General Information of the Compound
Compound ID
CP0385461
Compound Name
US10047103, 181
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Structure
Formula
C26H17F4N5O4S2
Molecular Weight
603.579
Canonical SMILES
COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)NCC(F)(F)F)cc(F)cc2o1
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InChI
InChI=1S/C26H17F4N5O4S2/c1-37-25-34-35-9-18(33-24(35)41-25)21-8-17-19(6-15(27)7-20(17)39-21)38-10-16-11-40-23(32-16)14-4-2-13(3-5-14)22(36)31-12-26(28,29)30/h2-9,11H,10,12H2,1H3,(H,31,36)
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InChIKey
RIAXJNQBSCCWKV-UHFFFAOYSA-N
Physicochemical Property
logP
6.3463
Rotatable Bonds
8
Heavy Atom Count
41
Polar Areas
103.78
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 89879381
ChEMBL ID
CHEMBL3717136
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04808, Proteinase-activated receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 0.72 nM
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