General Information of the Protein
Protein ID
PT02769
Protein Name
Retinoic acid receptor RXR-gamma
Secondarily
Protein Name
Nuclear receptor subfamily 2 group B member 3
Retinoid X receptor gamma
Gene Name
RXRG
Secondarily
Gene Name
NR2B3
Sequence
MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
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Organism
Homo sapiens, Human
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 2
>
Nuclear hormone receptor subfamily 2 group B
>
Nuclear hormone receptor subfamily 2 group B member 3
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
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Uniprot ID
Primary ID:
P48443

Secondarily ID:
A6NIP1
Q6IBU7
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Ensembl ID
ENSG00000143171
HGNC ID
HGNC:10479
Subcellular Location
Nucleus
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000044 , CV-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0056087
 Compound Info 
4-[[(E)-Methoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C24H29NO3
  1
1
EC50 = 4 nM
 Bioactivity Info 
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CP0112883
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
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C24H32O2
  1
1
EC50 = 7 nM
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CP0056124
 Compound Info 
4-[[(E)-Allyloxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C26H31NO3
  1
1
EC50 = 7 nM
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CP0724066
 Compound Info 
4-[[(E)-Hydroxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C23H27NO3
  1
1
EC50 = 7 nM
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CP0237364
 Compound Info 
4-[[(E)-Ethoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C25H31NO3
  1
1
EC50 = 9 nM
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CP0076349
 Compound Info 
4-[[(E)-Cyanomethoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C25H28N2O3
  1
1
EC50 = 11 nM
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CP0155052
 Compound Info 
(2E,4E)-6-((6-tert-butyl-1,1-dimethyl-2,3-dihydro-1H-inden-4-yl)(propyl)amino)-3-methylhexa-2,4-dienoic acid
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C25H37NO2
  1
1
EC50 = 19 nM
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CP0004259
 Compound Info 
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
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C24H28O2
  2
1
EC50 = 20 nM
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2
EC50 = 25 nM
 Bioactivity Info 
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CP0150625
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
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C23H30O2
  1
1
EC50 = 24 nM
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CP0741143
 Compound Info 
4-{(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-[(E)-hydroxyimino]-methyl}-benzoic acid
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C22H24BrNO3
  1
1
EC50 = 26 nM
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CP0105799
 Compound Info 
4-{(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-[(E)-propoxyimino]-methyl}-benzoic acid
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C26H33NO3
  1
1
EC50 = 28 nM
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CP0735262
 Compound Info 
4-[[(E)-Hydroxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C23H27NO3
  1
1
EC50 = 34 nM
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CP0057814
 Compound Info 
(2E,4E)-6-((3,5-di-tert-butylphenyl)(octyl)amino)-3-methylhexa-2,4-dienoic acid
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C29H47NO2
  1
1
EC50 = 35 nM
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CP0171792
 Compound Info 
(2E,4E)-6-(butyl(6-tert-butyl-1,1-dimethyl-2,3-dihydro-1H-inden-4-yl)amino)-3-methylhexa-2,4-dienoic acid
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C26H39NO2
  1
1
EC50 = 50 nM
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CP0155054
 Compound Info 
(2E,4E)-6-((3,5-di-tert-butylphenyl)(propyl)amino)-3-methylhexa-2,4-dienoic acid
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C24H37NO2
  1
1
EC50 = 63 nM
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CP0134367
 Compound Info 
(E)-3-Methyl-5-[2-methyl-2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
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C25H34O2
  1
1
EC50 = 71 nM
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CP0206847
 Compound Info 
4-[[(E)-Butoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C27H35NO3
  1
1
EC50 = 99 nM
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CP0109708
 Compound Info 
(2E,4E)-6-((6-tert-butyl-1,1-dimethyl-2,3-dihydro-1H-inden-4-yl)(cyclopropylmethyl)amino)-3-methylhexa-2,4-dienoic acid
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C26H37NO2
  1
1
EC50 = 100 nM
