All Bioactivity

Brief Information of the Cell Line and Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Synonyms	Hek293 HEK-293 HEK/293 HEK 293 HEK;293 293 293 HEK 293 Ad5 Graham 293 Graham-293 Human Embryonic Kidney 293
Category	Transformed cell line
Organism	Homo sapiens (Human)
Cellosaurus ID	CVCL_0045

Protein ID: PT02590 , N-formyl peptide receptor 2

Protein Info

Gene Name	FPR2
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor
Uniprot ID	P25090

Table of Molecular Bioactivities Related to the Cell Line and Protein

Cell Line ID: CL000006

Cell Line Info

Protein ID: PT02590

Protein Info

Compound ID	Compound Name	Compound Formula
CP0558578 Compound Info	1-(4-chloro-3-hydroxyphenyl)-3-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]urea Show/Hide	C18H16ClF2N3O4	1
1	EC50 = 0.05 nM Bioactivity Info	TI LI LO TS
CP0859201 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-piperidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H34BrN3O2	1
1	EC50 = 0.07 nM Bioactivity Info	TI LI LO TS
CP0568695 Compound Info	1-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-(3-hydroxy-4-methylphenyl)urea Show/Hide	C19H19F2N3O4	1
1	EC50 = 0.078 nM Bioactivity Info	TI LI LO TS
CP0422948 Compound Info	1-(4-fluorophenyl)-3-[(3S,4R)-4-(4-methoxyphenyl)-2-oxopyrrolidin-3-yl]urea Show/Hide	C18H18FN3O3	1
1	EC50 = 0.085 nM Bioactivity Info	TI LI LO TS
CP0422945 Compound Info	1-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-(4-fluoro-3-hydroxyphenyl)urea Show/Hide	C18H16F3N3O4	1
1	EC50 = 0.087 nM Bioactivity Info	TI LI LO TS
CP0866449 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H32BrN3O2	1
1	EC50 = 0.1 nM Bioactivity Info	TI LI LO TS
CP0555981 Compound Info	1-(4-chlorophenyl)-3-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]urea Show/Hide	C18H16ClF2N3O3	1
1	EC50 = 0.11 nM Bioactivity Info	TI LI LO TS
CP0568292 Compound Info	1-(4-chlorophenyl)-3-[(3S,4S)-4-(4-methoxyphenyl)-2-oxopiperidin-3-yl]urea Show/Hide	C19H20ClN3O3	1
1	EC50 = 0.11 nM Bioactivity Info	TI LI LO TS
CP0866094 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(cis-4-(aminomethyl)-cyclohexyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H30BrN3O2	1
1	EC50 = 0.13 nM Bioactivity Info	TI LI LO TS
CP0533415 Compound Info	1-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea Show/Hide	C18H16F3N3O3	1
1	EC50 = 0.14 nM Bioactivity Info	TI LI LO TS
CP0545858 Compound Info	1-[(3S,4R)-4-(2,5-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea Show/Hide	C18H16F3N3O3	1
1	EC50 = 0.15 nM Bioactivity Info	TI LI LO TS
CP0949170 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(5-amino-pentyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H28BrN3O2	1
1	EC50 = 0.16 nM Bioactivity Info	TI LI LO TS
CP0513825 Compound Info	1-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-(3,4-difluorophenyl)urea Show/Hide	C18H15F4N3O3	1
1	EC50 = 0.16 nM Bioactivity Info	TI LI LO TS
CP0422944 Compound Info	1-(4-bromophenyl)-3-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]urea Show/Hide	C18H16BrF2N3O3	1
1	EC50 = 0.19 nM Bioactivity Info	TI LI LO TS
CP0866468 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(piperidin-4-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H26BrN3O2	1
1	EC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0949171 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-isobutyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H25BrN2O2	1
1	EC50 = 0.24 nM Bioactivity Info	TI LI LO TS
CP0422946 Compound Info	1-(5-chlorothiophen-2-yl)-3-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]urea Show/Hide	C16H14ClF2N3O3S	1
1	EC50 = 0.29 nM Bioactivity Info	TI LI LO TS
CP0940775 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4((3R)-fluoropyrrolidino)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H31BrFN3O2	1
1	EC50 = 0.3 nM Bioactivity Info	TI LI LO TS
CP0422947 Compound Info	1-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-(3-methyl-1,2-thiazol-5-yl)urea Show/Hide	C16H16F2N4O3S	1
1	EC50 = 0.32 nM Bioactivity Info	TI LI LO TS
CP0949169 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-amino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H26BrN3O2	1
1	EC50 = 0.34 nM Bioactivity Info	TI LI LO TS
CP0864728 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H34BrN3O2	1
1	EC50 = 0.35 nM Bioactivity Info	TI LI LO TS
CP0900930 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-((3S)-fluoropyrrolidino)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H31BrFN3O2	1
1	EC50 = 0.35 nM Bioactivity Info	TI LI LO TS
CP0561083 Compound Info	1-[(3S,4R)-4-(3-fluoro-5-methoxypyridin-2-yl)-2-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea Show/Hide	C17H16F2N4O3	1
1	EC50 = 0.36 nM Bioactivity Info	TI LI LO TS
CP0900933 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(azetidin-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H30BrN3O2	1
1	EC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0949168 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-N,N-dimethyl-amino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H26BrN3O2	1
1	EC50 = 0.41 nM Bioactivity Info	TI LI LO TS
CP0545821 Compound Info	1-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-phenylurea Show/Hide	C18H17F2N3O3	1
1	EC50 = 0.41 nM Bioactivity Info	TI LI LO TS
CP0850626 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(5-amino-pentyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H27BrN4O2S	1
1	EC50 = 0.45 nM Bioactivity Info	TI LI LO TS
CP0935552 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-[(piperidin-3-yl)-methyl]-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H27BrN4O2S	1
1	EC50 = 0.45 nM Bioactivity Info	TI LI LO TS
CP0540456 Compound Info	1-[(3S,4R)-4-(2-fluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea Show/Hide	C18H17F2N3O3	1
1	EC50 = 0.45 nM Bioactivity Info	TI LI LO TS
CP0952725 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-carbamoyl-ethyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H24BrN3O3	1
1	EC50 = 0.46 nM Bioactivity Info	TI LI LO TS
CP0861885 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(4-amino-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C18H25BrN4O2S	1
1	EC50 = 0.5 nM Bioactivity Info	TI LI LO TS
CP0861882 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-morpholino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H32BrN3O3	1
1	EC50 = 0.53 nM Bioactivity Info	TI LI LO TS
CP0850383 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-((3-aminomethyl-phenyl)-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H26BrN3O2	1
1	EC50 = 0.55 nM Bioactivity Info	TI LI LO TS
CP0864304 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(5-pyrrolidino-pentyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H34BrN3O2	1
1	EC50 = 0.66 nM Bioactivity Info	TI LI LO TS
CP0867715 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(5-(dimethyl-amino)-pentyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H34BrN3O2	1
1	EC50 = 0.7 nM Bioactivity Info	TI LI LO TS
CP0924093 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-(2-(pyrrolidin-1-yl)ethoxy)ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H32BrN3O3	1
1	EC50 = 0.72 nM Bioactivity Info	TI LI LO TS
CP0565860 Compound Info	1-(1-benzothiophen-2-yl)-3-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]urea Show/Hide	C20H17F2N3O3S	1
1	EC50 = 0.76 nM Bioactivity Info	TI LI LO TS
CP0422949 Compound Info	1-(4-cyanophenyl)-3-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]urea Show/Hide	C19H16F2N4O3	1
1	EC50 = 0.78 nM Bioactivity Info	TI LI LO TS
CP0894644 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-piperidinyl-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H28BrN3O2	1
1	EC50 = 0.82 nM Bioactivity Info	TI LI LO TS
CP0952117 Compound Info	(5R)-N5-(4-Bromo-3-fluorophenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H31BrFN3O2	1
1	EC50 = 0.87 nM Bioactivity Info	TI LI LO TS
CP0900932 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(4-methyl-1,4-diazepan-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H37BrN4O2	1
1	EC50 = 0.89 nM Bioactivity Info	TI LI LO TS
CP0551700 Compound Info	1-[(3S,4R)-4-(3-fluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea Show/Hide	C18H17F2N3O3	1
1	EC50 = 0.9 nM Bioactivity Info	TI LI LO TS
CP0565781 Compound Info	1-(4-chlorophenyl)-3-[(3R,4R)-4-(4-methoxyphenyl)-2-oxopyrrolidin-3-yl]urea Show/Hide	C18H18ClN3O3	1
1	EC50 = 0.91 nM Bioactivity Info	TI LI LO TS
CP0877238 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(pyrrolidin-3-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H24BrN3O2	1
1	EC50 = 0.94 nM Bioactivity Info	TI LI LO TS
CP0552572 Compound Info	1-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-(3-fluorophenyl)urea Show/Hide	C18H16F3N3O3	1
1	EC50 = 0.95 nM Bioactivity Info	TI LI LO TS
CP0867726 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2,2-dimethyl-3-amino-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H28BrN3O2	1
1	EC50 = 0.98 nM Bioactivity Info	TI LI LO TS
CP0850384 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(N,N-diethyl-amino)-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H34BrN3O2	1
1	EC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0903388 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-hydroxy-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H23BrN2O3	1
1	EC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0949167 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-carbamoyl-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H22BrN3O3	1
1	EC50 = 1.1 nM Bioactivity Info	TI LI LO TS
CP0863156 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(N-tert-butoxycarbonyl-pyrrolidin-3-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H32BrN3O4	1
1	EC50 = 1.2 nM Bioactivity Info	TI LI LO TS
CP0861399 Compound Info	(5R)-N5-(4-Bromo-2-fluorophenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H31BrFN3O2	1
1	EC50 = 1.3 nM Bioactivity Info	TI LI LO TS
CP0861400 Compound Info	(5R)-N5-(2-Bromopyrid-5-yl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H35BrN4O2	1
1	EC50 = 1.3 nM Bioactivity Info	TI LI LO TS
CP0867725 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(cyclopentyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H25BrN2O2	1
1	EC50 = 1.3 nM Bioactivity Info	TI LI LO TS
CP0877229 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-(4-methyl-piperazin-1-yl)-propyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H35BrN4O2	1
