Protein Information

General Information of the Protein

Protein ID	PT01196
Protein Name	Somatostatin receptor type 5
Gene Name	SSTR5
Sequence	MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Peptide receptor (family A GPCR) > Short peptide receptor (family A GPCR) > Somatostatin receptor
Function	Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. Show/Hide
Uniprot ID	Primary ID: P35346 Secondarily ID: P34988 Q541E0 Q9UJI5 Show/Hide
HGNC ID	HGNC:11334
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0049566 Compound Info	15-28-Somatostatin-28 Show/Hide	C76H104N18O19S2	2
1	EC50 = 0.19 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0198320 Compound Info	3-[4-(4-Amino-butyl)-5-quinolin-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl]-1-(7-methyl-1H-indol-3-yl)-propan-1-one Show/Hide	C27H28N6OS	1
1	EC50 = 2.3 nM Bioactivity Info	TI LI LO TS
CP0050325 Compound Info	4-{3-[2-(7-Methyl-1H-indol-3-yl)-ethylsulfanyl]-5-quinolin-2-yl-[1,2,4]triazol-4-yl}-butylamine Show/Hide	C26H28N6S	1
1	EC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0152283 Compound Info	4-{3-[2-(6-Fluoro-1H-indol-3-yl)-ethylsulfanyl]-5-quinolin-2-yl-[1,2,4]triazol-4-yl}-butylamine Show/Hide	C25H25FN6S	1
1	EC50 = 44 nM Bioactivity Info	TI LI LO TS
CP0255232 Compound Info	4-{3-[2-(5-Chloro-1H-indol-3-yl)-ethylsulfanyl]-5-quinolin-2-yl-[1,2,4]triazol-4-yl}-butylamine Show/Hide	C25H25ClN6S	1
1	EC50 = 52 nM Bioactivity Info	TI LI LO TS
CP0396013 Compound Info	4-[8-[(4-cyclopropyl-1-propan-2-ylindol-3-yl)methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C29H33N3O4	2
1	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
CP0258604 Compound Info	4-[8-[[3-chloro-5-cyclopropyl-4-(2,4-difluorophenyl)phenyl]methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C30H27ClF2N2O4	2
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0444140 Compound Info	4-[2-oxo-8-[[1-propan-2-yl-4-(2,3,4-trifluorophenyl)indol-3-yl]methyl]-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C32H30F3N3O4	2
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.5 nM Bioactivity Info	TI LI LO TS
CP0407809 Compound Info	4-[8-[[4-(4-fluorophenyl)-1-propan-2-ylpyrrolo[2,3-b]pyridin-3-yl]methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C31H31FN4O4	1
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0422083 Compound Info	4-[8-[[4-chloro-2-cyclopropyl-5-(trifluoromethyl)phenyl]methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C25H24ClF3N2O4	2
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.7 nM Bioactivity Info	TI LI LO TS
CP0434967 Compound Info	4-[8-[(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C26H30N2O4S	2
1	IC50 = 0.6 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1.5 nM Bioactivity Info	TI LI LO TS
CP0467186 Compound Info	(4-amino-3-iodo)-D-Phe-c[Cys-(3-iodo)-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH2 Show/Hide	C50H66I2N12O10S2	1
1	IC50 = 0.65 nM Bioactivity Info	TI LI LO TS
CP0354747 Compound Info	4-[1-(benzenesulfonyl)piperidin-4-yl]-1-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]piperidine Show/Hide	C33H41FN2O4S	2
1	IC50 = 0.7 nM Bioactivity Info	TI LI LO TS
2	IC50 = 8.6 nM Bioactivity Info	TI LI LO TS
CP0109206 Compound Info	4-[8-[(4-cyclopropyl-1-propan-2-ylindol-3-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]benzoic acid Show/Hide	C30H35N3O3	2
1	IC50 = 0.7 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.8 nM Bioactivity Info	TI LI LO TS
CP0432457 Compound Info	4-[8-[[4-methyl-2-pyridin-4-yl-5-(trifluoromethyl)phenyl]methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C28H26F3N3O4	2
1	IC50 = 0.8 nM Bioactivity Info	TI LI LO TS
2	IC50 = 2.9 nM Bioactivity Info	TI LI LO TS
CP0407794 Compound Info	US8742110, 3-1 Show/Hide	C31H33FN2O6	2
1	IC50 = 0.8 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1.5 nM Bioactivity Info	TI LI LO TS
