| Compound ID |
Compound Name |
Compound Formula |
|
CP0547822
|
US10047103, 228
Show/Hide
|
C25H18FN5O3S
|
1
|
| 1 |
EC50 = 0.18 nM
|
|
|
|
CP0861554
|
1-(4-((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yloxy)methyl)thiazol-2-yl)-N,N-dimethylmethanamine
Show/Hide
|
C21H21N5O4S2
|
1
|
| 1 |
EC50 = 0.21 nM
|
|
|
|
CP0545177
|
US10047103, 69
Show/Hide
|
C25H20N4O5S2
|
1
|
| 1 |
EC50 = 0.23 nM
|
|
|
|
CP0544412
|
US10047103, 56
Show/Hide
|
C23H23N5O5S2
|
2
|
| 1 |
EC50 = 0.24 nM
|
|
|
| 2 |
IC50 = 0.2 nM
|
|
|
|
CP0575821
|
US10047103, 100
Show/Hide
|
C23H24N6O6S3
|
1
|
| 1 |
EC50 = 0.25 nM
|
|
|
|
CP0474355
|
US10047103, 51
Show/Hide
|
C24H25N5O5S2
|
1
|
| 1 |
EC50 = 0.26 nM
|
|
|
|
CP0486521
|
US10047103, 72
Show/Hide
|
C25H19N5O5S2
|
2
|
| 1 |
EC50 = 0.26 nM
|
|
|
| 2 |
IC50 = 0.3 nM
|
|
|
|
CP0512543
|
US10047103, 40
Show/Hide
|
C26H21N5O5S2
|
2
|
| 1 |
EC50 = 0.26 nM
|
|
|
| 2 |
IC50 = 0.4 nM
|
|
|
|
CP0550816
|
US10047103, 144
Show/Hide
|
C25H24N4O5S2
|
1
|
| 1 |
EC50 = 0.26 nM
|
|
|
|
CP0573790
|
US10047103, 167
Show/Hide
|
C24H24N4O5S2
|
1
|
| 1 |
EC50 = 0.26 nM
|
|
|
|
CP0411902
|
US10047103, 121
Show/Hide
|
C25H26N4O6S2
|
1
|
| 1 |
EC50 = 0.27 nM
|
|
|
|
CP0459992
|
US10047103, 171
Show/Hide
|
C27H31N5O7S3
|
1
|
| 1 |
EC50 = 0.27 nM
|
|
|
|
CP0474351
|
US10047103, 91
Show/Hide
|
C25H27N5O6S2
|
1
|
| 1 |
EC50 = 0.27 nM
|
|
|
|
CP0501021
|
US10047103, 292
Show/Hide
|
C30H26N6O5S2
|
1
|
| 1 |
EC50 = 0.27 nM
|
|
|
|
CP0545752
|
US10047103, 168
Show/Hide
|
C27H22N4O5S2
|
1
|
| 1 |
EC50 = 0.28 nM
|
|
|
|
CP0470080
|
US10047103, 124
Show/Hide
|
C24H24N4O6S2
|
1
|
| 1 |
EC50 = 0.29 nM
|
|
|
|
CP0486559
|
US10047103, 212
Show/Hide
|
C25H23FN4O4S
|
1
|
| 1 |
EC50 = 0.29 nM
|
|
|
|
CP0512541
|
US10047103, 86
Show/Hide
|
C23H20F3N5O5S2
|
2
|
| 1 |
EC50 = 0.3 nM
|
|
|
| 2 |
IC50 = 0.3 nM
|
|
|
|
CP0545775
|
US10047103, 182
Show/Hide
|
C29H26FN5O4S2
|
1
|
| 1 |
EC50 = 0.3 nM
|
|
|
|
CP0499723
|
US10047103, 227
Show/Hide
|
C26H20FN5O3S
|
1
|
| 1 |
EC50 = 0.31 nM
|
|
|
|
CP0539310
|
US10047103, 142
Show/Hide
|
C26H28N4O5S2
|
1
|
| 1 |
EC50 = 0.31 nM
|
|
|
|
CP0575819
|
US10047103, 103
Show/Hide
|
C25H25N5O6S2
|
1
|
| 1 |
EC50 = 0.31 nM
|
|
|
|
CP0333834
|
US10047103, 3
Show/Hide
|
C24H18N4O4S2
|
2
|
| 1 |
EC50 = 0.32 nM
|
|
|
| 2 |
IC50 = 0.3 nM
|
|
|
|
CP0403443
|
US10047103, 105
Show/Hide
|
C24H25N5O5S2
|
1
|
| 1 |
EC50 = 0.32 nM
|
|
|
|
CP0407163
|
US10047103, 75
Show/Hide
|
C23H17N5O4S2
|
1
|
| 1 |
EC50 = 0.32 nM
|
|
|
|
CP0544415
|
US10047103, 15
Show/Hide
|
C24H17FN4O4S2
|
1
|
| 1 |
EC50 = 0.32 nM
|
|
|
|
CP0574123
|
US10047103, 116
Show/Hide
|
C21H15N5O5S2
|
1
|
| 1 |
EC50 = 0.32 nM
|
|
|
|
CP0407155
|
US10047103, 118
Show/Hide
|
C23H22N4O6S2
|
1
|
| 1 |
EC50 = 0.33 nM
|
|
|
|
CP0515329
|
US10047103, 115
Show/Hide
|
C24H22F2N4O4S2
|
2
|
| 1 |
EC50 = 0.33 nM
|
|
|
| 2 |
IC50 = 0.3 nM
|
|
|
|
CP0539391
|
US10047103, 126
Show/Hide
|
C26H26N4O7S2
|
1
|
| 1 |
EC50 = 0.33 nM
|
|
|
|
CP0539394
|
US10047103, 90
Show/Hide
|
C24H25N5O6S2
|
1
|
| 1 |
EC50 = 0.33 nM
|
|
|
|
CP0539397
|
US10047103, 58
Show/Hide
|
C21H17F3N4O4S2
|
1
|
| 1 |
EC50 = 0.33 nM
|
|
|
|
CP0380495
|
US10047103, 43
Show/Hide
|
C26H22FN5O4S2
|
1
|
| 1 |
EC50 = 0.34 nM
|
|
|
|
CP0497821
|
US10047103, 197
Show/Hide
|
C24H22F2N4O4S2
|
1
|
| 1 |
EC50 = 0.34 nM
|
|
|
|
CP0545179
|
US10047103, 67
Show/Hide
|
C23H16FN5O4S2
|
1
|
| 1 |
EC50 = 0.34 nM
|
|
|
|
CP0566400
|
US10047103, 128
Show/Hide
|
C24H22N4O6S2
|
1
|
| 1 |
EC50 = 0.35 nM
|
|
|
|
CP0407157
|
US10047103, 101
Show/Hide
|
C29H25N7O6S3
|
1
|
| 1 |
EC50 = 0.36 nM
|
|
|
|
CP0407161
|
US10047103, 54
Show/Hide
|
C22H21N5O6S3
|
1
|
| 1 |
EC50 = 0.36 nM
|
|
|
|
CP0459991
|
US10047103, 183
Show/Hide
|
C28H22FN5O4S2
|
1
|
| 1 |
EC50 = 0.36 nM
|
|
|
|
CP0950957
|
N-(cyanomethyl)-N-ethyl-4-(4-((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yloxy)methyl)thiazol-2-yl)benzamide
Show/Hide
|
C29H24N6O5S2
|
1
|
| 1 |
EC50 = 0.36 nM
|
|
|
|
CP0375038
|
US10047103, 98
Show/Hide
|
C24H23N5O6S
|
1
|
| 1 |
EC50 = 0.37 nM
|
|
|
|
CP0515324
|
US10047103, 148
Show/Hide
|
C29H30N4O6S2
|
1
|
| 1 |
EC50 = 0.37 nM
|
|
|
|
CP0515327
|
US10047103, 133
Show/Hide
|
C24H24N4O5S2
|
1
|
| 1 |
EC50 = 0.37 nM
|
|
|
|
CP0515330
|
US10047103, 112
Show/Hide
|
C24H25N5O6S3
|
1
|
| 1 |
EC50 = 0.37 nM
|
|
|
|
CP0546301
|
US10047103, 314
Show/Hide
|
C30H27N5O5S2
|
1
|
| 1 |
EC50 = 0.37 nM
|
|
|
|
CP0403446
|
US10047103, 60
Show/Hide
|
C23H22N4O4S2
|
1
|
| 1 |
EC50 = 0.38 nM
|
|
|
|
CP0544722
|
US10047103, 184
Show/Hide
|
C27H19FN6O4S2
|
1
|
| 1 |
EC50 = 0.38 nM
|
|
|
|
CP0566399
|
US10047103, 143
Show/Hide
|
C21H17F3N4O5S2
|
1
|
| 1 |
EC50 = 0.39 nM
|
|
|
|
CP0539390
|
US10047103, 130
Show/Hide
|
C30H27N5O6S2
|
1
|
| 1 |
EC50 = 0.4 nM
|
|
|
|
CP0555448
|
US10047103, 294
Show/Hide
|
C29H25N5O6S2
|
1
|
| 1 |
EC50 = 0.4 nM
|
|
|
|
CP0913941
|
6-(4-((2-(2-fluoropyridin-3-yl)-5-methylthiazol-4-yl)methoxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C24H18FN5O4S2
|
1
|
| 1 |
EC50 = 0.4 nM
|
|
|
|
CP0407151
|
US10047103, 139
Show/Hide
|
C22H18F4N4O4S2
|
1
|
| 1 |
EC50 = 0.41 nM
|
|
|
|
CP0550815
|
US10047103, 159
Show/Hide
|
C30H28N4O6S2
|
1
|
| 1 |
EC50 = 0.41 nM
|
|
|
|
CP0552191
|
US10047103, 185
Show/Hide
|
C26H20FN5O4S2
|
1
|
| 1 |
EC50 = 0.41 nM
|
|
|
|
CP0474432
|
US10047103, 198
Show/Hide
|
C26H27FN4O5S2
|
1
|
| 1 |
EC50 = 0.42 nM
|
|
|
|
CP0486520
|
US10047103, 76
Show/Hide
|
C28H24N4O6S2
|
1
|
| 1 |
EC50 = 0.42 nM
|
|
|
|
CP0486532
|
US10047103, 2
Show/Hide
|
C19H13F3N4O4S2
|
1
|
| 1 |
EC50 = 0.42 nM
|
|
|
|
CP0547286
|
US10047103, 247
Show/Hide
|
C28H26N8O3S
|
1
|
| 1 |
EC50 = 0.42 nM
|
|
|
|
CP0570499
|
US10047103, 300
Show/Hide
|
C28H25N5O6S2
|
1
|
| 1 |
EC50 = 0.42 nM
|
|
|
|
CP0416343
|
US10047103, 113
Show/Hide
|
C29H27N5O6S3
|
1
|
| 1 |
EC50 = 0.43 nM
|
|
|
|
CP0470081
|
US10047103, 117
Show/Hide
|
C21H15N5O5S2
|
1
|
| 1 |
EC50 = 0.43 nM
|
|
|
|
CP0479453
|
US10047103, 94
Show/Hide
|
C23H23N5O5S2
|
2
|
| 1 |
EC50 = 0.43 nM
|
|
|
| 2 |
IC50 = 0.4 nM
|
|
|
|
CP0486530
|
US10047103, 21
Show/Hide
|
C23H23N5O4S2
|
2
|
| 1 |
EC50 = 0.43 nM
|
|
|
| 2 |
IC50 = 0.4 nM
|
|
|
|
CP0538924
|
US10047103, 313
Show/Hide
|
C33H33N5O5S2
|
1
|
| 1 |
EC50 = 0.43 nM
|
|
|
|
CP0385254
|
US10047103, 302
Show/Hide
|
C31H29N5O5S2
|
1
|
| 1 |
EC50 = 0.44 nM
|
|
|
|
CP0403024
|
US10047103, 235
Show/Hide
|
C25H23F2N5O3S
|
1
|
| 1 |
EC50 = 0.44 nM
|
|
|
|
CP0407154
|
US10047103, 120
Show/Hide
|
C24H24N4O6S2
|
1
|
| 1 |
EC50 = 0.45 nM
|
|
|
|
CP0474358
|
US10047103, 36
Show/Hide
|
C27H23N5O5S2
|
2
|
| 1 |
EC50 = 0.45 nM
|
|
|
| 2 |
IC50 = 0.4 nM
|
|
|
|
CP0486528
|
US10047103, 37
Show/Hide
|
C26H20N4O6S2
|
1
|
| 1 |
EC50 = 0.45 nM
|
|
|
|
CP0539387
|
US10047103, 145
Show/Hide
|
C26H18ClF3N4O5S2
|
1
|
| 1 |
EC50 = 0.45 nM
|
|
|
|
CP0545173
|
US10047103, 93
Show/Hide
|
C25H25N5O5S2
|
1
|
| 1 |
EC50 = 0.45 nM
|
|
|
|
CP0486522
|
US10047103, 71
Show/Hide
|
C24H18FN5O4S2
|
1
|
| 1 |
EC50 = 0.46 nM
|
|
|
|
CP0512544
|
US10047103, 39
Show/Hide
|
C29H27N5O6S2
|
1
|
| 1 |
EC50 = 0.46 nM
|
|
|
|
CP0554521
|
US10047103, 196
Show/Hide
|
C24H23FN4O5S2
|
1
|
| 1 |
EC50 = 0.46 nM
|
|
|
|
CP0486523
|
US10047103, 59
Show/Hide
|
C23H22N4O4S3
|
2
|
| 1 |
EC50 = 0.47 nM
|
|
|
| 2 |
IC50 = 0.5 nM
|
|
|
|
CP0486562
|
US10047103, 180
Show/Hide
|
C29H23FN6O4S2
|
1
|
| 1 |
EC50 = 0.47 nM
|
|
|
|
CP0515325
|
US10047103, 141
Show/Hide
|
C23H23FN4O4S2
|
1
|
| 1 |
EC50 = 0.47 nM
|
|
|
|
CP0967673
|
6-(6-Chloro-4-((2-(4-fluorotetrahydro-2H-pyran-4-yl)thiazol-4-yl)methoxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C22H19ClN4O5S2
|
1
|
| 1 |
EC50 = 0.47 nM
|
|
|
|
CP0539396
|
US10047103, 62
Show/Hide
|
C26H20N4O6S2
|
1
|
| 1 |
EC50 = 0.48 nM
|
|
|
|
CP0573862
|
US10047103, 287
Show/Hide
|
C30H29N5O5S2
|
1
|
| 1 |
EC50 = 0.48 nM
|
|
|
|
CP0545178
|
US10047103, 68
Show/Hide
|
C27H22N4O6S2
|
1
|
| 1 |
EC50 = 0.49 nM
|
|
|
|
CP0575818
|
US10047103, 114
Show/Hide
|
C24H22F3N5O6S3
|
1
|
| 1 |
EC50 = 0.49 nM
|
|
|
|
CP0515328
|
US10047103, 123
Show/Hide
|
C22H20N4O6S2
|
1
|
| 1 |
EC50 = 0.5 nM
|
|
|
|
CP0550814
|
US10047103, 160
Show/Hide
|
C31H28N4O7S2
|
1
|
| 1 |
EC50 = 0.5 nM
|
|
|
|
CP0486524
|
US10047103, 52
Show/Hide
|
C21H20N4O4S2
|
2
|
| 1 |
EC50 = 0.51 nM
|
|
|
| 2 |
IC50 = 0.5 nM
|
|
|
|
CP0486526
|
US10047103, 48
Show/Hide
|
C29H24N6O5S2
|
1
|
| 1 |
EC50 = 0.51 nM
|
|
|
|
CP0554520
|
US10047103, 200
Show/Hide
|
C25H25FN4O5S2
|
1
|
| 1 |
EC50 = 0.51 nM
|
|
|
|
CP0407148
|
US10047103, 156
Show/Hide
|
C29H25FN4O5S2
|
1
|
| 1 |
EC50 = 0.52 nM
|
|
|
|
CP0539399
|
US10047103, 53
Show/Hide
|
C22H21N5O4S3
|
1
|
| 1 |
EC50 = 0.52 nM
|
|
|
|
CP0573863
|
US10047103, 297
Show/Hide
|
C30H29N5O5S2
|
1
|
| 1 |
EC50 = 0.52 nM
|
|
|
|
CP0429154
|
US10047103, 310
Show/Hide
|
C29H27N5O5S2
|
1
|
| 1 |
EC50 = 0.53 nM
|
|
|
|
CP0403487
|
US10047103, 309
Show/Hide
|
C30H29N5O5S2
|
1
|
| 1 |
EC50 = 0.54 nM
|
|
|
|
CP0547823
|
US10047103, 225
Show/Hide
|
C30H27N5O4S
|
1
|
| 1 |
EC50 = 0.54 nM
|
|
|
|
CP0486529
|
US10047103, 25
Show/Hide
|
C24H17FN4O4S2
|
1
|
| 1 |
EC50 = 0.55 nM
|
|
|
|
CP0501022
|
US10047103, 299
Show/Hide
|
C30H27N5O5S2
|
1
|
| 1 |
EC50 = 0.55 nM
|
|
|
|
CP0545176
|
US10047103, 74
Show/Hide
|
C24H19N5O4S2
|
1
|
| 1 |
EC50 = 0.56 nM
|
|
|
|
CP0547825
|
US10047103, 218
Show/Hide
|
C25H25N5O4S
|
1
|
| 1 |
EC50 = 0.56 nM
|
|
|
|
CP0501025
|
US10047103, 259
Show/Hide
|
C26H27N5O3S
|
1
|
| 1 |
EC50 = 0.58 nM
|
|
|
|
CP0501031
|
US10047103, 186
Show/Hide
|
C26H20FN5O4S2
|
1
|
| 1 |
EC50 = 0.58 nM
|
|
|
|
CP0546272
|
US10047103, 239
Show/Hide
|
C26H24F2N4O3S
|
1
|
| 1 |
EC50 = 0.58 nM
|
|
|
|
CP0380497
|
US10047103, 31
Show/Hide
|
C23H21F2N5O4S2
|
1
|
| 1 |
EC50 = 0.59 nM
|
|
|
|
CP0547287
|
US10047103, 242
Show/Hide
|
C32H30N4O4S
|
1
|
| 1 |
EC50 = 0.59 nM
|
|
|
|
CP0468182
|
US10047103, 281
Show/Hide
|
C27H20N6O3S2
|
1
|
| 1 |
EC50 = 0.6 nM
|
|
|
|
CP0545422
|
US10047103, 290
Show/Hide
|
C28H23N5O6S2
|
1
|
| 1 |
EC50 = 0.6 nM
|
|
|
|
CP0403450
|
US10047103, 5
Show/Hide
|
C22H21N5O5S2
|
2
|
| 1 |
EC50 = 0.61 nM
|
|
|
| 2 |
IC50 = 0.6 nM
|
|
|
|
CP0546274
|
US10047103, 258
Show/Hide
|
C24H23N5O3S2
|
1
|
| 1 |
EC50 = 0.61 nM
|
|
|
|
CP0573816
|
US10047103, 177
Show/Hide
|
C27H23N5O4S2
|
1
|
| 1 |
EC50 = 0.61 nM
|
|
|
|
CP0407149
|
US10047103, 155
Show/Hide
|
C29H25ClN4O5S2
|
1
|
| 1 |
EC50 = 0.62 nM
|
|
|
|
CP0546273
|
US10047103, 223
Show/Hide
|
C29H25N5O4S
|
1
|
| 1 |
EC50 = 0.62 nM
|
|
|
|
CP0396416
|
US10047103, 92
Show/Hide
|
C24H23N5O5S2
|
2
|
| 1 |
EC50 = 0.63 nM
|
|
|
| 2 |
IC50 = 0.6 nM
|
|
|
|
CP0470083
|
US10047103, 63
Show/Hide
|
C24H18N4O5S2
|
1
|
| 1 |
EC50 = 0.63 nM
|
|
|
|
CP0501023
|
US10047103, 301
Show/Hide
|
C29H25N5O5S2
|
2
|
| 1 |
EC50 = 0.63 nM
|
|
|
| 2 |
IC50 = 0.6 nM
|
|
|
|
CP0573717
|
US10047103, 97
Show/Hide
|
C23H23N5O6S
|
1
|
| 1 |
EC50 = 0.63 nM
|
|
|
|
CP0380498
|
US10047103, 23
Show/Hide
|
C20H18N4O4S2
|
2
|
| 1 |
EC50 = 0.64 nM
|
|
|
| 2 |
IC50 = 0.6 nM
|
|
|
|
CP0486517
|
US10047103, 96
Show/Hide
|
C22H21N5O6S
|
2
|
| 1 |
EC50 = 0.64 nM
|
|
|
| 2 |
IC50 = 0.6 nM
|
|
|
|
CP0544411
|
US10047103, 61
Show/Hide
|
C25H17N5O4S2
|
1
|
| 1 |
EC50 = 0.64 nM
|
|
|
|
CP0563800
|
US10047103, 308
Show/Hide
|
C28H25N5O5S2
|
1
|
| 1 |
EC50 = 0.64 nM
|
|
|
|
CP0385255
|
US10047103, 311
Show/Hide
|
C29H24N6O5S2
|
1
|
| 1 |
EC50 = 0.65 nM
|
|
|
|
CP0403025
|
US10047103, 222
Show/Hide
|
C26H20N4O4S
|
1
|
| 1 |
EC50 = 0.65 nM
|
|
|
|
CP0407586
|
US10047103, 291
Show/Hide
|
C29H23F2N5O5S2
|
2
|
| 1 |
EC50 = 0.65 nM
|
|
|
| 2 |
IC50 = 0.6 nM
|
|
|
|
CP0417229
|
US10047103, 82
Show/Hide
|
C23H17N5O4S2
|
1
|
| 1 |
EC50 = 0.65 nM
|
|
|
|
CP0385224
|
US10047103, 234
Show/Hide
|
C27H22N4O5S2
|
1
|
| 1 |
EC50 = 0.66 nM
|
|
|
|
CP0411901
|
US10047103, 131
Show/Hide
|
C24H21F3N4O6S2
|
1
|
| 1 |
EC50 = 0.66 nM
|
|
|
|
CP0403442
|
US10047103, 140
Show/Hide
|
C23H24N4O5S2
|
1
|
| 1 |
EC50 = 0.67 nM
|
|
|
|
CP0417712
|
US10047103, 162
Show/Hide
|
C29H26N4O5S2
|
1
|
| 1 |
EC50 = 0.67 nM
|
|
|
|
CP0539398
|
US10047103, 57
Show/Hide
|
C25H18N4O6S2
|
1
|
| 1 |
EC50 = 0.67 nM
|
|
|
|
CP0574844
|
US10047103, 173
Show/Hide
|
C30H34N6O8S2
|
1
|
| 1 |
EC50 = 0.67 nM
|
|
|
|
CP0407166
|
US10047103, 6
Show/Hide
|
C22H22N4O6S2
|
1
|
| 1 |
EC50 = 0.68 nM
|
|
|
|
CP0470082
|
US10047103, 104
Show/Hide
|
C23H21N5O5S2
|
1
|
| 1 |
EC50 = 0.68 nM
|
|
|
|
CP0545183
|
US10047103, 152
Show/Hide
|
C28H28N6O6S2
|
1
|
| 1 |
EC50 = 0.68 nM
|
|
|
|
CP0474348
|
US10047103, 161
Show/Hide
|
C32H31N5O6S2
|
1
|
| 1 |
EC50 = 0.69 nM
|
|
|
|
CP0512539
|
US10047103, 89
Show/Hide
|
C23H23N5O6S2
|
1
|
| 1 |
EC50 = 0.69 nM
|
|
|
|
CP0550817
|
US10047103, 109
Show/Hide
|
C28H31N5O6S2
|
1
|
| 1 |
EC50 = 0.69 nM
|
|
|
|
CP0574128
|
US10047103, 22
Show/Hide
|
C23H24N6O4S2
|
2
|
| 1 |
EC50 = 0.69 nM
|
|
|
| 2 |
IC50 = 0.7 nM
|
|
|
|
CP0385460
|
US10047103, 220
Show/Hide
|
C25H22F3N5O4S
|
1
|
| 1 |
EC50 = 0.72 nM
|
|
|
|
CP0385461
|
US10047103, 181
Show/Hide
|
C26H17F4N5O4S2
|
1
|
| 1 |
EC50 = 0.72 nM
|
|
|
|
CP0424994
|
US10047103, 119
Show/Hide
|
C23H21FN4O5S2
|
1
|
| 1 |
EC50 = 0.72 nM
|
|
|
|
CP0538922
|
US10047103, 204
Show/Hide
|
C25H24N4O3S2
|
1
|
| 1 |
EC50 = 0.72 nM
|
|
|
|
CP0539392
|
US10047103, 122
Show/Hide
|
C25H25FN4O5S2
|
1
|
| 1 |
EC50 = 0.72 nM
|
|
|
|
CP0547288
|
US10047103, 232
Show/Hide
|
C25H19N5O3S
|
1
|
| 1 |
EC50 = 0.72 nM
|
|
|
|
CP0564151
|
US10047103, 293
Show/Hide
|
C27H23N5O6S2
|
1
|
| 1 |
EC50 = 0.72 nM
|
|
|
|
CP0403441
|
US10047103, 146
Show/Hide
|
C26H25F3N4O5S2
|
1
|
| 1 |
EC50 = 0.73 nM
|
|
|
|
CP0573788
|
US10047103, 238
Show/Hide
|
C26H27N5O4S
|
1
|
| 1 |