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CP0100614
 Compound Info 
4-[[(E)-Isobutoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C27H35NO3
  1
1
EC50 = 124 nM
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CP0109707
 Compound Info 
(2E,4E)-6-(ethyl(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino)-3-methylhexa-2,4-dienoic acid
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C24H35NO2
  1
1
EC50 = 125 nM
 Bioactivity Info 
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CP0109711
 Compound Info 
(2E,4E)-6-(ethyl(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino)-3-methylhexa-2,4-dienoic acid
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C23H33NO2
  1
1
EC50 = 128 nM
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CP0042977
 Compound Info 
9-cis retinoic acid
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C20H28O2
  1
1
EC50 = 140 nM
 Bioactivity Info 
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CP0342154
 Compound Info 
(S,2E,4E)-3-methyl-5-(1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyrrolidin-2-yl)penta-2,4-dienoic acid
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C24H33NO2
  1
1
EC50 = 147 nM
 Bioactivity Info 
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CP0179370
 Compound Info 
(2E,4E)-3-methyl-6-(propyl(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino)hexa-2,4-dienoic acid
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C24H35NO2
  1
1
EC50 = 170 nM
 Bioactivity Info 
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CP0144899
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C25H34O2
  1
1
EC50 = 192 nM
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CP0279556
 Compound Info 
4-[[(Z)-Methoxyimino]-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C23H27NO3
  1
1
EC50 = 206 nM
 Bioactivity Info 
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CP0057821
 Compound Info 
(2E,4E)-3-methyl-6-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)(propyl)amino)hexa-2,4-dienoic acid
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C25H37NO2
  1
1
EC50 = 223 nM
 Bioactivity Info 
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CP0109709
 Compound Info 
(2E,4E)-6-((3,5-di-tert-butylphenyl)(ethyl)amino)-3-methylhexa-2,4-dienoic acid
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C23H35NO2
  1
1
EC50 = 231 nM
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CP0092667
 Compound Info 
4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C23H26O3
  1
1
EC50 = 246 nM
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CP0043085
 Compound Info 
4-[(Z)-N-methoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid
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C24H29NO3
  1
1
EC50 = 254 nM
 Bioactivity Info 
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CP0109704
 Compound Info 
(2E,4E)-6-((6-tert-butyl-1,1-dimethyl-2,3-dihydro-1H-inden-4-yl)(isopropyl)amino)-3-methylhexa-2,4-dienoic acid
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C25H37NO2
  1
1
EC50 = 262 nM
 Bioactivity Info 
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CP0296657
 Compound Info 
4-[[(E)-2-Amino-ethoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C25H32N2O3
  1
1
EC50 = 306 nM
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CP0192954
 Compound Info 
(2E,4E)-6-((3,5-di-tert-butylphenyl)(methyl)amino)-3-methylhexa-2,4-dienoic acid
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C22H33NO2
  1
1
EC50 = 322 nM
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CP0047977
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H26O2
  1
1
EC50 = 404 nM
 Bioactivity Info 
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CP0211362
 Compound Info 
(2E,4E)-6-((3,5-di-tert-butylphenyl)(propyl)amino)-3-methyl-6-oxohexa-2,4-dienoic acid
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C24H35NO3
  1
1
EC50 = 669 nM
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CP0040160
 Compound Info 
9-cis-retinoic acid (9cRA)
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C20H28O2
  1
1
EC50 = 1100 nM
 Bioactivity Info 
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CP0347818
 Compound Info 
(R,2E,4E)-3-methyl-5-(1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyrrolidin-2-yl)penta-2,4-dienoic acid
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C24H33NO2
  1
1
EC50 = 1263 nM
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CP0100616
 Compound Info 
4-[[(E)-Carboxymethoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C25H29NO5
  1
1
EC50 = 1379 nM
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CP0073370
 Compound Info 
4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
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C25H30O2
  1
1
EC50 = 1500 nM
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CP0061828
 Compound Info 
