
  1
1
EC50 = 106 nM
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CP0420630
 Compound Info 
N-[1-(3-chloro-5-cyanopyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
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C20H17ClN6O
  1
1
EC50 = 138 nM
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CP0091077
 Compound Info 
N-[3-chloro-4-[(2-chloro-4-fluorobenzoyl)amino]phenyl]pyridine-2-carboxamide
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C19H12Cl2FN3O2
  1
1
EC50 = 169 nM
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CP0420634
 Compound Info 
N-[1-(3-chloro-5-fluoropyridin-2-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
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C19H17ClFN5O
  1
1
EC50 = 174 nM
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CP0444514
 Compound Info 
N-[1-(2,5-dichloropyridin-4-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
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C19H17Cl2N5O
  1
1
EC50 = 230 nM
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CP0469467
 Compound Info 
N-[1-(5-chloro-2-methoxypyridin-4-yl)azetidin-3-yl]-3,4-dimethylcinnoline-6-carboxamide
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C20H20ClN5O2
  1
1
EC50 = 356 nM
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CP0225124
 Compound Info 
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]-1,3-thiazole-2-carboxamide
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C18H14ClN3O3S
  1
1
EC50 = 377 nM
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CP0500469
 Compound Info 
N-(4-benzamido-3-chlorophenyl)pyridine-2-carboxamide
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C19H14ClN3O2
  1
1
EC50 = 518 nM
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CP0047495
 Compound Info 
N-[2-chloro-4-(pyridine-2-carbonylamino)phenyl]-1,3-thiazole-2-carboxamide
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C16H11ClN4O2S
  1
1
EC50 = 533 nM
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CP0112401
 Compound Info 
N-[3-chloranyl-4-[(2-chlorophenyl)carbonylamino]phenyl]pyridine-2-carboxamide
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C19H13Cl2N3O2
  1
1
EC50 = 570 nM
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CP0381483
 Compound Info 
N-[3-chloro-4-(cyclohexanecarbonylamino)phenyl]pyridine-2-carboxamide
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C19H20ClN3O2
  1
1
EC50 = 592 nM
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CP0057653
 Compound Info 
N-[4-[(2-chlorobenzoyl)amino]-3-fluoro-phenyl]picolinamide
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C19H13ClFN3O2
  1
1
EC50 = 739 nM
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CP0469181
 Compound Info 
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]-1,3-thiazole-4-carboxamide
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C18H14ClN3O3S
  1
1
EC50 = 753 nM
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CP0653640
 Compound Info 
N-(4-(2-chlorobenzamido)-3-methoxyphenyl)thiophene-2-carboxamide
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C19H15ClN2O3S
  1
1
EC50 = 860 nM
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CP0409522
 Compound Info 
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]pyrimidine-4-carboxamide
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C19H15ClN4O3
  1
1
EC50 = 894 nM
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CP0047498
 Compound Info 
N-[3-chloro-4-[(2-methylbenzoyl)amino]phenyl]pyridine-2-carboxamide
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C20H16ClN3O2
  1
1
EC50 = 915 nM
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CP0152699
 Compound Info 
5-bromo-N-(4-(2-chlorobenzamido)-3-methoxyphenyl)furan-2-carboxamide
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C19H14BrClN2O4
  1
1
EC50 = 1000 nM
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CP0047288
 Compound Info 
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]furan-2-carboxamide
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C19H15ClN2O4
  1
1
EC50 = 1010 nM
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CP0465473
 Compound Info 
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]pyrazine-2-carboxamide
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C19H15ClN4O3
  1
1
EC50 = 1120 nM
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CP0377238
 Compound Info 
N-[3-chloro-4-(thiophene-2-carbonylamino)phenyl]pyridine-2-carboxamide
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C17H12ClN3O2S
  1
1
EC50 = 1130 nM
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CP0261580
 Compound Info 
