Protein Information

General Information of the Protein

Protein ID	PT02590
Protein Name	N-formyl peptide receptor 2
Secondarily Protein Name	FMLP-related receptor I Formyl peptide receptor-like 1 HM63 Lipoxin A4 receptor RFP
Gene Name	FPR2
Secondarily Gene Name	FPRH1 FPRL1 LXA4R
Sequence	METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Peptide receptor (family A GPCR) > N-formyl methionyl peptide receptor
Function	Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity). Acts as a receptor for humanin (PubMed:15465011). Show/Hide
Uniprot ID	Primary ID: P25090 Secondarily ID: A8K3E2 Show/Hide
Ensembl ID	ENSG00000171049
HGNC ID	HGNC:3827
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0545821 Compound Info	1-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl]-3-phenylurea Show/Hide	C18H17F2N3O3	1
1	EC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0546958 Compound Info	(3S,4R)-3-[[5-(4-chlorophenyl)-1,2-oxazol-3-yl]amino]-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C20H16ClF2N3O3	1
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0395312 Compound Info	1-(3-tert-butyl-2-methyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-chlorophenyl)urea Show/Hide	C21H23ClN4O2	1
1	EC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0374845 Compound Info	1-(3-isopropyl-2-methyl-5-oxo-1-(quinolin-3-yl)-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-(methylthio)phenyl)urea Show/Hide	C24H25N5O2S	1
1	EC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0525163 Compound Info	1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-iodophenyl)urea Show/Hide	C18H17IN4O2	1
1	EC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0569103 Compound Info	(3S,4R)-3-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]amino]-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C19H15ClF2N4O3	1
1	EC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0446518 Compound Info	2-ethyl-1-[(3R)-1-[(5-methoxy-1H-indol-2-yl)carbonyl]pyrrolidin-3-yl]-1H-1,3-benzodiazole Show/Hide	C23H24N4O2	1
1	EC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0580015 Compound Info	(3S,4R)-3-[[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]amino]-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C19H15ClF2N4O2S	1
1	EC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0580225 Compound Info	(3S,4R)-3-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]amino]-4-(2-fluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C19H16ClFN4O3	1
1	EC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0965302 Compound Info	(3R,4R)-3-(6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C17H13ClF2N4O2	1
1	EC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0541744 Compound Info	1-(3-isopropyl-2-methyl-5-oxo-1-(pyrimidin-5-yl)-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-(methylthio)phenyl)urea Show/Hide	C19H22N6O2S	1
1	EC50 = 43 nM Bioactivity Info	TI LI LO TS
CP0259831 Compound Info	1-(4-chlorophenyl)-3-[1-methyl-3-oxo-2-phenyl-5-(propan-2-yl)-2,3-dihydro-1H-pyrazol-4-yl]urea Show/Hide	C20H21ClN4O2	1
1	EC50 = 44 nM Bioactivity Info	TI LI LO TS
CP0374827 Compound Info	1-(3-isopropyl-2-methyl-5-oxo-1-(quinolin-3-yl)-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-(trifluoromethyl)phenyl)urea Show/Hide	C24H22F3N5O2	1
1	EC50 = 44 nM Bioactivity Info	TI LI LO TS
CP0579427 Compound Info	(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-3-[[5-[4-(trifluoromethoxy)phenyl]-1,3,4-oxadiazol-2-yl]amino]pyrrolidin-2-one Show/Hide	C20H15F5N4O4	1
1	EC50 = 53 nM Bioactivity Info	TI LI LO TS
CP0499716 Compound Info	1-(4-chlorophenyl)-3-(3-isopropyl-2-methyl-5-oxo-1-(quinolin-3-yl)-2,5-dihydro-1H-pyrazol-4-yl)urea Show/Hide	C23H22ClN5O2	1
1	EC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0522966 Compound Info	1-(3-fluoro-4-methylphenyl)-3-(3-isopropyl-2-methyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)urea Show/Hide	C21H23FN4O2	1
