General Information of the Compound
Compound ID
CP0543368
Compound Name
US10047103, 253
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Structure
Formula
C24H23N5O4S
Molecular Weight
477.546
Canonical SMILES
COc1cc(OCc2csc(n2)N2CC[C@@H](O)C2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
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InChI
InChI=1S/C24H23N5O4S/c1-14-3-4-23-26-19(11-29(23)27-14)22-9-18-20(7-17(31-2)8-21(18)33-22)32-12-15-13-34-24(25-15)28-6-5-16(30)10-28/h3-4,7-9,11,13,16,30H,5-6,10,12H2,1-2H3/t16-/m1/s1
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InChIKey
OWWBBEJEQBVODJ-MRXNPFEDSA-N
Physicochemical Property
logP
4.06602
Rotatable Bonds
6
Heavy Atom Count
34
Polar Areas
98.15
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 117981538
ChEMBL ID
CHEMBL3717842
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04808, Proteinase-activated receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 9.7 nM
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