CP0397966 Compound Info	2-[9-(4-Amino-butyl)-3,18-dibenzyl-6-(1-hydroxy-ethyl)-12,15-bis-(1H-indol-3-ylmethyl)-2,5,8,11,14,17,20,25-octaoxo-1,4,7,10,13,16,19,24octaaza-cyclooctacos-1-yl]-acetamide Show/Hide	C60H74N12O10	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0431512 Compound Info	(4-amino)-D-Phe-c[Cys-(3-iodo)-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH2 Show/Hide	C50H67IN12O10S2	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0407797 Compound Info	4-[8-[[2-(1-methylpyrazol-4-yl)-5-(trifluoromethyl)phenyl]methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C26H25F3N4O4	2
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
2	IC50 = 5.5 nM Bioactivity Info	TI LI LO TS
CP0733024 Compound Info	4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoic acid trifluoromethyl acetate Show/Hide	C34H36F4N2O7	2
1	IC50 = 1.1 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1.2 nM Bioactivity Info	TI LI LO TS
CP0407795 Compound Info	4-[8-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]benzoic acid Show/Hide	C34H36F4N2O7	2
1	IC50 = 1.1 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1.2 nM Bioactivity Info	TI LI LO TS
CP0508415 Compound Info	US8742110, 5-10 Show/Hide	C26H30N2O5	2
1	IC50 = 1.1 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1.5 nM Bioactivity Info	TI LI LO TS
CP0871254 Compound Info	2-[25-Amino-13-(4-amino-butyl)-7,22-dibenzyl-10-(1-hydroxy-ethyl)-16,19-bis-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclohexacos-5-yl]-acetamide Show/Hide	C57H70N12O9S2	1
1	IC50 = 1.2 nM Bioactivity Info	TI LI LO TS
CP0411790 Compound Info	4-[8-[[3-cyclopropyl-4-(trifluoromethyl)phenyl]methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C25H25F3N2O4	2
1	IC50 = 1.2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1.8 nM Bioactivity Info	TI LI LO TS
CP0407799 Compound Info	4-[8-[[4-methyl-5-(trifluoromethyl)-2-(2,3,4-trifluorophenyl)phenyl]methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C29H24F6N2O4	2
1	IC50 = 1.2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 3.2 nM Bioactivity Info	TI LI LO TS
CP0461261 Compound Info	2-[13-(4-Amino-butyl)-7,22-dibenzyl-10-(1-hydroxy-ethyl)-16,19-bis-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclopentacos-5-yl]-acetamide Show/Hide	C56H67N11O9S2	1
1	IC50 = 1.3 nM Bioactivity Info	TI LI LO TS
CP0093165 Compound Info	N-[1-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]piperidin-4-yl]-5-methylpyridine-3-carboxamide Show/Hide	C29H34FN3O3	2
1	IC50 = 1.3 nM Bioactivity Info	TI LI LO TS
2	IC50 = 3.1 nM Bioactivity Info	TI LI LO TS
CP0078482 Compound Info	8-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-3-[(4-fluorophenyl)methyl]-1-oxa-8-azaspiro[4.5]decan-2-one Show/Hide	C32H35F2NO4	2
1	IC50 = 1.6 nM Bioactivity Info	TI LI LO TS
2	IC50 = 67 nM Bioactivity Info	TI LI LO TS
CP0109203 Compound Info	4-[8-[[2-cyclopropyl-5-(trifluoromethyl)phenyl]methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C25H25F3N2O4	2
1	IC50 = 2.1 nM Bioactivity Info	TI LI LO TS
2	IC50 = 2.4 nM Bioactivity Info	TI LI LO TS
CP0407806 Compound Info	4-[8-[[2-(2,4-dichlorophenyl)-4-methyl-5-(trifluoromethyl)phenyl]methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C29H25Cl2F3N2O4	2
1	IC50 = 2.4 nM Bioactivity Info	TI LI LO TS
2	IC50 = 3.2 nM Bioactivity Info	TI LI LO TS
CP0038580 Compound Info	(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37-[[2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-carboxybutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]propanoyl]amino]acetyl]amino]-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-10,16-bis[(1S)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-2-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecazacyclooctatriacontane-4-carboxylic acid Show/Hide	C137H207N41O39S3	1
1	IC50 = 2.5 nM Bioactivity Info	TI LI LO TS