1	EC50 = 81 nM Bioactivity Info	TI LI LO TS
CP0532343 Compound Info	1-(3-tert-butyl-2-methyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(3-fluoro-4-methylphenyl)urea Show/Hide	C22H25FN4O2	1
1	EC50 = 83 nM Bioactivity Info	TI LI LO TS
CP0395322 Compound Info	1-(4-bromophenyl)-3-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)urea Show/Hide	C18H17BrN4O2	1
1	EC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0529099 Compound Info	1-(2-ethyl-3-isopropyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(3-fluoro-4-methylphenyl)urea Show/Hide	C22H25FN4O2	1
1	EC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0542272 Compound Info	1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-(trifluoromethyl)phenyl)urea Show/Hide	C19H17F3N4O2	1
1	EC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0969958 Compound Info	(3R,4R)-3-(5-chloro-1H-benzo[d]imidazol-2-yl)-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C18H14ClF2N3O2	1
1	EC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0509978 Compound Info	2-ethyl-1-{1-[(5-methoxy-1H-indol-2-yl)carbonyl]pyrrolidin-3-yl}-1H-1,3-benzodiazole Show/Hide	C23H24N4O2	1
1	EC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0506065 Compound Info	1-(4-chlorophenyl)-3-(3-ethyl-2-methyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)urea Show/Hide	C19H19ClN4O2	1
1	EC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0541743 Compound Info	1-(3-isopropyl-2-methyl-5-oxo-1-(pyrimidin-5-yl)-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-(trifluoromethyl)phenyl)urea Show/Hide	C19H19F3N6O2	1
1	EC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0574646 Compound Info	(3S,4R)-3-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]amino]-4-(4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C19H17ClN4O3	1
1	EC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0393825 Compound Info	1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-(methylthio)phenyl)urea Show/Hide	C19H20N4O2S	1
1	EC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0496722 Compound Info	1-(4-chlorophenyl)-3-(3-isopropyl-2-methyl-5-oxo-1-(pyrimidin-5-yl)-2,5-dihydro-1H-pyrazol-4-yl)urea Show/Hide	C18H19ClN6O2	1
1	EC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0578828 Compound Info	(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-3-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]pyrrolidin-2-one Show/Hide	C19H16F2N4O3	1
1	EC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0580081 Compound Info	(3S,4R)-3-[[5-(4-chlorophenyl)-1,3-oxazol-2-yl]amino]-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C20H16ClF2N3O3	1
1	EC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0399583 Compound Info	2-ethyl-1-[(3R)-1-[(5-ethyl-1H-indol-2-yl)carbonyl]pyrrolidin-3-yl]-1H-1,3-benzodiazole Show/Hide	C24H26N4O	1
1	EC50 = 270 nM Bioactivity Info	TI LI LO TS
CP0442117 Compound Info	1-(3-ethyl-2-methyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(3-fluoro-4-methylphenyl)urea Show/Hide	C20H21FN4O2	1
1	EC50 = 310 nM Bioactivity Info	TI LI LO TS
CP0252495 Compound Info	1-(4-chlorophenyl)-3-(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyrazol-4-yl)urea Show/Hide	C18H17ClN4O2	1
1	EC50 = 490 nM Bioactivity Info	TI LI LO TS
CP0522965 Compound Info	1-(4-chlorophenyl)-3-(1-(4,5-dihydrothiazol-2-yl)-3-isopropyl-2-methyl-5-oxo-2,5-dihydro-1H-pyrazol-4-yl)urea Show/Hide	C17H20ClN5O2S	1
1	EC50 = 540 nM Bioactivity Info	TI LI LO TS
CP0969952 Compound Info	(3R,4R)-3-(1H-benzo[d]imidazol-2-yl)-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C18H15F2N3O2	1
1	EC50 = 680 nM Bioactivity Info	TI LI LO TS
CP0424810 Compound Info	2-ethyl-1-{1-[(5-methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl}-1H-1,3-benzodiazole Show/Hide	C24H26N4O2	1
1	EC50 = 690 nM Bioactivity Info	TI LI LO TS
