General Information of the Compound
Compound ID
CP0877377
Compound Name
(5R*)-N5-(5-Bromo-thiazol-2-yl)-(6R*)-N6-(4-(aminomethyl)phenyl-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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Structure
Formula
C22H23BrN4O2S
Molecular Weight
487.423
Canonical SMILES
NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3C=C[C@H]2C32CC2)cc1
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InChI
InChI=1S/C22H23BrN4O2S/c23-16-11-26-21(30-16)27-20(29)18-15-6-5-14(22(15)7-8-22)17(18)19(28)25-10-13-3-1-12(9-24)2-4-13/h1-6,11,14-15,17-18H,7-10,24H2,(H,25,28)(H,26,27,29)/t14-,15+,17-,18-/m1/s1
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InChIKey
XXXBXIFUDNKDGR-CYGHRXIMSA-N
Physicochemical Property
logP
3.4476
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
97.11
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 87422278
ChEMBL ID
CHEMBL3729184
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00605, FML2_HUMAN
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 1340 nM
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Protein ID: PT02590, N-formyl peptide receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 45 nM
   TI
   LI
   LO
   TS