4-[(E)-2-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
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C26H32O2
  1
1
EC50 = 2600 nM
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CP0148476
 Compound Info 
4-[(E)-2-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
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C27H34O2
  1
1
EC50 = 2700 nM
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CP0092680
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H36O2
  1
1
EC50 = 2714 nM
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CP0709525
 Compound Info 
4-[[(E)-Hydroxyimino]-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C22H25NO3
  1
1
EC50 = 2894 nM
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CP0041093
 Compound Info 
(E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-enyl)benzoic acid
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C24H28O2
  1
1
EC50 > 10000 nM
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CP0164065
 Compound Info 
4-[(Z)-N-ethoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid
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C25H31NO3
  1
1
EC50 > 100000 nM
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CP0216000
 Compound Info 
4-[(Z)-N-[(2-methylpropan-2-yl)oxy]-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid
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C27H35NO3
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0231108
 Compound Info 
4-[[(E)-tert-Butoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C27H35NO3
  1
1
EC50 > 100000 nM
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CP0215028
 Compound Info 
(2Z,4E)-3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
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C24H32O2
  1
1
EC50 > 1000 nM
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CP0280492
 Compound Info 
(2Z,4E)-3-methyl-5-[2-methyl-2-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
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C25H34O2
  1
1
EC50 > 1000 nM
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CP0384182
 Compound Info 
(2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-3',5'-difluoro-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
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C26H26F4O3
  1
1
Ki = 2.8 nM
 Bioactivity Info 
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CP0377687
 Compound Info 
(2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-3'-fluoro-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
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C26H27F3O3
  1
1
Ki = 2.9 nM
 Bioactivity Info 
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CP0377464
 Compound Info 
(2E,4E,6Z)-7-[2-(2,2-Difluoro-ethoxy)-3-isopropyl-5-thiophen-2-yl-phenyl]-3-methyl-octa-2,4,6-trienoic acid
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C24H26F2O3S
  1
1
Ki = 5.6 nM
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CP0448038
 Compound Info 
(2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-4'-fluoro-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
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C26H27F3O3
  1
1
Ki = 5.6 nM
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CP0394545
 Compound Info 
(2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroethyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid
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C22H25F5O3
  1
1
Ki = 7.7 nM
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CP0420322
 Compound Info 
(2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-2'-fluoro-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
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C26H27F3O3
  1
1
Ki = 10.9 nM
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CP0044243
 Compound Info 
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID
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C24H29NO2
  1
1
Ki = 12 nM
 Bioactivity Info 
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CP0397600
 Compound Info 
(2E,4E,6E)-7-[3,5-Di-tert-butyl-2-(2,2,2-trifluoro-ethoxy)-phenyl]-6-fluoro-3-methyl-octa-2,4,6-trienoic acid
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C25H32F4O3
  1
1
Ki = 12.4 nM
 Bioactivity Info 
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CP0004953
 Compound Info 
(2E,4E,6E)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-6-fluoro-3-methyl-octa-2,4,6-trienoic acid
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C25H33F3O3
  1
1
Ki = 13.2 nM
 Bioactivity Info 
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CP0406456
 Compound Info 
(2E,4E,6Z)-7-[2-(2,2-Difluoro-ethoxy)-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C26H28F2O3
  1
1
Ki = 22.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397602
 Compound Info 
(2E,4E,6Z)-7-(5-Isopropyl-3-pentafluoroethyl-2-propoxy-phenyl)-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C23H27F5O3