EC50 = 0.73 nM
|
|
|
|
CP0486519
|
US10047103, 80
Show/Hide
|
C23H16ClN5O4S2
|
1
|
| 1 |
EC50 = 0.74 nM
|
|
|
|
CP0403445
|
US10047103, 66
Show/Hide
|
C28H25N5O5S2
|
1
|
| 1 |
EC50 = 0.75 nM
|
|
|
|
CP0414772
|
US10047103, 262
Show/Hide
|
C30H28N6O3S
|
1
|
| 1 |
EC50 = 0.75 nM
|
|
|
|
CP0472012
|
US10047103, 224
Show/Hide
|
C27H19N5O3S
|
1
|
| 1 |
EC50 = 0.75 nM
|
|
|
|
CP0497820
|
US10047103, 203
Show/Hide
|
C26H20N4O3S
|
1
|
| 1 |
EC50 = 0.76 nM
|
|
|
|
CP0546556
|
US10047103, 229
Show/Hide
|
C30H26N4O5S
|
1
|
| 1 |
EC50 = 0.76 nM
|
|
|
|
CP0403032
|
US10047103, 312
Show/Hide
|
C31H29N5O5S2
|
1
|
| 1 |
EC50 = 0.77 nM
|
|
|
|
CP0416345
|
US10047103, 47
Show/Hide
|
C28H22F3N5O5S2
|
1
|
| 1 |
EC50 = 0.77 nM
|
|
|
|
CP0425416
|
US10047103, 110
Show/Hide
|
C30H27N5O5S2
|
1
|
| 1 |
EC50 = 0.78 nM
|
|
|
|
CP0474354
|
US10047103, 55
Show/Hide
|
C22H21N5O5S3
|
1
|
| 1 |
EC50 = 0.79 nM
|
|
|
|
CP0539388
|
US10047103, 135
Show/Hide
|
C24H22F2N4O5S2
|
1
|
| 1 |
EC50 = 0.79 nM
|
|
|
|
CP0407159
|
US10047103, 65
Show/Hide
|
C27H23N5O5S2
|
2
|
| 1 |
EC50 = 0.81 nM
|
|
|
| 2 |
IC50 = 0.8 nM
|
|
|
|
CP0501027
|
US10047103, 226
Show/Hide
|
C29H24N4O5S
|
1
|
| 1 |
EC50 = 0.81 nM
|
|
|
|
CP0407152
|
US10047103, 138
Show/Hide
|
C22H19F3N4O5S2
|
1
|
| 1 |
EC50 = 0.82 nM
|
|
|
|
CP0486525
|
US10047103, 49
Show/Hide
|
C27H23N5O5S2
|
1
|
| 1 |
EC50 = 0.82 nM
|
|
|
|
CP0546276
|
US10047103, 208
Show/Hide
|
C27H19F3N4O3S
|
1
|
| 1 |
EC50 = 0.82 nM
|
|
|
|
CP0573791
|
US10047103, 163
Show/Hide
|
C28H23ClN4O5S2
|
1
|
| 1 |
EC50 = 0.82 nM
|
|
|
|
CP0441520
|
US10047103, 95
Show/Hide
|
C24H24N4O5S2
|
1
|
| 1 |
EC50 = 0.83 nM
|
|
|
|
CP0515323
|
US10047103, 151
Show/Hide
|
C29H31N5O6S2
|
1
|
| 1 |
EC50 = 0.84 nM
|
|
|
|
CP0575823
|
US9688695, 99
Show/Hide
|
C27H30N6O6S2
|
1
|
| 1 |
EC50 = 0.84 nM
|
|
|
|
CP0470196
|
US10047103, 188
Show/Hide
|
C23H14Cl2N4O3S2
|
1
|
| 1 |
EC50 = 0.85 nM
|
|
|
|
CP0486518
|
US10047103, 81
Show/Hide
|
C25H20N4O6S3
|
2
|
| 1 |
EC50 = 0.85 nM
|
|
|
| 2 |
IC50 = 0.8 nM
|
|
|
|
CP0563797
|
US10047103, 303
Show/Hide
|
C31H29N5O5S2
|
1
|
| 1 |
EC50 = 0.85 nM
|
|
|
|
CP0546559
|
US10047103, 210
Show/Hide
|
C27H19F3N4O4S
|
1
|
| 1 |
EC50 = 0.86 nM
|
|
|
|
CP0574124
|
US10047103, 111
Show/Hide
|
C26H29N5O6S3
|
1
|
| 1 |
EC50 = 0.86 nM
|
|
|
|
CP0486564
|
US10047103, 178
Show/Hide
|
C24H18N6O4S2
|
1
|
| 1 |
EC50 = 0.87 nM
|
|
|
|
CP0563798
|
US10047103, 304
Show/Hide
|
C28H25N5O5S2
|
1
|
| 1 |
EC50 = 0.88 nM
|
|
|
|
CP0403444
|
US10047103, 70
Show/Hide
|
C26H21N5O5S2
|
1
|
| 1 |
EC50 = 0.89 nM
|
|
|
|
CP0474356
|
US10047103, 44
Show/Hide
|
C29H27N5O5S2
|
1
|
| 1 |
EC50 = 0.9 nM
|
|
|
|
CP0474357
|
US10047103, 41
Show/Hide
|
C29H27N5O5S2
|
1
|
| 1 |
EC50 = 0.9 nM
|
|
|
|
CP0573736
|
US10047103, 193
Show/Hide
|
C23H22FN5O4S2
|
1
|
| 1 |
EC50 = 0.91 nM
|
|
|
|
CP0474349
|
US10047103, 150
Show/Hide
|
C25H24N4O7S2
|
1
|
| 1 |
EC50 = 0.92 nM
|
|
|
|
CP0903337
|
4-(4-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)thiazol-2-yl)tetrahydro-2H-pyran-4-amine hydrochloride
Show/Hide
|
C23H24ClN5O5S2
|
1
|
| 1 |
EC50 = 0.94 nM
|
|
|
|
CP0515332
|
US10047103, 316
Show/Hide
|
C31H27N5O5S2
|
1
|
| 1 |
EC50 = 0.95 nM
|
|
|
|
CP0539385
|
US10047103, 158
Show/Hide
|
C30H28N4O6S2
|
1
|
| 1 |
EC50 = 0.95 nM
|
|
|
|
CP0407153
|
US10047103, 129
Show/Hide
|
C28H31N5O7S2
|
1
|
| 1 |
EC50 = 0.96 nM
|
|
|
|
CP0572097
|
US10047103, 147
Show/Hide
|
C23H23FN4O5S2
|
1
|
| 1 |
EC50 = 0.96 nM
|
|
|
|
CP0417709
|
US10047103, 166
Show/Hide
|
C28H23FN4O5S2
|
1
|
| 1 |
EC50 = 0.97 nM
|
|
|
|
CP0539395
|
US10047103, 84
Show/Hide
|
C22H20ClN5O5S2
|
1
|
| 1 |
EC50 = 0.97 nM
|
|
|
|
CP0491027
|
US10047103, 106
Show/Hide
|
C22H20N6O4S2
|
1
|
| 1 |
EC50 = 0.98 nM
|
|
|
|
CP0546557
|
US10047103, 216
Show/Hide
|
C26H27N5O4S
|
1
|
| 1 |
EC50 = 0.99 nM
|
|
|
|
CP0555449
|
US10047103, 298
Show/Hide
|
C29H25N5O6S2
|
1
|
| 1 |
EC50 = 0.99 nM
|
|
|
|
CP0403033
|
US10047103, 219
Show/Hide
|
C27H20N4O5S
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0407158
|
US10047103, 77
Show/Hide
|
C26H22N4O5S2
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0547289
|
US10047103, 179
Show/Hide
|
C23H15FN4O3S2
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0570500
|
US10047103, 305
Show/Hide
|
C27H20F3N5O5S2
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0574130
|
US10047103, 19
Show/Hide
|
C25H20N4O5S2
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0380501
|
US10047103, 4
Show/Hide
|
C24H18N4O4S2
|
2
|
| 1 |
EC50 = 1.1 nM
|
|
|
| 2 |
IC50 = 1.1 nM
|
|
|
|
CP0403447
|
US10047103, 24
Show/Hide
|
C24H16F2N4O4S2
|
1
|
| 1 |
EC50 = 1.1 nM
|
|
|
|
CP0407584
|
US10047103, 277
Show/Hide
|
C25H25N5O4S
|
1
|
| 1 |
EC50 = 1.1 nM
|
|
|
|
CP0472016
|
US10047103, 165
Show/Hide
|
C28H23ClN4O5S2
|
1
|
| 1 |
EC50 = 1.1 nM
|
|
|
|
CP0474352
|
US10047103, 85
Show/Hide
|
C24H17ClN4O4S2
|
1
|
| 1 |
EC50 = 1.1 nM
|
|
|
|
CP0474450
|
US10047103, 284
Show/Hide
|
C29H26ClN7O3S
|
1
|
| 1 |
EC50 = 1.1 nM
|
|
|
|
CP0512542
|
US10047103, 83
Show/Hide
|
C25H20N4O4S2
|
1
|
| 1 |
EC50 = 1.1 nM
|
|
|
|
CP0515322
|
US10047103, 154
Show/Hide
|
C29H25ClN4O5S2
|
1
|
| 1 |
EC50 = 1.1 nM
|
|
|
|
CP0544414
|
US10047103, 17
Show/Hide
|
C25H17F3N4O4S2
|
1
|
| 1 |
EC50 = 1.1 nM
|
|
|
|
CP0546560
|
US10047103, 199
Show/Hide
|
C26H26F2N4O4S2
|
1
|
| 1 |
EC50 = 1.1 nM
|
|
|
|
CP0574129
|
US10047103, 20
Show/Hide
|
C24H24N4O4S2
|
1
|
| 1 |
EC50 = 1.1 nM
|
|
|
|
CP0486531
|
US10047103, 14
Show/Hide
|
C23H22N4O5S2
|
2
|
| 1 |
EC50 = 1.2 nM
|
|
|
| 2 |
IC50 = 1.3 nM
|
|
|
|
CP0491028
|
US10047103, 34
Show/Hide
|
C18H14N4O4S2
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0497815
|
US10047103, 306
Show/Hide
|
C27H23N5O5S2
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0497818
|
US10047103, 214
Show/Hide
|
C27H22N4O4S
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0515326
|
US10047103, 137
Show/Hide
|
C26H19F3N4O5S2
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0538920
|
US10047103, 241
Show/Hide
|
C30H25ClN4O4S
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0539312
|
US10047103, 108
Show/Hide
|
C25H20BrN5O4S2
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0543796
|
US10047103, 263
Show/Hide
|
C29H27N7O3S
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0545421
|
US10047103, 289
Show/Hide
|
C28H23N5O5S2
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0547824
|
US10047103, 221
Show/Hide
|
C28H22N4O5S
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0567538
|
US10047103, 136
Show/Hide
|
C24H21F3N4O4S2
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0573813
|
US10047103, 209
Show/Hide
|
C26H19ClN4O3S
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0574122
|
US10047103, 134
Show/Hide
|
C24H23FN4O4S2
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0385462
|
US10047103, 164
Show/Hide
|
C29H26N4O5S2
|
1
|
| 1 |
EC50 = 1.3 nM
|
|
|
|
CP0403449
|
US10047103, 12
Show/Hide
|
C25H20N4O4S2
|
1
|
| 1 |
EC50 = 1.3 nM
|
|
|
|
CP0425344
|
US10047103, 176
Show/Hide
|
C27H23ClN4O4S2
|
1
|
| 1 |
EC50 = 1.3 nM
|
|
|
|
CP0441521
|
US10047103, 315
Show/Hide
|
C28H23N5O5S2
|
1
|
| 1 |
EC50 = 1.3 nM
|
|
|
|
CP0474359
|
US10047103, 11
Show/Hide
|
C25H17F3N4O4S2
|
2
|
| 1 |
EC50 = 1.3 nM
|
|
|
| 2 |
IC50 = 1.3 nM
|
|
|
|
CP0493443
|
US10047103, 169
Show/Hide
|
C27H20N4O5S2
|
1
|
| 1 |
EC50 = 1.3 nM
|
|
|
|
CP0501030
|
US10047103, 189
Show/Hide
|
C24H17ClN4O3S2
|
1
|
| 1 |
EC50 = 1.3 nM
|
|
|
|
CP0539400
|
US10047103, 35
Show/Hide
|
C18H13BrN4O4S2
|
1
|
| 1 |
EC50 = 1.3 nM
|
|
|
|
CP0539403
|
US10047103, 32
Show/Hide
|
C22H16N6O4S2
|
1
|
| 1 |
EC50 = 1.3 nM
|
|
|
|
CP0543918
|
US10047103, 230
Show/Hide
|
C28H24N4O4S
|
1
|
| 1 |
EC50 = 1.3 nM
|
|
|
|
CP0544413
|
US10047103, 45
Show/Hide
|
C30H28N4O6S2
|
1
|
| 1 |
EC50 = 1.3 nM
|
|
|
|
CP0544721
|
US10047103, 195
Show/Hide
|
C24H16F2N4O2S2
|
1
|
| 1 |
EC50 = 1.3 nM
|
|
|
|
CP0572988
|
US10047103, 271
Show/Hide
|
C27H29N5O3S
|
1
|
| 1 |
EC50 = 1.3 nM
|
|
|
|
CP0574125
|
US10047103, 107
Show/Hide
|
C24H25N5O5S2
|
1
|
| 1 |
EC50 = 1.3 nM
|
|
|
|
CP0407162
|
US10047103, 29
Show/Hide
|
C25H17F3N4O5S2
|
1
|
| 1 |
EC50 = 1.4 nM
|
|
|
|
CP0472015
|
US10047103, 175
Show/Hide
|
C27H24N4O4S2
|
1
|
| 1 |
EC50 = 1.4 nM
|
|
|
|
CP0540398
|
US10047103, 246
Show/Hide
|
C26H29N5O5S
|
1
|
| 1 |
EC50 = 1.4 nM
|
|
|
|
CP0564150
|
US10047103, 278
Show/Hide
|
C27H27N5O3S
|
1
|
| 1 |
EC50 = 1.4 nM
|
|
|
|
CP0407165
|
US10047103, 7
Show/Hide
|
C23H17N5O4S2
|
2
|
| 1 |
EC50 = 1.5 nM
|
|
|
| 2 |
IC50 = 1.5 nM
|
|
|
|
CP0407164
|
US10047103, 27
Show/Hide
|
C24H17ClN4O4S2
|
1
|
| 1 |
EC50 = 1.6 nM
|
|
|
|
CP0407167
|
US10047103, 317
Show/Hide
|
C31H29N5O5S2
|
1
|
| 1 |
EC50 = 1.6 nM
|
|
|
|
CP0540401
|
US10047103, 194
Show/Hide
|
C28H24FN5O4S2
|
1
|
| 1 |
EC50 = 1.6 nM
|
|
|
|
CP0573815
|
US10047103, 187
Show/Hide
|
C23H15ClN4O3S2
|
1
|
| 1 |
EC50 = 1.6 nM
|
|
|
|
CP0963543
|
6-(4-((2-(1,4-dioxaspiro-[4.5]dec-7-en-8-yl)thiazol-4-yl)methoxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C26H26N4O6S2
|
1
|
| 1 |
EC50 = 1.6 nM
|
|
|
|
CP0474442
|
US10047103, 255
Show/Hide
|
C23H23N5O3S
|
1
|
| 1 |
EC50 = 1.7 nM
|
|
|
|
CP0497822
|
US10047103, 170
Show/Hide
|
C27H31N5O6S3
|
1
|
| 1 |
EC50 = 1.7 nM
|
|
|
|
CP0539401
|
US10047103, 33
Show/Hide
|
C22H17N5O5S2
|
1
|
| 1 |
EC50 = 1.7 nM
|
|
|
|
CP0572096
|
US10047103, 153
Show/Hide
|
C29H25BrN4O5S2
|
1
|
| 1 |
EC50 = 1.7 nM
|
|
|
|
CP0573742
|
US10047103, 268
Show/Hide
|
C30H27ClN6O3S
|
1
|
| 1 |
EC50 = 1.7 nM
|
|
|
|
CP0385236
|
US10047103, 231
Show/Hide
|
C26H21N5O3S
|
1
|
| 1 |
EC50 = 1.8 nM
|
|
|
|
CP0512545
|
US10047103, 1
Show/Hide
|
C19H16N4O4S2
|
2
|
| 1 |
EC50 = 1.8 nM
|
|
|
| 2 |
IC50 = 1.8 nM
|
|
|
|
CP0574127
|
US10047103, 26
Show/Hide
|
C24H17FN4O4S2
|
1
|
| 1 |
EC50 = 1.8 nM
|
|
|
|
CP0474350
|
US10047103, 132
Show/Hide
|
C24H20F4N4O5S2
|
1
|
| 1 |
EC50 = 1.9 nM
|
|
|
|
CP0546561
|
US10047103, 192
Show/Hide
|
C25H19FN4O3S2
|
1
|
| 1 |
EC50 = 1.9 nM
|
|
|
|
CP0573789
|
US10047103, 236
Show/Hide
|
C25H26N6O5S2
|
1
|
| 1 |
EC50 = 1.9 nM
|
|
|
|
CP0385253
|
US10047103, 272
Show/Hide
|
C25H24FN5O3S
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
|
CP0539404
|
US10047103, 13
Show/Hide
|
C25H20N4O4S2
|
1
|
| 1 |
EC50 = 2.1 nM
|
|
|
|
CP0563795
|
US10047103, 296
Show/Hide
|
C29H25N5O5S2
|
1
|
| 1 |
EC50 = 2.2 nM
|
|
|
|
CP0407156
|
US10047103, 102
Show/Hide
|
C25H28N6O6S3
|
1
|
| 1 |
EC50 = 2.3 nM
|
|
|
|
CP0407160
|
US10047103, 64
Show/Hide
|
C25H17N5O4S2
|
1
|
| 1 |
EC50 = 2.3 nM
|
|
|
|
CP0574126
|
US10047103, 46
Show/Hide
|
C26H20N4O6S2
|
1
|
| 1 |
EC50 = 2.4 nM
|
|
|
|
CP0411903
|
US10047103, 38
Show/Hide
|
C27H24N4O5S2
|
2
|
| 1 |
EC50 = 2.5 nM
|
|
|
| 2 |
IC50 = 2.4 nM
|
|
|
|
CP0486527
|
US10047103, 42
Show/Hide
|
C30H29N5O5S2
|
1
|
| 1 |
EC50 = 2.5 nM
|
|
|
|
CP0491029
|
US10047103, 18
Show/Hide
|
C25H20N4O5S2
|
1
|
| 1 |
EC50 = 2.5 nM
|
|
|
|
CP0555445
|
US10047103, 269
Show/Hide
|
C29H28N6O3S
|
1
|
| 1 |
EC50 = 2.5 nM
|
|
|
|
CP0545175
|
US10047103, 79
Show/Hide
|
C24H19N5O5S2
|
1
|
| 1 |
EC50 = 2.6 nM
|
|
|
|
CP0573737
|
US10047103, 191
Show/Hide
|
C23H16N4O3S2
|
1
|
| 1 |
EC50 = 2.6 nM
|
|
|
|
CP0420219
|
US10047103, 233
Show/Hide
|
C25H18ClN5O3S
|
1
|
| 1 |
EC50 = 2.8 nM
|
|
|
|
CP0462804
|
US10047103, 283
Show/Hide
|
C27H23N5O4S
|
1
|
| 1 |
EC50 = 2.9 nM
|
|
|
|
CP0512540
|
US10047103, 88
Show/Hide
|
C23H21N5O6S2
|
1
|
| 1 |
EC50 = 2.9 nM
|
|
|
|
CP0549225
|
US10047103, 285
Show/Hide
|
C30H29N7O3S
|
1
|
| 1 |
EC50 = 2.9 nM
|
|
|
|
CP0575840
|
US10047103, 248
Show/Hide
|
C28H26N6O3S
|
1
|
| 1 |
EC50 = 3.1 nM
|
|
|
|
CP0546558
|
US10047103, 215
Show/Hide
|
C24H23N5O4S
|
1
|
| 1 |
EC50 = 3.3 nM
|
|
|
|
CP0403448
|
US10047103, 16
Show/Hide
|
C24H17ClN4O4S2
|
1
|
| 1 |
EC50 = 3.4 nM
|
|
|
|
CP0554510
|
US10047103, 274
Show/Hide
|
C25H25N5O3S
|
1
|
| 1 |
EC50 = 3.4 nM
|
|
|
|
CP0385459
|
US10047103, 237
Show/Hide
|
C31H27N7O5S2
|
1
|
| 1 |
EC50 = 3.5 nM
|
|
|
|
CP0540399
|
US10047103, 205
Show/Hide
|
C20H15BrN4O3S
|
1
|
| 1 |
EC50 = 3.5 nM
|
|
|
|
CP0543525
|
US10047103, 10
Show/Hide
|
C23H18N6O4S
|
1
|
| 1 |
EC50 = 3.5 nM
|
|
|
|
CP0385458
|
US10047103, 250
Show/Hide
|
C24H22N6O3S
|
1
|
| 1 |
EC50 = 3.6 nM
|
|
|
|
CP0403440
|
US10047103, 157
Show/Hide
|
C30H28N4O5S2
|
1
|
| 1 |
EC50 = 3.6 nM
|
|
|
|
CP0546275
|
US10047103, 213
Show/Hide
|
C25H24N4O4S
|
1
|
| 1 |
EC50 = 3.6 nM
|
|
|
|
CP0380499
|
US10047103, 8
Show/Hide
|
C23H17N5O4S2
|
2
|
| 1 |
EC50 = 3.9 nM
|
|
|
| 2 |
IC50 = 3.9 nM
|
|
|
|
CP0545172
|
US10047103, 149
Show/Hide
|
C29H32N4O7S2
|
1
|
| 1 |
EC50 = 4.1 nM
|
|
|
|
CP0491221
|
US10047103, 275
Show/Hide
|
C25H25N5O3S
|
1
|
| 1 |
EC50 = 4.2 nM
|
|
|
|
CP0573763
|
US10047103, 267
Show/Hide
|
C27H23N5O3S
|
1
|
| 1 |
EC50 = 4.2 nM
|
|
|
|
CP0539405
|
US10047103, 9
Show/Hide
|
C23H18N6O4S
|
1
|
| 1 |
EC50 = 5.3 nM
|
|
|
|
CP0554519
|
US10047103, 245
Show/Hide
|
C26H22N6O3S
|
1
|
| 1 |
EC50 = 5.5 nM
|
|
|
|
CP0550556
|
US10047103, 270
Show/Hide
|
C30H29N7O3S
|
1
|
| 1 |
EC50 = 5.8 nM
|
|
|
|
CP0389353
|
US10047103, 280
Show/Hide
|
C24H25N5O3S
|
1
|
| 1 |
EC50 = 6.2 nM
|
|
|
|
CP0409824
|
US10047103, 240
Show/Hide
|
C31H27ClN4O4S
|
1
|
| 1 |
EC50 = 6.9 nM
|
|
|
|
CP0546555
|
US10047103, 260
Show/Hide
|
C27H20N6O3S
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0420217
|
US10047103, 279
Show/Hide
|
C22H21N5O3S
|
1
|
| 1 |
EC50 = 7.3 nM
|
|
|
|
CP0543367
|
US10047103, 257
Show/Hide
|
C23H21N5O3S
|
1
|
| 1 |
EC50 = 7.5 nM
|
|
|
|
CP0501028
|
US10047103, 207
Show/Hide
|
C25H26N6O3S
|
1
|
| 1 |
EC50 = 7.7 nM
|
|
|
|
CP0414759
|
US10047103, 256
Show/Hide
