General Information of the Compound
Compound ID
CP0416341
Compound Name
2-Methoxy-6-(6-methoxy-4-((3′-(trifluoromethyl)-[1,1′-biphenyl]-3-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
    Show/Hide
Structure
Formula
C28H20F3N3O4S
Molecular Weight
551.546
Canonical SMILES
COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cccc(c3)C(F)(F)F)cc(OC)cc2o1
    Show/Hide
InChI
InChI=1S/C28H20F3N3O4S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-34-26(32-22)39-27(33-34)36-2)37-15-16-5-3-6-17(9-16)18-7-4-8-19(10-18)28(29,30)31/h3-14H,15H2,1-2H3
    Show/Hide
InChIKey
HVCZYPOMZHLRBQ-UHFFFAOYSA-N
Physicochemical Property
logP
7.486
Rotatable Bonds
7
Heavy Atom Count
39
Polar Areas
71.02
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 72192416
ChEMBL ID
CHEMBL3717423
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04808, Proteinase-activated receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 4.35 nM
   TI
   LI
   LO
   TS
2
IC50 = 4.4 nM
   TI
   LI
   LO
   TS