1	EC50 = 1.3 nM Bioactivity Info	TI LI LO TS
CP0891849 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-amino-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H24BrN3O2	1
1	EC50 = 1.4 nM Bioactivity Info	TI LI LO TS
CP0935545 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(2-(methoxymethyl)pyrrolidin-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C28H38BrN3O5	1
1	EC50 = 1.4 nM Bioactivity Info	TI LI LO TS
CP0540458 Compound Info	1-[(3S,4R)-4-[2,6-difluoro-4-(methylamino)phenyl]-2-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea Show/Hide	C18H17F3N4O2	1
1	EC50 = 1.4 nM Bioactivity Info	TI LI LO TS
CP0954128 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(tetrahydrofuran-2-yl-methyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H27BrN2O3	1
1	EC50 = 1.5 nM Bioactivity Info	TI LI LO TS
CP0548203 Compound Info	1-(4-fluorophenyl)-3-[(3S,4R)-4-(4-methoxy-2-methylphenyl)-2-oxopyrrolidin-3-yl]urea Show/Hide	C19H20FN3O3	1
1	EC50 = 1.6 nM Bioactivity Info	TI LI LO TS
CP0859415 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-hydroxy-propyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H25BrN2O3	1
1	EC50 = 1.8 nM Bioactivity Info	TI LI LO TS
CP0863182 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-ethoxy-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H27BrN2O3	1
1	EC50 = 1.8 nM Bioactivity Info	TI LI LO TS
CP0951280 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(pyrrolidin-1-yl)pentyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C27H36BrN3O4	1
1	EC50 = 1.8 nM Bioactivity Info	TI LI LO TS
CP0513823 Compound Info	1-(5-chloro-1,3-thiazol-2-yl)-3-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]urea Show/Hide	C15H13ClF2N4O3S	1
1	EC50 = 1.9 nM Bioactivity Info	TI LI LO TS
CP0850382 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-pyrrolidinyl-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H26BrN3O2	1
1	EC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0531871 Compound Info	1-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-(4-methylphenyl)urea Show/Hide	C19H19F2N3O3	1
1	EC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0900931 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(cis-4-(pyrrolidin-1-yl-methyl)-cyclohexyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C28H36BrN3O2	1
1	EC50 = 2.1 nM Bioactivity Info	TI LI LO TS
CP0903237 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(2,5-dimethylpyrrolidin-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H36BrN3O2	1
1	EC50 = 2.1 nM Bioactivity Info	TI LI LO TS
CP0935551 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-[(piperidin-2-yl)-methyl]-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H27BrN4O2S	1
1	EC50 = 2.1 nM Bioactivity Info	TI LI LO TS
CP0861849 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(4-ethyl-piperazin-1-yl)-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H37BrN4O2	1
1	EC50 = 2.3 nM Bioactivity Info	TI LI LO TS
CP0850381 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2,2,2-trifluoro-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H18BrF3N2O2	1
1	EC50 = 2.4 nM Bioactivity Info	TI LI LO TS
CP0900483 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-[(2-imidazolidin-2-on-1-yl)-ethyl]-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H27BrN4O3	1
1	EC50 = 2.4 nM Bioactivity Info	TI LI LO TS
CP0867727 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-fluoro-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H20BrFN2O2	1
1	EC50 = 2.7 nM Bioactivity Info	TI LI LO TS
CP0953577 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-((3R,6S)-6-(pyrrolidin-1-ylmethyl)tetrahydro-2H-pyran-3-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H34BrN3O3	1
1	EC50 = 2.7 nM Bioactivity Info	TI LI LO TS
CP0866448 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-(N-methyl-amino)-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H24BrN3O2	1
1	EC50 = 2.8 nM Bioactivity Info	TI LI LO TS
CP0552168 Compound Info	1-[(3S,4R)-4-(4-chloro-2-fluorophenyl)-2-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea Show/Hide	C17H14ClF2N3O2	1
1	EC50 = 3.1 nM Bioactivity Info	TI LI LO TS
CP0863259 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-methylamino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H24BrN3O3	1
1	EC50 = 3.2 nM Bioactivity Info	TI LI LO TS
CP0904417 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-tetrahydrofuranyl-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H25BrN2O3	1
1	EC50 = 3.2 nM Bioactivity Info	TI LI LO TS
CP0553031 Compound Info	1-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-(4-methoxyphenyl)urea Show/Hide	C19H19F2N3O4	1
1	EC50 = 3.2 nM Bioactivity Info	TI LI LO TS
CP0949166 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-hydroxy-cyclohexyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H29BrN2O3	1
1	EC50 = 3.3 nM Bioactivity Info	TI LI LO TS
CP0864306 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-dimethylamino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H26BrN3O3	1
1	EC50 = 3.4 nM Bioactivity Info	TI LI LO TS
CP0513821 Compound Info	2-[(4-chlorophenyl)carbamoylamino]-3-(4-methoxyphenyl)propanamide Show/Hide	C17H18ClN3O3	1
1	EC50 = 3.6 nM Bioactivity Info	TI LI LO TS
CP0867724 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-ethylsulfanyl-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H25BrN2O2S	1
1	EC50 = 3.7 nM Bioactivity Info	TI LI LO TS
CP0866467 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(5-(N,N-diethyl-amino)-pent-2-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H36BrN3O2	1
1	EC50 = 3.9 nM Bioactivity Info	TI LI LO TS
CP0951792 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(isobutyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H24BrN3O2S	1
1	EC50 = 3.9 nM Bioactivity Info	TI LI LO TS
CP0538091 Compound Info	1-[(3S,4R)-4-(2-chloro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea Show/Hide	C18H17ClFN3O3	1
1	EC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0864727 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-(1H-imidazol-1-yl)-propyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H27BrN4O2	1
1	EC50 = 4.1 nM Bioactivity Info	TI LI LO TS
CP0891842 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(4-methyl-piperazin-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H35BrN4O2	1
1	EC50 = 4.1 nM Bioactivity Info	TI LI LO TS
CP0850380 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-tert-butoxycarbonyl-amino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H30BrN3O4	1
1	EC50 = 4.2 nM Bioactivity Info	TI LI LO TS
CP0949165 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(piperidin-3-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H26BrN3O2	1
1	EC50 = 4.2 nM Bioactivity Info	TI LI LO TS
CP0858047 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(3,3-difluoropyrrolidin-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C26H32BrF2N3O4	1
1	EC50 = 4.4 nM Bioactivity Info	TI LI LO TS
CP0867729 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(1-hydroxy-prop-2-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H28BrN3O3	1
1	EC50 = 4.5 nM Bioactivity Info	TI LI LO TS
CP0538761 Compound Info	1-(5-chloropyridin-2-yl)-3-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]urea Show/Hide	C17H15ClF2N4O3	1
1	EC50 = 4.5 nM Bioactivity Info	TI LI LO TS
CP0903261 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-methoxy-propyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H27BrN2O3	1
1	EC50 = 4.8 nM Bioactivity Info	TI LI LO TS
CP0951773 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-imidazolidin-2-on-1-yl-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H25BrN4O3	1
1	EC50 = 4.8 nM Bioactivity Info	TI LI LO TS
CP0867762 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-pyrrolidin-1-yl-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H30BrN3O2	1
1	EC50 = 4.9 nM Bioactivity Info	TI LI LO TS
CP0850379 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-methoxy-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H23BrN2O3	1
1	EC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0967633 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-fluoro-4-(pyrrolidin-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C26H33BrFN3O4	1
1	EC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0866450 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-(1H-benzoimidazol-2-yl)-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H27BrN4O2	1
1	EC50 = 5.4 nM Bioactivity Info	TI LI LO TS
CP0952720 Compound Info	(5R)-N5-(4-Trifluoromethyl-phenyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H34F3N3O2	1
1	EC50 = 5.4 nM Bioactivity Info	TI LI LO TS
CP0931095 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(piperidin-4-yl-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H25BrN4O2S	1
1	EC50 = 5.7 nM Bioactivity Info	TI LI LO TS
CP0866451 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-(1-methyl-pyrrolidin-2-yl)-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H30BrN3O2	1
1	EC50 = 5.8 nM Bioactivity Info	TI LI LO TS
CP0422943 Compound Info	1-[(3S,4R)-4-(4-ethyl-2,6-difluorophenyl)-2-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea Show/Hide	C19H18F3N3O2	1
1	EC50 = 5.8 nM Bioactivity Info	TI LI LO TS
CP0895806 Compound Info	(5R)-N5-(2-Bromo-pyrid-5-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H21BrN4O3	1
1	EC50 = 5.9 nM Bioactivity Info	TI LI LO TS
CP0895805 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-pyrrolidino-4-oxobutyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H30BrN3O3	1
1	EC50 = 6.1 nM Bioactivity Info	TI LI LO TS
CP0902278 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-hydroxy-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H21BrN2O3	1
1	EC50 = 6.1 nM Bioactivity Info	TI LI LO TS
CP0903802 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6,N6-(3-(aminomethyl)pentane-1,5-diyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H27BrN4O2S	1
1	EC50 = 6.2 nM Bioactivity Info	TI LI LO TS
CP0891843 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-amino-2-oxoethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H20BrN3O3	1
1	EC50 = 6.5 nM Bioactivity Info	TI LI LO TS
CP0866447 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(cyano-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H18BrN3O2	1
1	EC50 = 6.7 nM Bioactivity Info	TI LI LO TS