|
C25H25N5O4S
|
1
|
| 1 |
EC50 = 7.8 nM
|
|
|
|
CP0543368
|
US10047103, 253
Show/Hide
|
C24H23N5O4S
|
1
|
| 1 |
EC50 = 9.7 nM
|
|
|
|
CP0414750
|
US10047103, 251
Show/Hide
|
C23H23N5O4S
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0497819
|
US9688695, 206
Show/Hide
|
C20H15ClN4O3S
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0547285
|
US10047103, 249
Show/Hide
|
C23H23N5O4S
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0572987
|
US10047103, 266
Show/Hide
|
C27H22FN5O3S
|
1
|
| 1 |
EC50 = 16 nM
|
|
|
|
CP0468172
|
US10047103, 254
Show/Hide
|
C27H28N6O4S
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0462795
|
US10047103, 307
Show/Hide
|
C29H28N6O5S2
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0539470
|
US10047103, 276
Show/Hide
|
C26H28N6O3S
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0545174
|
US10047103, 87
Show/Hide
|
C19H17N5O4S2
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0546277
|
2-(Dimethylamino)-N-(4-(4-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)-thiazol-2-yl)tetrahydro-2H-pyran-4-yl)acetamide
Show/Hide
|
C27H30N6O6S2
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0403023
|
US10047103, 243
Show/Hide
|
C26H28N6O4S
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
|
CP0414773
|
US10047103, 261
Show/Hide
|
C28H22N6O3S
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0486560
|
US10047103, 202
Show/Hide
|
C23H15F2N5O2S2
|
1
|
| 1 |
EC50 = 43 nM
|
|
|
|
CP0543312
|
US10047103, 265
Show/Hide
|
C26H19F2N5O3S
|
1
|
| 1 |
EC50 = 48 nM
|
|
|
|
CP0407583
|
US10047103, 273
Show/Hide
|
C29H32N6O4S
|
1
|
| 1 |
EC50 = 53 nM
|
|
|
|
CP0468183
|
US10047103, 295
Show/Hide
|
C28H23N5O6S2
|
1
|
| 1 |
EC50 = 92 nM
|
|
|
|
CP0472011
|
US10047103, 286
Show/Hide
|
C29H32N6O4S
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
|
CP0548135
|
US10047103, 264
Show/Hide
|
C27H24N6O3S
|
1
|
| 1 |
EC50 = 207 nM
|
|
|
|
CP0501026
|
US10047103, 252
Show/Hide
|
C27H30N6O3S
|
1
|
| 1 |
EC50 = 871 nM
|
|
|
|
CP0417794
|
US10047103, 244
Show/Hide
|
C26H28N6O4S
|
1
|
| 1 |
EC50 = 909 nM
|
|
|
|
CP0462803
|
US10047103, 282
Show/Hide
|
C26H21FN6O3S
|
1
|
| 1 |
EC50 = 3475 nM
|
|
|
|
CP0544442
|
4-(6-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)pyridin-2-yl)-N,N-dimethylbenzamide
Show/Hide
|
C29H25N5O5S
|
1
|
| 1 |
IC50 = 0.23 nM
|
|
|
|
CP0544445
|
2-Methoxy-6-(6-methoxy-4-((6-(4-methoxytetrahydro-2H-pyran-4-yl)pyridin-2-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C26H26N4O6S
|
1
|
| 1 |
IC50 = 0.23 nM
|
|
|
|
CP0544443
|
US9518064, Example 98
Show/Hide
|
C28H24N6O5S
|
1
|
| 1 |
IC50 = 0.29 nM
|
|
|
|
CP0416339
|
(S)-2-(1-Fluoroethyl)-6-(4-((6-(4-fluorotetrahydro-2H-pyran-4-yl)pyridin-2-yl)methoxy)-6-methoxybenzo-furan-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C26H24F2N4O4S
|
1
|
| 1 |
IC50 = 0.31 nM
|
|
|
|
CP0550802
|
US9862730, Example 349
Show/Hide
|
C28H22ClN3O5S
|
1
|
| 1 |
IC50 = 0.32 nM
|
|
|
|
CP0544446
|
6-(4-((6-(4-Fluorotetrahydro-2H-pyran-4-yl)pyridin-2-yl)methoxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C25H23FN4O5S
|
1
|
| 1 |
IC50 = 0.35 nM
|
|
|
|
CP0429593
|
6-(4-((2-(2-fluoropyridin-4-yl)pyrimidin-4-yl)methoxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C24H17FN6O4S
|
1
|
| 1 |
IC50 = 0.36 nM
|
|
|
|
CP0573721
|
US9518064, Example 37
Show/Hide
|
C28H25N5O5S
|
1
|
| 1 |
IC50 = 0.36 nM
|
|
|
|
CP0573727
|
(S)-2-(1-Fluoroethyl)-6-(6-methoxy-4-((6-(4-methoxytetrahydro-2H-pyran-4-yl)pyridin-2-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C27H27FN4O5S
|
1
|
| 1 |
IC50 = 0.36 nM
|
|
|
|
CP0573720
|
US9518064, Example 36
Show/Hide
|
C26H19ClN4O4S
|
1
|
| 1 |
IC50 = 0.38 nM
|
|
|
|
CP0417219
|
6-(4-((3-Fluoro-5-(2-methoxypyrimidin-5-yl)benzyl)oxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C26H20FN5O5S
|
1
|
| 1 |
IC50 = 0.39 nM
|
|
|
|
CP0543230
|
4-[4-[[6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]pyrimidin-2-yl]morpholine
Show/Hide
|
C23H22N6O5S
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0576938
|
2-methoxy-6-[6-methoxy-4-[(2-propyl-1,3-thiazol-4-yl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C21H20N4O4S2
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0558420
|
(S)-4-(6-(((2-(2-(1-Fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)-6-methoxybenzofuran-4-yl)oxy)methyl)pyridin-2-yl)tetrahydro-2H-pyran-4-ol
Show/Hide
|
C26H25FN4O5S
|
1
|
| 1 |
IC50 = 0.41 nM
|
|
|
|
CP0403468
|
4-(6-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo-furan-4-yl)oxy)methyl)pyridin-2-yl)tetrahydro-2H-pyran-4-ol
Show/Hide
|
C25H24N4O6S
|
1
|
| 1 |
IC50 = 0.45 nM
|
|
|
|
CP0408208
|
US9518064, Example 40
Show/Hide
|
C27H22N4O5S
|
2
|
| 1 |
IC50 = 0.47 nM
|
|
|
| 2 |
IC50 = 0.5 nM
|
|
|
|
CP0417216
|
US9518064, Example 34
Show/Hide
|
C27H22N4O5S
|
2
|
| 1 |
IC50 = 0.48 nM
|
|
|
| 2 |
IC50 = 0.5 nM
|
|
|
|
CP0472494
|
US9518064, Example 35
Show/Hide
|
C27H19N5O4S
|
2
|
| 1 |
IC50 = 0.49 nM
|
|
|
| 2 |
IC50 = 0.5 nM
|
|
|
|
CP0462739
|
US9518064, Example 71
Show/Hide
|
C27H23N5O6S
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0417217
|
US9518064, Example 39
Show/Hide
|
C27H21FN4O4S
|
1
|
| 1 |
IC50 = 0.53 nM
|
|
|
|
CP0416336
|
2-Methoxy-6-(6-methoxy-4-((3-(5-(1-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)pyridin-2-yl)benzyl)oxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C33H32N4O6S
|
1
|
| 1 |
IC50 = 0.56 nM
|
|
|
|
CP0544435
|
US9518064, Example 52
Show/Hide
|
C27H21ClN4O4S
|
1
|
| 1 |
IC50 = 0.56 nM
|
|
|
|
CP0416331
|
US9518064, Example 32
Show/Hide
|
C27H21FN4O4S
|
1
|
| 1 |
IC50 = 0.57 nM
|
|
|
|
CP0417218
|
6-(4-((3-(6-Chloropyridin-3-yl)-5-methoxybenzyl)oxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1b][1,3,4]thiadiazole
Show/Hide
|
C27H21ClN4O5S
|
1
|
| 1 |
IC50 = 0.57 nM
|
|
|
|
CP0408292
|
US9862730, Example 399
Show/Hide
|
C26H22N4O5S2
|
1
|
| 1 |
IC50 = 0.59 nM
|
|
|
|
CP0544434
|
US9518064, Example 43
Show/Hide
|
C27H19F3N4O4S
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
|
CP0564558
|
4-[6-[[6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]pyridin-2-yl]morpholine
Show/Hide
|
C24H23N5O5S
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
|
CP0564555
|
2-methoxy-6-[6-methoxy-4-[[3-methoxy-5-(trifluoromethyl)phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C23H18F3N3O5S
|
1
|
| 1 |
IC50 = 0.63 nM
|
|
|
|
CP0544432
|
US9518064, Example 33
Show/Hide
|
C26H18F2N4O4S
|
1
|
| 1 |
IC50 = 0.67 nM
|
|
|
|
CP0558419
|
US9518064, Example 38
Show/Hide
|
C27H21FN4O4S
|
1
|
| 1 |
IC50 = 0.68 nM
|
|
|
|
CP0429592
|
US9518064, Example 95
Show/Hide
|
C27H27N3O4S
|
1
|
| 1 |
IC50 = 0.69 nM
|
|
|
|
CP0559237
|
US9518064, Example 55
Show/Hide
|
C26H19FN4O4S
|
1
|
| 1 |
IC50 = 0.69 nM
|
|
|
|
CP0572101
|
US9518064, Example 47
Show/Hide
|
C26H21N5O5S
|
2
|
| 1 |
IC50 = 0.69 nM
|
|
|
| 2 |
IC50 = 0.7 nM
|
|
|
|
CP0578963
|
4-[3-[[6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]phenyl]morpholine
Show/Hide
|
C25H24N4O5S
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0417222
|
US9518064, Example 93
Show/Hide
|
C26H23N3O5S
|
1
|
| 1 |
IC50 = 0.71 nM
|
|
|
|
CP0416337
|
2-Methoxy-6-(6-methoxy-4-((3-(tetrahydro-2H-pyran-4-yl)benzyl)oxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C26H25N3O5S
|
1
|
| 1 |
IC50 = 0.72 nM
|
|
|
|
CP0429594
|
US9518064, Example 102
Show/Hide
|
C23H18N6O4S2
|
1
|
| 1 |
IC50 = 0.72 nM
|
|
|
|
CP0403684
|
US9862730, Example 314
Show/Hide
|
C28H21F2N3O5S
|
1
|
| 1 |
IC50 = 0.72 nM
|
|
|
|
CP0381765
|
US9862730, Example 389
Show/Hide
|
C30H27N3O7S
|
1
|
| 1 |
IC50 = 0.73 nM
|
|
|
|
CP0544436
|
US9518064, Example 56
Show/Hide
|
C26H19ClN4O4S
|
1
|
| 1 |
IC50 = 0.74 nM
|
|
|
|
CP0572607
|
US9518064, Example 100
Show/Hide
|
C26H21N5O5S
|
1
|
| 1 |
IC50 = 0.76 nM
|
|
|
|
CP0385567
|
US9862730, Example 350
Show/Hide
|
C28H22FN3O5S
|
1
|
| 1 |
IC50 = 0.76 nM
|
|
|
|
CP0385158
|
US9518064, Example 89
Show/Hide
|
C31H28N4O6S
|
1
|
| 1 |
IC50 = 0.79 nM
|
|
|
|
CP0413958
|
US9518064, Example 6
Show/Hide
|
C25H19N3O5S
|
2
|
| 1 |
IC50 = 0.8 nM
|
|
|
| 2 |
IC50 = 1.86 nM
|
|
|
|
CP0564557
|
2-methoxy-6-[6-methoxy-4-[[2-(6-methoxypyridin-3-yl)-1,3-thiazol-4-yl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C24H19N5O5S2
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
|
|
CP0571803
|
2-methoxy-6-[6-methoxy-4-(2-phenoxyethoxy)-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C22H19N3O5S
|
1
|
| 1 |
IC50 = 0.81 nM
|
|
|
|
CP0408212
|
6-(4-((3-Fluoro-5-(5-methoxypyridin-2-yl)benzyl)oxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C27H21FN4O5S
|
1
|
| 1 |
IC50 = 0.84 nM
|
|
|
|
CP0417223
|
US9518064, Example 104
Show/Hide
|
C27H21N5O6S
|
1
|
| 1 |
IC50 = 0.85 nM
|
|
|
|
CP0560259
|
US9862730, Example 345
Show/Hide
|
C28H23N3O4S2
|
1
|
| 1 |
IC50 = 0.86 nM
|
|
|
|
CP0550803
|
(R)-6-(4-((2,2-Dimethyl-1,3-dioxolan-4-yl)methoxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C20H21N3O6S
|
1
|
| 1 |
IC50 = 0.87 nM
|
|
|
|
CP0571813
|
2-methoxy-6-[6-methoxy-4-[(3-phenylsulfanylphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C27H21N3O4S2
|
1
|
| 1 |
IC50 = 0.89 nM
|
|
|
|
CP0559238
|
2-Methoxy-6-(6-methoxy-4-((2-phenylpyrimidin-4-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C25H19N5O4S
|
2
|
| 1 |
IC50 = 0.9 nM
|
|
|
| 2 |
IC50 = 0.92 nM
|
|
|
|
CP0403467
|
US9518064, Example 78
Show/Hide
|
C27H22N4O5S
|
1
|
| 1 |
IC50 = 0.95 nM
|
|
|
|
CP0552689
|
3-[[6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]benzonitrile
Show/Hide
|
C22H16N4O4S
|
1
|
| 1 |
IC50 = 0.98 nM
|
|
|
|
CP0385425
|
US9862730, Example 73
Show/Hide
|
C15H13N3O4S
|
1
|
| 1 |
IC50 = 0.99 nM
|
|
|
|
CP0544439
|
US9518064, Example 61
Show/Hide
|
C36H32N4O6S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0416333
|
US9518064, Example 45
Show/Hide
|
C26H19FN4O4S
|
1
|
| 1 |
IC50 = 1.03 nM
|
|
|
|
CP0548846
|
US9518064, Example 48
Show/Hide
|
C24H18N4O4S2
|
1
|
| 1 |
IC50 = 1.03 nM
|
|
|
|
CP0544433
|
US9518064, Example 42
Show/Hide
|
C26H18N6O4S
|
1
|
| 1 |
IC50 = 1.05 nM
|
|
|
|
CP0546624
|
US9518064, Example 105
Show/Hide
|
C28H23N5O4S
|
1
|
| 1 |
IC50 = 1.06 nM
|
|
|
|
CP0549395
|
2-Methoxy-6-(6-methoxy-4-((3-(pyrimidin-5-yl)benzyl)oxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C25H19N5O4S
|
2
|
| 1 |
IC50 = 1.06 nM
|
|
|
| 2 |
IC50 = 1.1 nM
|
|
|
|
CP0575835
|
6-(4-((5-(Furan-3-yl)pyridin-3-yl)methoxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C24H18N4O5S
|
1
|
| 1 |
IC50 = 1.08 nM
|
|
|
|
CP0559239
|
6-(6-Chloro-4-((3-(2-methoxypyrimidin-5-yl)benzyl)oxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C25H18ClN5O4S
|
1
|
| 1 |
IC50 = 1.09 nM
|
|
|
|
CP0546573
|
6-(4-((3-(Benzyloxy)benzyl)oxy)-6-(difluoromethoxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C28H21F2N3O5S
|
1
|
| 1 |
IC50 = 1.09 nM
|
|
|
|
CP0472495
|
US9518064, Example 88
Show/Hide
|
C32H29N3O6S
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0530114
|
2-methoxy-6-[6-methoxy-4-(2-phenylethoxy)-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C22H19N3O4S
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0578277
|
4-[4-[[6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]-1,3-thiazol-2-yl]benzoic acid
Show/Hide
|
C25H18N4O6S2
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0408219
|
1-(6-(3-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)phenyl)pyridin-3-yl)ethanol
Show/Hide
|
C28H24N4O5S
|
1
|
| 1 |
IC50 = 1.11 nM
|
|
|
|
CP0566992
|
US9862730, Example 380
Show/Hide
|
C31H29N3O8S
|
1
|
| 1 |
IC50 = 1.11 nM
|
|
|
|
CP0397582
|
US9862730, Example 344
Show/Hide
|
C27H20BrN3O4S
|
1
|
| 1 |
IC50 = 1.12 nM
|
|
|
|
CP0460240
|
US9862730, Example 407
Show/Hide
|
C29H24FN3O4S
|
1
|
| 1 |
IC50 = 1.12 nM
|
|
|
|
CP0408210
|
US9518064, Example 51
Show/Hide
|
C28H24N4O5S
|
1
|
| 1 |
IC50 = 1.19 nM
|
|
|
|
CP0438098
|
2-methoxy-6-[6-methoxy-4-[(3-phenoxyphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C27H21N3O5S
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0531035
|
US9862730, Example 71
Show/Hide
|
C14H11N3O3S
|
2
|
| 1 |
IC50 = 1.2 nM
|
|
|
| 2 |
IC50 = 1.22 nM
|
|
|
|
CP0416332
|
US9518064, Example 44
Show/Hide
|
C26H19FN4O4S
|
1
|
| 1 |
IC50 = 1.21 nM
|
|
|
|
CP0544437
|
US9518064, Example 58
Show/Hide
|
C27H23N5O6S
|
1
|
| 1 |
IC50 = 1.22 nM
|
|
|
|
CP0547215
|
US9862730, Example 309
Show/Hide
|
C29H25N3O6S
|
1
|
| 1 |
IC50 = 1.22 nM
|
|
|
|
CP0574055
|
US9862730, Example 229
Show/Hide
|
C15H13N3O3S2
|
1
|
| 1 |
IC50 = 1.22 nM
|
|
|
|
CP0538874
|
US9862730, Example 362
Show/Hide
|
C28H22ClN3O5S
|
1
|
| 1 |
IC50 = 1.24 nM
|
|
|
|
CP0384848
|
US9518064, Example 9
Show/Hide
|
C25H19N3O4S2
|
1
|
| 1 |
IC50 = 1.26 nM
|
|
|
|
CP0408290
|
US9862730, Example 401
Show/Hide
|
C29H24ClN3O6S
|
1
|
| 1 |
IC50 = 1.28 nM
|
|
|
|
CP0462691
|
US9518064, Example 7
Show/Hide
|
C26H19FN4O4S
|
1
|
| 1 |
IC50 = 1.29 nM
|
|
|
|
CP0533671
|
2-methoxy-6-[6-methoxy-4-[(4-phenylmethoxyphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C28H23N3O5S
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0546623
|
2-(6-Methoxy-4-((3-(2-methoxypyrimidin-5-yl)benzyl)oxy)benzofuran-2-yl)-6-methylimidazo[1,2-b]pyridazine
Show/Hide
|
C28H23N5O4
|
1
|
| 1 |
IC50 = 1.32 nM
|
|
|
|
CP0468520
|
US9862730, Example 361
Show/Hide
|
C30H26ClN3O7S
|
1
|
| 1 |
IC50 = 1.35 nM
|
|
|
|
CP0472496
|
US9518064, Example 103
Show/Hide
|
C22H19N5O4S
|
1
|
| 1 |
IC50 = 1.39 nM
|
|
|
|
CP0545212
|
6-(6-Chloro-4-((3-(5-methoxypyrazin-2-yl)benzyl)oxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C25H18ClN5O4S
|
1
|
