Protein Information

General Information of the Protein

Protein ID	PT05529
Protein Name	Transient receptor potential cation channel subfamily M member 8
Secondarily Protein Name	Cold menthol receptor 1
Gene Name	TRPM8
Secondarily Gene Name	Cmr1
Sequence	MSFEGARLSMRSRRNGTLGSTRTLYSSVSRSTDVSYSESDLVNFIQANFKKRECVFFTRDSKAMESICKCGYAQSQHIEGTQINQNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYLRLSCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLIRNCDDEGHFSAQYIMDDFMRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSKIPCVVVEGSGQIADVIASLVEVEDVLTSSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEILESPHLLTVIKMEEAGDEVVSSAISYALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRSFWKEDRSSREDLDVELHDASLTTRHPLQALFIWAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGLVSFRKKPIDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPELILYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEYNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAYFYMVVKKCFKCCCKEKNTESSACCFRNEDNETLAWEGVMKENYLVKINTKANDNAEEMRHRFRQLDTKLNDLKGLLKEIANKIK Show/Hide
Organism	Rattus norvegicus, Rat
Protein Classification	Ion channel > Voltage-gated ion channel > Transient receptor potential channel
Function	Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Show/Hide
Uniprot ID	Q8R455
Subcellular Location	Cell membrane Membrane raft

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0389427 Compound Info	N-[(S)-(3-fluoropyridin-2-yl)-[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-6-oxo-1H-pyridine-3-carboxamide Show/Hide	C19H12F5N3O2	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0389434 Compound Info	6-oxo-N-[(S)-[4-(trifluoromethyl)phenyl]-[3-(trifluoromethyl)pyridin-2-yl]methyl]-1H-pyridine-3-carboxamide Show/Hide	C20H13F6N3O2	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0476724 Compound Info	N-[(S)-(3-fluoropyridin-2-yl)-[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]-6-oxo-1H-pyridine-3-carboxamide Show/Hide	C19H12F5N3O3	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0466273 Compound Info	6-[[(S)-[4-(trifluoromethyl)phenyl]-[3-(trifluoromethyl)pyridin-2-yl]methyl]carbamoyl]pyridine-3-carboxylic acid Show/Hide	C21H13F6N3O3	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0116421 Compound Info	(1R)-1-[3-fluoro-4-(trifluoromethyl)phenyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C20H17F7N2O	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0219345 Compound Info	6-[[(S)-(3-fluoropyridin-2-yl)-[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]carbamoyl]pyridine-3-carboxylic acid Show/Hide	C20H12F5N3O4	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0389429 Compound Info	N-[(S)-(3-fluoropyridin-2-yl)-[4-(trifluoromethyl)phenyl]methyl]-6-oxo-1H-pyridine-3-carboxamide Show/Hide	C19H13F4N3O2	1
1	IC50 = 21 nM Bioactivity Info	TI LI LO TS
CP0389437 Compound Info	4-hydroxy-N-[(S)-[4-(trifluoromethyl)phenyl]-[3-(trifluoromethyl)pyridin-2-yl]methyl]benzamide Show/Hide	C21H14F6N2O2	1
1	IC50 = 21 nM Bioactivity Info	TI LI LO TS
CP0059507 Compound Info	(1R)-N-pyridin-3-yl-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C22H18F3N3O	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0059010 Compound Info	(8R)-8-[3-fluoro-4-(trifluoromethyl)phenyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-1,7-naphthyridine-7-carboxamide Show/Hide	C19H16F7N3O	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0499256 Compound Info	(1R)-1-[4-(trifluoromethyl)phenyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C20H18F6N2O	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0446361 Compound Info	4-[[(S)-(3-fluoropyridin-2-yl)-[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]carbamoyl]benzoic acid Show/Hide	C21H13F5N2O4	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0389426 Compound Info	N-[(S)-[4-(trifluoromethyl)phenyl]-[3-(trifluoromethyl)pyridin-2-yl]methyl]quinoline-7-carboxamide Show/Hide	C24H15F6N3O	1
1	IC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0244900 Compound Info	(8R)-N-(4-fluorophenyl)-8-[4-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-7-carboxamide Show/Hide	C22H17F4N3O	1