CP0565827 Compound Info	1-(4-chlorophenyl)-3-[1-hydroxy-3-(4-methoxyphenyl)propan-2-yl]urea Show/Hide	C17H19ClN2O3	1
1	EC50 = 6.8 nM Bioactivity Info	TI LI LO TS
CP0866466 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-1H-pyrazol-1-yl-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H25BrN4O2	1
1	EC50 = 7.1 nM Bioactivity Info	TI LI LO TS
CP0861394 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(piperidin-4-yl -methyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H27BrN4O2S	1
1	EC50 = 7.3 nM Bioactivity Info	TI LI LO TS
CP0946602 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-amino-4-oxobutyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C22H26BrN3O5	1
1	EC50 = 7.3 nM Bioactivity Info	TI LI LO TS
CP0867730 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-[(4-aminomethyl -phenyl)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H26BrN3O2	1
1	EC50 = 7.5 nM Bioactivity Info	TI LI LO TS
CP0867723 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-ethyl-N6-(2-diethylamino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamid Show/Hide	C25H34BrN3O2	1
1	EC50 = 7.6 nM Bioactivity Info	TI LI LO TS
CP0904332 Compound Info	(5R)-N5-(2-Bromopyrid-5-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H25BrN4O3	1
1	EC50 = 7.9 nM Bioactivity Info	TI LI LO TS
CP0958526 Compound Info	(5R)-N5-(2-Bromo-pyrazin-5-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride Show/Hide	C23H31BrClN5O2	1
1	EC50 = 7.9 nM Bioactivity Info	TI LI LO TS
CP0877373 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C17H19BrN4O3S	1
1	EC50 = 8.1 nM Bioactivity Info	TI LI LO TS
CP0867758 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(5-dimethyl-amino-pentyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H32BrN3O2	1
1	EC50 = 8.2 nM Bioactivity Info	TI LI LO TS
CP0868959 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-(4,5-dimethyl-1H-imidazol-2-yl)-ethyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H29BrN4O2	1
1	EC50 = 8.3 nM Bioactivity Info	TI LI LO TS
CP0937310 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-[(pyrrolidin-2-yl)-methyl]-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H25BrN4O2S	1
1	EC50 = 8.3 nM Bioactivity Info	TI LI LO TS
CP0900478 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(pyrrolidin-3-yl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C18H23BrN4O2S	1
1	EC50 = 8.9 nM Bioactivity Info	TI LI LO TS
CP0867722 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-1H-imidazol-1-yl-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H25BrN4O2	1
1	EC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0877374 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-((2-imidazolidin-2-on)-1-yl-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H22BrN5O3S	1
1	EC50 = 9.1 nM Bioactivity Info	TI LI LO TS
CP0896564 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(piperidin-3-yl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H25BrN4O2S	1
1	EC50 = 9.1 nM Bioactivity Info	TI LI LO TS
CP0866713 Compound Info	(5R)-N5-(4-Bromo-2,6-difluorophenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H30BrF2N3O2	1
1	EC50 = 9.4 nM Bioactivity Info	TI LI LO TS
CP0867731 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-([1,4]-dioxan-2-yl-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H25BrN2O4	1
1	EC50 = 9.5 nM Bioactivity Info	TI LI LO TS
CP0867760 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-(4-methyl-piperazin-1-yl)-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H33BrN4O2	1
1	EC50 = 9.5 nM Bioactivity Info	TI LI LO TS
CP0867761 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-hydroxy-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H25BrN2O3	1
1	EC50 = 9.6 nM Bioactivity Info	TI LI LO TS
CP0903264 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-dimethyl-amino-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H28BrN3O2	1
1	EC50 = 9.6 nM Bioactivity Info	TI LI LO TS
CP0555979 Compound Info	1-[(3S,4R)-4-(4-cyano-2,6-difluorophenyl)-2-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea Show/Hide	C18H13F3N4O2	1
1	EC50 = 9.7 nM Bioactivity Info	TI LI LO TS
CP0877228 Compound Info	(5R)-N5-(Benzothiazol-5-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H32N4O2S	1
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0894677 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-amino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H22BrN3O2	1
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0867732 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-methyl-N6-(2-dimethylamino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H28BrN3O2	1
1	EC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0867759 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-tert-butoxycarbonyl-amino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H34BrN3O4	1
1	EC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0900477 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(2-(2-hydroxyethoxy)ethyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C18H24BrN3O4S	1
1	EC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0940780 Compound Info	(5R)-N5-(2-Trifluoromethyl-pyridin-5-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride Show/Hide	C25H32ClF3N4O2	1
1	EC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0852681 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(2,2-dimethyl-3-amino-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H25BrN4O2S	1
1	EC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0863158 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-pyrrolidin-1-yl-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H28BrN3O2	1
1	EC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0867733 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-(methyl-tert-butoxycarbonyl-amino)-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H32BrN3O4	1
1	EC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0891848 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-1H-[1,2,4]-triazol-1-yl-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H22BrN5O2	1
1	EC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0422942 Compound Info	1-(4-chlorophenyl)-3-[(2S,3R)-2-(4-methoxyphenyl)-4-oxoazetidin-3-yl]urea Show/Hide	C17H16ClN3O3	1
1	EC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0866465 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(furan-3-yl-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H21BrN2O3	1
1	EC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0904288 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(trans-4-(aminomethyl)-cyclohexyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H30BrN3O2	1
1	EC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0935549 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(2-(N-methyl amino)-ethyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C17H23BrN4O2S	1
1	EC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0946873 Compound Info	(5R)-N5-(4-Bromo-2-fluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H35BrFN3O2	1
1	EC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0958528 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(3-(3,5-dimethyl-pyrazol-1-yl)-propionylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C25H29BrN4O2	1
1	EC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0935550 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(3-(N-methylamino)-propyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C18H25BrN4O2S	1
1	EC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0538760 Compound Info	1-[(3S,4R)-4-(4-ethoxy-2,6-difluorophenyl)-2-oxopyrrolidin-3-yl]-3-(4-fluorophenyl)urea Show/Hide	C19H18F3N3O3	1
1	EC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0952724 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C17H21BrN4O3S	1
1	EC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0850378 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-[(1-ethyl-pyrrolidin-2-yl)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H30BrN3O2	1
1	EC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0891847 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-methoxy-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H25BrN2O3	1
1	EC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0946871 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-pyrrolidin-1-yl-propyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H32BrN3O2	1
1	EC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0867734 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-(N-tert-butoxycarbonyl-amino)-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H32BrN3O4	1
1	EC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0873895 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(piperidin-4-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H23BrN4O2S	1
1	EC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0867757 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(N-tert-butoxycarbonyl -piperidin-3-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H34BrN3O4	1
1	EC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0903263 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-1H-[1,2,4]-triazol-1-yl-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H24BrN5O2	1
1	EC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0861397 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6,N6-(3-(aminomethyl)pentane-1,5-diyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H25BrN4O2S	1
1	EC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0866714 Compound Info	(5R)-N5-(4-Aminobutyl)-(6R)-N6-(4-bromophenyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H26BrN3O2	1
1	EC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0877235 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-(4,5-dimethyl-1H-imidazol-2-yl)-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H27BrN4O2	1
1	EC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0866464 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-methyl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H27BrN2O2	1
1	EC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0866443 Compound Info	(5R)-N5-(5-Acetyl-furan-2-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H37N3O4	1
1	EC50 = 21 nM Bioactivity Info	TI LI LO TS
CP0866463 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-[(2S)-1-hydroxy-4-methyl-pent-2-yl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H29BrN2O3	1
