General Information of the Compound
Compound ID
CP0267383
Compound Name
Bisanilinopyrimidine, 9h
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Structure
Formula
C20H20ClN5O
Molecular Weight
381.867
Canonical SMILES
Clc1ccccc1Nc1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
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InChI
InChI=1S/C20H20ClN5O/c21-17-3-1-2-4-18(17)24-19-9-10-22-20(25-19)23-15-5-7-16(8-6-15)26-11-13-27-14-12-26/h1-10H,11-14H2,(H2,22,23,24,25)
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InChIKey
SWLCIRDDAOKOHP-UHFFFAOYSA-N
Physicochemical Property
logP
4.4538
Rotatable Bonds
5
Heavy Atom Count
27
Polar Areas
62.31
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 70702155
SID: 163438968
ChEMBL ID
CHEMBL2170409
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01223, Aurora kinase B
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000196 MDA-MB-468 Homo sapiens (Human)  1
1
IC50 < 1000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 194 nM