General Information of the Protein
Protein ID
PT02226
Protein Name
Retinoic acid receptor RXR-gamma
Secondarily
Protein Name
Nuclear receptor subfamily 2 group B member 3
Retinoid X receptor gamma
Gene Name
RXRG
Secondarily
Gene Name
Nr2b3
Sequence
MYGNYSHFMKFPTGFGGSPGHTGSTSMSPSVALPTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECASSSHEDMPVERILEAELAVEPKTESYGDMNVENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDSFLMEMLETPLQIT
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Organism
Mus musculus, Mouse
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 2
>
Nuclear hormone receptor subfamily 2 group B
>
Nuclear hormone receptor subfamily 2 group B member 3
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
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Uniprot ID
P28705
Ensembl ID
ENSG00000143171
Subcellular Location
Nucleus
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000044 , CV-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0756593
 Compound Info 
3-Methyl-5-[5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-bicyclo[3.1.0]hex-1-yl]-penta-2,4-dienoic acid
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C26H34O2
  1
1
EC50 = 3 nM
 Bioactivity Info 
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CP0040160
 Compound Info 
9-cis-retinoic acid (9cRA)
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C20H28O2
  2
1
EC50 = 6 nM
 Bioactivity Info 
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2
EC50 = 961 nM
 Bioactivity Info 
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CP0135295
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C25H34O2
  1
1
EC50 = 6 nM
 Bioactivity Info 
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CP0042976
 Compound Info 
(2E,4E)-3-Methyl-6-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-hexa-2,4-dienoic acid
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C24H32O2
  1
1
EC50 = 14 nM
 Bioactivity Info 
   TI
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CP0059698
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2R)-1-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H36O2
  1
1
EC50 = 16 nM
 Bioactivity Info 
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CP0105557
 Compound Info 
(2E,4E)-6-[1-(6-tert-Butyl-1,1-dimethyl-indan-4-yl)-cyclopropyl]-3-methyl-hexa-2,4-dienoic acid
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C25H34O2
  1
1
EC50 = 20 nM
 Bioactivity Info 
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CP0004259
 Compound Info 
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
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C24H28O2
  2
1
EC50 = 20 nM
 Bioactivity Info 
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2
EC50 = 25 nM
 Bioactivity Info 
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CP0063990
 Compound Info 
(2E,4E)-6-[1-(3,5-Di-tert-butyl-phenyl)-cyclopropyl]-3-methyl-hexa-2,4-dienoic acid
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C24H34O2
  1
1
EC50 = 23 nM
 Bioactivity Info 
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CP0042888
 Compound Info 
(2E,4E)-3-Methyl-6-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-hexa-2,4-dienoic acid
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C26H36O2
  1
1
EC50 = 24 nM
 Bioactivity Info 
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CP0109273
 Compound Info 
(2E,4E)-3-Methyl-5-[(1S,2S)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C25H34O2
  1
1
EC50 = 25 nM
 Bioactivity Info 
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CP0111163
 Compound Info 
4-[1-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H25ClO2
  1
1
EC50 = 36 nM
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CP0122733
 Compound Info 
(2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-hexa-2,4-dienoic acid
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C25H34O2
  1
1
EC50 = 36 nM
 Bioactivity Info 
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CP0059678
 Compound Info 
3-Methyl-5-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopent-1-enyl]-penta-2,4-dienoic acid
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C25H32O2
  1
1
EC50 = 40 nM
 Bioactivity Info 
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CP0216905
 Compound Info 
(2Z,4E,6E)-8-[3-Ethyl-2-isopropyl-cyclohex-2-en-(E)-ylidene]-3,7-dimethyl-octa-2,4,6-trienoic acid
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C21H30O2
  1
1
EC50 = 42 nM
 Bioactivity Info 
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CP0063958
 Compound Info 
4-[1-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H25BrO2
  1
1
EC50 = 43 nM
 Bioactivity Info 
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CP0044733
 Compound Info 
(2E,4E)-3-Methyl-5-[(1S,2R)-1-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H36O2
  1
1
EC50 = 44 nM
 Bioactivity Info 
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CP0042977
 Compound Info 
9-cis retinoic acid
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C20H28O2
  1
1
EC50 = 124 nM
 Bioactivity Info 
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CP0277989
 Compound Info 
3-Methyl-5-[2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopent-1-enyl]-penta-2,4-dienoic acid
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C26H34O2
  1
1
EC50 = 128 nM
 Bioactivity Info 
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CP0149955
 Compound Info 
4-[1-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C25H30O2
  1
1
EC50 = 136 nM
 Bioactivity Info 
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CP0267152
 Compound Info 
(2E,4E)-3-Methyl-5-[(1S,2S)-4-methylene-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H34O2
  1
1
EC50 = 204 nM
 Bioactivity Info 
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CP0102521
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-4-methylene-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H34O2
  1
1
EC50 = 212 nM
 Bioactivity Info 
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CP0144133
 Compound Info 
4-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H23ClO3
  1
1
EC50 = 225 nM
 Bioactivity Info 
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CP0063793
 Compound Info 
4-[1-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C26H32O2
  1
1
EC50 = 227 nM
 Bioactivity Info 
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CP0105911
 Compound Info 
4-[1-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C24H28O3
  1
1
EC50 = 230 nM
 Bioactivity Info 
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CP0092667
 Compound Info 
4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C23H26O3
  1
1
EC50 = 246 nM
 Bioactivity Info 