| 1 |
IC50 = 1.43 nM
|
|
|
|
CP0573509
|
US9862730, Example 392
Show/Hide
|
C29H25N3O6S
|
1
|
| 1 |
IC50 = 1.44 nM
|
|
|
|
CP0403464
|
US9518064, Example 54
Show/Hide
|
C26H18Cl2N4O4S
|
1
|
| 1 |
IC50 = 1.47 nM
|
|
|
|
CP0416335
|
US9518064, Example 53
Show/Hide
|
C26H21N5O5S
|
2
|
| 1 |
IC50 = 1.48 nM
|
|
|
| 2 |
IC50 = 1.5 nM
|
|
|
|
CP0572102
|
US9518064, Example 70
Show/Hide
|
C26H17F3N4O4S
|
1
|
| 1 |
IC50 = 1.48 nM
|
|
|
|
CP0550806
|
US9862730, Example 323
Show/Hide
|
C28H21ClFN3O5S
|
1
|
| 1 |
IC50 = 1.48 nM
|
|
|
|
CP0417220
|
5-(3-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)phenyl)-N-(2-methoxyethyl)-N-methylpicolinamide
Show/Hide
|
C31H29N5O6S
|
1
|
| 1 |
IC50 = 1.49 nM
|
|
|
|
CP0413960
|
US9518064, Example 14
Show/Hide
|
C26H19FN4O4S
|
1
|
| 1 |
IC50 = 1.53 nM
|
|
|
|
CP0408216
|
US9518064, Example 74
Show/Hide
|
C25H18ClN5O4S
|
1
|
| 1 |
IC50 = 1.57 nM
|
|
|
|
CP0544444
|
(2-(3-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)phenyl)-5-methylthiazol-4-yl)methanol
Show/Hide
|
C26H22N4O5S2
|
1
|
| 1 |
IC50 = 1.59 nM
|
|
|
|
CP0468455
|
US9862730, Example 390
Show/Hide
|
C30H27N3O7S
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0566016
|
2-methoxy-6-[6-methoxy-4-[(4-methoxyphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C22H19N3O5S
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0572935
|
2-methoxy-6-[6-methoxy-4-[(2-methylphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C22H19N3O4S
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0416334
|
US9518064, Example 46
Show/Hide
|
C27H19N5O4S
|
1
|
| 1 |
IC50 = 1.64 nM
|
|
|
|
CP0547212
|
US9862730, Example 325
Show/Hide
|
C28H20F3N3O5S
|
1
|
| 1 |
IC50 = 1.64 nM
|
|
|
|
CP0474794
|
US9862730, Example 355
Show/Hide
|
C28H21N3O6S
|
1
|
| 1 |
IC50 = 1.65 nM
|
|
|
|
CP0403465
|
US9518064, Example 57
Show/Hide
|
C31H27N5O6S
|
1
|
| 1 |
IC50 = 1.66 nM
|
|
|
|
CP0566997
|
US9862730, Example 356
Show/Hide
|
C29H21F4N3O5S
|
1
|
| 1 |
IC50 = 1.66 nM
|
|
|
|
CP0547735
|
US9862730, Example 382
Show/Hide
|
C30H27N3O5S
|
1
|
| 1 |
IC50 = 1.67 nM
|
|
|
|
CP0548862
|
US9862730, Example 346
Show/Hide
|
C28H22FN3O5S
|
1
|
| 1 |
IC50 = 1.68 nM
|
|
|
|
CP0491033
|
US9518064, Example 8
Show/Hide
|
C29H25N3O5S
|
1
|
| 1 |
IC50 = 1.69 nM
|
|
|
|
CP0580233
|
4-[4-[[6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]-1,3-thiazol-2-yl]morpholin-3-one
Show/Hide
|
C22H19N5O6S2
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0462692
|
US9518064, Example 13
Show/Hide
|
C27H19N5O4S
|
1
|
| 1 |
IC50 = 1.74 nM
|
|
|
|
CP0408295
|
US9862730, Example 386
Show/Hide
|
C29H25N3O5S
|
1
|
| 1 |
IC50 = 1.77 nM
|
|
|
|
CP0562200
|
2-methoxy-6-[6-methoxy-4-(2-phenylmethoxyethoxy)-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C23H21N3O5S
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0546572
|
6-(4-((3-(Benzyloxy)benzyl)oxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C27H21N3O4S
|
1
|
| 1 |
IC50 = 1.82 nM
|
|
|
|
CP0548847
|
US9518064, Example 50
Show/Hide
|
C26H18ClFN4O4S
|
1
|
| 1 |
IC50 = 1.88 nM
|
|
|
|
CP0544736
|
US9862730, Example 427
Show/Hide
|
C27H20FN3O4S
|
1
|
| 1 |
IC50 = 1.91 nM
|
|
|
|
CP0468523
|
US9862730, Example 318
Show/Hide
|
C28H22FN3O5S
|
1
|
| 1 |
IC50 = 1.92 nM
|
|
|
|
CP0574056
|
6-(4-Ethoxy, 6-methoxybenzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C16H15N3O4S
|
1
|
| 1 |
IC50 = 2.01 nM
|
|
|
|
CP0573723
|
US9518064, Example 49
Show/Hide
|
C28H25N5O4S
|
1
|
| 1 |
IC50 = 2.02 nM
|
|
|
|
CP0420485
|
US9518064, Example 25
Show/Hide
|
C27H22N4O4S
|
1
|
| 1 |
IC50 = 2.04 nM
|
|
|
|
CP0538876
|
US9862730, Example 354
Show/Hide
|
C28H21BrFN3O5S
|
1
|
| 1 |
IC50 = 2.06 nM
|
|
|
|
CP0574041
|
US9862730, Example 313
Show/Hide
|
C31H29N3O5S
|
1
|
| 1 |
IC50 = 2.11 nM
|
|
|
|
CP0391642
|
US9862730, Example 312
Show/Hide
|
C30H27N3O5S
|
1
|
| 1 |
IC50 = 2.13 nM
|
|
|
|
CP0384783
|
US9518064, Example 75
Show/Hide
|
C25H20N6O5S
|
1
|
| 1 |
IC50 = 2.14 nM
|
|
|
|
CP0573508
|
US9862730, Example 398
Show/Hide
|
C27H22N4O5S
|
1
|
| 1 |
IC50 = 2.14 nM
|
|
|
|
CP0420487
|
US9518064, Example 73
Show/Hide
|
C27H22N4O5S
|
1
|
| 1 |
IC50 = 2.18 nM
|
|
|
|
CP0575838
|
US9518064, Example 77
Show/Hide
|
C25H20N6O5S
|
1
|
| 1 |
IC50 = 2.18 nM
|
|
|
|
CP0573724
|
US9518064, Example 94
Show/Hide
|
C27H25N3O4S
|
1
|
| 1 |
IC50 = 2.21 nM
|
|
|
|
CP0385570
|
US9862730, Example 340
Show/Hide
|
C24H28N4O6S
|
1
|
| 1 |
IC50 = 2.21 nM
|
|
|
|
CP0567000
|
US9862730, Example 351
Show/Hide
|
C29H25N3O6S
|
1
|
| 1 |
IC50 = 2.23 nM
|
|
|
|
CP0566998
|
US9862730, Example 353
Show/Hide
|
C30H27N3O7S
|
1
|
| 1 |
IC50 = 2.25 nM
|
|
|
|
CP0441500
|
US9862730, Example 348
Show/Hide
|
C29H25N3O5S
|
1
|
| 1 |
IC50 = 2.26 nM
|
|
|
|
CP0540601
|
US9862730, Example 372
Show/Hide
|
C34H27N3O6S
|
1
|
| 1 |
IC50 = 2.27 nM
|
|
|
|
CP0546109
|
US9862730, Example 397
Show/Hide
|
C35H28N4O6S
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
|
CP0566995
|
US9862730, Example 374
Show/Hide
|
C28H21F2N3O5S
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
|
CP0562201
|
6-[4-[(2-chlorophenyl)methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C21H16ClN3O4S
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
|
CP0411896
|
US9518064, Example 5
Show/Hide
|
C26H22N4O5S
|
1
|
| 1 |
IC50 = 2.36 nM
|
|
|
|
CP0533536
|
6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C28H23N3O5S
|
4
|
| 1 |
IC50 = 2.4 nM
|
|
|
| 2 |
IC50 = 2.42 nM
|
|
|
| 3 |
Kd = 1.4 nM
|
|
|
| 4 |
Kd = 3 nM
|
|
|
|
CP0571802
|
2-methoxy-6-[6-methoxy-4-[[3-(2-phenylethyl)phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C29H25N3O4S
|
1
|
| 1 |
IC50 = 2.4 nM
|
|
|
|
CP0544429
|
US9518064, Example 19
Show/Hide
|
C27H23N5O6S
|
1
|
| 1 |
IC50 = 2.42 nM
|
|
|
|
CP0566996
|
US9862730, Example 363
Show/Hide
|
C29H25N3O5S
|
1
|
| 1 |
IC50 = 2.42 nM
|
|
|
|
CP0493446
|
US9862730, Example 404
Show/Hide
|
C29H25N3O6S
|
1
|
| 1 |
IC50 = 2.44 nM
|
|
|
|
CP0474793
|
US9862730, Example 360
Show/Hide
|
C28H22BrN3O5S
|
1
|
| 1 |
IC50 = 2.47 nM
|
|
|
|
CP0385566
|
US9862730, Example 358
Show/Hide
|
C29H22F3N3O5S
|
1
|
| 1 |
IC50 = 2.54 nM
|
|
|
|
CP0527433
|
US9862730, Example 330
Show/Hide
|
C28H20F3N3O5S
|
1
|
| 1 |
IC50 = 2.62 nM
|
|
|
|
CP0474795
|
US9862730, Example 347
Show/Hide
|
C29H23F2N3O4S
|
1
|
| 1 |
IC50 = 2.74 nM
|
|
|
|
CP0538872
|
US9862730, Example 381
Show/Hide
|
C30H27N3O5S
|
1
|
| 1 |
IC50 = 2.77 nM
|
|
|
|
CP0540582
|
2-Methoxy-6-(7-methoxybenzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C14H11N3O3S
|
2
|
| 1 |
IC50 = 2.8 nM
|
|
|
| 2 |
IC50 = 7.65 nM
|
|
|
|
CP0578243
|
2-methoxy-6-[6-methoxy-4-[(5-phenyl-1,3-thiazol-2-yl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C24H18N4O4S2
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0429599
|
US9862730, Example 25
Show/Hide
|
C16H15N3O3S2
|
1
|
| 1 |
IC50 = 2.81 nM
|
|
|
|
CP0538873
|
US9862730, Example 369
Show/Hide
|
C28H21ClFN3O5S
|
1
|
| 1 |
IC50 = 2.98 nM
|
|
|
|
CP0493447
|
US9862730, Example 391
Show/Hide
|
C28H22IN3O5S
|
1
|
| 1 |
IC50 = 3.03 nM
|
|
|
|
CP0416342
|
2-Methoxy-6-(6-methoxy-4-((3-(pyrimidin-2-yl)benzyl)oxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C25H19N5O4S
|
1
|
| 1 |
IC50 = 3.08 nM
|
|
|
|
CP0468512
|
US9862730, Example 109
Show/Hide
|
C13H8ClN3O2S
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0421756
|
3-[[6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]phenol
Show/Hide
|
C21H17N3O5S
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0552604
|
2-methoxy-6-[6-methoxy-4-[[3-(trifluoromethyl)phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C22H16F3N3O4S
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0408294
|
US9862730, Example 388
Show/Hide
|
C30H27N3O7S
|
1
|
| 1 |
IC50 = 3.12 nM
|
|
|
|
CP0493449
|
US9862730, Example 385
Show/Hide
|
C29H21F4N3O5S
|
1
|
| 1 |
IC50 = 3.13 nM
|
|
|
|
CP0547815
|
6-(5-Chloro-6-methoxybenzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C14H10ClN3O2S2
|
1
|
| 1 |
IC50 = 3.15 nM
|
|
|
|
CP0552605
|
2-methoxy-6-[6-methoxy-4-[[3-(phenoxymethyl)phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C28H23N3O5S
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0555438
|
2-methoxy-6-[6-methoxy-4-[(2-phenylmethoxyphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C28H23N3O5S
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0468517
|
US9862730, Example 365
Show/Hide
|
C28H21Cl2N3O5S
|
1
|
| 1 |
IC50 = 3.27 nM
|
|
|
|
CP0560204
|
6-[4-[(3-chlorophenyl)methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C21H16ClN3O4S
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0547229
|
US9862730, Example 258
Show/Hide
|
C13H8BrN3OS2
|
1
|
| 1 |
IC50 = 3.32 nM
|
|
|
|
CP0574048
|
US9862730, Example 326
Show/Hide
|
C29H22F3N3O5S
|
1
|
| 1 |
IC50 = 3.36 nM
|
|
|
|
CP0408213
|
US9518064, Example 68
Show/Hide
|
C27H19F3N4O3S
|
1
|
| 1 |
IC50 = 3.37 nM
|
|
|
|
CP0381437
|
US9862730, Example 270-1
Show/Hide
|
C15H11ClFN3O2S
|
1
|
| 1 |
IC50 = 3.37 nM
|
|
|
|
CP0530115
|
2-methoxy-6-[6-methoxy-4-[[2-(trifluoromethyl)phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C22H16F3N3O4S
|
1
|
| 1 |
IC50 = 3.4 nM
|
|
|
|
CP0547810
|
US9862730, Example 300
Show/Hide
|
C17H17N3O4S
|
1
|
| 1 |
IC50 = 3.43 nM
|
|
|
|
CP0574042
|
US9862730, Example 310
Show/Hide
|
C32H25N3O5S
|
1
|
| 1 |
IC50 = 3.45 nM
|
|
|
|
CP0540577
|
US9862730, Example 279
Show/Hide
|
C13H8FN3O2S
|
1
|
| 1 |
IC50 = 3.46 nM
|
|
|
|
CP0474785
|
US9862730, Example 97
Show/Hide
|
C13H8FN3O2S
|
1
|
| 1 |
IC50 = 3.48 nM
|
|
|
|
CP0544428
|
US9518064, Example 18
Show/Hide
|
C28H21N3O6S
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0550805
|
US9862730, Example 324
Show/Hide
|
C29H24ClN3O5S
|
1
|
| 1 |
IC50 = 3.52 nM
|
|
|
|
CP0540579
|
US9862730, Example 20
Show/Hide
|
C14H11N3O2S2
|
1
|
| 1 |
IC50 = 3.53 nM
|
|
|
|
CP0411897
|
US9518064, Example 10
Show/Hide
|
C25H21N5O4S
|
1
|
| 1 |
IC50 = 3.55 nM
|
|
|
|
CP0441490
|
US9862730, Example 94
Show/Hide
|
C13H8ClN3O2S
|
1
|
| 1 |
IC50 = 3.58 nM
|
|
|
|
CP0566999
|
US9862730, Example 352
Show/Hide
|
C29H25N3O5S
|
1
|
| 1 |
IC50 = 3.61 nM
|
|
|
|
CP0491034
|
US9518064, Example 11
Show/Hide
|
C25H20N4O4S2
|
1
|
| 1 |
IC50 = 3.66 nM
|
|
|
|
CP0468454
|
US9862730, Example 394
Show/Hide
|
C29H22F3N3O6S
|
1
|
| 1 |
IC50 = 3.68 nM
|
|
|
|
CP0546675
|
US9518064, Example 12
Show/Hide
|
C29H21N3O4S2
|
1
|
| 1 |
IC50 = 3.76 nM
|
|
|
|
CP0420484
|
US9518064, Example 17
Show/Hide
|
C27H19F2N3O4S
|
1
|
| 1 |
IC50 = 3.78 nM
|
|
|
|
CP0560265
|
US9862730, Example 177
Show/Hide
|
C14H12N4O3S2
|
1
|
| 1 |
IC50 = 3.78 nM
|
|
|
|
CP0565945
|
US9862730, Example 72
Show/Hide
|
C16H15N3O4S
|
1
|
| 1 |
IC50 = 3.91 nM
|
|
|
|
CP0547213
|
US9862730, Example 320
Show/Hide
|
C27H21ClN4O5S
|
1
|
| 1 |
IC50 = 3.93 nM
|
|
|
|
CP0155479
|
6-(1-benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C13H9N3O2S
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0569510
|
2-methoxy-6-[6-methoxy-4-[(2-phenyl-1,3-thiazol-5-yl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C24H18N4O4S2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0403466
|
2-(1,1-Difluoroethyl)-6-(6-methoxy-4-((3-(pyrimidin-5-yl)benzyl)oxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C26H19F2N5O3S
|
1
|
| 1 |
IC50 = 4.04 nM
|
|
|
|
CP0548868
|
US9862730, Example 227
Show/Hide
|
C21H17N3O3S2
|
1
|
| 1 |
IC50 = 4.05 nM
|
|
|
|
CP0540602
|
US9862730, Example 367
Show/Hide
|
C29H24BrN3O6S
|
1
|
| 1 |
IC50 = 4.09 nM
|
|
|
|
CP0574040
|
US9862730, Example 316
Show/Hide
|
C29H21F4N3O5S
|
1
|
| 1 |
IC50 = 4.17 nM
|
|
|
|
CP0548848
|
US9518064, Example 60
Show/Hide
|
C31H28N4O6S
|
1
|
| 1 |
IC50 = 4.18 nM
|
|
|
|
CP0570020
|
6-(4-(Benzyloxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C21H17N3O4S
|
2
|
| 1 |
IC50 = 4.2 nM
|
|
|
| 2 |
IC50 = 15.08 nM
|
|
|
|
CP0547225
|
US9862730, Example 262
Show/Hide
|
C13H8FN3OS2
|
1
|
| 1 |
IC50 = 4.28 nM
|
|
|
|
CP0441518
|
US9518064, Example 27
Show/Hide
|
C27H22N4O4S
|
1
|
| 1 |
IC50 = 4.29 nM
|
|
|
|
CP0530116
|
2-methoxy-6-[6-methoxy-4-[[4-(trifluoromethyl)phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C22H16F3N3O4S
|
1
|
| 1 |
IC50 = 4.3 nM
|
|
|
|
CP0416341
|
2-Methoxy-6-(6-methoxy-4-((3′-(trifluoromethyl)-[1,1′-biphenyl]-3-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C28H20F3N3O4S
|
2
|
| 1 |
IC50 = 4.35 nM
|
|
|
| 2 |
IC50 = 4.4 nM
|
|
|
|
CP0574059
|
2-Methoxy-6-(5-chloro-6-methoxybenzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C14H10ClN3O3S
|
1
|
| 1 |
IC50 = 4.38 nM
|
|
|
|
CP0574051
|
US9862730, Example 260
Show/Hide
|
C13H8BrN3O2S
|
1
|
| 1 |
IC50 = 4.45 nM
|
|
|
|
CP0560261
|
US9862730, Example 328
Show/Hide
|
C28H20F3N3O5S
|
1
|
| 1 |
IC50 = 4.5 nM
|
|
|
|
CP0409784
|
US9862730, Example 396
Show/Hide
|
C30H24F3N3O5S
|
1
|
| 1 |
IC50 = 4.51 nM
|
|
|
|
CP0544734
|
6-(4-((3-(Benzyloxy)benzyl)oxy)-6-ethylbenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C29H25N3O4S
|
1
|
| 1 |
IC50 = 4.53 nM
|
|
|
|
CP0546744
|
US9862730, Example 261
Show/Hide
|
C14H10BrN3O2S2
|
1
|
| 1 |
IC50 = 4.53 nM
|
|
|
|
CP0575837
|
US9518064, Example 67
Show/Hide
|
C27H19F3N4O3S
|
1
|
| 1 |
IC50 = 4.54 nM
|
|
|
|
CP0463183
|
US9862730, Example 426
Show/Hide
|
C29H25N3O5S
|
1
|
| 1 |
IC50 = 4.56 nM
|
|
|
|
CP0408289
|
US9862730, Example 405
Show/Hide
|
C27H20ClN3O4S
|
1
|
| 1 |
IC50 = 4.69 nM
|
|
|
|
CP0560258
|
US9862730, Example 368
Show/Hide
|
C28H21Cl2N3O5S
|
1
|
| 1 |
IC50 = 4.69 nM
|
|
|
|
CP0550790
|
US9862730, Example 90
Show/Hide
|
C14H11N3O2S
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0544438