  1
1
Ki = 23.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0465377
 Compound Info 
(2E,4E,6Z)-7-(3-Isopropyl-5-pentafluoroethyl-2-propoxy-phenyl)-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C23H27F5O3
  1
1
Ki = 27.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0395224
 Compound Info 
(2E,4E,6E)-7-(2-Butoxy-3,5-diisopropyl-phenyl)-6-fluoro-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C25H35FO3
  1
1
Ki = 27.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0401559
 Compound Info 
(2E,4E,6E)-7-[2-(2,2-Difluoro-ethoxy)-3,5-bis-(1,1-dimethyl-propyl)-phenyl]-6-fluoro-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C27H37F3O3
  1
1
Ki = 40.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0403927
 Compound Info 
(2E,4E,6Z)-7-(2-Butoxy-3-isopropyl-5-pentafluoroethyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C24H29F5O3
  1
1
Ki = 45.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0006755
 Compound Info 
(2E,4E,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C25H34F2O3
  1
1
Ki = 84 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000109 , COS-1
 Cell Line Info 
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0040160
 Compound Info 
9-cis-retinoic acid (9cRA)
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C20H28O2
  7
1 EC50 = 2 nM
2 EC50 = 1100 nM
3 IC50 = 350 nM
4 Kd = 306 nM
5 Kd = 350 nM
6 Ki = 1.4 nM
7 Ki = 288 nM
CP0047977
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H26O2
  2
1 EC50 = 2 nM
2 Ki = 290 nM
CP0042977
 Compound Info 
9-cis retinoic acid
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C20H28O2
  9
1 EC50 = 4.3 nM
2 EC50 = 140 nM
3 IC50 = 4 nM
4 Kd = 14 nM
5 Kd = 16 nM
6 Kd = 30 nM
7 Ki = 13 nM
8 Ki = 14 nM
9 Ki = 27 nM
CP0004259
 Compound Info 
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
   Show/Hide
C24H28O2
  5
1 EC50 = 25 nM
2 EC50 = 122 nM
3 Ki = 8.3 nM
4 Ki = 29 nM
5 Ki = 75 nM
CP0092667
 Compound Info 
4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C23H26O3
  2
1 EC50 = 1200 nM
2 Ki = 299 nM
CP0061828
 Compound Info 
4-[(E)-2-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
   Show/Hide
C26H32O2
  1
1 IC50 = 10 nM
CP0148476
 Compound Info 
4-[(E)-2-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
   Show/Hide
C27H34O2
  1
1 IC50 = 10 nM
CP0073370
 Compound Info 
4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
   Show/Hide
C25H30O2
  1
1 IC50 = 100 nM
CP0041093
 Compound Info 
(E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-enyl)benzoic acid
   Show/Hide
C24H28O2
  1
1 IC50 > 1000 nM
CP0095234
 Compound Info 
(E)-3-Methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1 Kd = 1.8 nM
CP0091289
 Compound Info 
(2E,4E)-3-Methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1 Kd = 3.8 nM
CP0134367
 Compound Info 
(E)-3-Methyl-5-[2-methyl-2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1 Kd = 42 nM
CP0103897
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2R)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1 Kd = 180 nM
CP0215028
 Compound Info 
(2Z,4E)-3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1 Kd > 1000 nM
CP0280492
 Compound Info 
(2Z,4E)-3-methyl-5-[2-methyl-2-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1 Kd > 1000 nM
CP0112883
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1 Ki = 5 nM
CP0724066
 Compound Info 
4-[[(E)-Hydroxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
   Show/Hide
C23H27NO3
  1
1 Ki = 5 nM
CP0150625
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
   Show/Hide
C23H30O2
  1
1 Ki = 6 nM
CP0056087
 Compound Info 
4-[[(E)-Methoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
   Show/Hide
C24H29NO3
  1
1 Ki = 8 nM
CP0155052
 Compound Info 
(2E,4E)-6-((6-tert-butyl-1,1-dimethyl-2,3-dihydro-1H-inden-4-yl)(propyl)amino)-3-methylhexa-2,4-dienoic acid
   Show/Hide
C25H37NO2
  1
1 Ki = 10 nM
CP0044243
 Compound Info 
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID
   Show/Hide
C24H29NO2
  1
1 Ki = 12 nM
CP0076349
 Compound Info 
4-[[(E)-Cyanomethoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
   Show/Hide
C25H28N2O3
  1
1 Ki = 14 nM
CP0171792
 Compound Info 
(2E,4E)-6-(butyl(6-tert-butyl-1,1-dimethyl-2,3-dihydro-1H-inden-4-yl)amino)-3-methylhexa-2,4-dienoic acid
   Show/Hide
C26H39NO2
  1
1 Ki = 31 nM
CP0109709
 Compound Info 
(2E,4E)-6-((3,5-di-tert-butylphenyl)(ethyl)amino)-3-methylhexa-2,4-dienoic acid
   Show/Hide
C23H35NO2
  1
1 Ki = 35 nM
CP0155054
 Compound Info 
(2E,4E)-6-((3,5-di-tert-butylphenyl)(propyl)amino)-3-methylhexa-2,4-dienoic acid
   Show/Hide
C24H37NO2
  1
1 Ki = 38 nM
CP0006755
 Compound Info 
(2E,4E,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C25H34F2O3
  1
1 Ki = 39 nM
CP0237364
 Compound Info 
4-[[(E)-Ethoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
   Show/Hide
C25H31NO3
  1
1 Ki = 42 nM
CP0105799
