Protein Information

General Information of the Protein

Protein ID	PT01223
Protein Name	Aurora kinase B
Secondarily Protein Name	Aurora 1 Aurora- and IPL1-like midbody-associated protein 1 Aurora/IPL1-related kinase 2 STK-1 Serine/threonine-protein kinase 12 Serine/threonine-protein kinase 5 Serine/threonine-protein kinase aurora-B
Gene Name	AURKB
Secondarily Gene Name	AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5
Sequence	MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Kinase > Protein Kinase > Other protein kinase group > Other protein kinase AUR family
Function	Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11784863, PubMed:12689593, PubMed:14602875, PubMed:11856369, PubMed:16103226, PubMed:21658950, PubMed:11756469). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Show/Hide
Uniprot ID	Primary ID: Q96GD4 Secondarily ID: B4DNM4 C7G533 C7G534 C7G535 D3DTR4 J9JID1 O14630 O60446 O95083 Q96DV5 Q9UQ46 Show/Hide
Ensembl ID	ENSG00000178999
HGNC ID	HGNC:11390
Subcellular Location	Nucleus Chromosome Chromosome Centromere Chromosome Centromere Kinetochore Cytoplasm Cytoskeleton Spindle Midbody

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000023 , BTI-Tn-5B1-4

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0477498 Compound Info	N-[3-[(E)-2-[3-[(4-methylpiperazin-1-yl)methyl]phenyl]ethenyl]-1H-indazol-5-yl]-2-thiophen-2-ylacetamide Show/Hide	C27H29N5OS	1
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0376394 Compound Info	1-phenyl-N-(3-styryl-1H-indazol-5-yl)methanesulfonamide Show/Hide	C22H19N3O2S	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0430624 Compound Info	3-methyl-5-(4-methyl-3-(3-((4-methylpiperazin-1-yl)methyl)styryl)-1H-indazol-5-yl)aniline Show/Hide	C29H33N5	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0430625 Compound Info	4-methyl-N-(3-(2-(6-methyl-5-(2-(thiophen-2-yl)acetamido)-1H-indazol-3-yl)vinyl)phenyl)piperazine-1-carboxamide Show/Hide	C28H30N6O2S	1
1	IC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0470476 Compound Info	5-(pyridin-4-yl)-6-(pyrrolidin-1-yl)-3-styryl-1H-indazole Show/Hide	C24H22N4	1
1	IC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0470449 Compound Info	N-[6-methyl-3-[(E)-2-phenylethenyl]-1H-indazol-5-yl]-2-thiophen-2-ylacetamide Show/Hide	C22H19N3OS	1
1	IC50 = 47 nM Bioactivity Info	TI LI LO TS
CP0417624 Compound Info	4-methyl-3-(3-((4-methylpiperazin-1-yl)methyl)styryl)-1H-indazole-5-carbonitrile Show/Hide	C23H25N5	1
1	IC50 = 59 nM Bioactivity Info	TI LI LO TS
CP0430626 Compound Info	4-methyl-N-(3-(2-(5-(methylsulfonamido)-6-(pyrrolidin-1-yl)-1H-indazol-3-yl)vinyl)phenyl)piperazine-1-carboxamide Show/Hide	C26H33N7O3S	1
1	IC50 = 62 nM Bioactivity Info	TI LI LO TS
CP0477501 Compound Info	6-(pyrrolidin-1-yl)-3-styryl-1H-indazol-5-amine Show/Hide	C19H20N4	1
1	IC50 = 81 nM Bioactivity Info	TI LI LO TS
CP0470045 Compound Info	N-[4-methyl-3-[(E)-2-[3-[(4-methylpiperazin-1-yl)methyl]phenyl]ethenyl]-1H-indazol-5-yl]-2-thiophen-2-ylacetamide Show/Hide	C28H31N5OS	1
1	IC50 = 99 nM Bioactivity Info	TI LI LO TS
CP0376393 Compound Info	5-nitro-6-(pyrrolidin-1-yl)-3-styryl-1H-indazole Show/Hide	C19H18N4O2	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0477500 Compound Info	N-[3-[(E)-2-phenylethenyl]-6-pyrrolidin-1-yl-1H-indazol-5-yl]-2-thiophen-2-ylacetamide Show/Hide	C25H24N4OS	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0502849 Compound Info	N-[6-methyl-3-(2-phenylethynyl)-2H-indazol-5-yl]-2-thiophen-2-ylacetamide Show/Hide	C22H17N3OS	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0376392 Compound Info	N-[6-methyl-3-[(E)-2-[3-[(4-methylpiperazin-1-yl)methyl]phenyl]ethenyl]-1H-indazol-5-yl]-2-thiophen-2-ylacetamide Show/Hide	C28H31N5OS	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0494484 Compound Info	3-[(E)-2-phenylethenyl]-N-(pyridin-2-ylmethyl)-6-pyrrolidin-1-yl-1H-indazol-5-amine Show/Hide	C25H25N5	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0452085 Compound Info	2-(2,5-dimethoxyphenyl)-N-(6-methyl-3-styryl-1H-indazol-5-yl)acetamide Show/Hide	C26H25N3O3	1
1	IC50 = 180 nM Bioactivity Info	TI LI LO TS
CP0504238 Compound Info	6-(4-methylpiperazin-1-yl)-N-(pyridin-2-ylmethyl)-3-styryl-1H-indazol-5-amine Show/Hide	C26H28N6	1
1	IC50 = 810 nM Bioactivity Info	TI LI LO TS
CP0470451 Compound Info	2-phenyl-N-(3-(2-phenylcyclopropyl)-1H-indazol-5-yl)acetamide Show/Hide	C24H21N3O	1
1	IC50 = 1640 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000067 , HCT 116