|
US9518064, Example 59
Show/Hide
|
C30H27N5O5S
|
1
|
| 1 |
IC50 = 4.81 nM
|
|
|
|
CP0415081
|
US9862730, Example 428
Show/Hide
|
C27H20FN3O4S
|
1
|
| 1 |
IC50 = 4.81 nM
|
|
|
|
CP0574046
|
US9862730, Example 293
Show/Hide
|
C15H12FN3O2S
|
1
|
| 1 |
IC50 = 4.83 nM
|
|
|
|
CP0417221
|
US9518064, Example 90
Show/Hide
|
C27H21N3O5S
|
1
|
| 1 |
IC50 = 4.91 nM
|
|
|
|
CP0538875
|
US9862730, Example 357
Show/Hide
|
C36H31N3O7S
|
1
|
| 1 |
IC50 = 4.92 nM
|
|
|
|
CP0408286
|
US9862730, Example 417
Show/Hide
|
C28H20N4O4S
|
1
|
| 1 |
IC50 = 5.02 nM
|
|
|
|
CP0574189
|
US9862730, Example 419
Show/Hide
|
C28H20F3N3O7S2
|
1
|
| 1 |
IC50 = 5.02 nM
|
|
|
|
CP0408282
|
US9862730, Example 384
Show/Hide
|
C34H27N3O6S
|
1
|
| 1 |
IC50 = 5.05 nM
|
|
|
|
CP0414051
|
6-(4-((3-(Benzyloxy)benzyl)oxy)-6-chlorobenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C27H20ClN3O4S
|
1
|
| 1 |
IC50 = 5.17 nM
|
|
|
|
CP0547211
|
US9862730, Example 370
Show/Hide
|
C28H21ClFN3O5S
|
1
|
| 1 |
IC50 = 5.3 nM
|
|
|
|
CP0548861
|
US9862730, Example 359
Show/Hide
|
C31H29N3O6S
|
1
|
| 1 |
IC50 = 5.49 nM
|
|
|
|
CP0574063
|
6-Fluoro-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]thiazole
Show/Hide
|
C12H7FN4OS2
|
1
|
| 1 |
IC50 = 5.5 nM
|
|
|
|
CP0472613
|
US9862730, Example 303
Show/Hide
|
C21H16FN3O4S
|
1
|
| 1 |
IC50 = 5.68 nM
|
|
|
|
CP0574044
|
US9862730, Example 297
Show/Hide
|
C15H13N3O2S
|
1
|
| 1 |
IC50 = 5.88 nM
|
|
|
|
CP0550849
|
US9862730, Example 402
Show/Hide
|
C28H22ClN3O5S
|
1
|
| 1 |
IC50 = 6.2 nM
|
|
|
|
CP0416330
|
US9518064, Example 24
Show/Hide
|
C27H22N4O5S
|
2
|
| 1 |
IC50 = 6.3 nM
|
|
|
| 2 |
IC50 = 6.31 nM
|
|
|
|
CP0544828
|
US9518064, Example 15
Show/Hide
|
C26H20N4O4S
|
1
|
| 1 |
IC50 = 6.4 nM
|
|
|
|
CP0413796
|
6-Methoxy-2-(2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazole
Show/Hide
|
C13H10N4O2S2
|
1
|
| 1 |
IC50 = 6.63 nM
|
|
|
|
CP0544441
|
US9518064, Example 76
Show/Hide
|
C25H18ClN5O4S
|
1
|
| 1 |
IC50 = 6.66 nM
|
|
|
|
CP0574038
|
US9862730, Example 321
Show/Hide
|
C29H21F4N3O5S
|
1
|
| 1 |
IC50 = 6.73 nM
|
|
|
|
CP0527430
|
US9862730, Example 95
Show/Hide
|
C14H11N3O2S
|
1
|
| 1 |
IC50 = 6.89 nM
|
|
|
|
CP0566994
|
US9862730, Example 377
Show/Hide
|
C31H29N3O5S
|
1
|
| 1 |
IC50 = 6.91 nM
|
|
|
|
CP0544440
|
US9518064, Example 72
Show/Hide
|
C26H20N4O4S
|
1
|
| 1 |
IC50 = 7.19 nM
|
|
|
|
CP0385554
|
US9862730, Example 239
Show/Hide
|
C15H10ClF2N3O2S
|
1
|
| 1 |
IC50 = 7.24 nM
|
|
|
|
CP0474789
|
US9862730, Example 376
Show/Hide
|
C28H21Cl2N3O5S
|
1
|
| 1 |
IC50 = 7.27 nM
|
|
|
|
CP0544430
|
US9518064, Example 21
Show/Hide
|
C28H21N5O4S
|
1
|
| 1 |
IC50 = 7.34 nM
|
|
|
|
CP0566993
|
US9862730, Example 378
Show/Hide
|
C28H21Cl2N3O5S
|
1
|
| 1 |
IC50 = 7.38 nM
|
|
|
|
CP0408291
|
US9862730, Example 400
Show/Hide
|
C29H22F3N3O5S
|
1
|
| 1 |
IC50 = 7.47 nM
|
|
|
|
CP0904499
|
2-Methoxy-6-(4-(methoxymethoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C15H13N3O4S
|
1
|
| 1 |
IC50 = 7.51 nM
|
|
|
|
CP0548864
|
US9862730, Example 267
Show/Hide
|
C15H12BrN3O3S
|
1
|
| 1 |
IC50 = 7.53 nM
|
|
|
|
CP0566663
|
US9862730, Example 371
Show/Hide
|
C34H35N3O7S
|
1
|
| 1 |
IC50 = 7.56 nM
|
|
|
|
CP0470974
|
6-(4-Methoxybenzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1,3,4]thidiazole
Show/Hide
|
C14H11N3O3S
|
1
|
| 1 |
IC50 = 7.6 nM
|
|
|
|
CP0547210
|
US9862730, Example 373
Show/Hide
|
C36H31N3O7S
|
1
|
| 1 |
IC50 = 7.63 nM
|
|
|
|
CP0573679
|
4-((3-(Benzyloxy)benzyl)oxy)-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-6-ol
Show/Hide
|
C27H21N3O5S
|
1
|
| 1 |
IC50 = 7.79 nM
|
|
|
|
CP0549387
|
US9862730, Example 379
Show/Hide
|
C28H22IN3O5S
|
1
|
| 1 |
IC50 = 7.84 nM
|
|
|
|
CP0547246
|
US9862730, Example 96
Show/Hide
|
C13H8FN3O2S
|
1
|
| 1 |
IC50 = 7.92 nM
|
|
|
|
CP0385556
|
6-Methyl, 4-trifluoromethyl-2-(2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)furopyridine
Show/Hide
|
C14H9F3N4OS2
|
1
|
| 1 |
IC50 = 8.15 nM
|
|
|
|
CP0397584
|
US9862730, Example 287
Show/Hide
|
C13H7Cl2N3OS2
|
1
|
| 1 |
IC50 = 8.19 nM
|
|
|
|
CP0549388
|
US9862730, Example 317
Show/Hide
|
C34H27N3O5S
|
1
|
| 1 |
IC50 = 8.36 nM
|
|
|
|
CP0567715
|
2-methoxy-6-[6-methoxy-4-[[2-methyl-5-(trifluoromethyl)phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C23H18F3N3O4S
|
1
|
| 1 |
IC50 = 8.4 nM
|
|
|
|
CP0468529
|
US9862730, Example 37
Show/Hide
|
C15H13N3O2S
|
1
|
| 1 |
IC50 = 8.51 nM
|
|
|
|
CP0544774
|
US9518064, Example 20
Show/Hide
|
C27H19N5O4S2
|
1
|
| 1 |
IC50 = 8.54 nM
|
|
|
|
CP0547816
|
2-Bromo-6-(5-chloro-6-methoxybenzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C13H7BrClN3O2S
|
1
|
| 1 |
IC50 = 8.63 nM
|
|
|
|
CP0573722
|
US9518064, Example 41
Show/Hide
|
C26H20N4O6S
|
1
|
| 1 |
IC50 = 8.68 nM
|
|
|
|
CP0540580
|
US9862730, Example 14
Show/Hide
|
C14H11N3O2S2
|
1
|
| 1 |
IC50 = 8.68 nM
|
|
|
|
CP0540597
|
US9862730, Example 383
Show/Hide
|
C35H29N3O6S
|
1
|
| 1 |
IC50 = 8.68 nM
|
|
|
|
CP0547214
|
US9862730, Example 311
Show/Hide
|
C28H21F2N3O5S
|
1
|
| 1 |
IC50 = 8.82 nM
|
|
|
|
CP0403643
|
US9862730, Example 315
Show/Hide
|
C29H21F4N3O5S
|
1
|
| 1 |
IC50 = 8.88 nM
|
|
|
|
CP0429591
|
US9518064, Example 91
Show/Hide
|
C26H20N4O5S
|
1
|
| 1 |
IC50 = 9.05 nM
|
|
|
|
CP0574039
|
US9862730, Example 319
Show/Hide
|
C27H22N4O5S
|
1
|
| 1 |
IC50 = 9.2 nM
|
|
|
|
CP0397583
|
US9862730, Example 307
Show/Hide
|
C28H24N4O5S
|
1
|
| 1 |
IC50 = 9.23 nM
|
|
|
|
CP0546856
|
US9518064, Example 4
Show/Hide
|
C29H21N3O4S2
|
1
|
| 1 |
IC50 = 9.35 nM
|
|
|
|
CP0501035
|
US9862730, Example 418
Show/Hide
|
C29H21N3O4S
|
1
|
| 1 |
IC50 = 9.37 nM
|
|
|
|
CP0548065
|
2-methoxy-6-[6-methoxy-4-[(3-methoxyphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C22H19N3O5S
|
1
|
| 1 |
IC50 = 9.4 nM
|
|
|
|
CP0900956
|
rac-6-(5-chloro-6-methoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C15H11ClFN3O2S
|
1
|
| 1 |
IC50 = 9.53 nM
|
|
|
|
CP0560264
|
US9862730, Example 194
Show/Hide
|
C12H7FN4OS2
|
1
|
| 1 |
IC50 = 9.64 nM
|
|
|
|
CP0527434
|
US9862730, Example 322
Show/Hide
|
C29H22F3N3O6S
|
1
|
| 1 |
IC50 = 9.97 nM
|
|
|
|
CP0441495
|
(R)- and (S)-6-(4,6-Dichlorobenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C14H8Cl2FN3OS
|
1
|
| 1 |
IC50 = 10.35 nM
|
|
|
|
CP0547818
|
US9862730, Example 126
Show/Hide
|
C12H7FN4OS2
|
1
|
| 1 |
IC50 = 10.39 nM
|
|
|
|
CP0468518
|
US9862730, Example 364
Show/Hide
|
C36H31N3O5S
|
1
|
| 1 |
IC50 = 10.51 nM
|
|
|
|
CP0542615
|
4-(Benzyloxy)-6-methoxy-2-(2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazole
Show/Hide
|
C20H16N4O3S2
|
1
|
| 1 |
IC50 = 10.56 nM
|
|
|
|
CP0547245
|
US9862730, Example 101
Show/Hide
|
C16H15N3O2S
|
1
|
| 1 |
IC50 = 10.67 nM
|
|
|
|
CP0438097
|
US9862730, Example 103
Show/Hide
|
C15H13N3O4S
|
2
|
| 1 |
IC50 = 10.71 nM
|
|
|
| 2 |
IC50 = 11 nM
|
|
|
|
CP0552863
|
6-(Benzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C13H9N3OS2
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 13.98 nM
|
|
|
|
CP0565256
|
6-[4-[(4-chlorophenyl)methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C21H16ClN3O4S
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0967691
|
6-(4-Methoxybenzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C14H11N3O2S2
|
1
|
| 1 |
IC50 = 11.05 nM
|
|
|
|
CP0574075
|
US9862730, Example 105
Show/Hide
|
C15H13N3O3S2
|
1
|
| 1 |
IC50 = 11.43 nM
|
|
|
|
CP0527436
|
US9862730, Example 295
Show/Hide
|
C15H13N3OS2
|
1
|
| 1 |
IC50 = 12.14 nM
|
|
|
|
CP0470373
|
US9862730, Example 425
Show/Hide
|
C28H21N3O5S2
|
1
|
| 1 |
IC50 = 12.39 nM
|
|
|
|
CP0381440
|
4-Chloro-2-(2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)furo[3,2-c]pyridine
Show/Hide
|
C12H7ClN4OS2
|
1
|
| 1 |
IC50 = 12.5 nM
|
|
|
|
CP0468532
|
2-(2-(Methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]thiazole
Show/Hide
|
C12H8N4S3
|
1
|
| 1 |
IC50 = 12.88 nM
|
|
|
|
CP0575803
|
US9862730, Example 92
Show/Hide
|
C15H13N3O2S
|
1
|
| 1 |
IC50 = 12.96 nM
|
|
|
|
CP0574070
|
4-(Benzyloxy)-6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazole
Show/Hide
|
C20H16N4O4S
|
1
|
| 1 |
IC50 = 13.04 nM
|
|
|
|
CP0403685
|
US9862730, Example 305
Show/Hide
|
C14H9F3N4O2S
|
1
|
| 1 |
IC50 = 13.57 nM
|
|
|
|
CP0381450
|
US9862730, Example 149
Show/Hide
|
C13H10N4O2S2
|
1
|
| 1 |
IC50 = 13.62 nM
|
|
|
|
CP0403667
|
US9862730, Example 106
Show/Hide
|
C15H13N3O2S2
|
1
|
| 1 |
IC50 = 13.9 nM
|
|
|
|
CP0544735
|
US9862730, Example 423
Show/Hide
|
C29H25N3O4S2
|
1
|
| 1 |
IC50 = 15.14 nM
|
|
|
|
CP0574072
|
5-Methyl-2-(2-methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazole
Show/Hide
|
C13H10N4OS2
|
1
|
| 1 |
IC50 = 15.16 nM
|
|
|
|
CP0391630
|
US9862730, Example 164
Show/Hide
|
C13H10N4O3S
|
1
|
| 1 |
IC50 = 15.37 nM
|
|
|
|
CP0403697
|
US9862730, Example 233
Show/Hide
|
C15H11F2N3OS
|
1
|
| 1 |
IC50 = 15.74 nM
|
|
|
|
CP0573779
|
6-(4-(Methoxymethoxy)benzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C15H13N3O3S2
|
1
|
| 1 |
IC50 = 16.72 nM
|
|
|
|
CP0391638
|
US9862730, Example 128
Show/Hide
|
C13H10N4OS2
|
1
|
| 1 |
IC50 = 17.11 nM
|
|
|
|
CP0425184
|
US9862730, Example 41
Show/Hide
|
C13H9N3OS
|
2
|
| 1 |
IC50 = 18.56 nM
|
|
|
| 2 |
IC50 = 37 nM
|
|
|
|
CP0560262
|
US9862730, Example 298
Show/Hide
|
C17H17N3O3S2
|
1
|
| 1 |
IC50 = 18.64 nM
|
|
|
|
CP0533677
|
2-methoxy-6-[6-methoxy-4-[(2-methoxyphenyl)methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C22H19N3O5S
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0574076
|
US9862730, Example 91
Show/Hide
|
C13H8ClN3O2S
|
1
|
| 1 |
IC50 = 19.08 nM
|
|
|
|
CP0547238
|
5-Fluoro-2-(2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]thiazole
Show/Hide
|
C12H7FN4S3
|
1
|
| 1 |
IC50 = 19.38 nM
|
|
|
|
CP0397588
|
US9862730, Example 249
Show/Hide
|
C20H14FN3O2S2
|
1
|
| 1 |
IC50 = 19.4 nM
|
|
|
|
CP0547221
|
US9862730, Example 271
Show/Hide
|
C15H11F2N3O2S
|
1
|
| 1 |
IC50 = 19.4 nM
|
|
|
|
CP0574045
|
US9862730, Example 294
Show/Hide
|
C14H10BrN3O3S
|
1
|
| 1 |
IC50 = 19.46 nM
|
|
|
|
CP0574069
|
US9862730, Example 133
Show/Hide
|
C14H12N4OS2
|
1
|
| 1 |
IC50 = 19.66 nM
|
|
|
|
CP0397585
|
US9862730, Example 263
Show/Hide
|
C13H8FN3O2S
|
1
|
| 1 |
IC50 = 20.69 nM
|
|
|
|
CP0409809
|
US9862730, Example 424
Show/Hide
|
C28H21F2N3O4S2
|
1
|
| 1 |
IC50 = 21.44 nM
|
|
|
|
CP0532717
|
4-Chloro-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)furo[3,2-c]pyridine
Show/Hide
|
C12H7ClN4O2S
|
1
|
| 1 |
IC50 = 21.65 nM
|
|
|
|
CP0548863
|
US9862730, Example 268
Show/Hide
|
C16H15N3O3S2
|
1
|
| 1 |
IC50 = 21.84 nM
|
|
|
|
CP0391640
|
US9862730, Example 341
Show/Hide
|
C26H23FN4O5S
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0384784
|
4-((3-(Furan-3-yl)benzyl)oxy)-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazole
Show/Hide
|
C23H16N4O4S
|
1
|
| 1 |
IC50 = 22.13 nM
|
|
|
|
CP0407507
|
US9862730, Example 21
Show/Hide
|
C14H11N3OS2
|
1
|
| 1 |
IC50 = 22.13 nM
|
|
|
|
CP0547233
|
US9862730, Example 231
Show/Hide
|
C14H8F3N3OS
|
1
|
| 1 |
IC50 = 22.28 nM
|
|
|
|
CP0904498
|
6-(4,6-dichlorobenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C13H7Cl2N3O2S
|
1
|
| 1 |
IC50 = 22.68 nM
|
|
|
|
CP0538628
|
US9862730, Example 301
Show/Hide
|
C21H16FN3O3S2
|
1
|
| 1 |
IC50 = 23.01 nM
|
|
|
|
CP0532716
|
US9862730, Example 275
Show/Hide
|
C13H7Br2N3O2S
|
1
|
| 1 |
IC50 = 23.14 nM
|
|
|
|
CP0544431
|
US9518064, Example 22
Show/Hide
|
C27H20N6O4S
|
1
|
| 1 |
IC50 = 23.56 nM
|
|
|
|
CP0381453
|
US9862730, Example 137
Show/Hide
|
C12H6F2N4OS2
|
1
|
| 1 |
IC50 = 23.92 nM
|
|
|
|
CP0418007
|
6-(4-(Benzyloxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C20H15N3O3S
|
2
|
| 1 |
IC50 = 24 nM
|
|
|
| 2 |
IC50 = 24.54 nM
|
|
|
|
CP0940827
|
6-(5-bromo-7-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C14H10BrN3O3S
|
1
|
| 1 |
IC50 = 24.22 nM
|
|
|
|
CP0472608
|
US9862730, Example 421
Show/Hide
|
C27H21N3O4S2
|
1
|
| 1 |
IC50 = 24.49 nM
|
|
|
|
CP0547244
|
US9862730, Example 104
Show/Hide
|
C20H15N3O3S
|
2
|
| 1 |
IC50 = 26 nM
|
|
|
| 2 |
IC50 = 26.23 nM
|
|
|
|
CP0570037
|
[3-[[6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]phenyl]methanol
Show/Hide
|
C22H19N3O5S
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0548876
|
US9862730, Example 142
Show/Hide
|
C13H10N4O3S
|
1
|
| 1 |
IC50 = 27.8 nM
|
|
|
|
CP0391637
|
US9862730, Example 127
Show/Hide
|
C13H10N4O2S
|
1
|
| 1 |
IC50 = 27.89 nM
|
|
|
|
CP0527439
|
US9862730, Example 265
Show/Hide
|
C22H17F2N3O3S
|
1
|
| 1 |
IC50 = 27.98 nM
|
|
|
|
CP0527431
|
US9862730, Example 89
Show/Hide
|
C14H11N3O2S
|
1
|
| 1 |
IC50 = 28.19 nM
|
|
|
|
CP0524268
|
US9862730, Example 159
Show/Hide
|
C15H14N4O2S2
|
1
|
| 1 |
IC50 = 28.42 nM
|
|
|
|
CP0385555
|
US9862730, Example 237
Show/Hide
|
C14H8ClF2N3OS
|
1
|
| 1 |
IC50 = 28.76 nM
|
|
|
|
CP0549390
|
US9862730, Example 272
Show/Hide
|
C15H10BrF2N3O2S
|
1
|
| 1 |
IC50 = 29.08 nM
|
|
|
|
CP0560263
|
US9862730, Example 289
Show/Hide
|
C14H10BrN3O3S
|
1
|
| 1 |
IC50 = 29.64 nM
|
|
|
|
CP0403701
|
US9862730, Example 191
Show/Hide
|
C12H7FN4S3
|
1
|
| 1 |
IC50 = 30.71 nM
|
|
|
|
CP0391636
|
US9862730, Example 129
Show/Hide
|
C13H10N4O2S
|
1
|
| 1 |
IC50 = 31.98 nM
|
|
|
|
CP0474736
|
US9862730, Example 393
Show/Hide
|
C32H31N3O5S
|
1
|
| 1 |
IC50 = 35.88 nM
|
|
|
|
CP0547223
|
US9862730, Example 264
Show/Hide
|
C12H5BrFN3OS
|
1
|
| 1 |
IC50 = 37.83 nM
|
|
|
|
CP0407501
|
US9862730, Example 47
Show/Hide
|
C14H11N3OS
|
2
|
| 1 |
IC50 = 38 nM
|
|
|
| 2 |
IC50 = 67.98 nM
|
|
|
|
CP0853653
|
2-methoxy-6-(6-nitrobenzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C13H8N4O4S