1	EC50 = 21 nM Bioactivity Info	TI LI LO TS
CP0857659 Compound Info	(5R)-N5-(4-Bromo-2-fluorophenyl-methyl)-(6R)-N6-(5-amino-pentyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H31BrFN3O2	1
1	EC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0867756 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-(methoxy-carbonyl)-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H23BrN2O4	1
1	EC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0947058 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H31BrN4O2S	1
1	EC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0861398 Compound Info	(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-(piperidin-4-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H28BrN3O2	1
1	EC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0891844 Compound Info	(5R)-N5-(4-Acetyl-phenyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H35N3O3	1
1	EC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0904416 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-(4-aminosulfonyl-phenyl)-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H26BrN3O4S	1
1	EC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0571855 Compound Info	1-(4-chlorophenyl)-3-[1-(4-methoxyphenyl)propan-2-yl]urea Show/Hide	C17H19ClN2O2	1
1	EC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0852680 Compound Info	(5R)-N5-(2-Chloro-pyridin-5-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H23ClN4O3	1
1	EC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0861395 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(piperidin-4-yl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H25BrN4O2S	1
1	EC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0864632 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-(1-ethyl-5-methyl-1H-pyrazol-3-yl)-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H29BrN4O2	1
1	EC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0870029 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-[(1S)-1-carbamoyl-ethyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H22BrN3O3	1
1	EC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0940770 Compound Info	(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-(2,2-dimethyl-3-amino-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H30BrN3O2	1
1	EC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0952721 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(5-tert-butoxycarbonyl-amino-pentyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H36BrN3O4	1
1	EC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0954150 Compound Info	(5R)-N5-(5-Acetyl-furan-2-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H35N3O4	1
1	EC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0963532 Compound Info	(5R)-N5-(4-Bromo-2,6-difluorophenyl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H32BrF2N3O2	1
1	EC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0952745 Compound Info	(5R)-N5-(5-Aminopentyl)-(6R)-N6-(4-bromophenyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H28BrN3O2	1
1	EC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0868026 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-pyrrolidino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H28BrN3O3	1
1	EC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0904333 Compound Info	(5R)-N5-(2-Chloropyrid-5-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H23ClN4O3	1
1	EC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0959585 Compound Info	(5R)-N5-(4-Chloro-phenyl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C27H36ClN3O4	1
1	EC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0422941 Compound Info	2-[(4-chlorophenyl)carbamoylamino]-3-(4-methoxyphenyl)propanoic acid Show/Hide	C17H17ClN2O4	1
1	EC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0873892 Compound Info	(5R)-N5-(4-Methoxyphenyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H25N3O4	1
1	EC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0946603 Compound Info	(5R)-N5-(2-Bromo-thiophen-4-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H32BrN3O2S	1
1	EC50 = 33 nM Bioactivity Info	TI LI LO TS
CP0864633 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-diethyl-amino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H30BrN3O2	1
1	EC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0877233 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(pentyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H27BrN2O2	1
1	EC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0538094 Compound Info	1-(4-chlorophenyl)-3-[(3R,4S)-4-(4-methoxyphenyl)-2-oxopyrrolidin-3-yl]urea Show/Hide	C18H18ClN3O3	1
1	EC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0867112 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-{[(5-phenyl-isoxazole-4-carbonyl)-amino]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C27H24BrN3O3	1
1	EC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0877220 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(4-acetyl-piperazin-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H35BrN4O3	1
1	EC50 = 38 nM Bioactivity Info	TI LI LO TS
CP0850498 Compound Info	(5R)-N5-(4-Bromo-2,3-difluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H32BrF2N3O2	1
1	EC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0866498 Compound Info	(5R)-N5-(5-Methyl -isoxazol-3-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride Show/Hide	C24H35ClN4O3	1
1	EC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0850495 Compound Info	(5R)-N5-(4-Iodophenyl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H34IN3O2	1
1	EC50 = 42 nM Bioactivity Info	TI LI LO TS
CP0565782 Compound Info	1-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-(2-fluorophenyl)urea Show/Hide	C18H16F3N3O3	1
1	EC50 = 43 nM Bioactivity Info	TI LI LO TS
CP0952118 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(2-methoxy-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C17H20BrN3O3S	1
1	EC50 = 44 nM Bioactivity Info	TI LI LO TS
CP0877377 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(4-(aminomethyl)phenyl-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H23BrN4O2S	1
1	EC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0850374 Compound Info	(5R)-N5-[(4-Methyl-phenyl)-methyl]-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H37N3O2	1
1	EC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0866054 Compound Info	(5R)-N5-(4-Bromo-3,5-difluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H32BrF2N3O2	1
1	EC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0859933 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(4-(2-oxo-pyrrolidin-1-yl)-butyryl amino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C25H30BrN3O3	1
1	EC50 = 47 nM Bioactivity Info	TI LI LO TS
CP0867750 Compound Info	(5R)-N5-(4-Bromo-phenyl-methyl)-(6R)-N6-(3-pyrrolidin-1-yl-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H32BrN3O2	1
1	EC50 = 49 nM Bioactivity Info	TI LI LO TS
CP0961783 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(3-(4-methyl piperazin-1-yl)-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H30BrN5O2S	1
1	EC50 = 49 nM Bioactivity Info	TI LI LO TS
CP0873894 Compound Info	(5R)-N5-(4-Bromo-2-fluorophenyl-methyl)-(6R)-N6-(4-amino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H27BrFN3O2	1
1	EC50 = 52 nM Bioactivity Info	TI LI LO TS
CP0904446 Compound Info	(5R)-N5-(2-Methoxycarbonyl-ethyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H35N3O4	1
1	EC50 = 52 nM Bioactivity Info	TI LI LO TS
CP0846042 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(4-diethylamino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H31BrN4O2S	1
1	EC50 = 54 nM Bioactivity Info	TI LI LO TS
CP0850497 Compound Info	(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-(piperidin-4-yl-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H30BrN3O2	1
1	EC50 = 54 nM Bioactivity Info	TI LI LO TS
CP0865014 Compound Info	(5R)-N5-(4-Bromo-2-fluorophenyl-methyl)-(6R)-N6-(5-amino-pentyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H29BrFN3O2	1
1	EC50 = 55 nM Bioactivity Info	TI LI LO TS
CP0873852 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(azetidin-3-yl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C17H21BrN4O2S	1
1	EC50 = 57 nM Bioactivity Info	TI LI LO TS
CP0896531 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(N-(3-methyl-butyl)-piperidin-4-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H36BrN3O2	1
1	EC50 = 58 nM Bioactivity Info	TI LI LO TS
CP0952732 Compound Info	(5R)-N5-(4-Methoxyphenyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H27N3O4	1
1	EC50 = 59 nM Bioactivity Info	TI LI LO TS
CP0952737 Compound Info	(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-(3-(aminomethyl)phenyl-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H28BrN3O2	1
1	EC50 = 59 nM Bioactivity Info	TI LI LO TS
CP0900484 Compound Info	(5R)-N5-(Cyclohexyl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H41N3O2	1
1	EC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0850624 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(3-dimethylamino-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C19H25BrN4O2S	1
1	EC50 = 61 nM Bioactivity Info	TI LI LO TS
CP0859190 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(2-(2-chloro-phenyl)-acetylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C25H24BrClN2O2	1
1	EC50 = 61 nM Bioactivity Info	TI LI LO TS
CP0894082 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-pyridin-2-yl-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H24BrN3O2	1
1	EC50 = 61 nM Bioactivity Info	TI LI LO TS
CP0964069 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(cis-4-(hydroxymethyl)-cyclohexyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H28BrN3O3S	1
1	EC50 = 61 nM Bioactivity Info	TI LI LO TS
CP0859410 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(cyclopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H21BrN2O2	1
1	EC50 = 63 nM Bioactivity Info	TI LI LO TS
CP0867195 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2,2-dimethyl-3-N-tert-butoxycarbonyl-amino-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H36BrN3O4	1
1	EC50 = 63 nM Bioactivity Info	TI LI LO TS
CP0873891 Compound Info	(5R)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R)-N6-(2-dimethylamino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H28N4O3S	1
1	EC50 = 65 nM Bioactivity Info	TI LI LO TS