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000017 , HeLa

Cell Line Info

Cell Line ID: CL000007 , HT-29

Cell Line Info

Cell Line ID: CL000196 , MDA-MB-468

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0036050 Compound Info	2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide Show/Hide	C26H30FN7O3	6
1	IC50 = 0.3 nM
2	IC50 = 0.37 nM
3	IC50 < 1 nM
4	Kd = 4.6 nM
5	Kd = 7.2 nM
6	Ki < 1 nM
CP0057301 Compound Info	4-fluoro-N-[4-[(6-oxo-5H-benzo[c][1,8]naphthyridin-1-yl)amino]phenyl]-2-(trifluoromethyl)benzamide Show/Hide	C26H16F4N4O2	1
1	IC50 = 0.4 nM
CP0045201 Compound Info	2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-6-methoxyquinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide Show/Hide	C27H32FN7O4	2
1	IC50 = 1 nM
2	Ki = 1 nM
CP0045203 Compound Info	N-(2,3-difluorophenyl)-2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide Show/Hide	C27H31F2N7O4	2
1	IC50 < 1 nM
2	Ki < 1 nM
CP0058393 Compound Info	N-(2,3-difluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(propyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide Show/Hide	C28H33F2N7O4	2
1	IC50 < 1 nM
2	Ki < 1 nM
CP0161066 Compound Info	N-(2,3-difluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(2-methylpropyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide Show/Hide	C29H35F2N7O4	2
1	IC50 < 1 nM
2	Ki < 1 nM
CP0057282 Compound Info	N-[4-[(6-oxo-5H-benzo[c][1,8]naphthyridin-1-yl)amino]phenyl]benzamide Show/Hide	C25H18N4O2	1
1	IC50 = 1 nM
CP0674596 Compound Info	(-)-Ethyl 8-Oxo-9-[3-(1H-benzimidazol-2-yloxy)phenyl]-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b]quinoline-3-carboxylate Show/Hide	C27H24N4O4	1
1	IC50 = 1 nM
CP0058391 Compound Info	N-(3-fluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(propyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide Show/Hide	C28H34FN7O4	2
1	IC50 = 2 nM
2	Ki = 2 nM
CP0294246 Compound Info	N-(3-fluorophenyl)-2-[3-[[7-[3-[4-(hydroxymethyl)piperidin-1-yl]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide Show/Hide	C29H34FN7O4	1
1	IC50 = 2 nM
CP0361417 Compound Info	CHEMBL4563026 Show/Hide	C33H34ClFN7O3	1
1	IC50 = 2.55 nM
CP0042568 Compound Info	3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-2-yl]-1H-pyrazol-4-yl}urea Show/Hide	C19H23N7O2	3
1	IC50 = 2.7 nM
2	IC50 = 3 nM
3	IC50 = 62 nM
CP0026409 Compound Info	2-anilino-N-[4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxyphenyl]benzamide Show/Hide	C29H24N6O2	1
1	IC50 = 9 nM
CP0025009 Compound Info	Bisanilinopyrimidine, 9m Show/Hide	C17H13ClFN5O	1
1	IC50 = 10.7 nM
CP0043422 Compound Info	4-[6-amino-7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridin-3-yl]-3,6-dihydro-2H-pyridine-1-carboxamide Show/Hide	C21H19Cl2FN4O3	1
1	IC50 = 11 nM
CP0645780 Compound Info	2-(ethyl((5-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino)isothiazol-3-yl)methyl)amino)-2-methylpropan-1-ol Hydrochloride Show/Hide	C20H27ClN8OS	1
1	IC50 <= 13 nM
CP0647070 Compound Info	N-[3-[(3,3-Difluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride Show/Hide	C18H19ClF2N8S	1
1	IC50 <= 13 nM
CP0647442 Compound Info	6-Methyl-3-(1H-pyrazol-4-yl)-N-[3-[[(3,3,3-trifluoropropyl)-amino]methyl]-5-isothiazolyl]imidazo[1,2-a]pyrazin-8-amine Hydrochloride Show/Hide	C17H18ClF3N8S	1
1	IC50 <= 13 nM
CP0647443 Compound Info	N-[3-[(4-Fluoro-1-piperidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride Show/Hide	C19H22ClFN8S	1
1	IC50 <= 13 nM
CP0647444 Compound Info	N-[3-[(3(R)-Fluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride Show/Hide	C18H20ClFN8S	1
1	IC50 <= 13 nM
CP0647445 Compound Info	6-Methyl-3-(1H-pyrazol-4-yl)-N-[3-[(3,3,4,4-tetrafluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]imidazo[1,2-a]pyrazin-8-amine Hydrochloride Show/Hide	C18H17ClF4N8S	1
1	IC50 <= 13 nM
CP0656034 Compound Info	N-[3-[(4,4-Difluoro-1-piperidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride Show/Hide	C19H21ClF2N8S	1
1	IC50 <= 13 nM
CP0656035 Compound Info	2-[(2,2-Difluoroethyl)[[5-[[6-methyl-3-(1Hpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-isothiazolyl]methyl]-amino]-2-methyl-1-propanol Hydrochloride Show/Hide	C20H25ClF2N8OS	1
1	IC50 <= 13 nM
CP0657138 Compound Info	Deuterated N-[3-[(3,3-Difluoro-1-pyrrolidinyl)methyl-(d2)]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride Show/Hide	C18H19ClF2N8S	1
1	IC50 <= 13 nM
CP0680616 Compound Info	6-Methyl-N-[3-(1-piperidinylmethyl)-5-isothiazolyl]-3-(1Hpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride Show/Hide	C19H23ClN8S	1
1	IC50 <= 13 nM
CP0701989 Compound Info	6-Methyl-N-[3-[[(2,2,3,3,3-pentafluoropropyl)amino]methyl]-5-isothiazolyl]-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride Show/Hide	C17H16ClF5N8S	1
1	IC50 <= 13 nM
CP0702733 Compound Info	6-Methyl-3-(1H-pyrazol-4-yl)-N-[3-[[4-(trifluoromethyl)-1-piperidinyl]methyl]-5-isothiazolyl]imidazo[1,2-a]pyrazin-8-amine Hydrochloride Show/Hide	C20H22ClF3N8S	1
1	IC50 <= 13 nM
CP0712128 Compound Info	2-Methyl-2-[[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-isothiazolyl]methyl](2,2,2-trifluoroethyl)amino]-1-propanol Hydrochloride Show/Hide	C20H24ClF3N8OS	1
1	IC50 <= 13 nM
CP0751381 Compound Info	N-[3-[(3-Fluoro-1-azetidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Trifluoroacetate Show/Hide	C19H18F4N8O2S	1
1	IC50 <= 13 nM
CP0784483 Compound Info	N-[3-[(3-Fluoro-1-piperidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride Show/Hide	C19H22ClFN8S	1
