Brief Information of the Compound and Protein
Compound Name
4-(2-(4-(6-methyl-8-(3-((3-methylpiperidin-1-yl)methyl)isothiazol-5-ylamino)imidazo[1,2-a]pyrazin-3-yl)-1H-pyrazol-1-yl)acetamido)pyridine 1-oxide
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Canonical SMILES
Cc1cn2c(-c3cnn(CC(=O)Nc4cc[n+]([O-])cc4)c3)cnc2c(Nc2cc(CN3CCCC(C)C3)ns2)n1
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Compound Formula C27H30N10O2S
Compound Structure
Protein Name
Aurora kinase B
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
Other protein kinase group
>
Other protein kinase AUR family
Uniprot ID
Q96GD4
Gene Name
AURKB
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  1
1
EC50 = 402 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 91 nM