|
1
|
| 1 |
IC50 = 38.19 nM
|
|
|
|
CP0408293
|
US9862730, Example 395
Show/Hide
|
C35H28FN3O6S
|
1
|
| 1 |
IC50 = 38.32 nM
|
|
|
|
CP0385563
|
US9862730, Example 136
Show/Hide
|
C14H12N4O2S
|
1
|
| 1 |
IC50 = 38.85 nM
|
|
|
|
CP0385558
|
US9862730, Example 173
Show/Hide
|
C26H20N4O3S2
|
1
|
| 1 |
IC50 = 39.38 nM
|
|
|
|
CP0951786
|
6-(4-(3-(benzyloxy)benzyloxy)benzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C27H21N3O3S2
|
1
|
| 1 |
IC50 = 39.38 nM
|
|
|
|
CP0474801
|
US9862730, Example 163
Show/Hide
|
C14H12N4O3S2
|
1
|
| 1 |
IC50 = 39.52 nM
|
|
|
|
CP0550789
|
US9862730, Example 160
Show/Hide
|
C14H12N4O2S2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0391634
|
US9862730, Example 141
Show/Hide
|
C13H10N4O2S2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0385565
|
US9862730, Example 130
Show/Hide
|
C12H7ClN4O2S
|
1
|
| 1 |
IC50 = 41.3 nM
|
|
|
|
CP0574065
|
US9862730, Example 175
Show/Hide
|
C16H14N4O2S2
|
1
|
| 1 |
IC50 = 41.3 nM
|
|
|
|
CP0491235
|
US9862730, Example 387
Show/Hide
|
C36H31N3O5S
|
1
|
| 1 |
IC50 = 41.47 nM
|
|
|
|
CP0407539
|
US9862730, Example 238
Show/Hide
|
C14H7Cl2F2N3OS
|
1
|
| 1 |
IC50 = 42.53 nM
|
|
|
|
CP0574050
|
US9862730, Example 266
Show/Hide
|
C20H14FN3O3S
|
1
|
| 1 |
IC50 = 43.08 nM
|
|
|
|
CP0860155
|
6-(5-Bromo-4-(methoxymethoxy)benzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C15H12BrN3O4S
|
1
|
| 1 |
IC50 = 45.1 nM
|
|
|
|
CP0574054
|
US9862730, Example 247
Show/Hide
|
C14H10FN3OS
|
1
|
| 1 |
IC50 = 47.87 nM
|
|
|
|
CP0547817
|
US9862730, Example 171
Show/Hide
|
C19H12F2N4O2S2
|
1
|
| 1 |
IC50 = 48.11 nM
|
|
|
|
CP0524267
|
US9862730, Example 256
Show/Hide
|
C16H15N3O4S
|
1
|
| 1 |
IC50 = 48.35 nM
|
|
|
|
CP0573726
|
US9518064, Example 99
Show/Hide
|
C26H18N6O4S
|
1
|
| 1 |
IC50 = 48.66 nM
|
|
|
|
CP0472611
|
US9862730, Example 143
Show/Hide
|
C12H7FN4OS2
|
1
|
| 1 |
IC50 = 48.81 nM
|
|
|
|
CP0547820
|
2-(2-(Methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazol-4-amine
Show/Hide
|
C12H9N5OS2
|
1
|
| 1 |
IC50 = 48.92 nM
|
|
|
|
CP0468509
|
US9862730, Example 135
Show/Hide
|
C12H7FN4O2S
|
1
|
| 1 |
IC50 = 49.57 nM
|
|
|
|
CP0542617
|
US9862730, Example 282
Show/Hide
|
C14H10BrN3O2S2
|
1
|
| 1 |
IC50 = 49.58 nM
|
|
|
|
CP0527440
|
US9862730, Example 257
Show/Hide
|
C13H8FN3OS2
|
1
|
| 1 |
IC50 = 50.21 nM
|
|
|
|
CP0550787
|
US9862730, Example 242
Show/Hide
|
C16H13F2N3O3S
|
1
|
| 1 |
IC50 = 50.51 nM
|
|
|
|
CP0527432
|
6-(4,6-Dimethoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo-[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C16H14FN3O3S
|
1
|
| 1 |
IC50 = 50.85 nM
|
|
|
|
CP0415080
|
US9862730, Example 420
Show/Hide
|
C28H20F3N3O6S3
|
1
|
| 1 |
IC50 = 51.08 nM
|
|
|
|
CP0532715
|
US9862730, Example 278
Show/Hide
|
C14H10BrN3O3S
|
1
|
| 1 |
IC50 = 52.6 nM
|
|
|
|
CP0547202
|
US9862730, Example 68
Show/Hide
|
C12H6BrN3OS
|
1
|
| 1 |
IC50 = 55.28 nM
|
|
|
|
CP0468524
|
US9862730, Example 304
Show/Hide
|
C22H16F3N3O3S
|
1
|
| 1 |
IC50 = 55.61 nM
|
|
|
|
CP0408218
|
5-(3-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)phenyl)picolinic acid
Show/Hide
|
C27H20N4O6S
|
1
|
| 1 |
IC50 = 65.01 nM
|
|
|
|
CP0566909
|
US9862730, Example 82
Show/Hide
|
C20H15ClN4O2S
|
1
|
| 1 |
IC50 = 66.03 nM
|
|
|
|
CP0547206
|
US9862730, Example 38
Show/Hide
|
C13H8F2N4OS
|
1
|
| 1 |
IC50 = 66.57 nM
|
|
|
|
CP0544773
|
US9518064, Example 16
Show/Hide
|
C28H20F3N3O4S
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0470986
|
6-(1-benzofuran-2-yl)-2-ethoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C14H11N3O2S
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0391635
|
US9862730, Example 140
Show/Hide
|
C13H7F3N4O3S
|
1
|
| 1 |
IC50 = 68.9 nM
|
|
|
|
CP0574067
|
US9862730, Example 158
Show/Hide
|
C14H12N4O2S2
|
1
|
| 1 |
IC50 = 69.28 nM
|
|
|
|
CP0391629
|
US9862730, Example 169
Show/Hide
|
C19H13ClN4O2S2
|
1
|
| 1 |
IC50 = 70.47 nM
|
|
|
|
CP0548878
|
US9862730, Example 100
Show/Hide
|
C13H8N4O4S
|
1
|
| 1 |
IC50 = 71.38 nM
|
|
|
|
CP0574047
|
US9862730, Example 329
Show/Hide
|
C26H21N5O5S
|
1
|
| 1 |
IC50 = 71.6 nM
|
|
|
|
CP0385552
|
US9862730, Example 245
Show/Hide
|
C14H9F2N3OS
|
1
|
| 1 |
IC50 = 72.28 nM
|
|
|
|
CP0550848
|
N-(4-((3-(Benzyloxy)benzyl)oxy)-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-6-yl)acetamide
Show/Hide
|
C29H24N4O5S
|
1
|
| 1 |
IC50 = 72.48 nM
|
|
|
|
CP0574049
|
US9862730, Example 269
Show/Hide
|
C14H10ClN3OS2
|
1
|
| 1 |
IC50 = 74.5 nM
|
|
|
|
CP0574071
|
6-(Benzyloxy)-2-(2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazole
Show/Hide
|
C19H14N4O2S2
|
1
|
| 1 |
IC50 = 74.93 nM
|
|
|
|
CP0524269
|
US9862730, Example 147
Show/Hide
|
C12H8N4O2S2
|
1
|
| 1 |
IC50 = 78.29 nM
|
|
|
|
CP0403646
|
US9862730, Example 299
Show/Hide
|
C16H14BrN3O3S
|
1
|
| 1 |
IC50 = 78.75 nM
|
|
|
|
CP0391631
|
US9862730, Example 161
Show/Hide
|
C15H14N4O2S2
|
1
|
| 1 |
IC50 = 79.93 nM
|
|
|
|
CP0381451
|
US9862730, Example 139
Show/Hide
|
C13H7F3N4O2S2
|
1
|
| 1 |
IC50 = 80.4 nM
|
|
|
|
CP0381447
|
US9862730, Example 165
Show/Hide
|
C20H13F3N4O3S
|
1
|
| 1 |
IC50 = 81.01 nM
|
|
|
|
CP0567002
|
(R)-tert-Butyl 2-(((2-(2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazol-4-yl)oxy)methyl)pyrrolidine-1-carboxylate
Show/Hide
|
C22H25N5O4S2
|
1
|
| 1 |
IC50 = 84.33 nM
|
|
|
|
CP0441485
|
US9862730, Example 132
Show/Hide
|
C16H16N4OS2
|
1
|
| 1 |
IC50 = 87.24 nM
|
|
|
|
CP0407503
|
US9862730, Example 43
Show/Hide
|
C14H12N4O2S
|
1
|
| 1 |
IC50 = 91.12 nM
|
|
|
|
CP0542614
|
US9862730, Example 144
Show/Hide
|
C12H7FN4O2S
|
1
|
| 1 |
IC50 = 91.28 nM
|
|
|
|
CP0532714
|
US9862730, Example 288
Show/Hide
|
C12H4BrCl2N3OS
|
1
|
| 1 |
IC50 = 94.11 nM
|
|
|
|
CP0860154
|
5-Benzyl-6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-ol
Show/Hide
|
C21H17N3O4S
|
1
|
| 1 |
IC50 = 97.09 nM
|
|
|
|
CP0548879
|
US9862730, Example 84
Show/Hide
|
C21H18N4O3S
|
1
|
| 1 |
IC50 = 101.2 nM
|
|
|
|
CP0573812
|
US9862730, Example 67
Show/Hide
|
C20H16N4O2S
|
1
|
| 1 |
IC50 = 102.7 nM
|
|
|
|
CP0527435
|
US9862730, Example 296
Show/Hide
|
C14H10BrN3OS
|
1
|
| 1 |
IC50 = 106.3 nM
|
|
|
|
CP0474783
|
US9862730, Example 131
Show/Hide
|
C17H18N4OS2
|
1
|
| 1 |
IC50 = 107 nM
|
|
|
|
CP0425180
|
US9862730, Example 69
Show/Hide
|
C13H10N4OS
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 407.2 nM
|
|
|
|
CP0472614
|
2-(2-Methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-ol
Show/Hide
|
C13H9N3O3S
|
1
|
| 1 |
IC50 = 111.3 nM
|
|
|
|
CP0397586
|
US9862730, Example 255
Show/Hide
|
C27H21N3O4S
|
1
|
| 1 |
IC50 = 112.9 nM
|
|
|
|
CP0547812
|
US9862730, Example 234
Show/Hide
|
C15H11F2N3OS
|
1
|
| 1 |
IC50 = 113.2 nM
|
|
|
|
CP0547231
|
US9862730, Example 253
Show/Hide
|
C27H21N3O3S2
|
1
|
| 1 |
IC50 = 114.2 nM
|
|
|
|
CP0953258
|
(R)-6-(5-chloro-6-methoxybenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C15H11ClFN3O2S
|
1
|
| 1 |
IC50 = 114.4 nM
|
|
|
|
CP0548872
|
US9862730, Example 170
Show/Hide
|
C20H16N4O3S2
|
1
|
| 1 |
IC50 = 115.8 nM
|
|
|
|
CP0567004
|
US9862730, Example 276
Show/Hide
|
C12H5BrFN3OS
|
1
|
| 1 |
IC50 = 120.4 nM
|
|
|
|
CP0574053
|
US9862730, Example 252
Show/Hide
|
C15H12BrN3O3S
|
1
|
| 1 |
IC50 = 120.8 nM
|
|
|
|
CP0547204
|
US9862730, Example 40
Show/Hide
|
C13H9ClN4OS
|
1
|
| 1 |
IC50 = 122.5 nM
|
|
|
|
CP0385557
|
6-(Benzofuran-2-yl)-2-(1,1-difluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C14H9F2N3OS
|
1
|
| 1 |
IC50 = 127.4 nM
|
|
|
|
CP0385073
|
US9862730, Example 45
Show/Hide
|
C13H9ClN4OS
|
1
|
| 1 |
IC50 = 135.4 nM
|
|
|
|
CP0959566
|
6-(5-chloro-6-methylbenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C14H10ClN3O2S
|
1
|
| 1 |
IC50 = 138.3 nM
|
|
|
|
CP0547219
|
US9862730, Example 284
Show/Hide
|
C14H10BrN3O2S2
|
1
|
| 1 |
IC50 = 138.7 nM
|
|
|
|
CP0574066
|
US9862730, Example 166
Show/Hide
|
C18H13N5O2S2
|
1
|
| 1 |
IC50 = 139.3 nM
|
|
|
|
CP0548877
|
2-(2-Methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazole
Show/Hide
|
C12H8N4O2S
|
1
|
| 1 |
IC50 = 139.7 nM
|
|
|
|
CP0407506
|
US9862730, Example 23
Show/Hide
|
C13H8ClN3OS2
|
1
|
| 1 |
IC50 = 143.8 nM
|
|
|
|
CP0548866
|
US9862730, Example 248
Show/Hide
|
C15H10N4O2S2
|
1
|
| 1 |
IC50 = 145 nM
|
|
|
|
CP0540581
|
6-(7-Ethoxybenzofuran-2-yl)-2-ethylimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C16H15N3O2S
|
1
|
| 1 |
IC50 = 146.6 nM
|
|
|
|
CP0407505
|
US9862730, Example 34
Show/Hide
|
C15H13N3O3S
|
1
|
| 1 |
IC50 = 149.1 nM
|
|
|
|
CP0407499
|
US9862730, Example 53
Show/Hide
|
C16H12N4O2S
|
1
|
| 1 |
IC50 = 149.3 nM
|
|
|
|
CP0403699
|
US9862730, Example 232
Show/Hide
|
C15H11F2N3OS
|
1
|
| 1 |
IC50 = 151.8 nM
|
|
|
|
CP0474797
|
US9862730, Example 236
Show/Hide
|
C14H8ClF2N3OS
|
1
|
| 1 |
IC50 = 158.9 nM
|
|
|
|
CP0468516
|
US9862730, Example 366
Show/Hide
|
C35H29N3O6S
|
1
|
| 1 |
IC50 = 164.3 nM
|
|
|
|
CP0546747
|
US9862730, Example 174
Show/Hide
|
C16H14N4O2S2
|
1
|
| 1 |
IC50 = 166.8 nM
|
|
|
|
CP0574057
|
6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-ol
Show/Hide
|
C14H11N3O4S
|
1
|
| 1 |
IC50 = 170.5 nM
|
|
|
|
CP0550788
|
US9862730, Example 162
Show/Hide
|
C14H12N4O3S2
|
1
|
| 1 |
IC50 = 171 nM
|
|
|
|
CP0527438
|
US9862730, Example 273
Show/Hide
|
C14H8F3N3OS
|
1
|
| 1 |
IC50 = 179.6 nM
|
|
|
|
CP0574043
|
US9862730, Example 308
Show/Hide
|
C28H24N4O5S
|
1
|
| 1 |
IC50 = 186.8 nM
|
|
|
|
CP0538624
|
US9862730, Example 98
Show/Hide
|
C14H8F3N3O3S
|
1
|
| 1 |
IC50 = 186.9 nM
|
|
|
|
CP0546746
|
2-(2-(Methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)-6-(trifluoromethoxy)benzo[d]thiazole
Show/Hide
|
C13H7F3N4OS3
|
1
|
| 1 |
IC50 = 188.6 nM
|
|
|
|
CP0472612
|
6-(2-Fluoroethoxy)-2-(2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazole
Show/Hide
|
C14H11FN4O2S2
|
1
|
| 1 |
IC50 = 190.8 nM
|
|
|
|
CP0549389
|
US9862730, Example 302
Show/Hide
|
C20H13BrFN3O3S
|
1
|
| 1 |
IC50 = 195.4 nM
|
|
|
|
CP0533676
|
US9862730, Example 63
Show/Hide
|
C15H11N3OS
|
2
|
| 1 |
IC50 = 200.9 nM
|
|
|
| 2 |
IC50 = 530 nM
|
|
|
|
CP0550795
|
US9862730, Example 190
Show/Hide
|
C13H10N4S3
|
1
|
| 1 |
IC50 = 203.5 nM
|
|
|
|
CP0540587
|
US9862730, Example 125
Show/Hide
|
C12H7ClN4OS2
|
1
|
| 1 |
IC50 = 206.3 nM
|
|
|
|
CP0381455
|
2-(2-(Methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)-6-(2-(pyrrolidin-1-yl)ethoxy)benzo[d]oxazole
Show/Hide
|
C18H19N5O2S2
|
1
|
| 1 |
IC50 = 206.5 nM
|
|
|
|
CP0547243
|
2-(2-(Methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazole
Show/Hide
|
C12H8N4OS2
|
1
|
| 1 |
IC50 = 212.9 nM
|
|
|
|
CP0539600
|
US9862730, Example 22
Show/Hide
|
C14H11N3OS2
|
1
|
| 1 |
IC50 = 216.7 nM
|
|
|
|
CP0413797
|
US9862730, Example 93
Show/Hide
|
C14H11N3O3S
|
2
|
| 1 |
IC50 = 220 nM
|
|
|
| 2 |
IC50 = 222.1 nM
|
|
|
|
CP0547205
|
US9862730, Example 39
Show/Hide
|
C14H12N4O2S
|
1
|
| 1 |
IC50 = 220.4 nM
|
|
|
|
CP0547241
|
US9862730, Example 148
Show/Hide
|
C19H14N4O2S2
|
1
|
| 1 |
IC50 = 224.2 nM
|
|
|
|
CP0381443
|
US9862730, Example 179
Show/Hide
|
C15H12F2N4OS
|
1
|
| 1 |
IC50 = 225.1 nM
|
|
|
|
CP0548865
|
US9862730, Example 251
Show/Hide
|
C21H16FN3O2S
|
1
|
| 1 |
IC50 = 230.5 nM
|
|
|
|
CP0381442
|
2-(2-(1-Fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]thiazole
Show/Hide
|
C13H9FN4S2
|
1
|
| 1 |
IC50 = 252 nM
|
|
|
|
CP0547808
|
US9862730, Example 342-343
Show/Hide
|
C24H28N4O6S
|
1
|
| 1 |
IC50 = 253.2 nM
|
|
|
|
CP0550804
|
(S)-tert-Butyl 2-(((2-(2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazol-4-yl)oxy)methyl)pyrrolidine-1-carboxylate
Show/Hide
|
C22H25N5O4S2
|
1
|
| 1 |
IC50 = 253.2 nM
|
|
|
|
CP0560274
|
US9862730, Example 375
Show/Hide
|
C35H28ClN3O6S
|
1
|
| 1 |
IC50 = 259.9 nM
|
|
|
|
CP0397587
|
US9862730, Example 250
Show/Hide
|
C21H15F2N3O2S
|
1
|
| 1 |
IC50 = 267.3 nM
|
|
|
|
CP0403686
|
US9862730, Example 286
Show/Hide
|
C13H7Br2N3O2S
|
1
|
| 1 |
IC50 = 275.8 nM
|
|
|
|
CP0472617
|
US9862730, Example 145
Show/Hide
|
C18H13N5O2S2
|
1
|
| 1 |
IC50 = 285.6 nM
|
|
|
|
CP0407498
|
US9862730, Example 59
Show/Hide
|
C14H11N3O2S
|
1
|
| 1 |
IC50 = 288.5 nM
|
|
|
|
CP0550794
|
US9862730, Example 241
Show/Hide
|
C21H15F2N3O2S
|
1
|
| 1 |
IC50 = 290.1 nM
|
|
|
|
CP0549386
|
US9862730, Example 75
Show/Hide
|
C17H16N4O2S
|
1
|
| 1 |
IC50 = 293.6 nM
|
|
|
|
CP0860153
|
6-(7-Bromo-4,6-dimethoxybenzofuran-2-yl)-2-(1,1-difluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C15H10BrF2N3O3S
|
1
|
| 1 |
IC50 = 300.5 nM
|
|
|
|
CP0381448
|
US9862730, Example 155
Show/Hide
|
C20H13F3N4O2S2
|
1
|
| 1 |
IC50 = 300.9 nM
|
|
|
|
CP0547814
|
N-Benzyl-2-(2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-6-carboxamide
Show/Hide
|
C21H16N4O2S2
|
1
|
| 1 |
IC50 = 307 nM
|
|
|
|
CP0567003
|
US9862730, Example 285
Show/Hide
|
C13H7Br2N3O2S
|
1
|
| 1 |
IC50 = 317.2 nM
|
|
|
|
CP0385551
|
US9862730, Example 246
Show/Hide
|
C21H16FN3O2S
|
1
|
| 1 |
IC50 = 318.1 nM
|
|
|
|
CP0385564
|
US9862730, Example 134
Show/Hide
|
C16H16N4O2S
|
1
|
| 1 |
IC50 = 321.3 nM
|
|
|
|
CP0573780
|
2-(2-(Methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-ol
Show/Hide
|
C13H9N3O2S2
|
1
|
| 1 |
IC50 = 322.4 nM
|
|
|
|
CP0547227
|
US9862730, Example 259
Show/Hide
|
C12H5BrFN3OS
|
1
|
| 1 |
IC50 = 322.6 nM
|
|
|
|
CP0967841
|
(R)-6-(4,6-Dichlorobenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C14H8Cl2FN3OS
|
1
|
| 1 |
IC50 = 332.8 nM
|
|
|
|
CP0574074
|
US9862730, Example 107
Show/Hide
|
C15H13N3OS2
|
1
|
| 1 |
IC50 = 339.1 nM
|
|
|
|
CP0407099
|
US9862730, Example 152
Show/Hide
|
C19H12F2N4O2S2
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0403703
|
