| Compound ID |
Compound Name |
Compound Formula |
|
CP0069320
|
2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C23H26F2N6O
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0280018
|
2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)azetidin-3-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C21H22F2N6O
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0310455
|
2-[[6-cyclopropyl-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C22H25N5O
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0557875
|
2-[[6-cyclobutyloxy-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C23H27N5O2
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0090025
|
1-[4-[2-(3,3-difluoropyrrolidin-1-yl)-6-[[4-(trifluoromethyl)pyridin-2-yl]amino]pyridin-4-yl]piperidin-1-yl]ethanone
Show/Hide
|
C22H24F5N5O
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0069314
|
2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-(oxan-4-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C20H21F2N5O
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0334594
|
2-[[4-(4-cyanooxan-4-yl)-6-(3,3-difluoropyrrolidin-1-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C21H20F2N6O
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0477226
|
CHEMBL4128619
Show/Hide
|
C21H26F3N5O
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
|
CP0090028
|
6-piperidin-3-yl-2-pyrrolidin-1-yl-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine
Show/Hide
|
C19H23F3N6
|
1
|
| 1 |
IC50 = 109 nM
|
|
|
|
CP0338914
|
2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C18H19F2N5O
|
1
|
| 1 |
IC50 = 125 nM
|
|
|
|
CP0016719
|
5-[5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethoxy)pyridin-2-amine
Show/Hide
|
C20H24F3N5O2
|
2
|
| 1 |
IC50 = 129 nM
|
|
|
| 2 |
IC50 = 195 nM
|
|
|
|
CP0338913
|
2-[[6-(azetidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C22H26N6O
|
1
|
| 1 |
IC50 = 141 nM
|
|
|
|
CP0023938
|
CHEMBL3715238
Show/Hide
|
C21H24F3N5O
|
1
|
| 1 |
IC50 = 144 nM
|
|
|
|
CP0224284
|
CHEMBL3718522
Show/Hide
|
C19H19F6N5O
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0350211
|
2-[[4-(2-cyanopropan-2-yl)-6-(3,3-difluoropyrrolidin-1-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C19H18F2N6
|
1
|
| 1 |
IC50 = 193 nM
|
|
|
|
CP0478051
|
5-[1-(cyclopentylmethyl)-5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine
Show/Hide
|
C23H28F3N5O
|
1
|
| 1 |
IC50 = 202 nM
|
|
|
|
CP0389292
|
CHEMBL4128889
Show/Hide
|
C20H26F3N5O
|
1
|
| 1 |
IC50 = 208 nM
|
|
|
|
CP0122103
|
5-[1-(cyclobutylmethyl)-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine
Show/Hide
|
C22H26F3N5O
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0429458
|
2-[[6-ethyl-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C21H25N5O
|
1
|
| 1 |
IC50 = 213 nM
|
|
|
|
CP0116371
|
[3-[2-methyl-6-[[4-(trifluoromethyl)pyridin-2-yl]amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
Show/Hide
|
C23H22F3N5O
|
1
|
| 1 |
IC50 = 229 nM
|
|
|
|
CP0069301
|
2-[[6-(3-methoxyazetidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C23H28N6O2
|
1
|
| 1 |
IC50 = 233 nM
|
|
|
|
CP0133222
|
CHEMBL3717481
Show/Hide
|
C20H24F3N5O
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0538682
|
5-[5-[(1S,5R)-3-(2-methoxyethyl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine
Show/Hide
|
C20H26F3N5O
|
1
|
| 1 |
IC50 = 265 nM
|
|
|
|
CP0396483
|
5-[5-[(1S,5R)-3-(oxetan-3-ylmethyl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine
Show/Hide
|
C21H26F3N5O
|
1
|
| 1 |
IC50 = 274 nM
|
|
|
|
CP0069316
|
1-[4-[2-(3,3-difluoropyrrolidin-1-yl)-6-[[4-(trifluoromethyl)pyridin-2-yl]amino]pyrimidin-4-yl]piperidin-1-yl]ethanone
Show/Hide
|
C21H23F5N6O
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0122104
|
CHEMBL3718265
Show/Hide
|
C19H22F3N5O
|
1
|
| 1 |
IC50 = 302 nM
|
|
|
|
CP0261263
|
3-methyl-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C22H29N5O
|
1
|
| 1 |
IC50 = 303 nM
|
|
|
|
CP0477225
|
CHEMBL4125721
Show/Hide
|
C21H24F3N5O2
|
1
|
| 1 |
IC50 = 304 nM
|
|
|
|
CP0074414
|
CHEMBL3714987
Show/Hide
|
C20H25F2N5O2
|
1
|
| 1 |
IC50 = 328 nM
|
|
|
|
CP0552526
