General Information of the Protein
Protein ID
PT03457
Protein Name
Metabotropic glutamate receptor 7
Gene Name
GRM7
Secondarily
Gene Name
Gprc1g
Mglur7
Sequence
MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Function
G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits.
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Uniprot ID
P35400
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0498675
 Compound Info 
3-(3-methoxyphenyl)-5-methyl-6-phenylisoxazolo[4,5-c]pyridin-4(5H)-one
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C20H16N2O3
  1
1
IC50 = 12 nM
 Bioactivity Info 
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CP0217082
 Compound Info 
5-methyl-3,6-diphenylisoxazolo[4,5-c]pyridin-4(5H)-one
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C19H14N2O2
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0507755
 Compound Info 
3-(2-methoxyphenyl)-5-methyl-6-phenylisoxazolo[4,5-c]pyridin-4(5H)-one
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C20H16N2O3
  1
1
IC50 = 21 nM
 Bioactivity Info 
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CP0372282
 Compound Info 
6-(4-methoxyphenyl)-5-methyl-3-phenylisoxazolo[4,5-c]pyridin-4(5H)-one
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C20H16N2O3
  1
1
IC50 = 22 nM
 Bioactivity Info 
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CP0464011
 Compound Info 
6-(benzo[d][1,3]dioxol-5-yl)-5-methyl-3-phenylisoxazolo[4,5-c]pyridin-4(5H)-one
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C20H14N2O4
  1
1
IC50 = 26 nM
 Bioactivity Info 
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CP0507758
 Compound Info 
6-(4-methoxyphenyl)-5-methyl-3-(pyridin-4-yl)isoxazolo[4,5-c]pyridin-4(5H)-one
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C19H15N3O3
  1
1
IC50 = 26 nM
 Bioactivity Info 
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CP0534052
 Compound Info 
3-(4-methoxyphenyl)-5-methyl-6-phenylisoxazolo[4,5-c]pyridin-4(5H)-one
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C20H16N2O3
  1
1
IC50 = 29 nM
 Bioactivity Info 
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CP0520393
 Compound Info 
6-(3-(dimethylamino)phenyl)-5-methyl-3-phenylisoxazolo[4,5-c]pyridin-4(5H)-one
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C21H19N3O2
  1
1
IC50 = 31 nM
 Bioactivity Info 
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CP0378881
 Compound Info 
5-methyl-3-phenyl-6-p-tolylisoxazolo[4,5-c]pyridin-4(5H)-one
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C20H16N2O2
  1
1
IC50 = 51 nM
 Bioactivity Info 
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CP0534048
 Compound Info 
6-(4-fluorophenyl)-5-methyl-3-phenylisoxazolo[4,5-c]pyridin-4(5H)-one
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C19H13FN2O2
  1
1
IC50 = 72 nM
 Bioactivity Info 
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CP0464010
 Compound Info 
5-methyl-3-phenyl-6-(3-(trifluoromethyl)phenyl)isoxazolo[4,5-c]pyridin-4(5H)-one
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C20H13F3N2O2
  1
1
IC50 = 96 nM
 Bioactivity Info 
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CP0534053
 Compound Info 
5-methyl-6-phenyl-3-(pyridin-4-yl)isoxazolo[4,5-c]pyridin-4(5H)-one
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C18H13N3O2
  1
1
IC50 = 101 nM
 Bioactivity Info 
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CP0533975
 Compound Info 
6-(4-(dimethylamino)phenyl)-5-methyl-3-phenylisoxazolo[4,5-c]pyridin-4(5H)-one
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C21H19N3O2
  1
1
IC50 = 140 nM
 Bioactivity Info 
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CP0507757
 Compound Info 
5-methyl-3-phenyl-6-(4-propylphenyl)isoxazolo[4,5-c]pyridin-4(5H)-one
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C22H20N2O2
  1
1
IC50 = 150 nM
 Bioactivity Info 
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CP0430845
 Compound Info 
6-(3-fluoro-4-methoxyphenyl)-5-methyl-3-phenylisoxazolo[4,5-c]pyridin-4(5H)-one
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C20H15FN2O3
  1
1
IC50 = 210 nM
 Bioactivity Info 
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CP0498676
 Compound Info 
5-methyl-6-phenyl-3-(pyridin-3-yl)isoxazolo[4,5-c]pyridin-4(5H)-one
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C18H13N3O2
  1
1
IC50 = 240 nM
 Bioactivity Info 
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CP0498678
 Compound Info 
6-(3-bromo-4-methoxyphenyl)-5-methyl-3-phenylisoxazolo[4,5-c]pyridin-4(5H)-one
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C20H15BrN2O3
  1
1
IC50 = 580 nM
 Bioactivity Info 
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CP0447681
 Compound Info 
5-ethyl-3,6-diphenylisoxazolo[4,5-c]pyridin-4(5H)-one
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C20H16N2O2
  1
1
IC50 = 910 nM
 Bioactivity Info 
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CP0534054
 Compound Info 
5-methyl-6-phenyl-3-(pyridin-2-yl)isoxazolo[4,5-c]pyridin-4(5H)-one
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C18H13N3O2
  1
1
IC50 = 1000 nM
 Bioactivity Info 
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CP0421696
 Compound Info 
5-isopropyl-3,6-diphenylisoxazolo[4,5-c]pyridin-4(5H)-one
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C21H18N2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0507756
 Compound Info 
6-(4-isopropoxyphenyl)-5-methyl-3-phenylisoxazolo[4,5-c]pyridin-4(5H)-one
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C22H20N2O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0377729
 Compound Info 
(1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl)cyclopropanecarboxylic acid
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C20H19NO5
  1
1
Ki = 110 nM
 Bioactivity Info 
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CP0211752
 Compound Info 
(1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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C15H14Cl2FNO5
  1
1
Ki = 664 nM
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Cell Line ID: CL000006 , HEK293
 Cell Line Info