US9862730, Example 153
Show/Hide
|
C20H13F3N4O2S2
|
1
|
| 1 |
IC50 = 345.3 nM
|
|
|
|
CP0425185
|
2-(2-Methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]thiazole
Show/Hide
|
C12H8N4OS2
|
1
|
| 1 |
IC50 = 351.2 nM
|
|
|
|
CP0425183
|
US9862730, Example 49
Show/Hide
|
C13H9FN4OS
|
1
|
| 1 |
IC50 = 361 nM
|
|
|
|
CP0547811
|
US9862730, Example 243
Show/Hide
|
C13H5ClF3N3OS
|
1
|
| 1 |
IC50 = 363.9 nM
|
|
|
|
CP0407508
|
US9862730, Example 16
Show/Hide
|
C14H11N3O2S2
|
1
|
| 1 |
IC50 = 368.6 nM
|
|
|
|
CP0574073
|
5-Methyl-2-(2-methylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazole
Show/Hide
|
C13H10N4OS
|
1
|
| 1 |
IC50 = 381.6 nM
|
|
|
|
CP0403696
|
US9862730, Example 244
Show/Hide
|
C14H8ClF2N3OS
|
1
|
| 1 |
IC50 = 382.8 nM
|
|
|
|
CP0385569
|
US9862730, Example 85
Show/Hide
|
C17H18N4O2S
|
1
|
| 1 |
IC50 = 392.2 nM
|
|
|
|
CP0407500
|
US9862730, Example 51
Show/Hide
|
C16H16N4O2S
|
1
|
| 1 |
IC50 = 393.5 nM
|
|
|
|
CP0539599
|
US9862730, Example 70
Show/Hide
|
C14H8F3N3O2S2
|
1
|
| 1 |
IC50 = 399.5 nM
|
|
|
|
CP0560260
|
N—((R)-2-((S)-2-(((2-(2-(Methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazol-4-yl)oxy)methyl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)benzamide
Show/Hide
|
C32H28N6O4S2
|
1
|
| 1 |
IC50 = 401 nM
|
|
|
|
CP0460261
|
2-(2-Bromoimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-6-fluorobenzo[d]thiazole
Show/Hide
|
C11H4BrFN4S2
|
1
|
| 1 |
IC50 = 412.4 nM
|
|
|
|
CP0574064
|
2-(2-(Methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)-4-(trifluoromethoxy)benzo[d]thiazole
Show/Hide
|
C13H7F3N4OS3
|
1
|
| 1 |
IC50 = 419.3 nM
|
|
|
|
CP0573781
|
6-(Benzofuran-2-yl)-2-(chlorodifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C13H6ClF2N3OS
|
1
|
| 1 |
IC50 = 442.2 nM
|
|
|
|
CP0575804
|
US9862730, Example 87
Show/Hide
|
C16H16N4O2S
|
1
|
| 1 |
IC50 = 450.1 nM
|
|
|
|
CP0538634
|
6-(Benzofuran-2-yl)-2-(1,1,2,2-tetrafluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C14H7F4N3OS
|
1
|
| 1 |
IC50 = 456.6 nM
|
|
|
|
CP0391639
|
US9862730, Example 108
Show/Hide
|
C13H9N3O3S
|
1
|
| 1 |
IC50 = 461.2 nM
|
|
|
|
CP0407504
|
US9862730, Example 42
Show/Hide
|
C14H12N4OS
|
1
|
| 1 |
IC50 = 462.3 nM
|
|
|
|
CP0547813
|
2-(2-Bromoimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-4-chlorofuro[3,2-c]pyridine
Show/Hide
|
C11H4BrClN4OS
|
1
|
| 1 |
IC50 = 463.6 nM
|
|
|
|
CP0381452
|
US9862730, Example 138
Show/Hide
|
C12H6F2N4O2S
|
1
|
| 1 |
IC50 = 470.5 nM
|
|
|
|
CP0542618
|
2-(Methylthio)-6-(4-(pyridin-3-ylmethoxy)benzofuran-2-yl) imidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C19H14N4O2S2
|
1
|
| 1 |
IC50 = 482.5 nM
|
|
|
|
CP0403670
|
US9862730, Example 81
Show/Hide
|
C20H15ClN4O2S
|
1
|
| 1 |
IC50 = 506.6 nM
|
|
|
|
CP0441486
|
2-(2-(1,1-Difluoro ethyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)-4-methylbenzo[d]oxazole
Show/Hide
|
C14H10F2N4OS
|
1
|
| 1 |
IC50 = 508.7 nM
|
|
|
|
CP0474796
|
US9862730, Example 277
Show/Hide
|
C13H7BrClN3OS
|
1
|
| 1 |
IC50 = 511.5 nM
|
|
|
|
CP0470372
|
6-(4-((3-(Benzyloxy)benzyl)oxy)-7-chloro-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
|
C28H22ClN3O5S
|
1
|
| 1 |
IC50 = 512.6 nM
|
|
|
|
CP0468522
|
N—((R)-2-((R)-2-(((2-(2-(Methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazol-4-yl)oxy)methyl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)benzamide
Show/Hide
|
C32H28N6O4S2
|
1
|
| 1 |
IC50 = 537 nM
|
|
|
|
CP0524270
|
US9862730, Example 102
Show/Hide
|
C15H13N3O2S
|
1
|
| 1 |
IC50 = 542 nM
|
|
|
|
CP0540578
|
US9862730, Example 58
Show/Hide
|
C15H14N4OS
|
1
|
| 1 |
IC50 = 564.8 nM
|
|
|
|
CP0407502
|
US9862730, Example 46
Show/Hide
|
C15H14N4OS
|
1
|
| 1 |
IC50 = 565.4 nM
|
|
|
|
CP0381435
|
US9862730, Example 333
Show/Hide
|
C30H32N6O5S2
|
1
|
| 1 |
IC50 = 565.6 nM
|
|
|
|
CP0548873
|
US9862730, Example 154
Show/Hide
|
C18H13N5O2S2
|
1
|
| 1 |
IC50 = 571.4 nM
|
|
|
|
CP0468528
|
US9862730, Example 57
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C17H18N4OS
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1
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| 1 |
IC50 = 574.9 nM
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CP0546718
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US9862730, Example 78
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C22H20N4O2S
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1
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| 1 |
IC50 = 575.8 nM
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CP0903389
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ethyl 2-(2-(2-ethylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-7-yloxy)acetate
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C18H17N3O4S
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1
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| 1 |
IC50 = 587.1 nM
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CP0547234
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6-(4-(Benzyloxy)-7-bromo-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
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C21H16BrN3O4S
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1
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| 1 |
IC50 = 590.9 nM
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CP0425182
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US9862730, Example 56
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C17H17N3O2S
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1
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| 1 |
IC50 = 600.7 nM
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CP0550786
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US9862730, Example 254
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C26H18BrN3O3S
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1
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| 1 |
IC50 = 603.5 nM
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CP0407509
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4-Methoxy-2-(2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]thiazole
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C13H10N4OS3
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1
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| 1 |
IC50 = 618 nM
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CP0548875
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US9862730, Example 150
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C20H13N5O2S2
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1
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| 1 |
IC50 = 620.6 nM
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CP0871194
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ethyl 4-(2-(2-ethylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-7-yloxy)butanoate
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C20H21N3O4S
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1
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| 1 |
IC50 = 623.2 nM
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CP0472615
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2-(2-(1,1-Difluoroethyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]thiazole
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C13H8F2N4S2
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1
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| 1 |
IC50 = 625.5 nM
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CP0441487
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2-(2-(Methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)-6-(pyridin-2-ylmethoxy)benzo[d]oxazole
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C18H13N5O2S2
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1
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| 1 |
IC50 = 654.2 nM
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CP0548867
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US9862730, Example 240
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C15H8F5N3O2S
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1
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| 1 |
IC50 = 670.7 nM
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CP0573782
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US9862730, Example 151
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C19H13ClN4O2S2
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1
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| 1 |
IC50 = 673.3 nM
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CP0407495
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US9862730, Example 74
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C17H16N4O2S
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1
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| 1 |
IC50 = 681.1 nM
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CP0474786
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US9862730, Example 80
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C19H20N4O2S
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1
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| 1 |
IC50 = 694.6 nM
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CP0468531
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US9862730, Example 24
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C15H13N3O2S2
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1
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| 1 |
IC50 = 695.5 nM
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CP0493445
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US9862730, Example 422
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C29H20F5N3O6S2
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1
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| 1 |
IC50 = 698.2 nM
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CP0547239
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US9862730, Example 176
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C12H9N5OS2
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1
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| 1 |
IC50 = 701.3 nM
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CP0421752
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6-(1-benzofuran-2-yl)-2-propan-2-yloxyimidazo[2,1-b][1,3,4]thiadiazole
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C15H13N3O2S
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1
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| 1 |
IC50 = 760 nM
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CP0547236
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US9862730, Example 187
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C12H7ClN4S3
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1
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| 1 |
IC50 = 771.4 nM
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CP0472616
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US9862730, Example 167
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C18H13N5O2S2
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1
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| 1 |
IC50 = 784.6 nM
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CP0574061
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US9862730, Example 196
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C12H7ClN4OS2
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1
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| 1 |
IC50 = 791.4 nM
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CP0472619
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US9862730, Example 79
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C17H18N4O2S
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1
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| 1 |
IC50 = 800.9 nM
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CP0548871
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US9862730, Example 172
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C20H16N4O3S2
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1
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| 1 |
IC50 = 814.4 nM
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CP0531030
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6-(1-benzofuran-2-yl)-2-methylsulfonylimidazo[2,1-b][1,3,4]thiadiazole
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C13H9N3O3S2
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1
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| 1 |
IC50 = 820 nM
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CP0538627
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N—((R)-2-((R)-2-(((2-(2-(Methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazol-4-yl)oxy)methyl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)thiophene-2-carboxamide
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C30H26N6O4S3
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1
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| 1 |
IC50 = 897.2 nM
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CP0441483
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US9862730, Example 146
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C18H13N5O2S2
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1
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| 1 |
IC50 = 910.8 nM
