Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide

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PubChem ID

CID: 91649

SID: 14898038

Canonical SMILES	CC(C)(O)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O Show/Hide
Compound Formula	C11H11F3N2O4

Compound Structure

Protein Name

Protein Info

Androgen receptor

Protein Classification

Transcription factor

Nuclear receptor

Nuclear hormone receptor subfamily 3

Nuclear hormone receptor subfamily 3 group C

Nuclear hormone receptor subfamily 3 group C member 4

Uniprot ID

P10275

Gene Name

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000237	22Rv1 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 230 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	IC50 = 200 nM	TI LI LO TS
CL000109	COS-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	3
1	IC50 = 223.87 nM	TI LI LO TS
2	Ki = 27 nM	TI LI LO TS
3	Ki = 34 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	IC50 = 25 nM	TI LI LO TS
CL000044	CV-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	2
1	IC50 = 15 nM	TI LI LO TS
2	IC50 = 43 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 300 nM	TI LI LO TS
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 31 nM	TI LI LO TS
CL000141	LNCaP Cell Line Info	Homo sapiens (Human)	2
1	Ki = 2 nM	TI LI LO TS
2	Ki = 3 nM	TI LI LO TS
CL000284	MDA-MB-453 Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 26 nM	TI LI LO TS
2	Ki = 43 nM	TI LI LO TS
CL000370	SC-3 Cell Line Info	Mus musculus (Mouse)	1
1	IC50 = 350 nM	TI LI LO TS

Biochemical Assays

1	Ki = 430 nM