1	IC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0369137 Compound Info	(1R)-N-tert-butyl-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C21H23F3N2O	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0566623 Compound Info	(1R)-N-propan-2-yl-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C20H21F3N2O	1
1	IC50 = 47 nM Bioactivity Info	TI LI LO TS
CP0554053 Compound Info	(8R)-N-pyridin-3-yl-8-[4-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-7-carboxamide Show/Hide	C21H17F3N4O	1
1	IC50 = 48 nM Bioactivity Info	TI LI LO TS
CP0416503 Compound Info	N-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C23H18F4N2O	1
1	IC50 = 53 nM Bioactivity Info	TI LI LO TS
CP0059508 Compound Info	(1R)-N-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C23H18F4N2O	2
1	IC50 = 56 nM Bioactivity Info	TI LI LO TS
2	IC50 = 57 nM Bioactivity Info	TI LI LO TS
CP0316452 Compound Info	(1R)-N-pyridin-2-yl-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C22H18F3N3O	1
1	IC50 = 81 nM Bioactivity Info	TI LI LO TS
CP0548884 Compound Info	N-(4-fluorophenyl)-4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-[1,3]thiazolo[4,5-c]pyridine-5-carboxamide Show/Hide	C20H15F4N3OS	1
1	IC50 = 93 nM Bioactivity Info	TI LI LO TS
CP0489826 Compound Info	5-fluoro-N-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C23H17F5N2O	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0316453 Compound Info	(1R)-N-(2-cyanophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C24H18F3N3O	1
1	IC50 = 104 nM Bioactivity Info	TI LI LO TS
CP0244901 Compound Info	(8R)-8-[4-(trifluoromethyl)phenyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-1,7-naphthyridine-7-carboxamide Show/Hide	C19H17F6N3O	1
1	IC50 = 115 nM Bioactivity Info	TI LI LO TS
CP0059509 Compound Info	(8R)-N-(4-cyanophenyl)-8-[4-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-7-carboxamide Show/Hide	C23H17F3N4O	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0059510 Compound Info	(1S)-1-[6-(trifluoromethyl)pyridin-3-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C19H17F6N3O	1
1	IC50 = 127 nM Bioactivity Info	TI LI LO TS
CP0433049 Compound Info	4-(2-chlorophenyl)-N-phenyl-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C20H17ClN2OS	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0340884 Compound Info	(1R)-1-[4-(trifluoromethyl)phenyl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C20H18F6N2O	1
1	IC50 = 146 nM Bioactivity Info	TI LI LO TS
CP0550359 Compound Info	N-(4-fluorophenyl)-7-[4-(trifluoromethyl)phenyl]-5,7-dihydro-4H-thieno[2,3-c]pyridine-6-carboxamide Show/Hide	C21H16F4N2OS	1
1	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0116419 Compound Info	(1R)-N-(4-cyanophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C24H18F3N3O	1
1	IC50 = 154 nM Bioactivity Info	TI LI LO TS
CP0480972 Compound Info	(1R)-1-[4-(trifluoromethyl)phenyl]-N-(2,2,2-trifluoro-1-phenylethyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C25H20F6N2O	1
1	IC50 = 168 nM Bioactivity Info	TI LI LO TS
CP0524807 Compound Info	N-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carboxamide Show/Hide	C21H17F4N3O	1
1	IC50 = 180 nM Bioactivity Info	TI LI LO TS
CP0433052 Compound Info	7-fluoro-N-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C23H17F5N2O	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0094938 Compound Info	(1R)-N-(3-cyanophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C24H18F3N3O	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0369785 Compound Info	(1R)-N-(2-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C23H18F4N2O	1
1	IC50 = 197 nM Bioactivity Info	TI LI LO TS
CP0454757 Compound Info	N-(4-fluorophenyl)-7-[4-(trifluoromethyl)phenyl]-5,7-dihydro-4H-furo[2,3-c]pyridine-6-carboxamide Show/Hide	C21H16F4N2O2	1
1	IC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0436435 Compound Info	N-phenyl-4-[2-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C21H17F3N2OS	1
1	IC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0385344 Compound Info	N-(4-fluorophenyl)-1-methyl-4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-imidazo[4,5-c]pyridine-5-carboxamide Show/Hide	C21H18F4N4O	1
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