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CP0524272
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US9862730, Example 188
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C12H7ClN4S3
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1
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| 1 |
IC50 = 920.4 nM
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CP0460260
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US9862730, Example 192
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C13H9ClN4S3
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1
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| 1 |
IC50 = 989.7 nM
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CP0575806
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US9862730, Example 83
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C20H15ClN4O2S
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1
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| 1 |
IC50 = 1006 nM
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CP0391633
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US9862730, Example 156
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C20H13N5O2S2
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1
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| 1 |
IC50 = 1018 nM
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CP0574062
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US9862730, Example 193
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C11H4BrFN4S2
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1
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| 1 |
IC50 = 1036 nM
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CP0574060
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US9862730, Example 197
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C13H10N4OS2
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1
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| 1 |
IC50 = 1053 nM
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CP0547216
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US9862730, Example 306
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C13H6BrF3N4OS
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1
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| 1 |
IC50 = 1098 nM
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CP0381454
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2-(2-(1,1-Difluoroethyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)-4-nitrobenzo[d]oxazole
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C13H7F2N5O3S
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1
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| 1 |
IC50 = 1118 nM
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CP0381446
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US9862730, Example 168
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C18H19N5O3S2
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1
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| 1 |
IC50 = 1147 nM
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CP0540609
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N—((R)-2-((S)-2-(((2-(2-(Methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazol-4-yl)oxy)methyl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)thiophene-2-carboxamide
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C30H26N6O4S3
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1
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| 1 |
IC50 = 1165 nM
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CP0575805
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US9862730, Example 86
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C19H15N5O2S
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1
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| 1 |
IC50 = 1213 nM
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CP0403700
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2-(2-(Methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-carboxylic acid
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C14H9N3O3S2
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1
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| 1 |
IC50 = 1285 nM
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CP0403647
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US9862730, Example 281
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C21H14N4O3S
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1
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| 1 |
IC50 = 1344 nM
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CP0565944
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US9862730, Example 77
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C18H20N4O2S
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1
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| 1 |
IC50 = 1369 nM
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CP0953252
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ethyl 6-(2-(2-ethylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-7-yloxy)hexanoate
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C22H25N3O4S
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1
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| 1 |
IC50 = 1467 nM
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CP0407497
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US9862730, Example 64
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C18H19N3O2S
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1
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| 1 |
IC50 = 1592 nM
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CP0547203
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US9862730, Example 61
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C15H13N3O2S
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1
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| 1 |
IC50 = 1653 nM
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CP0574068
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US9862730, Example 157
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C19H13ClN4O2S2
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1
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| 1 |
IC50 = 1653 nM
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CP0547207
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US9862730, Example 36
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C16H15N3O4S
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1
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| 1 |
IC50 = 1662 nM
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CP0474812
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US9862730, Example 27
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C13H10N4OS2
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1
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| 1 |
IC50 = 1777 nM
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CP0530113
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6-(6,7-Dimethoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
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C15H13N3O4S
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2
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| 1 |
IC50 = 1800 nM
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| 2 |
IC50 = 1801 nM
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CP0530112
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6-(1-benzofuran-2-yl)-2-phenylsulfanylimidazo[2,1-b][1,3,4]thiadiazole
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C18H11N3OS2
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1
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| 1 |
IC50 = 1900 nM
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CP0381436
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US9862730, Example 274
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C15H10ClF2N3OS
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1
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| 1 |
IC50 = 1972 nM
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CP0381441
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US9862730, Example 189
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C14H12N4O2S3
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1
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| 1 |
IC50 = 2195 nM
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CP0381439
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US9862730, Example 230
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C20H15N3O2S2
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1
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| 1 |
IC50 = 2298 nM
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CP0407540
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US9862730, Example 178
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C13H8F2N4OS
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1
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| 1 |
IC50 = 2340 nM
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CP0567001
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US9862730, Example 334
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C30H32N6O5S2
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1
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| 1 |
IC50 = 2365 nM
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CP0542619
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US9862730, Example 195
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C13H7F3N4O2S2
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1
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| 1 |
IC50 = 2417 nM
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CP0407496
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US9862730, Example 66
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C18H16N4O2S
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1
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| 1 |
IC50 = 2624 nM
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CP0548869
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US9862730, Example 199
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C14H10F2N4S2
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1
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| 1 |
IC50 = 2681 nM
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CP0527437
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US9862730, Example 283
Show/Hide
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C14H10BrN3O2S2
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1
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| 1 |
IC50 = 2706 nM
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CP0857911
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6-(7-bromo-5-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
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C14H10BrN3O3S
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1
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| 1 |
IC50 = 2727 nM
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CP0418005
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6-(1-benzofuran-2-yl)-2-ethylsulfanylimidazo[2,1-b][1,3,4]thiadiazole
Show/Hide
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C14H11N3OS2
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1
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| 1 |
IC50 = 2900 nM
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CP0566899
|
US9518064, Example 80
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C25H18N4O2S2
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1
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| 1 |
IC50 = 3133 nM
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CP0425179
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US9862730, Example 76
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C20H22N4O2S
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1
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| 1 |
IC50 = 3401 nM
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CP0547819
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2-(2-(1,1-Difluoroethyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)-4-aminobenzo[d]oxazole
Show/Hide
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C13H9F2N5OS
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1
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| 1 |
IC50 = 3482 nM
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CP0544859
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6-(7-((3-(Benzyloxy)benzyl)oxy)-5-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
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C28H23N3O5S
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1
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| 1 |
IC50 = 3711 nM
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CP0441498
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US9862730, Example 198
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C13H7ClF2N4S2
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1
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| 1 |
IC50 = 4715 nM
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