1	IC50 <= 13 nM
CP0790429 Compound Info	N-[3-[(3,3-Difluoro-1-piperidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride Show/Hide	C19H21ClF2N8S	1
1	IC50 <= 13 nM
CP0802122 Compound Info	N-[3-[(3,3-Difluoro-1-azetidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Trifluoroacetate Show/Hide	C19H17F5N8O2S	1
1	IC50 <= 13 nM
CP0814301 Compound Info	N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-(pyrrolidin-1-ylmethyl)isothiazol-5-amine Hydrochloride Show/Hide	C18H21ClN8S	1
1	IC50 <= 13 nM
CP0817001 Compound Info	N-[3-[(3(S)-Fluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride Show/Hide	C18H20ClFN8S	1
1	IC50 <= 13 nM
CP0105279 Compound Info	6-Methyl-N-[3-(1-piperidinylmethyl)-5-isothiazolyl]-3-(1Hpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride Show/Hide	C19H22N8S	2
1	IC50 < 13 nM
2	IC50 <= 13 nM
CP0105267 Compound Info	N-(2,3-difluorophenyl)-2-[4-[6-methyl-8-[[3-(piperidin-1-ylmethyl)-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C27H27F2N9OS	1
1	IC50 <= 13 nM
CP0105278 Compound Info	N-[(4-fluorophenyl)methyl]-2-[4-[6-methyl-8-[[3-(piperidin-1-ylmethyl)-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C28H30FN9OS	1
1	IC50 <= 13 nM
CP0125882 Compound Info	2-[4-[6-methyl-8-[[3-[(3-methylpiperidin-1-yl)methyl]-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]-N-pyridin-4-ylacetamide Show/Hide	C27H30N10OS	1
1	IC50 <= 13 nM
CP0146469 Compound Info	N-[6-methyl-3-[1-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]-3-(piperidin-1-ylmethyl)-1,2-thiazol-5-amine Show/Hide	C28H28N10OS	1
1	IC50 <= 13 nM
CP0146474 Compound Info	2-[4-[6-methyl-8-[[3-[(3-methylpiperidin-1-yl)methyl]-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]-N-(thiophen-2-ylmethyl)acetamide Show/Hide	C27H31N9OS2	1
1	IC50 <= 13 nM
CP0181883 Compound Info	N-[(2-fluorophenyl)methyl]-2-[4-[6-methyl-8-[[3-(piperidin-1-ylmethyl)-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C28H30FN9OS	1
1	IC50 <= 13 nM
CP0248286 Compound Info	N-(3-fluoropyridin-4-yl)-2-[4-[6-methyl-8-[[3-[(3-methylpiperidin-1-yl)methyl]-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C27H29FN10OS	1
1	IC50 <= 13 nM
CP0248287 Compound Info	N-[(3-fluorophenyl)methyl]-2-[4-[6-methyl-8-[[3-(piperidin-1-ylmethyl)-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C28H30FN9OS	1
1	IC50 <= 13 nM
CP0248288 Compound Info	2-[4-[6-methyl-8-[[3-[(3-methylpiperidin-1-yl)methyl]-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]-N-(1,3-thiazol-2-yl)acetamide Show/Hide	C25H28N10OS2	1
1	IC50 <= 13 nM
CP0248304 Compound Info	N-[3-[1-(1H-benzimidazol-2-ylmethyl)pyrazol-4-yl]-6-methylimidazo[1,2-a]pyrazin-8-yl]-3-[(3-methylpiperidin-1-yl)methyl]-1,2-thiazol-5-amine Show/Hide	C28H30N10S	1
1	IC50 <= 13 nM
CP0333218 Compound Info	N-(3-fluorophenyl)-2-[4-[6-methyl-8-[[3-(piperidin-1-ylmethyl)-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C27H28FN9OS	1
1	IC50 <= 13 nM
CP0333907 Compound Info	N-benzyl-2-[4-[6-methyl-8-[[3-[(3-methylpiperidin-1-yl)methyl]-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C29H33N9OS	1
1	IC50 <= 13 nM
CP0338008 Compound Info	N-[(2,3-difluorophenyl)methyl]-2-[4-[6-methyl-8-[[3-(piperidin-1-ylmethyl)-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C28H29F2N9OS	1
1	IC50 <= 13 nM
CP0340347 Compound Info	N-[(3,5-difluorophenyl)methyl]-2-[4-[6-methyl-8-[[3-(piperidin-1-ylmethyl)-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C28H29F2N9OS	1
1	IC50 <= 13 nM
CP0517504 Compound Info	N-[6-methyl-3-[1-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]-3-(piperidin-1-ylmethyl)-1,2-thiazol-5-amine Show/Hide	C28H28N10OS	1
1	IC50 <= 13 nM
CP0068126 Compound Info	2-[ethyl-[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-1,2-thiazol-3-yl]methyl]amino]ethanol Show/Hide	C18H22N8OS	1
1	IC50 < 13 nM
CP0080498 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(pyrimidin-2-ylmethyl)-1,2-thiazol-5-amine Show/Hide	C18H15N9S	1
1	IC50 < 13 nM
CP0080506 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-[(3-methylpyridin-2-yl)methyl]-1,2-thiazol-5-amine Show/Hide	C20H18N8S	1
1	IC50 < 13 nM
CP0101516 Compound Info	3-[(6-methoxypyridin-2-yl)methyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine Show/Hide	C20H18N8OS	1
1	IC50 < 13 nM
CP0101517 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-[(5-methylpyridin-2-yl)methyl]-1,2-thiazol-5-amine Show/Hide	C20H18N8S	1
1	IC50 < 13 nM
CP0101571 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-[pyridin-2-yl(pyrrolidin-1-yl)methyl]-1,2-thiazol-5-amine Show/Hide	C23H23N9S	1
1	IC50 < 13 nM
CP0101572 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-[(4-methylpyridin-2-yl)methyl]-1,2-thiazol-5-amine Show/Hide	C20H18N8S	1
1	IC50 < 13 nM
CP0102956 Compound Info	[6-[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-1,2-thiazol-3-yl]methyl]pyridin-2-yl]-piperidin-1-ylmethanone Show/Hide	C25H25N9OS	1
1	IC50 < 13 nM
CP0102957 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(pyridin-2-ylmethyl)-1,2-thiazol-5-amine Show/Hide	C19H16N8S	2
1	IC50 < 13 nM
2	Kd = 0.1 nM
CP0225496 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(pyridin-4-ylmethyl)-1,2-thiazol-5-amine Show/Hide	C19H16N8S	1
1	IC50 < 13 nM
CP0225497 Compound Info	3-(imidazol-1-ylmethyl)-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine Show/Hide	C17H15N9S	1
1	IC50 < 13 nM
CP0225498 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(1,3-thiazol-2-ylmethyl)-1,2-thiazol-5-amine Show/Hide	C17H14N8S2	1
