General Information of the Compound
Compound ID
CP0902188
Compound Name
(5R)-N5-(2-Bromo-thiazol-5-yl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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Structure
Formula
C23H31BrN4O2S
Molecular Weight
507.498
Canonical SMILES
O=C(NCCCCN1CCCC1)[C@H]1[C@H](C(=O)NCc2cnc(Br)s2)[C@@H]2C=C[C@H]1C21CC1
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InChI
InChI=1S/C23H31BrN4O2S/c24-22-27-14-15(31-22)13-26-21(30)19-17-6-5-16(23(17)7-8-23)18(19)20(29)25-9-1-2-10-28-11-3-4-12-28/h5-6,14,16-19H,1-4,7-13H2,(H,25,29)(H,26,30)/t16-,17+,18-,19-/m1/s1
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InChIKey
DWCFMSPSZNUHTH-FCGDIQPGSA-N
Physicochemical Property
logP
3.3424
Rotatable Bonds
9
Heavy Atom Count
31
Polar Areas
74.33
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 67495690
ChEMBL ID
CHEMBL3727792
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00605, FML2_HUMAN
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 208 nM
   TI
   LI
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Protein ID: PT02590, N-formyl peptide receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 213 nM
   TI
   LI
   LO
   TS