CP0050675 Compound Info	(4R,7R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37-{2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]propanamido]-3-carbamoylpropanamido]-3-hydroxypropanamido]-3-carbamoylpropanoyl]pyrrolidin-2-yl]formamido}propanamido]-4-(methylsulfanyl)butanamido]propanoyl]pyrrolidin-2-yl]formamido}-5-carbamimidamidopentanamido]-4-carboxybutanamido]-5-carbamimidamidopentanamido]hexanamido]propanamido]a Show/Hide	C137H207N41O39S3	2
1	IC50 = 2.5 nM Bioactivity Info	TI LI LO TS
2	IC50 = 3.2 nM Bioactivity Info	TI LI LO TS
CP0136363 Compound Info	2-[[(3aS,6aR)-1-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrol-4-yl]amino]-1,3-benzoxazole-6-carboxylic acid Show/Hide	C32H34FN3O5	2
1	IC50 = 2.5 nM Bioactivity Info	TI LI LO TS
2	IC50 = 4.5 nM Bioactivity Info	TI LI LO TS
CP0406391 Compound Info	2-[13-(4-Amino-butyl)-7,22-dibenzyl-10-(1-hydroxy-ethyl)-16,19-bis-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclohexacos-5-yl]-acetamide Show/Hide	C57H69N11O9S2	1
1	IC50 = 2.8 nM Bioactivity Info	TI LI LO TS
CP0502524 Compound Info	(4-amino-3-iodo)-D-Phe-c[Cys-(3-iodo)-Tyr-D-Trp-Lys-Val-Cys]-Asp-NH2 Show/Hide	C50H64I2N12O11S2	1
1	IC50 = 2.9 nM Bioactivity Info	TI LI LO TS
CP0136365 Compound Info	8-[[1-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]piperidin-4-yl]methoxy]quinoline Show/Hide	C32H35FN2O3	2
1	IC50 = 2.9 nM Bioactivity Info	TI LI LO TS
2	IC50 = 67.8 nM Bioactivity Info	TI LI LO TS
CP0392742 Compound Info	4-[8-[[4-cyclopropyl-3-(trifluoromethyl)phenyl]methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C25H25F3N2O4	2
1	IC50 = 3.2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 4.1 nM Bioactivity Info	TI LI LO TS
CP0436081 Compound Info	(4-amino)-D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-D-Thr-NH2 Show/Hide	C50H68N12O10S2	1
1	IC50 = 3.4 nM Bioactivity Info	TI LI LO TS
CP0874662 Compound Info	2-amino-N-[(7R,10S,13R,16R,19R,22S)-13-(4-aminobutyl)-7,22-dibenzyl-5-(carbamoylmethyl)-10-[(1R)-1-hydroxyethyl]-16,19-bis(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaazacyclohexacosan-25-yl]-3-phenylpropanamide Show/Hide	C66H79N13O10S2	1
1	IC50 = 4.5 nM Bioactivity Info	TI LI LO TS
CP0489518 Compound Info	4-[8-[[4-methyl-5-(trifluoromethyl)-2-(2,3,4-trifluorophenyl)phenyl]methyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]benzoic acid Show/Hide	C30H26F6N2O3	2
1	IC50 = 4.9 nM Bioactivity Info	TI LI LO TS
2	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0042009 Compound Info	(4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-19-((R)-2-amino-3-phenylpropanamido)-10-(4-aminobutyl)-16-benzyl-7-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide Show/Hide	C49H65N11O10S2	1
1	IC50 = 5.1 nM Bioactivity Info	TI LI LO TS
CP0483646 Compound Info	(3S)-4-amino-3-[[(4S,7R,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2S)-2-amino-3-phenylpropanoyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-4-oxobutanoic acid Show/Hide	C50H65N11O11S2	1
1	IC50 = 5.6 nM Bioactivity Info	TI LI LO TS
CP0411791 Compound Info	4-[8-[(5-cyclopropyl-2-methoxypyridin-3-yl)methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C24H27N3O5	2
1	IC50 = 5.7 nM Bioactivity Info	TI LI LO TS
2	IC50 = 8.2 nM Bioactivity Info	TI LI LO TS
CP0251256 Compound Info	(4S,7S,10S,13S,16R,19S,22S,25S)-25-Acetylamino-13-(4-amino-butyl)-7,19,22-tribenzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclohexacosane-4-carboxylic acid Show/Hide	C56H68N10O11S2	1
1	IC50 = 7.4 nM Bioactivity Info	TI LI LO TS
CP0109190 Compound Info	1-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-4-[5-(4-fluorophenyl)-1H-imidazol-2-yl]piperidine Show/Hide	C31H33F2N3O2	2
1	IC50 = 7.6 nM Bioactivity Info	TI LI LO TS
2	IC50 = 247 nM Bioactivity Info	TI LI LO TS