1	IC50 < 13 nM
CP0225500 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-[piperidin-1-yl(pyridin-2-yl)methyl]-1,2-thiazol-5-amine Show/Hide	C24H25N9S	1
1	IC50 < 13 nM
CP0311219 Compound Info	3-[(4-fluoropiperidin-1-yl)-pyridin-2-ylmethyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine Show/Hide	C24H24FN9S	1
1	IC50 < 13 nM
CP0323338 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-[[6-(piperidin-1-ylmethyl)pyridin-2-yl]methyl]-1,2-thiazol-5-amine Show/Hide	C25H27N9S	1
1	IC50 < 13 nM
CP0329737 Compound Info	3-methyl-1-[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-1,2-thiazol-3-yl]methyl]pyridin-2-one Show/Hide	C20H18N8OS	1
1	IC50 < 13 nM
CP0329738 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(pyrazol-1-ylmethyl)-1,2-thiazol-5-amine Show/Hide	C17H15N9S	1
1	IC50 < 13 nM
CP0329739 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-[(6-methylpyridin-2-yl)methyl]-1,2-thiazol-5-amine Show/Hide	C20H18N8S	1
1	IC50 < 13 nM
CP0340785 Compound Info	3-[(3-fluoropyridin-2-yl)methyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine Show/Hide	C19H15FN8S	1
1	IC50 < 13 nM
CP0364547 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(pyrazin-2-ylmethyl)-1,2-thiazol-5-amine Show/Hide	C18H15N9S	1
1	IC50 < 13 nM
CP0364548 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(pyrrol-1-ylmethyl)-1,2-thiazol-5-amine Show/Hide	C18H16N8S	1
1	IC50 < 13 nM
CP0364549 Compound Info	[6-[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-1,2-thiazol-3-yl]methyl]pyridin-2-yl]methanol Show/Hide	C20H18N8OS	1
1	IC50 < 13 nM
CP0364550 Compound Info	3-[(5-fluoropyridin-2-yl)methyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine Show/Hide	C19H15FN8S	1
1	IC50 < 13 nM
CP0404218 Compound Info	N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(pyridin-3-ylmethyl)-1,2-thiazol-5-amine Show/Hide	C19H16N8S	1
1	IC50 < 13 nM
CP0469385 Compound Info	3-[(cyclopentylamino)-pyridin-2-ylmethyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine Show/Hide	C24H25N9S	1
1	IC50 < 13 nM
CP0564662 Compound Info	3-[(6-fluoropyridin-2-yl)methyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine Show/Hide	C19H15FN8S	1
1	IC50 < 13 nM
CP0018039 Compound Info	N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide Show/Hide	C23H28N8OS	14
1	IC50 = 14.7 nM
2	IC50 = 15.7 nM
3	IC50 = 17 nM
4	IC50 = 18 nM
5	IC50 = 18.6 nM
6	IC50 = 30 nM
7	IC50 = 40 nM
8	IC50 = 43 nM
9	IC50 = 68 nM
10	Kd = 7 nM
11	Kd = 7.4 nM
12	Ki = 1.8 nM
13	Ki = 3.36 nM
14	Ki = 18 nM
CP0025073 Compound Info	4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)-pyridin-2-yloxy)phenyl)phthalazin-1-amine Show/Hide	C30H22FN7O	1
1	IC50 = 15 nM
CP0026408 Compound Info	2-anilino-N-[3-methyl-4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxyphenyl]benzamide Show/Hide	C30H26N6O2	1
1	IC50 = 17 nM
CP0110915 Compound Info	N-[6-methyl-3-[1-[(5-phenyl-1H-imidazol-2-yl)methyl]pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]-3-(piperidin-1-ylmethyl)-1,2-thiazol-5-amine Show/Hide	C29H30N10S	1
1	IC50 = 21 nM
CP0015614 Compound Info	N-[4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxyphenyl]-4-phenylphthalazin-1-amine Show/Hide	C30H23N7O	1
1	IC50 = 22 nM
CP0238983 Compound Info	Bisanilinopyrimidine, 9j Show/Hide	C20H19ClFN5O	1
1	IC50 = 25.6 nM
CP0061157 Compound Info	N-[4-(1,3-benzothiazol-2-yl)-3-fluorophenyl]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4-amine Show/Hide	C30H31FN6O2S	1
1	IC50 = 27 nM
CP0151244 Compound Info	N-[4-(1,3-benzothiazol-2-yl)-2-fluorophenyl]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4-amine Show/Hide	C30H31FN6O2S	1
1	IC50 = 28 nM
CP0146467 Compound Info	2-[4-[6-methyl-8-[[3-(piperidin-1-ylmethyl)-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C21H25N9OS	1
1	IC50 = 28 nM
CP0333908 Compound Info	N-(6-fluoropyridin-2-yl)-2-[4-[6-methyl-8-[[3-[(3-methylpiperidin-1-yl)methyl]-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C27H29FN10OS	1
1	IC50 = 28 nM
CP0125881 Compound Info	N-(4-fluorophenyl)-2-[4-[6-methyl-8-[[3-(piperidin-1-ylmethyl)-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C27H28FN9OS	1
1	IC50 = 30 nM
CP0318290 Compound Info	Bisanilinopyrimidine, 9k Show/Hide	C21H21ClFN5O	1
1	IC50 = 30 nM
CP0338488 Compound Info	2-[4-[6-methyl-8-[[3-[(3-methylpiperidin-1-yl)methyl]-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]-N-pyridin-2-ylacetamide Show/Hide	C27H30N10OS	1
1	IC50 = 32 nM
CP0110916 Compound Info	2-[4-[6-methyl-8-[[3-[(3-methylpiperidin-1-yl)methyl]-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]-N-[[3-(trifluoromethyl)phenyl]methyl]acetamide Show/Hide	C30H32F3N9OS	1
1	IC50 = 35 nM
CP0176075 Compound Info	N-(2-fluorophenyl)-2-[4-[6-methyl-8-[[3-(piperidin-1-ylmethyl)-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C27H28FN9OS	1
1	IC50 = 35 nM
CP0267380 Compound Info	Bisanilinopyrimidine, 9l Show/Hide	C19H18ClN5O2	1
1	IC50 = 40.4 nM
CP0069712 Compound Info	N-[4-(6-fluoro-1,3-benzothiazol-2-yl)phenyl]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4-amine Show/Hide	C30H31FN6O2S	1
1	IC50 = 41 nM
CP0176074 Compound Info	N-[(3-methoxyphenyl)methyl]-2-[4-[6-methyl-8-[[3-[(3-methylpiperidin-1-yl)methyl]-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C30H35N9O2S	1
1	IC50 = 41 nM
CP0168034 Compound Info	4-[(7-hydroxy-6-methoxyquinazolin-4-yl)amino]-N-phenylbenzamide Show/Hide	C22H18N4O3	1
1	IC50 = 41 nM