CP0450500 Compound Info	N-(4-fluorophenyl)-4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-furo[3,2-c]pyridine-5-carboxamide Show/Hide	C21H16F4N2O2	1
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
CP0436460 Compound Info	N-phenyl-4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C21H17F3N2OS	1
1	IC50 = 290 nM Bioactivity Info	TI LI LO TS
CP0454754 Compound Info	N-phenyl-4-propyl-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C17H20N2OS	1
1	IC50 = 293 nM Bioactivity Info	TI LI LO TS
CP0525001 Compound Info	6-fluoro-N-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C23H17F5N2O	1
1	IC50 = 302 nM Bioactivity Info	TI LI LO TS
CP0382666 Compound Info	(1R)-N-pyridin-4-yl-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C22H18F3N3O	1
1	IC50 = 306 nM Bioactivity Info	TI LI LO TS
CP0436466 Compound Info	N-(4-fluorophenyl)-4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C21H16F4N2OS	1
1	IC50 = 340 nM Bioactivity Info	TI LI LO TS
CP0522489 Compound Info	N-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-1,3-dihydroisoindole-2-carboxamide Show/Hide	C22H16F4N2O	1
1	IC50 = 340 nM Bioactivity Info	TI LI LO TS
CP0369140 Compound Info	(5R)-N-(4-fluorophenyl)-5-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-pyrido[3,4-b]pyrazine-6-carboxamide Show/Hide	C21H16F4N4O	1
1	IC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0436436 Compound Info	(2-fluorophenyl)-[4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]methanone Show/Hide	C21H15F4NOS	1
1	IC50 = 510 nM Bioactivity Info	TI LI LO TS
CP0094939 Compound Info	(5R)-N-(4-fluorophenyl)-5-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-1,6-naphthyridine-6-carboxamide Show/Hide	C22H17F4N3O	1
1	IC50 = 534 nM Bioactivity Info	TI LI LO TS
CP0340885 Compound Info	4,4-difluoro-N-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-1,3-dihydroisoquinoline-2-carboxamide Show/Hide	C23H16F6N2O	1
1	IC50 = 548 nM Bioactivity Info	TI LI LO TS
CP0524190 Compound Info	N-propan-2-yl-4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C18H19F3N2OS	1
1	IC50 = 550 nM Bioactivity Info	TI LI LO TS
CP0433050 Compound Info	4-(4-chlorophenyl)-N-phenyl-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C20H17ClN2OS	1
1	IC50 = 560 nM Bioactivity Info	TI LI LO TS
CP0369139 Compound Info	N-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-2,7-naphthyridine-2-carboxamide Show/Hide	C22H17F4N3O	1
1	IC50 = 574 nM Bioactivity Info	TI LI LO TS
CP0491579 Compound Info	N-(2-fluorophenyl)-4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C21H16F4N2OS	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0495384 Compound Info	N-(3-fluorophenyl)-4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C21H16F4N2OS	1
1	IC50 = 780 nM Bioactivity Info	TI LI LO TS
CP0542350 Compound Info	8-fluoro-N-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C23H17F5N2O	1
1	IC50 = 790 nM Bioactivity Info	TI LI LO TS
CP0542349 Compound Info	2-(4-fluorophenyl)-1-[4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone Show/Hide	C22H17F4NOS	1
1	IC50 = 890 nM Bioactivity Info	TI LI LO TS
CP0524094 Compound Info	N-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-2,6-naphthyridine-2-carboxamide Show/Hide	C22H17F4N3O	1
1	IC50 = 1157 nM Bioactivity Info	TI LI LO TS
CP0566624 Compound Info	N-(4-fluorophenyl)-8-[4-(trifluoromethyl)phenyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide Show/Hide	C21H16F4N4O	1
1	IC50 = 1168 nM Bioactivity Info	TI LI LO TS
CP0436464 Compound Info	N-cyclopropyl-4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C18H17F3N2OS	1
1	IC50 = 1210 nM Bioactivity Info	TI LI LO TS
CP0450499 Compound Info	2-methyl-1-[4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]propan-1-one Show/Hide	C18H18F3NOS	1
1	IC50 = 1260 nM Bioactivity Info	TI LI LO TS
CP0494879 Compound Info	4-(3-fluorophenyl)-N-phenyl-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C20H17FN2OS	1
1	IC50 = 1320 nM Bioactivity Info	TI LI LO TS
CP0436434 Compound Info	N-(4-chlorophenyl)-4-propyl-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C17H19ClN2OS	1
1	IC50 = 1390 nM Bioactivity Info	TI LI LO TS