CP0952458 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(4-hydroxy-cyclohexyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H26BrN3O3S	1
1	EC50 = 69 nM Bioactivity Info	TI LI LO TS
CP0850865 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(1-phenyl-1H-pyrazol-5-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H23BrN4O2	1
1	EC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0859934 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(2-(2,5-dimethyl-thiazol-4-yl)-acetylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C24H26BrN3O2S	1
1	EC50 = 71 nM Bioactivity Info	TI LI LO TS
CP0863222 Compound Info	(5R)-N5-(4-Bromo-2-fluorophenyl-methyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H25BrFN3O3	1
1	EC50 = 71 nM Bioactivity Info	TI LI LO TS
CP0867754 Compound Info	(5R)-N5-(4-Methyl-cyclohex-1-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H41N3O2	1
1	EC50 = 71 nM Bioactivity Info	TI LI LO TS
CP0850492 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H25BrN2O2	1
1	EC50 = 72 nM Bioactivity Info	TI LI LO TS
CP0863201 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(3-methoxy-propionylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C21H25BrN2O3	1
1	EC50 = 72 nM Bioactivity Info	TI LI LO TS
CP0864635 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(hexyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H29BrN2O2	1
1	EC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0892127 Compound Info	(5R)-N5-(4-Bromo-thiazol-2-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H31BrN4O2S	1
1	EC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0911533 Compound Info	(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-(3-amino-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H26BrN3O2	1
1	EC50 = 76 nM Bioactivity Info	TI LI LO TS
CP0900486 Compound Info	(5R)-N5-(2-(4,5-Dimethyl -1H-imidazol-2-yl)-ethyl)-(6R)-N6-(4-bromophenyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H27BrN4O2	1
1	EC50 = 77 nM Bioactivity Info	TI LI LO TS
CP0903262 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-(1-ethyl-3-methyl-1H-pyrazol-5-yl)-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H29BrN4O2	1
1	EC50 = 77 nM Bioactivity Info	TI LI LO TS
CP0911532 Compound Info	(5R)-N5-Pentyl-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H39N3O2	1
1	EC50 = 79 nM Bioactivity Info	TI LI LO TS
CP0859189 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(3-(N,N-dimethyl-aminocarbonyl)-propionyl-amino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C23H28BrN3O3	1
1	EC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0860085 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-phenyl-2-morpholino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C29H32BrN3O3	1
1	EC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0880921 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(4-hydroxybutyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C18H24BrN3O3S	1
1	EC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0902294 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-diethyl-amino-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H32BrN3O2	1
1	EC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0866057 Compound Info	(5R)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R)-N6-((2-imidazolidin-2-on)-1-yl-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H27N5O4S	1
1	EC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0894112 Compound Info	(5R)-N5-(5-Trifluoromethyl-pyridin-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride Show/Hide	C26H33ClF3N3O2	1
1	EC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0900488 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(isobutyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C18H24BrN3O2S	1
1	EC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0954196 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(cyclopropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H23BrN2O2	1
1	EC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0859188 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-{[(2,2-dichloro-1-methyl-cyclopropylcarbonyl)-amino]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C22H23BrCl2N2O2	1
1	EC50 = 87 nM Bioactivity Info	TI LI LO TS
CP0877225 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-{[(4-methoxycarbonyl-butanoyl)-amino]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C23H27BrN2O4	1
1	EC50 = 88 nM Bioactivity Info	TI LI LO TS
CP0904331 Compound Info	(5R)-N5-(2-Acetyl-oxazol-5-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H34N4O4	1
1	EC50 = 92 nM Bioactivity Info	TI LI LO TS
CP0850496 Compound Info	(5R)-N5-(5-(iso-Butyl)-isoxazol-3-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H40N4O3	1
1	EC50 = 93 nM Bioactivity Info	TI LI LO TS
CP0867714 Compound Info	(5R)-N5-(5-Methyl-pyridin-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H34N4O2	1
1	EC50 = 95 nM Bioactivity Info	TI LI LO TS
CP0868024 Compound Info	(5R)-N5-(5-oxo-hexyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H39N3O3	1
1	EC50 = 95 nM Bioactivity Info	TI LI LO TS
CP0873889 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(N-tert-butoxycarbonyl-pyrrolidin-2-yl-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H34BrN3O4	1
1	EC50 = 96 nM Bioactivity Info	TI LI LO TS
CP0940779 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(3-hydroxypropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C17H22BrN3O3S	1
1	EC50 = 96 nM Bioactivity Info	TI LI LO TS
CP0904451 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-morpholino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H28BrN3O3	1
1	EC50 = 97 nM Bioactivity Info	TI LI LO TS
CP0946859 Compound Info	(5R)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R)-N6-(4-diethylamino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H36N4O3S	1
1	EC50 = 97 nM Bioactivity Info	TI LI LO TS
CP0934295 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(2-methylamino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C17H21BrN4O2S	1
1	EC50 = 98 nM Bioactivity Info	TI LI LO TS
CP0860086 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-carbamoyl-cyclohexyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H28BrN3O3	1
1	EC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0867752 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-(pentanoylamino-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C22H27BrN2O2	1
1	EC50 = 103 nM Bioactivity Info	TI LI LO TS
CP0872923 Compound Info	(5R)-N5-(4-Bromo-2,5-difluorophenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H30BrF2N3O2	1
1	EC50 = 103 nM Bioactivity Info	TI LI LO TS
CP0900929 Compound Info	(5R)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R)-N6-(3-(1H-benzoimidazol-2-yl)-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H29N5O3S	1
1	EC50 = 106 nM Bioactivity Info	TI LI LO TS
CP0867751 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-{[(1-phenyl-1H-pyrazole-5-carbonyl)-amino]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C27H25BrN4O2	1
1	EC50 = 112 nM Bioactivity Info	TI LI LO TS
CP0877376 Compound Info	(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H26BrN3O3	1
1	EC50 = 113 nM Bioactivity Info	TI LI LO TS
CP0850494 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-{[(3-aminocarbonyl-propionyl)-amino]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C21H24BrN3O3	1
1	EC50 = 114 nM Bioactivity Info	TI LI LO TS
CP0891845 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-{[(1,5-dimethyl -1H-pyrazole-3-carbonyl)-amino]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C23H25BrN4O2	1
1	EC50 = 115 nM Bioactivity Info	TI LI LO TS
CP0952742 Compound Info	(5R)-N5-(4-Bromo-3-fluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H33BrFN3O2	1
1	EC50 = 117 nM Bioactivity Info	TI LI LO TS
CP0868961 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-{[(4-methyl -pyridine-3-carbonyl)-amino]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C24H24BrN3O2	1
1	EC50 = 118 nM Bioactivity Info	TI LI LO TS
CP0900482 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(1-piperidin-1-yl-propan-1-on-2-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H30BrN3O3	1
1	EC50 = 118 nM Bioactivity Info	TI LI LO TS
CP0867111 Compound Info	(5R)-N5-(3,5-Difluoro-4-methoxy-phenyl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl -butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C28H37F2N3O5	1
1	EC50 = 119 nM Bioactivity Info	TI LI LO TS
CP0859195 Compound Info	(5R)-N5-(5-Nitro-thiazol-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H29N5O4S	1
1	EC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0861883 Compound Info	(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-(4-diethylamino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H36BrN3O2	1
1	EC50 = 121 nM Bioactivity Info	TI LI LO TS
CP0867753 Compound Info	(5R)-N5-(5-Chloro-thiazol-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H29ClN4O2S	1
1	EC50 = 121 nM Bioactivity Info	TI LI LO TS
CP0873844 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(N-benzyl -piperidin-4-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C29H32BrN3O2	1
1	EC50 = 123 nM Bioactivity Info	TI LI LO TS
CP0961794 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(isobutyrylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C21H25BrN2O2	1
1	EC50 = 125 nM Bioactivity Info	TI LI LO TS
CP0946860 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-[(1-hydroxy-cyclohexyl)methyl]-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H28BrN3O3S	1
1	EC50 = 129 nM Bioactivity Info	TI LI LO TS
CP0901903 Compound Info	(5R)-N5-(2-Methyl-pyridin-5-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride Show/Hide	C25H35ClN4O2	1
1	EC50 = 131 nM Bioactivity Info	TI LI LO TS
CP0947057 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-{[(N-ethyl -piperidine-4-carbonyl)-amino]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C25H32BrN3O2	1
1	EC50 = 131 nM Bioactivity Info	TI LI LO TS
CP0867720 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-methyl-N6-hexyl-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H31BrN2O2	1
1	EC50 = 133 nM Bioactivity Info	TI LI LO TS
CP0946872 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(3-pyridin-3-yl-propionylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C25H26BrN3O2	1
1	EC50 = 136 nM Bioactivity Info	TI LI LO TS