N-[1-(2-methoxybenzoyl)indol-5-yl]pyridine-2-carboxamide
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C22H17N3O3
  1
1
EC50 = 1340 nM
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CP0381482
 Compound Info 
2-chloro-N-(4-(cyclohexanecarboxamido)-2-methoxyphenyl)benzamide
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C21H23ClN2O3
  1
1
EC50 = 1520 nM
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CP0377240
 Compound Info 
N-[1-(2-chloro-4-fluorobenzoyl)indol-5-yl]pyridine-2-carboxamide
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C21H13ClFN3O2
  1
1
EC50 = 1660 nM
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CP0381487
 Compound Info 
N-[2-chloro-4-(pyridine-2-carbonylamino)phenyl]-1,3-thiazole-5-carboxamide
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C16H11ClN4O2S
  1
1
EC50 = 1730 nM
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CP0381486
 Compound Info 
N-[3-chloro-4-[(2,4-difluorobenzoyl)amino]phenyl]pyridine-2-carboxamide
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C19H12ClF2N3O2
  1
1
EC50 = 2100 nM
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CP0377236
 Compound Info 
N-[4-[(2-chlorobenzoyl)amino]phenyl]pyridine-2-carboxamide
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C19H14ClN3O2
  1
1
EC50 = 2260 nM
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CP0501864
 Compound Info 
N-[3-chloro-4-[(3,5-dichlorobenzoyl)amino]phenyl]pyridine-2-carboxamide
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C19H12Cl3N3O2
  1
1
EC50 = 2340 nM
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CP0377235
 Compound Info 
N-[4-[(2-chlorobenzoyl)amino]-3-(trifluoromethyl)phenyl]pyridine-2-carboxamide
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C20H13ClF3N3O2
  1
1
EC50 = 2360 nM
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CP0120363
 Compound Info 
(1aS,7E,7aS)-7-hydroxyimino-N-phenyl-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide
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C17H14N2O3
  1
1
EC50 = 2820 nM
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CP0381485
 Compound Info 
N-[2-chloro-4-(pyridine-2-carbonylamino)phenyl]-1-methylindole-2-carboxamide
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C22H17ClN4O2
  1
1
EC50 = 2970 nM
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CP0377239
 Compound Info 
N-[3-chloro-4-[(5-phenylfuran-2-carbonyl)amino]phenyl]pyridine-2-carboxamide
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C23H16ClN3O3
  1
1
EC50 = 3350 nM
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CP0377237
 Compound Info 
N-[3-chloro-4-[(2-fluorobenzoyl)amino]phenyl]pyridine-2-carboxamide
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C19H13ClFN3O2
  1
1
EC50 = 4390 nM
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CP0381484
 Compound Info 
N-[3-chloro-4-(2-methylpropanoylamino)phenyl]pyridine-2-carboxamide
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C16H16ClN3O2
  1
1
EC50 = 4820 nM
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CP0377241
 Compound Info 
N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]oxolane-2-carboxamide
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C19H19ClN2O4
  1
1
EC50 > 10000 nM
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CP0211752
 Compound Info 
(1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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C15H14Cl2FNO5
  1
1
IC50 = 1740 nM
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CP0377729
 Compound Info 
(1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl)cyclopropanecarboxylic acid
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C20H19NO5
  1
1
IC50 = 2650 nM
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Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0040676
 Compound Info 
N-[3-(difluoromethoxy)phenyl]pyridine-2-carboxamide
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C13H10F2N2O2
  1
1 EC50 = 80 nM
CP0063510
 Compound Info 
(S)-2-Amino-4-phosphono-butyric acid
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C4H10NO5P
  2
1 EC50 = 200 nM
2 EC50 = 910 nM
CP0164536
 Compound Info 
N-(3-chlorophenyl)pyridine-2-carboxamide
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C12H9ClN2O
  1
1 EC50 = 330 nM
CP0100084
 Compound Info 
(2R)-2-aminopentanedioic acid
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C5H9NO4
  1
1 EC50 = 12000 nM
CP0002355
 Compound Info 
(2S)-2-aminopentanedioic acid
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C5H9NO4
  1
1 EC50 = 12000 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02199 Metabotropic glutamate receptor 4 Homo sapiens, Human
 Protein Info