|
5-[1-ethyl-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine
Show/Hide
|
C19H22F3N5O
|
1
|
| 1 |
IC50 = 406 nM
|
|
|
|
CP0116367
|
2-(3,3-difluoropyrrolidin-1-yl)-6-piperidin-3-yl-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine
Show/Hide
|
C19H21F5N6
|
1
|
| 1 |
IC50 = 408 nM
|
|
|
|
CP0090027
|
2-(3,3-difluoropyrrolidin-1-yl)-6-piperidin-4-yl-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine
Show/Hide
|
C19H21F5N6
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0387150
|
2-(3,3-difluoropyrrolidin-1-yl)-6-(oxan-4-yl)-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine
Show/Hide
|
C19H20F5N5O
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0345784
|
2-[[1-cyclopentyl-5-[1-(oxetan-3-yl)azetidin-3-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C20H24N6O
|
1
|
| 1 |
IC50 = 459 nM
|
|
|
|
CP0390422
|
5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C22H26F3N5O
|
1
|
| 1 |
IC50 = 485 nM
|
|
|
|
CP0310487
|
[3-[6-[(4-cyclopropylpyridin-2-yl)amino]-2-methylpyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
Show/Hide
|
C25H27N5O
|
1
|
| 1 |
IC50 = 486 nM
|
|
|
|
CP0024698
|
2-[[1-cyclopentyl-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C22H28N6O
|
1
|
| 1 |
IC50 = 536 nM
|
|
|
|
CP0552789
|
3-chloro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C21H26ClN5O
|
1
|
| 1 |
IC50 = 574 nM
|
|
|
|
CP0116207
|
CHEMBL3717769
Show/Hide
|
C19H22F5N5
|
1
|
| 1 |
IC50 = 611 nM
|
|
|
|
CP0252750
|
2-[[1-cyclopentyl-5-[1-(oxetan-3-yl)pyrrolidin-3-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C21H26N6O
|
1
|
| 1 |
IC50 = 632 nM
|
|
|
|
CP0398650
|
[3-[2-methyl-6-[(5-methyl-1,3-thiazol-2-yl)amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
Show/Hide
|
C21H23N5OS
|
1
|
| 1 |
IC50 = 641 nM
|
|
|
|
CP0313241
|
2-[[1-cyclopentyl-5-(oxolan-3-yl)pyrazol-3-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C18H21N5O
|
1
|
| 1 |
IC50 = 698 nM
|
|
|
|
CP0345783
|
2-[[1-(3,3-difluorocyclopentyl)-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C22H26F2N6O
|
1
|
| 1 |
IC50 = 721 nM
|
|
|
|
CP0069318
|
[3-[2-methyl-6-[(4-methylpyridin-2-yl)amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
Show/Hide
|
C23H25N5O
|
1
|
| 1 |
IC50 = 767 nM
|
|
|
|
CP0456375
|
CHEMBL4127238
Show/Hide
|
C21H26F3N5O2
|
1
|
| 1 |
IC50 = 829 nM
|
|
|
|
CP0555734
|
CHEMBL3715469
Show/Hide
|
C20H27N5O2
|
1
|
| 1 |
IC50 = 873 nM
|
|
|
|
CP0116369
|
2-[[6-(1-benzoylpiperidin-3-yl)-2-methylpyrimidin-4-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C23H22N6O
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0557876
|
[3-[6-[(4-methoxypyridin-2-yl)amino]-2-methylpyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
Show/Hide
|
C23H25N5O2
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0210720
|
CHEMBL3717627
Show/Hide
|
C20H25F2N5O
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0429459
|
[3-[2-methyl-6-[(4-propan-2-ylpyridin-2-yl)amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
Show/Hide
|
C25H29N5O
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0538684
|
CHEMBL4127922
Show/Hide
|
C18H20F3N5O2
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0206891
|
2-[[1-(cyclobutylmethyl)-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C22H28N6O
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0089908
|
2-[[6-methyl-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C20H23N5O
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0088423
|
3-chloro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]pyridin-2-amine
Show/Hide
|
C19H26ClN5O
|
1
|
| 1 |
IC50 = 1700 nM
|
|
|
|
CP0550383
|
CHEMBL4126530
Show/Hide
|
C18H20F3N5O
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0088424
|
5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine
Show/Hide
|
C20H26F3N5O
|
1
|
| 1 |
IC50 = 1900 nM
|
|
|
|
CP0332421
|
3-fluoro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C21H26FN5O
|
1
|
| 1 |
IC50 = 2800 nM
|
|
|
|
CP0318746
|
2-[[4-cyclopropyl-5-[1-(oxetan-3-yl)piperidin-4-yl]-1,3-thiazol-2-yl]amino]pyridine-4-carbonitrile
Show/Hide
|
C20H23N5OS
|
1
|
| 1 |
IC50 = 8600 nM
|
|
|