CP0523092 Compound Info	1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-ethylphenyl)urea Show/Hide	C20H22N4O2	1
1	EC50 = 770 nM Bioactivity Info	TI LI LO TS
CP0457626 Compound Info	1-[(3R)-1-[(5-bromo-1H-indol-2-yl)carbonyl]pyrrolidin-3-yl]-2-ethyl-1H-1,3-benzodiazole Show/Hide	C22H21BrN4O	1
1	EC50 = 810 nM Bioactivity Info	TI LI LO TS
CP0424809 Compound Info	1-{1-[(5-methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl}-2-(2-methylpropyl)-1H-1,3-benzodiazole Show/Hide	C26H30N4O2	1
1	EC50 = 830 nM Bioactivity Info	TI LI LO TS
CP0579426 Compound Info	(3S,4R)-3-[[5-(4-chloro-2-fluorophenyl)-1,3,4-oxadiazol-2-yl]amino]-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C19H14ClF3N4O3	1
1	EC50 = 840 nM Bioactivity Info	TI LI LO TS
CP0393823 Compound Info	1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(3-fluoro-4-methylphenyl)urea Show/Hide	C19H19FN4O2	1
1	EC50 = 980 nM Bioactivity Info	TI LI LO TS
CP0486809 Compound Info	1-{1-[(5-methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl}-2-methyl-1H-1,3-benzodiazole Show/Hide	C23H24N4O2	1
1	EC50 = 1020 nM Bioactivity Info	TI LI LO TS
CP0407255 Compound Info	1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-p-tolylurea Show/Hide	C19H20N4O2	1
1	EC50 = 1260 nM Bioactivity Info	TI LI LO TS
CP0968206 Compound Info	(3S,4R)-3-((1H-benzo[d]imidazol-2-yl)amino)-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C18H16F2N4O2	1
1	EC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0541742 Compound Info	1-(1-(4,5-dihydrothiazol-2-yl)-3-isopropyl-2-methyl-5-oxo-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-(trifluoromethyl)phenyl)urea Show/Hide	C18H20F3N5O2S	1
1	EC50 = 1470 nM Bioactivity Info	TI LI LO TS
CP0440710 Compound Info	2-ethyl-1-[(3R)-1-[(5-fluoro-1H-indol-2-yl)carbonyl]pyrrolidin-3-yl]-1H-1,3-benzodiazole Show/Hide	C22H21FN4O	1
1	EC50 = 1490 nM Bioactivity Info	TI LI LO TS
CP0440811 Compound Info	1-{1-[(5-methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl}-2-(trifluoromethyl)-1H-1,3-benzodiazole Show/Hide	C23H21F3N4O2	1
1	EC50 = 1520 nM Bioactivity Info	TI LI LO TS
CP0447652 Compound Info	2-ethyl-1-[(3R)-1-[(5-methoxy-1H-1,3-benzodiazol-2-yl)carbonyl]pyrrolidin-3-yl]-1H-1,3-benzodiazole Show/Hide	C22H23N5O2	1
1	EC50 = 1870 nM Bioactivity Info	TI LI LO TS
CP0579428 Compound Info	(3S,4R)-3-[[3-(4-chlorophenyl)-1,2-oxazol-5-yl]amino]-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C20H16ClF2N3O3	1
1	EC50 = 2200 nM Bioactivity Info	TI LI LO TS
CP0970277 Compound Info	(3R,4R)-3-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C17H13ClF2N4O2	1
1	EC50 = 2300 nM Bioactivity Info	TI LI LO TS
CP0580014 Compound Info	(3S,4R)-3-[[5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl]amino]-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C19H15ClF2N4O3	1
1	EC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0440810 Compound Info	1-{1-[(5-methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl}-2-phenyl-1H-1,3-benzodiazole Show/Hide	C28H26N4O2	1
1	EC50 = 2710 nM Bioactivity Info	TI LI LO TS
CP0449432 Compound Info	1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-methoxyphenyl)urea Show/Hide	C19H20N4O3	1
1	EC50 = 2730 nM Bioactivity Info	TI LI LO TS
CP0446515 Compound Info	2-ethyl-1-[(3S)-1-[(5-methoxy-1H-indol-2-yl)carbonyl]pyrrolidin-3-yl]-1H-1,3-benzodiazole Show/Hide	C23H24N4O2	1
1	EC50 = 3500 nM Bioactivity Info	TI LI LO TS
CP0546956 Compound Info	(3S,4R)-3-[[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]amino]-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C19H15ClF2N4O3	1
1	EC50 = 3500 nM Bioactivity Info	TI LI LO TS
CP0523091 Compound Info	1-(4-cyanophenyl)-3-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)urea Show/Hide	C19H17N5O2	1
1	EC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0580080 Compound Info	(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-3-[[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]amino]pyrrolidin-2-one Show/Hide	C20H18F2N4O4	1
