General Information of the Compound
Compound ID
CP0574047
Compound Name
US9862730, Example 329
    Show/Hide
Structure
Formula
C26H21N5O5S
Molecular Weight
515.551
Canonical SMILES
COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4cncnc4)c3)cc(OC)cc2o1
    Show/Hide
InChI
InChI=1S/C26H21N5O5S/c1-32-19-7-22(35-13-16-4-3-5-18(6-16)34-14-17-10-27-15-28-11-17)20-9-24(36-23(20)8-19)21-12-31-25(29-21)37-26(30-31)33-2/h3-12,15H,13-14H2,1-2H3
    Show/Hide
InChIKey
BYKFSXVFGQWUPM-UHFFFAOYSA-N
Physicochemical Property
logP
5.1692
Rotatable Bonds
9
Heavy Atom Count
37
Polar Areas
106.03
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
11
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 118068674
ChEMBL ID
CHEMBL3730607
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04808, Proteinase-activated receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 71.6 nM
   TI
   LI
   LO
   TS