CP0867030 Compound Info	(5R)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H34N4O3S	1
1	EC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0940776 Compound Info	(5R)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R)-N6-(3-pyrrolidino-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H32N4O3S	1
1	EC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0877232 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3,3-dimethyl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H29BrN2O2	1
1	EC50 = 146 nM Bioactivity Info	TI LI LO TS
CP0951745 Compound Info	(5R)-N5-(4-Bromo-2-fluorophenyl-methyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H23BrFN3O3	1
1	EC50 = 146 nM Bioactivity Info	TI LI LO TS
CP0850493 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(N-methyl-piperidin-4-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H28BrN3O2	1
1	EC50 = 147 nM Bioactivity Info	TI LI LO TS
CP0863202 Compound Info	(5R)-N5-(2-Acetyl-oxazol-4-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H34N4O4	1
1	EC50 = 153 nM Bioactivity Info	TI LI LO TS
CP0951787 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-{[N-(3-methoxy-propionyl)-N-methyl-amino]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C22H27BrN2O3	1
1	EC50 = 155 nM Bioactivity Info	TI LI LO TS
CP0850390 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-morpholino-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H30BrN3O3	1
1	EC50 = 156 nM Bioactivity Info	TI LI LO TS
CP0866710 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-{[(2-chloro-3-fluoro-phenyl-carbonyl)-amino]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C24H21BrClFN2O2	1
1	EC50 = 158 nM Bioactivity Info	TI LI LO TS
CP0937309 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(2-hydroxyethyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C16H20BrN3O3S	1
1	EC50 = 158 nM Bioactivity Info	TI LI LO TS
CP0871281 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(4-pyrrolidin-1-yl-butanoylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C25H32BrN3O2	1
1	EC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0900485 Compound Info	(5R)-N5-(5-Cyano-thiazol-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H29N5O2S	1
1	EC50 = 166 nM Bioactivity Info	TI LI LO TS
CP0850866 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-(5-methyl-1H-pyrazol-4-yl)-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H27BrN4O2	1
1	EC50 = 168 nM Bioactivity Info	TI LI LO TS
CP0952459 Compound Info	(5R)-N5-(2-Bromo-3-fluoro-pyridin-5-yl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H30BrFN4O2	1
1	EC50 = 168 nM Bioactivity Info	TI LI LO TS
CP0873890 Compound Info	(5R)-N5-(4-Acetyl-oxazol-2-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H34N4O4	1
1	EC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0935341 Compound Info	(5R)-N5-(Furan-2-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H33N3O3	1
1	EC50 = 173 nM Bioactivity Info	TI LI LO TS
CP0871313 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(3-(1H-benzoimidazol-2-yl)-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H24BrN5O2S	1
1	EC50 = 174 nM Bioactivity Info	TI LI LO TS
CP0882511 Compound Info	(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-((2-imidazolidin-2-on)-1-yl-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H27BrN4O3	1
1	EC50 = 181 nM Bioactivity Info	TI LI LO TS
CP0868023 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-tert-butoxycarbonyl-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H31BrN2O4	1
1	EC50 = 191 nM Bioactivity Info	TI LI LO TS
CP0951059 Compound Info	(5R)-N5-(4-Bromo-phenyl-methyl)-(6R)-N6-(isobutyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H27BrN2O2	1
1	EC50 = 191 nM Bioactivity Info	TI LI LO TS
CP0873845 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-{[(3-N-tert-butoxycarbonyl-aminomethyl)-phenyl]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C30H34BrN3O4	1
1	EC50 = 194 nM Bioactivity Info	TI LI LO TS
CP0850623 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-{[(cyclopentyl-carbonyl)-amino]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C23H27BrN2O2	1
1	EC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0904429 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-propyl-N6-(cyclopropylmethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H29BrN2O2	1
1	EC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0894655 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(N-tert-butoxycarbonyl-piperidin-4-yl-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C28H36BrN3O4	1
1	EC50 = 204 nM Bioactivity Info	TI LI LO TS
CP0859200 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(trans-4-(pyrrolidin-1-yl-methyl)-cyclohexyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C28H36BrN3O2	1
1	EC50 = 208 nM Bioactivity Info	TI LI LO TS
CP0902188 Compound Info	(5R)-N5-(2-Bromo-thiazol-5-yl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H31BrN4O2S	1
1	EC50 = 213 nM Bioactivity Info	TI LI LO TS
CP0940771 Compound Info	(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-(3-(4-methylpiperazin-1-yl)-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H35BrN4O2	1
1	EC50 = 213 nM Bioactivity Info	TI LI LO TS
CP0868020 Compound Info	(5R)-N5-(4-Bromo-phenyl-methyl)-(6R)-N6-(3-(1H-benzoimidazol-2-yl)-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C28H29BrN4O2	1
1	EC50 = 216 nM Bioactivity Info	TI LI LO TS
CP0951791 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(cyclohexyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H27BrN2O2	1
1	EC50 = 216 nM Bioactivity Info	TI LI LO TS
CP0850389 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(N-tert-butoxycarbonyl-piperidin-4-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H34BrN3O4	1
1	EC50 = 218 nM Bioactivity Info	TI LI LO TS
CP0866444 Compound Info	(5R)-N5-(5-Acetyl-thiophen-2-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H35N3O3S	1
1	EC50 = 223 nM Bioactivity Info	TI LI LO TS
CP0867719 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-[(1S)-1-carbamoyl-2-phenyl-ethyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H26BrN3O3	1
1	EC50 = 223 nM Bioactivity Info	TI LI LO TS
CP0932454 Compound Info	(5R)-N5-(4-Bromo-2,3-difluorophenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H30BrF2N3O2	1
1	EC50 = 236 nM Bioactivity Info	TI LI LO TS
CP0850392 Compound Info	(5R)-N5-(4-Bromo-phenyl-methyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H24BrN3O3	1
1	EC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0952722 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(2-(2-methyl-thiazol-4-yl)-acetylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C23H24BrN3O2S	1
1	EC50 = 252 nM Bioactivity Info	TI LI LO TS
CP0849529 Compound Info	(5R)-N5-(5-Bromopyrid-2-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H23BrN4O3	1
1	EC50 = 258 nM Bioactivity Info	TI LI LO TS
CP0859194 Compound Info	(5R)-N5-(4-Trifluoromethoxyphenyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H32F3N3O3	1
1	EC50 = 263 nM Bioactivity Info	TI LI LO TS
CP0952719 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(2-(N,N-dimethyl-amino)-acetylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C21H26BrN3O2	1
1	EC50 = 265 nM Bioactivity Info	TI LI LO TS
CP0867983 Compound Info	(5R)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R)-N6-(3-amino-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H26N4O3S	1
1	EC50 = 273 nM Bioactivity Info	TI LI LO TS
CP0946858 Compound Info	(5R)-N5-(4-Bromo-2-methylphenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H34BrN3O2	1
1	EC50 = 275 nM Bioactivity Info	TI LI LO TS
CP0877375 Compound Info	(5R)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R)-N6-(3-dimethylamino-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H30N4O3S	1
1	EC50 = 288 nM Bioactivity Info	TI LI LO TS
CP0859935 Compound Info	(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-(2-dimethylamino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H28BrN3O2	1
1	EC50 = 290 nM Bioactivity Info	TI LI LO TS
CP0902302 Compound Info	(5R)-N5-(2,3-Difluoro-4-methoxy-phenyl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C28H37F2N3O5	1
1	EC50 = 290 nM Bioactivity Info	TI LI LO TS
CP0940772 Compound Info	(5R)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H24N4O4S	1
1	EC50 = 297 nM Bioactivity Info	TI LI LO TS
CP0871332 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-{[N-(2-(2-chloro-phenyl)-acetyl)-N-methyl-amino]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C26H26BrClN2O2	1
1	EC50 = 298 nM Bioactivity Info	TI LI LO TS
CP0864609 Compound Info	(5R)-N5-(4-Bromo-2,5-difluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H32BrF2N3O2	1
1	EC50 = 301 nM Bioactivity Info	TI LI LO TS
CP0861847 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-{[N-(1,5-dimethyl-1H-pyrazole-3-carbonyl)-N-methyl-amino]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C24H27BrN4O2	1
1	EC50 = 303 nM Bioactivity Info	TI LI LO TS
CP0934305 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(3-pyrrolidin-1-yl -propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H27BrN4O2S	1
1	EC50 = 305 nM Bioactivity Info	TI LI LO TS
CP0903051 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(2-cyclopropyl-acetylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C22H25BrN2O2	1
1	EC50 = 315 nM Bioactivity Info	TI LI LO TS
CP0868960 Compound Info	(5R)-N5-(2-Phenoxy-ethyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H37N3O3	1
1	EC50 = 319 nM Bioactivity Info	TI LI LO TS
CP0849526 Compound Info	(5R)-N5-(5-Methyl-pyridin-2-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H24N4O3	1
1	EC50 = 330 nM Bioactivity Info	TI LI LO TS
CP0951279 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(2-methyl-3-hydroxyprop-2-yl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C18H24BrN3O3S	1
1	EC50 = 333 nM Bioactivity Info	TI LI LO TS
CP0902293 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(3-(1-methyl-1H-benzoimidazol-2-yl)-propionylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C28H29BrN4O2	1
1	EC50 = 336 nM Bioactivity Info	TI LI LO TS
CP0904289 Compound Info	(5R)-N5-(2-Bromo-3-fluoro-pyridin-5-yl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H34BrFN4O4	1
1	EC50 = 349 nM Bioactivity Info	TI LI LO TS
CP0866055 Compound Info	(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-(2-methylamino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H26BrN3O2	1