CP0397351 Compound Info	2-Amino-N-[13-(4-amino-butyl)-7,22-dibenzyl-5-carbamoylmethyl-10-(1-hydroxy-ethyl)-16,19-bis-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclohexacos-25-yl]-3-phenyl-propionamide Show/Hide	C58H72N12O9S2	1
1	IC50 = 7.8 nM Bioactivity Info	TI LI LO TS
CP0396015 Compound Info	4-[8-[(2,2-dimethyl-3,4-dihydrochromen-8-yl)methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C26H30N2O5	2
1	IC50 = 7.9 nM Bioactivity Info	TI LI LO TS
2	IC50 = 8.4 nM Bioactivity Info	TI LI LO TS
CP0137483 Compound Info	(4S,7S,10S,13S,16R,19S,22S,25S)-25-Amino-13-(4-amino-butyl)-7,19,22-tribenzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclohexacosane-4-carboxylic acid Show/Hide	C54H66N10O10S2	1
1	IC50 = 8.7 nM Bioactivity Info	TI LI LO TS
CP0137482 Compound Info	(4R,7S,10S,13S,16R,19S,22S,25R)-25-Acetylamino-13-(4-amino-butyl)-7,19,22-tribenzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclopentacosane-4-carboxylic acid Show/Hide	C55H66N10O11S2	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0158450 Compound Info	(4R,7S,10S,13S,16R,19S,22S,25S)-25-Acetylamino-13-(4-amino-butyl)-7,19,22-tribenzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclohexacosane-4-carboxylic acid Show/Hide	C56H68N10O11S2	1
1	IC50 = 9.1 nM Bioactivity Info	TI LI LO TS
CP0160829 Compound Info	(4R,7S,10S,13S,16R,19S,22S,25R)-25-Amino-13-(4-amino-butyl)-7,19,22-tribenzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclohexacosane-4-carboxylic acid Show/Hide	C54H66N10O10S2	1
1	IC50 = 9.5 nM Bioactivity Info	TI LI LO TS
CP0514278 Compound Info	(4-amino-3-iodo)-D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH2 Show/Hide	C50H67IN12O10S2	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0847876 Compound Info	Radiolabeled octreotide derivative Show/Hide	C49H66N10O11S2	1
1	IC50 = 10.8 nM Bioactivity Info	TI LI LO TS
CP0153525 Compound Info	(4S,7S,10S,13S,16R,19S,22S,25R)-25-Acetylamino-13-(4-amino-butyl)-7,19,22-tribenzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclohexacosane-4-carboxylic acid Show/Hide	C56H68N10O11S2	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0154491 Compound Info	9-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-3-pyridin-3-ylsulfonyl-3,9-diazaspiro[5.5]undecane Show/Hide	C31H38FN3O4S	2
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
2	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0431525 Compound Info	(4-amino)-D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH2 Show/Hide	C50H68N12O10S2	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0251255 Compound Info	(3S,6S,9S,12S,15R,18S,21S,24S)-24-Acetylamino-12-(4-amino-butyl)-6,18,21-tribenzyl-9-((R)-1-hydroxy-ethyl)-15-(1H-indol-3-ylmethyl)-5,8,11,14,17,20,23-heptaoxo-1,2-dithia-4,7,10,13,16,19,22-heptaaza-cyclopentacosane-3-carboxylic acid Show/Hide	C55H66N10O11S2	1
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0407800 Compound Info	4-[8-[[4-(4-fluorophenyl)-3,5-dimethylphenyl]methyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]benzoic acid Show/Hide	C30H31FN2O3	2
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
2	IC50 = 36 nM Bioactivity Info	TI LI LO TS
CP0907790 Compound Info	2-[(7R,10S,13R,16R,19R,22S)-26-(2-amino-3-phenylpropanoyl)-13-(4-aminobutyl)-7,22-dibenzyl-10-[(1R)-1-hydroxyethyl]-16,19-bis(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclooctacosan-5-yl]acetamide Show/Hide	C67H81N13O10S2	1
1	IC50 = 18.2 nM Bioactivity Info	TI LI LO TS
CP0407812 Compound Info	4-[8-[[4-chloro-2-cyclopropyl-5-(trifluoromethyl)phenyl]methyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]benzoic acid Show/Hide	C26H26ClF3N2O3	2
1	IC50 = 19 nM Bioactivity Info	TI LI LO TS
2	IC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0160828 Compound Info	(3S,6S,9S,12S,15R,18S,21S,24S)-24-Acetylamino-12-(4-amino-butyl)-6,18,21-tribenzyl-9-((R)-1-hydroxy-ethyl)-15-(1H-indol-3-ylmethyl)-5,8,11,14,17,20,23-heptaoxo-1,2-dithia-4,7,10,13,16,19,22-heptaaza-cyclotetracosane-3-carboxylic acid Show/Hide	C54H64N10O11S2	1