CP0314266 Compound Info	Bisanilinopyrimidine, 9i Show/Hide	C16H14ClN5O2S	1
1	IC50 = 43.3 nM
CP0333195 Compound Info	N-(3-methylbutyl)-2-[4-[6-methyl-8-[[3-(piperidin-1-ylmethyl)-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C26H35N9OS	1
1	IC50 = 44 nM
CP0181888 Compound Info	2-[4-[6-methyl-8-[[3-[(3-methylpiperidin-1-yl)methyl]-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]-N-(3H-pyridazin-2-yl)acetamide Show/Hide	C26H31N11OS	1
1	IC50 = 45 nM
CP0284644 Compound Info	Bisanilinopyrimidine, 6p Show/Hide	C17H14ClN5O	1
1	IC50 = 50.2 nM
CP0181858 Compound Info	2-[4-[6-methyl-8-[[3-[(3-methylpiperidin-1-yl)methyl]-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]-N-phenylacetamide Show/Hide	C28H31N9OS	1
1	IC50 = 51 nM
CP0016235 Compound Info	N-[3-methyl-4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxyphenyl]-2-phenoxybenzamide Show/Hide	C30H25N5O3	1
1	IC50 = 56 nM
CP0103207 Compound Info	Bisanilinopyrimidine, 9n Show/Hide	C16H13ClFN5O2S	1
1	IC50 = 56.6 nM
CP0151301 Compound Info	2-(1,3-benzothiazol-2-yl)-5-[[6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4-yl]amino]phenol Show/Hide	C30H32N6O3S	1
1	IC50 = 59 nM
CP0091117 Compound Info	N-[4-(5-chloro-1,3-benzothiazol-2-yl)phenyl]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4-amine Show/Hide	C30H31ClN6O2S	1
1	IC50 = 62 nM
CP0015507 Compound Info	2-(4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazolin-4-yloxy)phenyl)benzo[d]thiazole Show/Hide	C30H31N5O3S	1
1	IC50 = 63 nM
CP0023880 Compound Info	N-[3-methyl-4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxyphenyl]-3-(trifluoromethyl)benzamide Show/Hide	C25H20F3N5O2	1
1	IC50 = 66 nM
CP0166275 Compound Info	N-[4-(1,3-benzothiazol-2-yl)-3-chlorophenyl]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4-amine Show/Hide	C30H31ClN6O2S	1
1	IC50 = 78 nM
CP0327179 Compound Info	N-(2-fluoropyridin-3-yl)-2-[4-[6-methyl-8-[[3-[(3-methylpiperidin-1-yl)methyl]-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C27H29FN10OS	1
1	IC50 = 81 nM
CP0274623 Compound Info	Bisanilinopyrimidine, 12b Show/Hide	C17H12ClFN8	1
1	IC50 = 83.7 nM
CP0151259 Compound Info	N-[4-(1,3-benzothiazol-2-yl)-2-methoxyphenyl]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4-amine Show/Hide	C31H34N6O3S	1
1	IC50 = 90 nM
CP0032546 Compound Info	4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-ylamino)-2-methoxybenzoic acid Show/Hide	C27H20ClFN4O4	5
1	IC50 = 90 nM
2	IC50 = 396 nM
3	IC50 = 396.5 nM
4	IC50 = 1100 nM
5	IC50 > 200 nM
CP0675722 Compound Info	4-(2-(4-(6-methyl-8-(3-((3-methylpiperidin-1-yl)methyl)isothiazol-5-ylamino)imidazo[1,2-a]pyrazin-3-yl)-1H-pyrazol-1-yl)acetamido)pyridine 1-oxide Show/Hide	C27H30N10O2S	1
1	IC50 = 91 nM
CP0193836 Compound Info	Bisanilinopyrimidine, 9b Show/Hide	C21H23ClN6O	1
1	IC50 = 93.9 nM
CP0248307 Compound Info	N-(3,5-difluorophenyl)-2-[4-[6-methyl-8-[[3-(piperidin-1-ylmethyl)-1,2-thiazol-5-yl]amino]imidazo[1,2-a]pyrazin-3-yl]pyrazol-1-yl]acetamide Show/Hide	C27H27F2N9OS	1
1	IC50 = 94 nM
CP0356087 Compound Info	Bisanilinopyrimidine, 12d Show/Hide	C17H12Cl2N8	1
1	IC50 = 106 nM
CP0020460 Compound Info	2-anilino-N-[2-methyl-4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxyphenyl]benzamide Show/Hide	C30H26N6O2	1
1	IC50 = 110 nM
CP0128578 Compound Info	6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]-N-[4-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]phenyl]quinazolin-4-amine Show/Hide	C31H31F3N6O2S	1
1	IC50 = 120 nM
CP0147199 Compound Info	Bisanilinopyrimidine, 9c Show/Hide	C20H20ClN5O2	1
1	IC50 = 123 nM
CP0015511 Compound Info	2-[3-fluoro-4-[6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4-yl]oxyphenyl]-1,3-benzothiazole Show/Hide	C30H30FN5O3S	1
1	IC50 = 130 nM
CP0051782 Compound Info	1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 18 Show/Hide	C28H35N7O2	1
1	IC50 = 135 nM
CP0016366 Compound Info	2-(4-(6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-yloxy)phenyl)benzo[d]thiazole Show/Hide	C29H28N4O3S	1
1	IC50 = 162 nM
CP0017774 Compound Info	4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid Show/Hide	C25H15ClF2N4O2	2
1	IC50 = 172 nM
2	Kd = 43 nM
CP0247099 Compound Info	Bisanilinopyrimidine, 9e Show/Hide	C18H16ClN5O	1
1	IC50 = 174 nM
CP0170069 Compound Info	Bisanilinopyrimidine, 9d Show/Hide	C17H15ClN4O2S	1
1	IC50 = 180 nM
CP0267383 Compound Info	Bisanilinopyrimidine, 9h Show/Hide	C20H20ClN5O	1
1	IC50 = 194 nM
CP0117152 Compound Info	Bisanilinopyrimidine, 12a Show/Hide	C17H13ClN8	1
1	IC50 = 226 nM
CP0301029 Compound Info	Bisanilinopyrimidine, 9a Show/Hide	C23H25ClN6O2	1
1	IC50 = 232 nM
CP0020487 Compound Info	N-[3-methyl-4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxyphenyl]-3-phenoxybenzamide Show/Hide	C30H25N5O3	1
1	IC50 = 251 nM
CP0135618 Compound Info	N-[4-(1,3-benzothiazol-2-yl)-3-methoxyphenyl]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4-amine Show/Hide	C31H34N6O3S	1
1	IC50 = 300 nM
CP0026752 Compound Info	4-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)-pyridin-2-yloxy)phenyl)benzamide Show/Hide	C24H20ClN5O2	1
1	IC50 = 335 nM
CP0704813 Compound Info	N4-(2-Chlorophenyl)-N2-[6-(1H-benzo[d]imidazol-2(3H)-one)]pyrimidine-2,4-diamine Show/Hide	C17H13ClN6O	1
1	IC50 = 361 nM
CP0019760 Compound Info	3-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)-pyridin-2-yloxy)phenyl)benzamide Show/Hide	C24H20ClN5O2	1
1	IC50 = 430 nM
CP0296124 Compound Info	4-[[6-chloro-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-7-yl]oxy]-N-(3-methyl-1,2-oxazol-5-yl)benzamide Show/Hide	C22H18ClN7O3	1