1	EC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0502962 Compound Info	1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-fluorophenyl)urea Show/Hide	C18H17FN4O2	1
1	EC50 = 4850 nM Bioactivity Info	TI LI LO TS
CP0424807 Compound Info	1-{1-[(5-methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl}-1H-1,3-benzodiazole Show/Hide	C22H22N4O2	1
1	EC50 = 5100 nM Bioactivity Info	TI LI LO TS
CP0395311 Compound Info	1-(1-(4,5-dihydrothiazol-2-yl)-3-isopropyl-2-methyl-5-oxo-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-(methylthio)phenyl)urea Show/Hide	C18H23N5O2S2	1
1	EC50 = 5130 nM Bioactivity Info	TI LI LO TS
CP0274397 Compound Info	1-(benzo[d][1,3]dioxol-5-yl)-3-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)urea Show/Hide	C19H18N4O4	1
1	EC50 = 5880 nM Bioactivity Info	TI LI LO TS
CP0393824 Compound Info	1-(2-chlorophenyl)-3-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)urea Show/Hide	C18H17ClN4O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0424808 Compound Info	1-(2-chlorophenyl)-3-[1-methyl-3-oxo-2-phenyl-5-(propan-2-yl)-2,3-dihydro-1H-pyrazol-4-yl]urea Show/Hide	C20H21ClN4O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0499715 Compound Info	1-(1,5-dimethyl-3-oxo-2-phenylpyrazolidin-4-yl)-3-(4-iodophenyl)-1,3-dimethylurea Show/Hide	C20H23IN4O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0502562 Compound Info	1-(3-chlorophenyl)-3-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)urea Show/Hide	C18H17ClN4O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0515765 Compound Info	1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-fluoro-3-methylphenyl)urea Show/Hide	C19H19FN4O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0523090 Compound Info	1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(thiazol-2-yl)urea Show/Hide	C15H15N5O2S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0526722 Compound Info	1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-phenylurea Show/Hide	C18H18N4O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0567905 Compound Info	(3S,4R)-3-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]amino]-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C19H15ClF2N4O3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0569104 Compound Info	(3S,4R)-3-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]amino]-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C19H15ClF2N4O3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0579430 Compound Info	(3S,4R)-3-[[5-(4-chlorophenyl)-1-methylpyrazol-3-yl]amino]-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C21H19ClF2N4O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0953133 Compound Info	(3R,4R)-3-(4-chloro-1H-benzo[d]imidazol-2-yl)-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C18H14ClF2N3O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0969959 Compound Info	(3S,4R)-3-((5-(4-chlorophenyl)-1H-pyrazol-3-yl)amino)-4-(2,6-difluoro-4-methoxyphenyl)pyrrolidin-2-one Show/Hide	C20H17ClF2N4O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0424811 Compound Info	2-ethyl-1-[(3R)-1-{[5-(trifluoromethoxy)-1H-indol-2-yl]carbonyl}pyrrolidin-3-yl]-1H-1,3-benzodiazole Show/Hide	C23H21F3N4O2	1
1	EC50 = 12200 nM Bioactivity Info	TI LI LO TS
CP0453035 Compound Info	1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-isopropylphenyl)urea Show/Hide	C21H24N4O2	1
1	EC50 = 12300 nM Bioactivity Info	TI LI LO TS
CP0458640 Compound Info	1-[(3R)-1-[(5-chloro-1H-indol-2-yl)carbonyl]pyrrolidin-3-yl]-2-ethyl-1H-1,3-benzodiazole Show/Hide	C22H21ClN4O	1
1	EC50 = 14100 nM Bioactivity Info	TI LI LO TS
CP0953132 Compound Info	(3R,4R)-4-(2,6-difluoro-4-methoxyphenyl)-3-(5-methoxy-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one Show/Hide	C19H17F2N3O3	1
1	EC50 > 5000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000386 , Flp-In-CHO