 Compound Info 
4-{(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-[(E)-propoxyimino]-methyl}-benzoic acid
   Show/Hide
C26H33NO3
  1
1 Ki = 57 nM
CP0741143
 Compound Info 
4-{(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-[(E)-hydroxyimino]-methyl}-benzoic acid
   Show/Hide
C22H24BrNO3
  1
1 Ki = 57 nM
CP0056124
 Compound Info 
4-[[(E)-Allyloxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
   Show/Hide
C26H31NO3
  1
1 Ki = 80 nM
CP0109707
 Compound Info 
(2E,4E)-6-(ethyl(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino)-3-methylhexa-2,4-dienoic acid
   Show/Hide
C24H35NO2
  1
1 Ki = 99 nM
CP0342154
 Compound Info 
(S,2E,4E)-3-methyl-5-(1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyrrolidin-2-yl)penta-2,4-dienoic acid
   Show/Hide
C24H33NO2
  1
1 Ki = 100 nM
CP0179370
 Compound Info 
(2E,4E)-3-methyl-6-(propyl(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino)hexa-2,4-dienoic acid
   Show/Hide
C24H35NO2
  1
1 Ki = 110 nM
CP0109704
 Compound Info 
(2E,4E)-6-((6-tert-butyl-1,1-dimethyl-2,3-dihydro-1H-inden-4-yl)(isopropyl)amino)-3-methylhexa-2,4-dienoic acid
   Show/Hide
C25H37NO2
  1
1 Ki = 121 nM
CP0192954
 Compound Info 
(2E,4E)-6-((3,5-di-tert-butylphenyl)(methyl)amino)-3-methylhexa-2,4-dienoic acid
   Show/Hide
C22H33NO2
  1
1 Ki = 131 nM
CP0109708
 Compound Info 
(2E,4E)-6-((6-tert-butyl-1,1-dimethyl-2,3-dihydro-1H-inden-4-yl)(cyclopropylmethyl)amino)-3-methylhexa-2,4-dienoic acid
   Show/Hide
C26H37NO2
  1
1 Ki = 150 nM
CP0109711
 Compound Info 
(2E,4E)-6-(ethyl(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino)-3-methylhexa-2,4-dienoic acid
   Show/Hide
C23H33NO2
  1
1 Ki = 162 nM
CP0144899
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1 Ki = 172 nM
CP0347818
 Compound Info 
(R,2E,4E)-3-methyl-5-(1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyrrolidin-2-yl)penta-2,4-dienoic acid
   Show/Hide
C24H33NO2
  1
1 Ki = 202 nM
CP0735262
 Compound Info 
4-[[(E)-Hydroxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
   Show/Hide
C23H27NO3
  1
1 Ki = 209 nM
CP0057821
 Compound Info 
(2E,4E)-3-methyl-6-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)(propyl)amino)hexa-2,4-dienoic acid
   Show/Hide
C25H37NO2
  1
1 Ki = 211 nM
CP0057814
 Compound Info 
(2E,4E)-6-((3,5-di-tert-butylphenyl)(octyl)amino)-3-methylhexa-2,4-dienoic acid
   Show/Hide
C29H47NO2
  1
1 Ki = 221 nM
CP0206847
 Compound Info 
4-[[(E)-Butoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
   Show/Hide
C27H35NO3
  1
1 Ki = 224 nM
CP0043085
 Compound Info 
4-[(Z)-N-methoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid
   Show/Hide
C24H29NO3
  1
1 Ki = 238 nM
CP0211362
 Compound Info 
(2E,4E)-6-((3,5-di-tert-butylphenyl)(propyl)amino)-3-methyl-6-oxohexa-2,4-dienoic acid
   Show/Hide
C24H35NO3
  1
1 Ki = 299 nM
CP0100614
 Compound Info 
4-[[(E)-Isobutoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
   Show/Hide
C27H35NO3
  1
1 Ki = 323 nM
CP0231108
 Compound Info 
4-[[(E)-tert-Butoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
   Show/Hide
C27H35NO3
  1
1 Ki = 445 nM
CP0164065
 Compound Info 
4-[(Z)-N-ethoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid
   Show/Hide
C25H31NO3
  1
1 Ki = 467 nM
CP0279556
 Compound Info 
4-[[(Z)-Methoxyimino]-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
   Show/Hide
C23H27NO3
  1
1 Ki = 558 nM
CP0709525
 Compound Info 
4-[[(E)-Hydroxyimino]-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
   Show/Hide
C22H25NO3
  1
1 Ki = 5051 nM
CP0092680
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
   Show/Hide
C26H36O2
  1
1 Ki > 1000 nM
CP0100616
 Compound Info 
4-[[(E)-Carboxymethoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
   Show/Hide
C25H29NO5
  1
1 Ki > 1000 nM
CP0216000
 Compound Info 
4-[(Z)-N-[(2-methylpropan-2-yl)oxy]-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid
   Show/Hide
C27H35NO3
  1
1 Ki > 1000 nM
CP0296657
 Compound Info 
4-[[(E)-2-Amino-ethoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
   Show/Hide
C25H32N2O3
  1
1 Ki > 1000 nM
Clinical Information about the Protein
Target 1 ( Retinoic acid receptor RXR-gamma (RXRG) )
Target Type Successful Target
Disease 5 Target-related Diseases  5
1 Kaposi sarcoma [ICD-11: 2B57]
2 Night blindness [ICD-11: 9D45]
3 Diabetic complication [ICD-11: 5A2Y]
4 Prostate cancer [ICD-11: 2C82.0]
5 Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Approved Drug(s) 2 Approved Drugs  2
1 Alitretinoin
 Drug Info 
Approved
Kaposi sarcoma
2 Vitamin A
 Drug Info 
Approved
Night blindness
Clinical Trial Drug(s) 2 Clinical Trial Drugs  2
1 NRX-4204
 Drug Info 
Phase 2
Diabetic complication
2 IRX4204
 Drug Info 
Phase 1
Prostate cancer
Discontinued Drug(s) 1 Discontinued Drug  1
1 SR-11237
 Drug Info 
Terminated
Solid tumour/cancer
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02226 Retinoic acid receptor RXR-gamma Mus musculus, Mouse
 Protein Info