1	IC50 = 693 nM
CP0157791 Compound Info	Bisanilinopyrimidine, 9g Show/Hide	C18H15ClN4O3	1
1	IC50 = 1510 nM
CP0026997 Compound Info	Alternariol Show/Hide	C14H10O5	1
1	IC50 = 1626.457034 nM
CP0204584 Compound Info	4-[[6-chloro-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-7-yl]oxy]-N-pyridin-3-ylbenzamide Show/Hide	C23H18ClN7O2	1
1	IC50 = 1676 nM
CP0075920 Compound Info	4-[[6-chloro-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-7-yl]oxy]-N-cyclobutylbenzamide Show/Hide	C22H21ClN6O2	1
1	IC50 = 3045 nM
CP0296123 Compound Info	4-[[6-chloro-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-7-yl]oxy]-N-pyridin-4-ylbenzamide Show/Hide	C23H18ClN7O2	1
1	IC50 = 3447 nM
CP0270630 Compound Info	4-[[6-chloro-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-7-yl]oxy]-N-phenylbenzamide Show/Hide	C24H19ClN6O2	1
1	IC50 = 12710 nM
CP0203400 Compound Info	2-[(3S,4S)-3-fluoro-4-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C22H23FN8O2S	1
1	Kd = 1 nM
CP0120735 Compound Info	2-[(3R)-3-(2-hydroxyethoxy)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C24H28N8O3S	1
1	Kd = 1.7 nM
CP0178025 Compound Info	2-[(3R)-3-(3,3-difluoropyrrolidine-1-carbonyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C27H29F2N9O2S	1
1	Kd = 1.7 nM
CP0178029 Compound Info	(3R)-N-cyclopentyl-1-[2-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylanilino]-2-oxoethyl]pyrrolidine-3-carboxamide Show/Hide	C28H33N9O2S	1
1	Kd = 1.9 nM
CP0178032 Compound Info	N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]-2-[(3S)-3-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]acetamide Show/Hide	C27H31N9O2S	1
1	Kd = 1.9 nM
CP0203396 Compound Info	2-[(3S,4S)-3-(cyclopropylmethoxy)-4-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C26H30N8O3S	1
1	Kd = 2 nM
CP0203398 Compound Info	2-[(3S,4S)-3-hydroxy-4-(2-methoxyethoxy)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C25H30N8O4S	1
1	Kd = 2 nM
CP0256641 Compound Info	(3R)-1-[2-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylanilino]-2-oxoethyl]-N-(2,2,2-trifluoroethyl)pyrrolidine-3-carboxamide Show/Hide	C25H26F3N9O2S	1
1	Kd = 2.2 nM
CP0767144 Compound Info	rac-N-(4-((4-((5-Methyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)phenyl)-2-(3-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl)acetamide Show/Hide	C27H31N9O2S	1
1	Kd = 2.4 nM
CP0178031 Compound Info	N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]-2-[(3R)-3-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]acetamide Show/Hide	C27H31N9O2S	1
1	Kd = 2.5 nM
CP0153379 Compound Info	N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]-2-[(3R)-3-(morpholine-4-carbonyl)pyrrolidin-1-yl]acetamide Show/Hide	C27H31N9O3S	1
1	Kd = 2.6 nM
CP0087504 Compound Info	(3R)-1-[2-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylanilino]-2-oxoethyl]-N-(2-morpholin-4-ylethyl)pyrrolidine-3-carboxamide Show/Hide	C29H36N10O3S	1
1	Kd = 2.9 nM
CP0160241 Compound Info	2-[(3R)-3-[2-(4-methylpiperazin-1-yl)ethoxy]pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C29H38N10O2S	1
1	Kd = 2.9 nM
CP0199882 Compound Info	N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]-2-[(3R)-3-(piperidine-1-carbonyl)pyrrolidin-1-yl]acetamide Show/Hide	C28H33N9O2S	1
1	Kd = 2.9 nM
CP0120734 Compound Info	2-[(3R)-3-(2-methoxyethoxy)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C25H30N8O3S	1
1	Kd = 3.1 nM
CP0160243 Compound Info	(3R)-N-tert-butyl-1-[2-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylanilino]-2-oxoethyl]pyrrolidine-3-carboxamide Show/Hide	C27H33N9O2S	1
1	Kd = 3.1 nM
CP0256639 Compound Info	2-[(3R)-3-tert-butylsulfinylpyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C26H32N8O2S2	1
1	Kd = 3.1 nM
CP0208183 Compound Info	2-[(3R)-3-(methanesulfonamido)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C23H27N9O3S2	1
1	Kd = 3.2 nM
CP0084970 Compound Info	(3R)-N-cyclobutyl-1-[2-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylanilino]-2-oxoethyl]pyrrolidine-3-carboxamide Show/Hide	C27H31N9O2S	1
1	Kd = 3.3 nM
CP0208185 Compound Info	2-[(3R)-3-[(2-methylpropan-2-yl)oxy]pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C26H32N8O2S	1
1	Kd = 3.6 nM
CP0178030 Compound Info	2-[(3R)-3-(4-hydroxypiperidine-1-carbonyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C28H33N9O3S	1
1	Kd = 3.7 nM
CP0256640 Compound Info	N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]-2-[(3R)-3-(3-morpholin-4-ylpropoxy)pyrrolidin-1-yl]acetamide Show/Hide	C29H37N9O3S	1
1	Kd = 3.7 nM
CP0203395 Compound Info	2-[(3S,4S)-3-cyclopentyloxy-4-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C27H32N8O3S	1
1	Kd = 4 nM
CP0203397 Compound Info	2-[(3S,4S)-3-hydroxy-4-propan-2-yloxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C25H30N8O3S	1
1	Kd = 4 nM
CP0203408 Compound Info	2-[(2S,4S)-4-fluoro-2-(hydroxymethyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C23H25FN8O2S	1
1	Kd = 4 nM
CP0232139 Compound Info	N-[4-[6-[[2-(4-methylpiperazin-1-yl)-2-oxoacetyl]amino]-4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]cyclopropanecarboxamide Show/Hide	C27H30N10O3S	1
1	Kd = 4 nM
CP0255607 Compound Info	2-[(3S,4S)-3-hydroxy-4-(2-methylbutan-2-yloxy)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C27H34N8O3S	1
1	Kd = 4 nM
CP0299339 Compound Info	2-[(3S,4S)-3-hydroxy-4-(1,1,1-trifluoro-2-methylpropan-2-yl)oxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C26H29F3N8O3S	1