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CP0186182
 Compound Info 
4-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H23BrO3
  1
1
EC50 = 261 nM
 Bioactivity Info 
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CP0076318
 Compound Info 
4-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C25H30O3
  1
1
EC50 = 357 nM
 Bioactivity Info 
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CP0149843
 Compound Info 
4-[1-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H25FO2
  1
1
EC50 = 383 nM
 Bioactivity Info 
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CP0063697
 Compound Info 
4-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C24H28O3
  1
1
EC50 = 384 nM
 Bioactivity Info 
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CP0047977
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H26O2
  1
1
EC50 = 404 nM
 Bioactivity Info 
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CP0100503
 Compound Info 
4-[1-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H26O3
  1
1
EC50 = 558 nM
 Bioactivity Info 
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CP0209249
 Compound Info 
4-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C23H26O4
  1
1
EC50 = 2191 nM
 Bioactivity Info 
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CP0184156
 Compound Info 
4-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H23FO3
  1
1
EC50 = 2246 nM
 Bioactivity Info 
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CP0049287
 Compound Info 
4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H24O3
  1
1
EC50 = 2836 nM
 Bioactivity Info 
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CP0041092
 Compound Info 
4-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H24O4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0100726
 Compound Info 
4-(5,5,8,8-Tetramethyl-3-propyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C25H30O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0123457
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-3-propyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C26H32O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0043939
 Compound Info 
(2E,4Z,6Z)-8-[3,4-Dihydro-2H-naphthalen-(1E)-ylidene]-3,7-dimethyl-octa-2,4,6-trienoic acid
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C20H22O2
  1
1
EC50 > 2000 nM
 Bioactivity Info 
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CP0162300
 Compound Info 
(2Z,4E,6E)-8-[3,4-Dihydro-2H-naphthalen-(1E)-ylidene]-3,7-dimethyl-octa-2,4,6-trienoic acid
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C20H22O2
  1
1
EC50 > 2000 nM
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0040160
 Compound Info 
9-cis-retinoic acid (9cRA)
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C20H28O2
  2
1 IC50 > 50000 nM
2 Kd = 350 nM
CP0042977
 Compound Info 
9-cis retinoic acid
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C20H28O2
  1
1 Kd = 4 nM
CP0004259
 Compound Info 
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
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C24H28O2
  2
1 Kd = 29 nM
2 Ki = 29 nM
CP0063958
 Compound Info 
4-[1-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H25BrO2
  1
1 Kd = 35 nM
CP0111163
 Compound Info 
4-[1-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C23H25ClO2
  1
1 Kd = 44 nM
CP0149955
 Compound Info 
4-[1-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C25H30O2
  1
1 Kd = 59 nM
CP0149843
 Compound Info 
4-[1-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C23H25FO2
  1
1 Kd = 94 nM
CP0105911
 Compound Info 
4-[1-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C24H28O3
  1
1 Kd = 113 nM
CP0144133
 Compound Info 
4-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H23ClO3
  1
1 Kd = 135 nM
CP0063793
 Compound Info 
4-[1-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C26H32O2
  1
1 Kd = 142 nM
CP0186182
 Compound Info 
4-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H23BrO3
  1
1 Kd = 150 nM
CP0047977
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H26O2
  1
1 Kd = 290 nM
CP0092667
 Compound Info 
4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C23H26O3
  2
1 Kd = 299 nM
2 Kd = 424 nM
CP0076318
 Compound Info 
4-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C25H30O3
  1
1 Kd = 309 nM
CP0123457
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-3-propyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C26H32O2
  1
1 Kd = 332 nM
CP0063697
 Compound Info 
4-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C24H28O3
  1
1 Kd = 424 nM
CP0100726
 Compound Info 
4-(5,5,8,8-Tetramethyl-3-propyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C25H30O3
  1
1 Kd = 704 nM
CP0100503
 Compound Info 
4-[1-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C23H26O3
  1
1 Kd = 812 nM
CP0184156
 Compound Info 
4-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C22H23FO3
  1
1 Kd = 911 nM
CP0041092
 Compound Info 
4-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C22H24O4
  1
1 Kd > 1000 nM
CP0049287
 Compound Info 
4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C22H24O3
  1
1 Kd > 1000 nM
CP0209249
 Compound Info 
4-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C23H26O4
  1
1 Kd > 1000 nM
CP0135295
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1 Ki = 5 nM
CP0756593
 Compound Info 
3-Methyl-5-[5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-bicyclo[3.1.0]hex-1-yl]-penta-2,4-dienoic acid
   Show/Hide
C26H34O2
  1
1 Ki = 5 nM
CP0044733
 Compound Info 
(2E,4E)-3-Methyl-5-[(1S,2R)-1-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
   Show/Hide
C26H36O2
  1
1 Ki = 7 nM
CP0059698
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2R)-1-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
   Show/Hide
C26H36O2
  1
1 Ki = 7 nM
CP0277989
 Compound Info 
3-Methyl-5-[2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopent-1-enyl]-penta-2,4-dienoic acid
   Show/Hide
C26H34O2
  1
1 Ki = 22 nM
CP0109273
 Compound Info 
(2E,4E)-3-Methyl-5-[(1S,2S)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1 Ki = 26 nM
CP0102521
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-4-methylene-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H34O2
  1
1 Ki = 54 nM
CP0059678
 Compound Info 
3-Methyl-5-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopent-1-enyl]-penta-2,4-dienoic acid
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C25H32O2
  1
1 Ki = 58 nM
CP0267152
 Compound Info 
(2E,4E)-3-Methyl-5-[(1S,2S)-4-methylene-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H34O2
  1
1 Ki = 161 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02769 Retinoic acid receptor RXR-gamma Homo sapiens, Human
 Protein Info