1	IC50 = 21 nM Bioactivity Info	TI LI LO TS
CP0432478 Compound Info	4-chloro-2-[1-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]piperidin-4-yl]oxypyrimidine Show/Hide	C26H29ClFN3O3	2
1	IC50 = 21 nM Bioactivity Info	TI LI LO TS
2	IC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0049568 Compound Info	(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2S,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide Show/Hide	C49H66N10O10S2	1
1	IC50 = 21.8 nM Bioactivity Info	TI LI LO TS
CP0109204 Compound Info	4-[8-[(8-chloro-4,4-dimethyl-2,3-dihydrochromen-6-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]benzoic acid Show/Hide	C27H31ClN2O4	2
1	IC50 = 24 nM Bioactivity Info	TI LI LO TS
2	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0158451 Compound Info	(4R,7S,10S,13S,16R,19S,22S,25R)-25-Acetylamino-13-(4-amino-butyl)-7,19,22-tribenzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclohexacosane-4-carboxylic acid Show/Hide	C56H68N10O11S2	1
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0251257 Compound Info	(4S,7S,10S,13S,16R,19S,22S,25R)-25-Amino-13-(4-amino-butyl)-7,19,22-tribenzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclohexacosane-4-carboxylic acid Show/Hide	C54H66N10O10S2	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0251254 Compound Info	(4R,7S,10S,13S,16R,19S,22S,25R)-25-Acetylamino-13-(4-amino-butyl)-7,19,22-tribenzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cycloheptacosane-4-carboxylic acid Show/Hide	C57H70N10O11S2	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0455771 Compound Info	4-[8-[(7-methyl-1-propan-2-ylindol-3-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]benzoic acid Show/Hide	C28H33N3O3	2
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
2	IC50 = 33 nM Bioactivity Info	TI LI LO TS
CP0469425 Compound Info	(4-amino)-D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-D-Asp-NH2 Show/Hide	C50H66N12O11S2	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0440457 Compound Info	4-[8-[(4,4-dimethyl-1,1-dioxo-2,3-dihydrothiochromen-6-yl)methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C26H30N2O6S	2
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
2	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0036365 Compound Info	H-c(Cys3-Phe6-Phe7-DTrp8-Lys9-Thr10-Phe11-Cys14)-OH Show/Hide	C54H66N10O10S2	1
1	IC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0360266 Compound Info	(4R,7S,10S,13S,16R,19S,22S,25S)-25-Acetylamino-13-(4-amino-butyl)-7,19,22-tribenzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclopentacosane-4-carboxylic acid Show/Hide	C55H66N10O11S2	1
1	IC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0847825 Compound Info	Radiolabeled octreotide derivative Show/Hide	C49H65IN10O11S2	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0137479 Compound Info	(4S,7S,10S,13S,16R,19S,22S,25S)-25-Acetylamino-13-(4-amino-butyl)-7,19,22-tribenzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclopentacosane-4-carboxylic acid Show/Hide	C55H66N10O11S2	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0262548 Compound Info	(4S,7S,10S,13S,16R,19S,22S,25R)-25-Acetylamino-13-(4-amino-butyl)-7,19,22-tribenzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclopentacosane-4-carboxylic acid Show/Hide	C55H66N10O11S2	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0350110 Compound Info	(3R,6S,9S,12S,15R,18S,21S,24R)-24-Acetylamino-12-(4-amino-butyl)-6,18,21-tribenzyl-9-((R)-1-hydroxy-ethyl)-15-(1H-indol-3-ylmethyl)-5,8,11,14,17,20,23-heptaoxo-1,2-dithia-4,7,10,13,16,19,22-heptaaza-cyclopentacosane-3-carboxylic acid Show/Hide	C55H66N10O11S2	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0153218 Compound Info	(3R,6S,9S,12S,15R,18S,21S,24S)-24-Acetylamino-12-(4-amino-butyl)-6,18,21-tribenzyl-9-((R)-1-hydroxy-ethyl)-15-(1H-indol-3-ylmethyl)-5,8,11,14,17,20,23-heptaoxo-1,2-dithia-4,7,10,13,16,19,22-heptaaza-cyclopentacosane-3-carboxylic acid Show/Hide	C55H66N10O11S2	1