1	EC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0871280 Compound Info	(5R)-N5-(3-Methyl-butyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H39N3O2	1
1	EC50 = 352 nM Bioactivity Info	TI LI LO TS
CP0846043 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(2-fluoro-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C16H17BrFN3O2S	1
1	EC50 = 354 nM Bioactivity Info	TI LI LO TS
CP0867209 Compound Info	(5R)-N5-Butyl-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H37N3O2	1
1	EC50 = 365 nM Bioactivity Info	TI LI LO TS
CP0850625 Compound Info	(5R)-N5-(4-Bromo-3-chlorophenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H31BrClN3O2	1
1	EC50 = 367 nM Bioactivity Info	TI LI LO TS
CP0863312 Compound Info	(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-(4-(aminomethyl)phenyl-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H28BrN3O2	1
1	EC50 = 367 nM Bioactivity Info	TI LI LO TS
CP0949189 Compound Info	(5R)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R)-N6-(isobutyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H27N3O4	1
1	EC50 = 369 nM Bioactivity Info	TI LI LO TS
CP0867718 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H30BrN3O3	1
1	EC50 = 373 nM Bioactivity Info	TI LI LO TS
CP0951744 Compound Info	(5R)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R)-N6-(piperidin-4-yl-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H30N4O3S	1
1	EC50 = 384 nM Bioactivity Info	TI LI LO TS
CP0859298 Compound Info	(5R)-N5-(3-Fluoro-4-methoxy-phenyl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C28H38FN3O5	1
1	EC50 = 389 nM Bioactivity Info	TI LI LO TS
CP0867717 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-[(4-N-tert-butoxycarbonyl-aminomethyl-phenyl)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C30H34BrN3O4	1
1	EC50 = 391 nM Bioactivity Info	TI LI LO TS
CP0894111 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(3-1H-indol-3-yl-propionylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C28H28BrN3O2	1
1	EC50 = 463 nM Bioactivity Info	TI LI LO TS
CP0899832 Compound Info	(5R)-N5-(5-Methyl-thiazol-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H32N4O2S	1
1	EC50 = 463 nM Bioactivity Info	TI LI LO TS
CP0901904 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(4-tert-butoxycarbonyl-amino-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H33BrN4O4S	1
1	EC50 = 467 nM Bioactivity Info	TI LI LO TS
CP0861401 Compound Info	(5R)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R)-N6-(3-(4-methylpiperazin-1-yl)-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H35N5O3S	1
1	EC50 = 477 nM Bioactivity Info	TI LI LO TS
CP0877230 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(N-tert-butoxycarbonyl-azetidin-3-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H30BrN3O4	1
1	EC50 = 477 nM Bioactivity Info	TI LI LO TS
CP0954131 Compound Info	(5R)-N5-(Benzo[d]oxazol-6-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride Show/Hide	C26H33ClN4O3	1
1	EC50 = 492 nM Bioactivity Info	TI LI LO TS
CP0880631 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(butanoylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C21H25BrN2O2	1
1	EC50 = 505 nM Bioactivity Info	TI LI LO TS
CP0924083 Compound Info	(5R)-N5-(4-Fluoro-phenyl -methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C27H36FN3O4	1
1	EC50 = 514 nM Bioactivity Info	TI LI LO TS
CP0900487 Compound Info	(5R)-N5-(4-Methoxyphenyl)-(6R)-N6-(3-hydroxyl-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H24N2O5	1
1	EC50 = 516 nM Bioactivity Info	TI LI LO TS
CP0951741 Compound Info	(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(5-tert-butoxycarbonyl-amino-pentyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H35BrN4O4S	1
1	EC50 = 519 nM Bioactivity Info	TI LI LO TS
CP0903386 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(3-(4-fluoro-phenyl)-propionylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C26H26BrFN2O2	1
1	EC50 = 529 nM Bioactivity Info	TI LI LO TS
CP0867755 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-(N-tert-butoxycarbonyl-piperidin-3-yl)-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C29H38BrN3O4	1
1	EC50 = 552 nM Bioactivity Info	TI LI LO TS
CP0904445 Compound Info	(5R)-N5-(5-Methyl-furan-2-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H35N3O3	1
1	EC50 = 556 nM Bioactivity Info	TI LI LO TS
CP0859193 Compound Info	(5R)-N5-(2-Methyl-benzothiazol-5-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H34N4O2S	1
1	EC50 = 570 nM Bioactivity Info	TI LI LO TS
CP0866403 Compound Info	(5R)-N5-(2-Methoxy-pyrid-5-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride Show/Hide	C25H35ClN4O3	1
1	EC50 = 673 nM Bioactivity Info	TI LI LO TS
CP0873846 Compound Info	(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-(2-fluoroethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H22BrFN2O2	1
1	EC50 = 673 nM Bioactivity Info	TI LI LO TS
CP0871282 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-[(3-phenyl-acryloylamino)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C26H25BrN2O2	1
1	EC50 = 697 nM Bioactivity Info	TI LI LO TS
CP0947060 Compound Info	(5R)-N5-(2-Phenyl-ethyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H37N3O2	1
1	EC50 = 731 nM Bioactivity Info	TI LI LO TS
CP0877370 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-[(1S)-2-methoxy-1-benzyl-ethyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H29BrN2O3	1
1	EC50 = 735 nM Bioactivity Info	TI LI LO TS
CP0859192 Compound Info	(5R)-N5-(4-oxo-pentyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H37N3O3	1
1	EC50 = 748 nM Bioactivity Info	TI LI LO TS
CP0867716 Compound Info	(5R)-N5-(4-Bromophenyl)-(6R)-N6-[(5-methyl-3-phenyl-isoxazol-4-yl)-methyl]-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C28H26BrN3O3	1
1	EC50 = 812 nM Bioactivity Info	TI LI LO TS
CP0930474 Compound Info	(5R)-N5-(3-(1H-Imidazol-1-yl)-propyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H37N5O2	1
1	EC50 = 835 nM Bioactivity Info	TI LI LO TS
CP0861447 Compound Info	(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(trans-4-(hydroxymethyl)-cyclohexyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C21H28BrN3O3S	1
1	EC50 = 855 nM Bioactivity Info	TI LI LO TS
CP0846041 Compound Info	(5R)-N5-(2-Bromothiazol-5-yl-methyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C18H21BrN4O3S	1
1	EC50 = 884 nM Bioactivity Info	TI LI LO TS
CP0868025 Compound Info	(5R)-N5-(1-(4-Bromophenyl)-ethyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H36BrN3O2	1
1	EC50 = 898 nM Bioactivity Info	TI LI LO TS
CP0954129 Compound Info	(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-(3-ethoxy-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H29BrN2O3	1
1	EC50 = 899 nM Bioactivity Info	TI LI LO TS
CP0850388 Compound Info	(5R)-N5-(2,6-Difluoro-4-methoxy-phenyl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C28H37F2N3O5	1
1	EC50 = 912 nM Bioactivity Info	TI LI LO TS
CP0868962 Compound Info	(5R)-N5-(4-Bromo-phenyl)-(6R)-6-{[(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)-amino]-methyl}-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide Show/Hide	C23H24BrClN4O2	1
1	EC50 = 963 nM Bioactivity Info	TI LI LO TS
CP0908268 Compound Info	1-(4-chlorophenyl)-3-(4-methoxyphenethyl)urea Show/Hide	C16H17ClN2O2	1
1	EC50 = 990 nM Bioactivity Info	TI LI LO TS
CP0958527 Compound Info	(5R)-N5-(2-Acetyl-thiazol-5-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H34N4O3S	1
1	EC50 = 994 nM Bioactivity Info	TI LI LO TS
CP0904290 Compound Info	(5R)-N5-[(4-Acetyl-thiazol-2-yl)methyl]-(6R)-N6-(2-methylamino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C20H26N4O3S	1
1	EC50 = 1040 nM Bioactivity Info	TI LI LO TS
CP0858048 Compound Info	(5R)-N5-(4-Bromo-3,5-difluorophenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H34BrF2N3O2	1
1	EC50 = 1190 nM Bioactivity Info	TI LI LO TS
CP0935344 Compound Info	(5R)-N5-(4-Trifluoromethoxy-phenyl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate saltc Show/Hide	C28H36F3N3O5	1
1	EC50 = 1260 nM Bioactivity Info	TI LI LO TS
CP0946605 Compound Info	(5R)-N5-(2-Chloro-pyrimidin-5-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H30ClN5O2	1
1	EC50 = 1330 nM Bioactivity Info	TI LI LO TS
CP0952750 Compound Info	(5R)-N5-(2,4,6-Trifluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H32F3N3O2	1
1	EC50 = 1540 nM Bioactivity Info	TI LI LO TS
CP0935732 Compound Info	(5R)-N5-(4-Bromo-thiazol-2-yl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C22H29BrN4O2S	1
1	EC50 = 1550 nM Bioactivity Info	TI LI LO TS
CP0903240 Compound Info	(5R)-N5-(2-(Cyclohexen-1-yl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H41N3O2	1
1	EC50 = 1740 nM Bioactivity Info	TI LI LO TS
CP0852697 Compound Info	(5R)-N5-(2,4-Dimethylphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C28H39N3O2	1
1	EC50 = 1800 nM Bioactivity Info	TI LI LO TS
CP0859932 Compound Info	(5R)-N5-(3-Bromophenyl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H34BrN3O2	1
1	EC50 = 2060 nM Bioactivity Info	TI LI LO TS
CP0952967 Compound Info	(5R)-N5-(Benzothiazol-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H32N4O2S	1
1	EC50 = 2270 nM Bioactivity Info	TI LI LO TS
CP0848744 Compound Info	(5R)-N5-(3-Chloro-4-methoxyphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C28H38ClN3O5	1
1	EC50 = 2620 nM Bioactivity Info	TI LI LO TS
CP0911526 Compound Info	(5R)-N5-(4-Ethoxyphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C29H41N3O5	1
1	EC50 = 2910 nM Bioactivity Info	TI LI LO TS
CP0859937 Compound Info	(5R)-N5-[(2-Acetyl-thiazol-4-yl)methyl]-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H34N4O3S	1
1	EC50 = 3230 nM Bioactivity Info	TI LI LO TS
CP0954711 Compound Info	(5R)-N5-(5-tert-Butyl-isoxazol-3-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H38N4O3	1
1	EC50 = 3650 nM Bioactivity Info	TI LI LO TS
CP0900476 Compound Info	(5R)-N5-(4-Bromo-3-trifluoromethyl phenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H31BrF3N3O2	1
1	EC50 = 3800 nM Bioactivity Info	TI LI LO TS
CP0951739 Compound Info	(5R)-N5-(2-(4-Methylphenyl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C29H41N3O4	1
1	EC50 = 3900 nM Bioactivity Info	TI LI LO TS
CP0900816 Compound Info	(5R)-N5-(3-Methyl-benzo[d]isothiazol-5-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H34N4O2S	1
1	EC50 = 4420 nM Bioactivity Info	TI LI LO TS
CP0861393 Compound Info	(5R)-N5-(3-Chloro-2-fluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H33ClFN3O2	1