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000050 , HEK293-A

Cell Line Info

Cell Line ID: CL000018 , HL-60

Cell Line Info

Cell Line ID: CL000278 , RBL-2H3

Cell Line Info

Cell Line ID: CL000040 , THP-1

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0659136 Compound Info	(S)-3-(1H-Indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]-N-[[1-(5-methoxy-2-pyridinyl)cyclohexyl]methyl]propanamide Show/Hide	C32H37N5O4	2
1	EC50 = 60 nM
2	EC50 = 64 nM
CP0659140 Compound Info	(S)-3-(1H-Indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]-N-[[1-(3-pyridinyl)cyclohexyl]methyl]propanamide Show/Hide	C31H35N5O3	2
1	EC50 = 270 nM
2	EC50 = 1800 nM
CP0667419 Compound Info	(S)-3-(1H-Indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]-N-[[1-(2-pyridinyl)cyclohexyl]methyl]propanamide Show/Hide	C31H35N5O3	2
1	EC50 = 450 nM
2	EC50 = 1800 nM
CP0659138 Compound Info	(R)-3-(1H-Indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]-N-[[1-(2-pyridinyl)cyclohexyl]methyl]propanamide Show/Hide	C31H35N5O3	2
1	EC50 = 490 nM
2	EC50 = 620 nM
CP0659139 Compound Info	(S)-N-[[(1-(2-Fluoro-4-pyridinyl)cyclohexyl]methyl]-3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamide Show/Hide	C31H34FN5O3	2
1	EC50 = 660 nM
2	EC50 = 12600 nM
CP0658395 Compound Info	(R)-3-(1H-Indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]-N-[[1-(5-methoxy-2-pyridinyl)cyclohexyl]methyl]propanamide Show/Hide	C32H37N5O4	2
1	EC50 = 880 nM
2	EC50 = 920 nM
CP0727506 Compound Info	(R)-3-(1H-Indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]-N-[(1-phenylcyclohexyl)methyl]propanamide Show/Hide	C32H36N4O3	1
1	EC50 = 970 nM
CP0659137 Compound Info	(S)-N-[[1-(4-Fluorophenyl)cyclohexyl]methyl]-3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamide Show/Hide	C32H35FN4O3	1
1	EC50 = 1100 nM
CP0046087 Compound Info	(S)-2-[(S)-2-((S)-2-Formylamino-4-methylsulfanyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid Show/Hide	C21H31N3O5S	1
1	Kd > 300 nM

Clinical Information about the Protein

Target 1 ( FMLP-related receptor I (FPR2) )

Target Type	Literature-reported Target
Disease	1 Target-related Disease				1
1	Alzheimer disease [ICD-11: 8A20]
Preclinical Drug(s)	1 Preclinical Drug				1
1	humanin	Drug Info	Preclinical	Alzheimer disease

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT00605	FML2_HUMAN	Homo sapiens, Human	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han