1	IC50 = 51 nM Bioactivity Info	TI LI LO TS
CP0483640 Compound Info	(4-amino)-D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Asp-NH2 Show/Hide	C50H66N12O11S2	1
1	IC50 = 54 nM Bioactivity Info	TI LI LO TS
CP0192734 Compound Info	(3R,6S,9S,12S,15R,18S,21S,24R)-24-Acetylamino-12-(4-amino-butyl)-6,18,21-tribenzyl-9-((R)-1-hydroxy-ethyl)-15-(1H-indol-3-ylmethyl)-5,8,11,14,17,20,23-heptaoxo-1,2-dithia-4,7,10,13,16,19,22-heptaaza-cyclotetracosane-3-carboxylic acid Show/Hide	C54H64N10O11S2	1
1	IC50 = 57 nM Bioactivity Info	TI LI LO TS
CP0158449 Compound Info	(3S,6S,9S,12S,15R,18S,21S,24R)-24-Acetylamino-12-(4-amino-butyl)-6,18,21-tribenzyl-9-((R)-1-hydroxy-ethyl)-15-(1H-indol-3-ylmethyl)-5,8,11,14,17,20,23-heptaoxo-1,2-dithia-4,7,10,13,16,19,22-heptaaza-cyclotetracosane-3-carboxylic acid Show/Hide	C54H64N10O11S2	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0854295 Compound Info	Radiolabeled octreotide derivative Show/Hide	C55H75IN10O16S2	1
1	IC50 = 64 nM Bioactivity Info	TI LI LO TS
CP0847877 Compound Info	Radiolabeled octreotide derivative Show/Hide	C49H65IN10O11S2	1
1	IC50 = 65 nM Bioactivity Info	TI LI LO TS
CP0407796 Compound Info	4-[8-[[3,5-dichloro-4-(trifluoromethoxy)phenyl]methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C22H19Cl2F3N2O5	2
1	IC50 = 66 nM Bioactivity Info	TI LI LO TS
2	IC50 = 95 nM Bioactivity Info	TI LI LO TS
CP0378916 Compound Info	(4-amino-3-iodo)-D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Asp-NH2 Show/Hide	C50H65IN12O11S2	1
1	IC50 = 74 nM Bioactivity Info	TI LI LO TS
CP0899676 Compound Info	Radiolabeled octreotide derivative Show/Hide	C61H85IN10O21S2	1
1	IC50 = 75 nM Bioactivity Info	TI LI LO TS
CP0457507 Compound Info	4-[8-[[4-(2,4-dichlorophenyl)-3-(trifluoromethoxy)phenyl]methyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]benzoic acid Show/Hide	C29H25Cl2F3N2O4	1
1	IC50 = 78 nM Bioactivity Info	TI LI LO TS
CP0146015 Compound Info	(3S,6S,9S,12S,15R,18S,21S,24R)-24-Acetylamino-12-(4-amino-butyl)-6,18,21-tribenzyl-9-((R)-1-hydroxy-ethyl)-15-(1H-indol-3-ylmethyl)-5,8,11,14,17,20,23-heptaoxo-1,2-dithia-4,7,10,13,16,19,22-heptaaza-cyclopentacosane-3-carboxylic acid Show/Hide	C55H66N10O11S2	1
1	IC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0303496 Compound Info	8-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione Show/Hide	C24H28FN3O4	2
1	IC50 = 83 nM Bioactivity Info	TI LI LO TS
2	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0160827 Compound Info	(4R,7S,10S,13S,16R,19S,22S,25S)-25-Acetylamino-13-(4-amino-butyl)-7,19,22-tribenzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cycloheptacosane-4-carboxylic acid Show/Hide	C57H70N10O11S2	1
1	IC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0845475 Compound Info	2-[(7R,10S,13R,16R,19R,22S)-26-[2-amino-3-(naphthalen-1-yl)propanoyl]-13-(4-aminobutyl)-7,22-dibenzyl-10-[(1R)-1-hydroxyethyl]-16,19-bis(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclooctacosan-5-yl]acetamide Show/Hide	C71H83N13O10S2	1
1	IC50 = 91 nM Bioactivity Info	TI LI LO TS
CP0192735 Compound Info	(3R,6S,9S,12S,15R,18S,21S,24S)-24-Acetylamino-12-(4-amino-butyl)-6,18,21-tribenzyl-9-((R)-1-hydroxy-ethyl)-15-(1H-indol-3-ylmethyl)-5,8,11,14,17,20,23-heptaoxo-1,2-dithia-4,7,10,13,16,19,22-heptaaza-cyclotetracosane-3-carboxylic acid Show/Hide	C54H64N10O11S2	1
1	IC50 = 107 nM Bioactivity Info	TI LI LO TS
CP0436365 Compound Info	(5R,8S,11S,14R,17S,20R)-11-(4-aminobutyl)-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-20-[[(2R)-2-amino-3-phenylpropanoyl]amino]-17-benzyl-8-[(1R)-1-hydroxyethyl]-14-(1H-indol-3-ylmethyl)-7,10,13,16,19-pentaoxo-1,2-dithia-6,9,12,15,18-pentazacyclodocosane-5-carboxamide Show/Hide	C51H69N11O10S2	1