1	Kd = 4 nM
CP0299340 Compound Info	2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C23H26N8O2S	1
1	Kd = 4 nM
CP0078576 Compound Info	2-[(3R)-3-tert-butylsulfonylpyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C26H32N8O3S2	1
1	Kd = 4.3 nM
CP0297797 Compound Info	2-[(2S)-4,4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C23H24F2N8O2S	1
1	Kd = 5 nM
CP0314104 Compound Info	2-[(3S,4S)-3-hydroxy-4-[(2-methylpropan-2-yl)oxy]pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C26H32N8O3S	1
1	Kd = 5 nM
CP0713838 Compound Info	E/Z-(S,E)-2-(3-tert-butoxy-4-(hydroxyimino)pyrrolidin-1-yl)-N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f][1,2,4]triazin-2-ylthio)phenyl)acetamide Show/Hide	C26H31N9O3S	1
1	Kd = 5 nM
CP0315665 Compound Info	2-methyl-N-[(3R)-1-[2-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylanilino]-2-oxoethyl]pyrrolidin-3-yl]propanamide Show/Hide	C26H31N9O2S	1
1	Kd = 5.7 nM
CP0120732 Compound Info	2-[3-(2,2-dimethylpropanoyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C27H32N8O2S	1
1	Kd = 6.1 nM
CP0120733 Compound Info	N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]-2-[(3R)-3-(2-morpholin-4-ylethoxy)pyrrolidin-1-yl]acetamide Show/Hide	C28H35N9O3S	1
1	Kd = 6.6 nM
CP0178027 Compound Info	2-[(3R)-3-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C22H24N8O2S	1
1	Kd = 6.6 nM
CP0084971 Compound Info	(3R)-N-(4-fluorophenyl)-1-[2-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylanilino]-2-oxoethyl]pyrrolidine-3-carboxamide Show/Hide	C29H28FN9O2S	1
1	Kd = 6.9 nM
CP0180529 Compound Info	2-[(3S,4S)-3-(4-fluorophenoxy)-4-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C28H27FN8O3S	1
1	Kd = 8 nM
CP0255608 Compound Info	2-(dimethylamino)-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C20H22N8OS	1
1	Kd = 8 nM
CP0271602 Compound Info	2-[(3S,4R)-3-(4-fluorophenoxy)-4-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C28H27FN8O3S	1
1	Kd = 8 nM
CP0297798 Compound Info	2-[(2S,4R)-2-(hydroxymethyl)-4-[(2-methylpropan-2-yl)oxy]pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C27H34N8O3S	1
1	Kd = 8 nM
CP0203409 Compound Info	2-[(2S,4R)-4-fluoro-2-(hydroxymethyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C23H25FN8O2S	1
1	Kd = 9 nM
CP0232138 Compound Info	N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-[(2-morpholin-4-ylacetyl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]cyclopropanecarboxamide Show/Hide	C26H29N9O3S	1
1	Kd = 9 nM
CP0305823 Compound Info	2-[(3S,4S)-3-(2-fluorophenoxy)-4-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C28H27FN8O3S	1
1	Kd = 9 nM
CP0203394 Compound Info	2-[(3S,4S)-3-(3-fluorophenoxy)-4-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C28H27FN8O3S	1
1	Kd = 10 nM
CP0334840 Compound Info	2-[(3R)-3-tert-butylsulfanylpyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C26H32N8OS2	1
1	Kd = 14.2 nM
CP0314405 Compound Info	2-[(3S)-3-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C22H24N8O2S	1
1	Kd = 14.8 nM
CP0203402 Compound Info	2-[(2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C23H26N8O3S	1
1	Kd = 15 nM
CP0203406 Compound Info	2-[(1R,2S,5S)-2-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C24H26N8O2S	1
1	Kd = 15 nM
CP0271591 Compound Info	N-[4-[6-[[2-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]acetyl]amino]-4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]cyclopropanecarboxamide Show/Hide	C27H31N9O3S	1
1	Kd = 16 nM
CP0299338 Compound Info	2-[(3S,4S)-3-(2,4-difluorophenoxy)-4-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C28H26F2N8O3S	1
1	Kd = 17 nM
CP0235845 Compound Info	N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]cyclopropanecarboxamide Show/Hide	C20H19N7OS	1
1	Kd = 20 nM
CP0203404 Compound Info	2-[(2S,4R)-4-(4-fluorophenoxy)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C29H29FN8O3S	1
1	Kd = 21 nM
CP0305822 Compound Info	2-[(3S,4S)-3-(3,5-difluorophenoxy)-4-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C28H26F2N8O3S	1
1	Kd = 21 nM
CP0235846 Compound Info	N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-(3-piperidin-1-ylpropanoylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]cyclopropanecarboxamide Show/Hide	C28H33N9O2S	1
1	Kd = 37 nM
CP0252947 Compound Info	2-[(2S,4R)-4-tert-butylsulfanyl-2-(hydroxymethyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C27H34N8O2S2	1
1	Kd = 39 nM
CP0203410 Compound Info	N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]-2-morpholin-4-ylacetamide Show/Hide	C22H24N8O2S	1
1	Kd = 41 nM
CP0252950 Compound Info	2-(cyclopropylamino)-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C21H22N8OS	1
1	Kd = 41 nM
CP0164886 Compound Info	2-(cyclopentylamino)-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C23H26N8OS	1
1	Kd = 42 nM
CP0088050 Compound Info	US9447092, 1 Show/Hide	C22H23Cl2N7	1
1	Kd = 48 nM
CP0235848 Compound Info	N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-[(2-pyrrolidin-1-ylacetyl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]cyclopropanecarboxamide Show/Hide	C26H29N9O2S	1
1	Kd = 49 nM
CP0248466 Compound Info	2-[(2R,4R)-2-(hydroxymethyl)-4-[(2-methylpropan-2-yl)oxy]pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C27H34N8O3S	1
1	Kd = 69 nM
CP0248465 Compound Info	2-[(2S,4R)-4-amino-2-(hydroxymethyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide Show/Hide	C23H27N9O2S	1
1	Kd = 144 nM