1	EC50 = 4720 nM Bioactivity Info	TI LI LO TS
CP0864611 Compound Info	(5R)-N5-(4-Methyl-oxazol-2-yl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H32N4O3	1
1	EC50 = 5730 nM Bioactivity Info	TI LI LO TS
CP0953506 Compound Info	(5R)-N5-(5-Trifluoromethyl -1,3,4-thiadiazol-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride Show/Hide	C22H29ClF3N5O2S	1
1	EC50 = 6010 nM Bioactivity Info	TI LI LO TS
CP0902253 Compound Info	(5R)-N5-[(5-Acetyl-thiazol-2-yl)methyl]-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H34N4O3S	1
1	EC50 = 6330 nM Bioactivity Info	TI LI LO TS
CP0873901 Compound Info	(5R)-N5-(2-(4-Fluorophenyl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C28H38FN3O4	1
1	EC50 = 6360 nM Bioactivity Info	TI LI LO TS
CP0861852 Compound Info	(5R)-N5-(3-Acetylphenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H35N3O3	1
1	EC50 = 6700 nM Bioactivity Info	TI LI LO TS
CP0852678 Compound Info	(5R)-N5-(4-Methyl-thiazol-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride Show/Hide	C23H33ClN4O2S	1
1	EC50 = 6720 nM Bioactivity Info	TI LI LO TS
CP0852698 Compound Info	(5R)-N5-(2-Bromo-4-fluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H33BrFN3O2	1
1	EC50 = 6900 nM Bioactivity Info	TI LI LO TS
CP0903265 Compound Info	(5R)-N5-(4-Isopropoxy-phenyl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C30H43N3O5	1
1	EC50 = 7220 nM Bioactivity Info	TI LI LO TS
CP0864612 Compound Info	(5R)-N5-(3-Bromo-4-fluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H33BrFN3O2	1
1	EC50 = 7410 nM Bioactivity Info	TI LI LO TS
CP0867210 Compound Info	(5R)-N5-(1H-Indol-5-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H34N4O2	1
1	EC50 = 7410 nM Bioactivity Info	TI LI LO TS
CP0903795 Compound Info	(5R)-N5-(2,3,5-Trifluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H32F3N3O2	1
1	EC50 = 7500 nM Bioactivity Info	TI LI LO TS
CP0902899 Compound Info	(5R)-N5-(6-Fluoro-benzothiazol-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H31FN4O2S	1
1	EC50 = 7600 nM Bioactivity Info	TI LI LO TS
CP0894566 Compound Info	(5R)-N5-(2-(Benzo[d][1,3]dioxol-5-yl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C29H39N3O6	1
1	EC50 = 7680 nM Bioactivity Info	TI LI LO TS
CP0850627 Compound Info	(5R)-N5-[(4-Methyl-1,2,5-oxadiazol-3-yl)methyl]-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H33N5O3	1
1	EC50 = 7710 nM Bioactivity Info	TI LI LO TS
CP0864610 Compound Info	(5R)-N5-(4-Acetyl-thiazol-2-yl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H32N4O3S	1
1	EC50 = 7850 nM Bioactivity Info	TI LI LO TS
CP0931094 Compound Info	(5R)-N5-(2-Fluoro-3-trifluoromethyl phenyl -methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H33F4N3O2	1
1	EC50 = 7910 nM Bioactivity Info	TI LI LO TS
CP0850628 Compound Info	(5R)-N5-(3,5-Dimethylphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C28H39N3O2	1
1	EC50 = 7980 nM Bioactivity Info	TI LI LO TS
CP0859191 Compound Info	(5R)-N5-(2-Ethyl-butyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H41N3O2	1
1	EC50 = 8090 nM Bioactivity Info	TI LI LO TS
CP0904328 Compound Info	(5R)-N5-(2-(4-Chlorophenyl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H36ClN3O2	1
1	EC50 = 8270 nM Bioactivity Info	TI LI LO TS
CP0899822 Compound Info	(5R)-N5-(3-Acetylphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C28H37N3O3	1
1	EC50 = 8350 nM Bioactivity Info	TI LI LO TS
CP0937373 Compound Info	(5R)-N5-(4-(4-Chlorophenyl)-thiazol-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C28H33ClN4O2S	1
1	EC50 = 8440 nM Bioactivity Info	TI LI LO TS
CP0873899 Compound Info	(5R)-N5-(2-(4-Methoxyphenyl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C29H41N3O5	1
1	EC50 = 8610 nM Bioactivity Info	TI LI LO TS
CP0866053 Compound Info	(5R)-N5-(3-Difluoromethoxyphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H35F2N3O3	1
1	EC50 = 8700 nM Bioactivity Info	TI LI LO TS
CP0857654 Compound Info	(5R)-N5-(2-(4-Bromophenyl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C28H38BrN3O4	1
1	EC50 = 8810 nM Bioactivity Info	TI LI LO TS
CP0864613 Compound Info	(5R)-N5-[(2-Methoxypyridin-4-yl)methyl]-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H36N4O3	1
1	EC50 = 8870 nM Bioactivity Info	TI LI LO TS
CP0911523 Compound Info	(5R)-N5-(3,4-Dimethoxyphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C29H41N3O6	1
1	EC50 = 9050 nM Bioactivity Info	TI LI LO TS
CP0903796 Compound Info	(5R)-N5-(3-Fluoro-5-trifluoromethylphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H33F4N3O2	1
1	EC50 = 9090 nM Bioactivity Info	TI LI LO TS
CP0954194 Compound Info	(5R)-N5-(Benzo[2,1,3]oxadiazol-4-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H31N5O3	1
1	EC50 = 9120 nM Bioactivity Info	TI LI LO TS
CP0934294 Compound Info	(5R)-N5-(4-tert-Butyl-thiazol-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H38N4O2S	1
1	EC50 = 9630 nM Bioactivity Info	TI LI LO TS
CP0904291 Compound Info	(5R)-N5-(2-(2,4-Dichlorophenyl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H35Cl2N3O2	1
1	EC50 = 9710 nM Bioactivity Info	TI LI LO TS
CP0931093 Compound Info	(5R)-N5-(4-Acetylphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C28H37N3O3	1
1	EC50 = 9740 nM Bioactivity Info	TI LI LO TS
CP0946604 Compound Info	(5R)-N5-(3-Phenyl-[1,2,4]thiadiazol-5-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H33N5O2S	1
1	EC50 = 9890 nM Bioactivity Info	TI LI LO TS
CP0852699 Compound Info	(5R)-N5-(2-Chloro-5-trifluoromethylphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H33ClF3N3O2	1
1	EC50 = 9970 nM Bioactivity Info	TI LI LO TS
CP0902254 Compound Info	(5R)-N5-(2-Fluoro-5-trifluoromethyl phenyl -methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H33F4N3O2	1
1	EC50 = 9970 nM Bioactivity Info	TI LI LO TS
CP0895804 Compound Info	(5R)-N5-(6-Chloro-benzothiazol-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H31ClN4O2S	1
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0911530 Compound Info	(5R)-N5-(4-Fluoro-3-trifluoromethylphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H33F4N3O2	1
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0848742 Compound Info	(5R)-N5-(2,4-Dimethoxyphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C29H41N3O6	1
1	EC50 = 10300 nM Bioactivity Info	TI LI LO TS
CP0911525 Compound Info	(5R)-N5-(2-(3-Bromo-4-methoxyphenyl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C29H40BrN3O5	1
1	EC50 = 10300 nM Bioactivity Info	TI LI LO TS
CP0935546 Compound Info	(5R)-N5-(2-(4-Chlorophenyl)ethyl)-(6R)-N6-(N-isopentyl-piperidin-4-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C29H40ClN3O2	1
1	EC50 = 10400 nM Bioactivity Info	TI LI LO TS
CP0903238 Compound Info	(5R)-N5-[(2,6-Dichloropyridin-4-yl)methyl]-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C25H32Cl2N4O2	1
1	EC50 = 10600 nM Bioactivity Info	TI LI LO TS
CP0904292 Compound Info	(5R)-N5-(2,5-Dimethylphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C28H39N3O2	1
1	EC50 = 11100 nM Bioactivity Info	TI LI LO TS
CP0857656 Compound Info	(5R)-N5-(2-Chloro-6-fluoro-3-methyl phenyl -methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H35ClFN3O2	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0857657 Compound Info	(5R)-N5-(4-Trifluoromethyl-thiazol-2-yl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H29F3N4O2S	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0868772 Compound Info	(5R)-N5-(2-(4-Chlorophenyl)ethyl)-(6R)-N6-(2-(4-aminosulfonyl-phenyl)-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C27H30ClN3O4S	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0873900 Compound Info	(5R)-N5-(2-(3,4-Dimethylphenyl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C30H43N3O4	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0896560 Compound Info	(5R)-N5-(2-(2-Methoxy-phenyl)-ethyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C28H39N3O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0900470 Compound Info	(5R)-N5-(2-Methoxy-5-methylphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C28H39N3O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0900471 Compound Info	(5R)-N5-(2-(4-Chlorophenyl)ethyl)-(6R)-N6-(2-dimethylamino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C23H30ClN3O2	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0903336 Compound Info	(5R)-N5-(3-(2-Methyl-1H-indol-1-yl)-propyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C31H42N4O2	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0904327 Compound Info	(5R)-N5-(2-Isopropoxyphenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C29H41N3O3	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0904366 Compound Info	(5R)-N5-(2-(4-Chlorophenyl)ethyl)-(6R)-N6-(2-(pyridin-2-yl)ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H28ClN3O2	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0911524 Compound Info	(5R)-N5-(2-(3,4-Dimethoxyphenyl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C29H41N3O4	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0935342 Compound Info	(5R)-N5-(4,5-Dimethyl-thiazol-2-yl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C24H34N4O2S	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0935725 Compound Info	(5R)-N5-(2-Chloro-3,6-difluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H32ClF2N3O2	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0946856 Compound Info	(5R)-N5-(2-(2,4-Dimethyl phenyl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt Show/Hide	C30H43N3O4	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0952723 Compound Info	(5R)-N5-(2-(1H-Indol-1-yl)-ethyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C29H38N4O2	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0958529 Compound Info	(5R)-N5-(2-(1-Methyl-1H-benzoimidazol-2-yl)-ethyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C29H39N5O2	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0513824 Compound Info	1-(4-chlorophenyl)-3-[(2S,3S)-2-(4-methoxyphenyl)-4-oxoazetidin-3-yl]urea Show/Hide	C17H16ClN3O3	1
1	EC50 > 100 nM Bioactivity Info	TI LI LO TS
CP0857658 Compound Info	(5R)-N5-(4-tert-Butyl-cyclohexyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C29H47N3O2	1
1	EC50 > 2390 nM Bioactivity Info	TI LI LO TS
CP0951413 Compound Info	(5R)-N5-(2-(Pyridin-2-yl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide Show/Hide	C26H36N4O2	1
1	EC50 > 2390 nM Bioactivity Info	TI LI LO TS

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Prof. Feng ZHU

Prof. Leo, Lianyi Han