1	IC50 = 109 nM Bioactivity Info	TI LI LO TS
CP0455770 Compound Info	4-[8-[(4,4-dimethyl-2,3-dihydrochromen-6-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]benzoic acid Show/Hide	C27H32N2O4	2
1	IC50 = 109 nM Bioactivity Info	TI LI LO TS
2	IC50 = 161 nM Bioactivity Info	TI LI LO TS
CP0847824 Compound Info	Radiolabeled octreotide derivative Show/Hide	C67H95IN10O26S2	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0422746 Compound Info	4-[(2R)-2-amino-3-[[(5R,8S,11S,14R,17S,20S)-11-(4-aminobutyl)-5-[[(2S)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]carbamoyl]-8-[(1R)-1-hydroxyethyl]-17-[(4-hydroxyphenyl)methyl]-14-(1H-indol-3-ylmethyl)-7,10,13,16,19-pentaoxo-1,2-dithia-6,9,12,15,18-pentazacyclodocos-20-yl]amino]-3-oxopropyl]-1H-pyrrole-2-carboxylic acid Show/Hide	C59H72N12O12S2	1
1	IC50 = 199 nM Bioactivity Info	TI LI LO TS
CP0860572 Compound Info	Radiolabeled octreotide derivative Show/Hide	C61H83IN10O22S2	1
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
CP0431909 Compound Info	4-[(2R)-2-amino-3-[[(4R,7S,10S,13R,16S,19S)-10-(4-aminobutyl)-4-[[(2S)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]carbamoyl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-3-oxopropyl]-1H-pyrrole-2-carboxylic acid Show/Hide	C57H68N12O12S2	1
1	IC50 = 218 nM Bioactivity Info	TI LI LO TS
CP0407810 Compound Info	4-[8-[[4-(4-fluorophenyl)-1-propan-2-ylindazol-3-yl]methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl]benzoic acid Show/Hide	C31H31FN4O4	2
1	IC50 = 222 nM Bioactivity Info	TI LI LO TS
2	IC50 = 276 nM Bioactivity Info	TI LI LO TS
CP0844993 Compound Info	Radiolabeled octreotide derivative Show/Hide	C58H77IN10O18S3	1
1	IC50 = 310 nM Bioactivity Info	TI LI LO TS
CP0441408 Compound Info	(5S)-1-(4-phenylbutyl)-5-[(4-phenylmethoxyphenyl)methyl]-3-(2-pyrrolidin-1-ylethyl)imidazolidine-2,4-dione Show/Hide	C33H39N3O3	1
1	IC50 = 316.23 nM Bioactivity Info	TI LI LO TS
CP0523960 Compound Info	(5S)-1-(4-phenylbut-3-ynyl)-5-[(4-phenylmethoxyphenyl)methyl]-3-(2-pyrrolidin-1-ylethyl)imidazolidine-2,4-dione Show/Hide	C33H35N3O3	1
1	IC50 = 316.23 nM Bioactivity Info	TI LI LO TS
CP0844992 Compound Info	Radiolabeled octreotide derivative Show/Hide	C67H93IN10O27S2	1
1	IC50 = 327 nM Bioactivity Info	TI LI LO TS
CP0395163 Compound Info	2-[4-[2-[[(2R)-1-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-4-[[(2R,3R)-1,3-dihydroxybutan-2-yl]carbamoyl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Show/Hide	C65H92N14O18S2	1
1	IC50 = 393 nM Bioactivity Info	TI LI LO TS
CP0381778 Compound Info	(5S)-5-(naphthalen-1-ylmethyl)-1-(4-phenylbut-3-ynyl)-3-(2-pyrrolidin-1-ylethyl)imidazolidine-2,4-dione Show/Hide	C30H31N3O2	1
1	IC50 = 398.11 nM Bioactivity Info	TI LI LO TS
CP0847861 Compound Info	Radiolabeled octreotide derivative Show/Hide	C58H77IN10O18S3	1
1	IC50 = 413 nM Bioactivity Info	TI LI LO TS
CP0402774 Compound Info	(5S)-1-[4-(4-methoxyphenyl)butyl]-5-[(4-phenylmethoxyphenyl)methyl]-3-(2-pyrrolidin-1-ylethyl)imidazolidine-2,4-dione Show/Hide	C34H41N3O4	1
1	IC50 = 501.19 nM Bioactivity Info	TI LI LO TS
CP0913773 Compound Info	Radiolabeled octreotide derivative Show/Hide	C55H73IN10O17S2	1
1	IC50 = 521 nM Bioactivity Info	TI LI LO TS
CP0395143 Compound Info	(2S,3R)-2-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-[[(2R)-3-phenyl-2-[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetyl]amino]propanoyl]amino]-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-hydroxybutanoic acid Show/Hide	C65H90N14O19S2	1
1	IC50 = 547 nM Bioactivity Info	TI LI LO TS
CP0460878 Compound Info	(2R)-6-amino-2-[[2-[3-[(2S)-1-amino-1-oxo-3-(4-phenylphenyl)propan-2-yl]-4-oxo-2-phenyl-1,3-thiazolidin-5-yl]acetyl]amino]hexanamide Show/Hide	C32H37N5O4S	1
1	IC50 = 1412.54 nM Bioactivity Info	TI LI LO TS