Clinical Information about the Protein

Target 1 ( Aurora kinase B (AURKB) )

Target Type	Clinical trial Target
Disease	6 Target-related Diseases				6
1	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
2	Haematological malignancy [ICD-11: 2B33.Y]
3	Prostate cancer [ICD-11: 2C82.0]
4	Advanced solid tumour [ICD-11: 2A00-2F9Z]
5	Diabetic complication [ICD-11: 5A2Y]
6	Esophageal squamous cell carcinoma [ICD-11: 2E60.1]
Clinical Trial Drug(s)	13 Clinical Trial Drugs				13
1	AT9283	Drug Info	Phase 3	Solid tumour/cancer
2	ABT-348	Drug Info	Phase 2	Haematological malignancy
3	PHA-739358	Drug Info	Phase 2	Prostate cancer
4	VX-680	Drug Info	Phase 2	Solid tumour/cancer
5	AMG 900	Drug Info	Phase 1	Solid tumour/cancer
6	AZD-1152-HQPA	Drug Info	Phase 1	Solid tumour/cancer
7	CYC116	Drug Info	Phase 1	Solid tumour/cancer
8	GSK1070916	Drug Info	Phase 1	Advanced solid tumour
9	MK-5108	Drug Info	Phase 1	Solid tumour/cancer
10	R763	Drug Info	Phase 1	Haematological malignancy
11	Rosiglitazone + metformin	Drug Info	Phase 3	Diabetic complication
12	SNS-314	Drug Info	Phase 1	Solid tumour/cancer
13	TAK-901	Drug Info	Phase 1	Haematological malignancy
Discontinued Drug(s)	1 Discontinued Drug				1
1	PF-03814735	Drug Info	Discontinued in Phase 1	Advanced solid tumour
Investigative Drug(s)	1 Investigative Drug				1
1	Deguelin	Drug Info	Investigative	Esophageal squamous cell carcinoma

Target 2 ( Aurora B messenger RNA (AURKB mRNA) )

Target Type	Clinical trial Target
Disease	1 Target-related Disease				1
1	Prostate cancer [ICD-11: 2C82.0]
Clinical Trial Drug(s)	1 Clinical Trial Drug				1
1	PHA-739358	Drug Info	Phase 2	Prostate cancer

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han