CP0436467 Compound Info	N-(4-fluorophenyl)-4-[4-(trifluoromethyl)phenyl]-1,4,6,7-tetrahydroimidazo[4,5-c]pyridine-5-carboxamide Show/Hide	C20H16F4N4O	1
1	IC50 = 1430 nM Bioactivity Info	TI LI LO TS
CP0491578 Compound Info	N-(4-chlorophenyl)-4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C21H16ClF3N2OS	1
1	IC50 = 1630 nM Bioactivity Info	TI LI LO TS
CP0548883 Compound Info	N,4-diphenyl-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C20H18N2OS	1
1	IC50 = 1690 nM Bioactivity Info	TI LI LO TS
CP0433048 Compound Info	N-phenyl-4-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C21H17F3N2OS	1
1	IC50 = 1830 nM Bioactivity Info	TI LI LO TS
CP0433051 Compound Info	4-(4-fluorophenyl)-N-phenyl-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C20H17FN2OS	1
1	IC50 = 1840 nM Bioactivity Info	TI LI LO TS
CP0308480 Compound Info	4-[[(1R)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]amino]benzoic acid Show/Hide	C24H19F3N2O3	1
1	IC50 = 2053 nM Bioactivity Info	TI LI LO TS
CP0550358 Compound Info	4-(2-fluorophenyl)-N-phenyl-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C20H17FN2OS	1
1	IC50 = 2270 nM Bioactivity Info	TI LI LO TS
CP0522488 Compound Info	N-(4-methoxyphenyl)-4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C22H19F3N2O2S	1
1	IC50 = 2320 nM Bioactivity Info	TI LI LO TS
CP0495385 Compound Info	N-(4-fluorophenyl)-2-[4-(trifluoromethyl)phenyl]piperidine-1-carboxamide Show/Hide	C19H18F4N2O	1
1	IC50 = 2664 nM Bioactivity Info	TI LI LO TS
CP0494878 Compound Info	4-(3-chlorophenyl)-N-phenyl-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C20H17ClN2OS	1
1	IC50 = 2890 nM Bioactivity Info	TI LI LO TS
CP0549435 Compound Info	4-cyclopropyl-N-phenyl-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C17H18N2OS	1
1	IC50 = 5570 nM Bioactivity Info	TI LI LO TS
CP0454755 Compound Info	4-methyl-N-phenyl-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C15H16N2OS	1
1	IC50 = 6800 nM Bioactivity Info	TI LI LO TS
CP0296792 Compound Info	4-[4-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Show/Hide	C14H12F3NS	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0436463 Compound Info	(3-fluorophenyl)-[4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]methanone Show/Hide	C21H15F4NOS	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0436465 Compound Info	morpholin-4-yl-[4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]methanone Show/Hide	C19H19F3N2O2S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0454756 Compound Info	(4-fluorophenyl)-[4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]methanone Show/Hide	C21H15F4NOS	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0522468 Compound Info	5-benzyl-4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine Show/Hide	C21H18F3NS	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0542347 Compound Info	N-phenyl-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxamide Show/Hide	C14H14N2OS	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0542348 Compound Info	5-propan-2-yl-4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine Show/Hide	C17H18F3NS	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0542351 Compound Info	(1S)-N-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C23H18F4N2O	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0548885 Compound Info	N-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-1,3,4,5-tetrahydro-2-benzazepine-2-carboxamide Show/Hide	C24H20F4N2O	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0549436 Compound Info	5-(2-methylpropyl)-4-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine Show/Hide	C18H20F3NS	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0369138 Compound Info	N-(4-fluorophenyl)-1-methyl-1-[4-(trifluoromethyl)phenyl]-3,4-dihydroisoquinoline-2-carboxamide Show/Hide	C24H20F4N2O	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT00608	Transient receptor potential M8 protein	Canis lupus familiaris, Dog, Canis familiaris	Protein Info
PT03065	Transient receptor potential cation channel subfamily M member 8	Homo sapiens, Human	Protein Info
PT06117	Transient receptor potential cation channel subfamily M member 8	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han