General Information of the Compound
Compound ID
CP0903051
Compound Name
(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(2-cyclopropyl-acetylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
    Show/Hide
Structure
Formula
C22H25BrN2O2
Molecular Weight
429.358
Canonical SMILES
O=C(CC1CC1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1
    Show/Hide
InChI
InChI=1S/C22H25BrN2O2/c23-14-3-5-15(6-4-14)25-21(27)20-16(12-24-19(26)11-13-1-2-13)17-7-8-18(20)22(17)9-10-22/h3-8,13,16-18,20H,1-2,9-12H2,(H,24,26)(H,25,27)/t16-,17-,18+,20+/m1/s1
    Show/Hide
InChIKey
LOIZIRILYVYQTC-XSYGEPLQSA-N
Physicochemical Property
logP
4.1323
Rotatable Bonds
6
Heavy Atom Count
27
Polar Areas
58.2
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 67495617
ChEMBL ID
CHEMBL3728604
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00605, FML2_HUMAN
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 > 14505 nM
   TI
   LI
   LO
   TS
Protein ID: PT02590, N-formyl peptide receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 315 nM
   TI
   LI
   LO
   TS