General Information of the Compound
Compound ID
CP0675722
Compound Name
4-(2-(4-(6-methyl-8-(3-((3-methylpiperidin-1-yl)methyl)isothiazol-5-ylamino)imidazo[1,2-a]pyrazin-3-yl)-1H-pyrazol-1-yl)acetamido)pyridine 1-oxide
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Formula
C27H30N10O2S
Molecular Weight
558.672
Canonical SMILES
Cc1cn2c(-c3cnn(CC(=O)Nc4cc[n+]([O-])cc4)c3)cnc2c(Nc2cc(CN3CCCC(C)C3)ns2)n1
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InChI
InChI=1S/C27H30N10O2S/c1-18-4-3-7-34(13-18)16-22-10-25(40-33-22)32-26-27-28-12-23(37(27)14-19(2)30-26)20-11-29-35(15-20)17-24(38)31-21-5-8-36(39)9-6-21/h5-6,8-12,14-15,18H,3-4,7,13,16-17H2,1-2H3,(H,30,32)(H,31,38)
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InChIKey
ZXMSLCHJMUQKLG-UHFFFAOYSA-N
Physicochemical Property
logP
3.60532
Rotatable Bonds
8
Heavy Atom Count
40
Polar Areas
132.21
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
11
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL2022709
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01223, Aurora kinase B
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  1
1
EC50 = 402 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 91 nM