CP0434974 Compound Info	(3R,6S,9S,12R,15S,18R)-9-(4-aminobutyl)-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-18-[[(2R)-2-amino-3-phenylpropanoyl]amino]-15-benzyl-6-[(1R)-1-hydroxyethyl]-12-(1H-indol-3-ylmethyl)-5,8,11,14,17-pentaoxo-1,2-dithia-4,7,10,13,16-pentazacyclooctadecane-3-carboxamide Show/Hide	C47H61N11O10S2	1
1	IC50 > 1000 nM Bioactivity Info	TI LI LO TS
CP0490319 Compound Info	(4R,7S,10R,13S,16R,19S,22R,25S,28R,31S)-13,28-bis(4-aminobutyl)-25-(2-amino-2-oxoethyl)-31-[[2-[[(2S)-2-aminopropanoyl]amino]acetyl]amino]-19,22-dibenzyl-10-[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30-nonaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29-nonazacyclodotriacontane-4-carboxylic acid Show/Hide	C63H88N16O16S2	1
1	Kd = 0.32 nM Bioactivity Info	TI LI LO TS
CP0180818 Compound Info	[(1S,2R,3S,5R,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[3-[[(2R)-3-amino-2-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-oxopropyl]disulfanyl]propanoyl-methylamino]propanoate Show/Hide	C83H109ClN14O20S4	1
1	Kd = 9.6 nM Bioactivity Info	TI LI LO TS
CP0377595 Compound Info	Ala-Gly-cyclo[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys] (SRIF14) Show/Hide	C76H104N18O19S2	1
1	Ki = 2.32 nM Bioactivity Info	TI LI LO TS
CP0358208 Compound Info	(3R)-1,1-dibutyl-3-(5-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydropyrido[3,4-b]indole Show/Hide	C28H34N4	1
1	Ki = 2200 nM Bioactivity Info	TI LI LO TS
CP0389613 Compound Info	1'N-[1-[3-aminomethyl-(1R,3S)-cyclohexylmethylcarbamoyl]-2-(1H-3-indolyl)-(1S)-ethyl]spiro[1H-indene-1,4'-(hexahydropyridine)]-1'-carboxamide Show/Hide	C33H41N5O2	1
1	Ki = 3316 nM Bioactivity Info	TI LI LO TS
CP0406258 Compound Info	(3S)-1,1-dibutyl-3-(5-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydropyrido[3,4-b]indole Show/Hide	C28H34N4	1
1	Ki = 3700 nM Bioactivity Info	TI LI LO TS
CP0374362 Compound Info	1'N-[1-[3-aminomethyl-(1S,3R)-cyclohexylmethylcarbamoyl]-2-(1H-3-indolyl)-(1S)-ethyl]spiro[1H-indene-1,4'-(hexahydropyridine)]-1'-carboxamide Show/Hide	C33H41N5O2	1
1	Ki = 4470 nM Bioactivity Info	TI LI LO TS
CP0389612 Compound Info	1'N-[1-(3-aminomethylcyclohexylmethylcarbamoyl)-2-(1H-3-indolyl)-(1S)-ethyl]spiro[1H-indene-1,4'-(hexahydropyridine)]-1'-carboxamide Show/Hide	C33H41N5O2	1
1	Ki = 5017 nM Bioactivity Info	TI LI LO TS
CP0374364 Compound Info	1'N-[1-(4-aminobutylcarbamoyl)-2-(1H-3-indolyl)ethyl]spiro[1H-indene-1,4'-(hexahydropyridine)]-1'-carboxamide Show/Hide	C29H35N5O2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0374375 Compound Info	N-[(2R)-1-(5-aminopentylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide Show/Hide	C30H37N5O2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0847298 Compound Info	1-Cyclohexyl-3-(4-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydro-1H-beta-carboline oxalate salt Show/Hide	C28H30N4O4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0849672 Compound Info	1-Cyclohexyl-1-methyl-3-(4-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydro-1H-beta-carboline Show/Hide	C27H30N4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0893218 Compound Info	1,1-Dipentyl-3-(4-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydro-1H-beta-carboline Show/Hide	C30H38N4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000389 , CHO-DXB11

Cell Line Info

Cell Line ID: CL000880 , COS

Cell Line Info

Cell Line ID: CL000351 , Dede

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000050 , HEK293-A

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0049566 Compound Info	15-28-Somatostatin-28 Show/Hide	C76H104N18O19S2	8
1	EC50 = 0.065 nM
2	IC50 = 0.88 nM
3	IC50 = 10 nM
4	Ki = 0.44 nM
5	Ki = 1.4 nM
6	Ki < 2 nM
7	Ki = 2.32 nM
8	Ki = 120 nM
CP0407794 Compound Info	US8742110, 3-1 Show/Hide	C31H33FN2O6	1
1	IC50 = 0.7683 nM
CP0049568 Compound Info	(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2S,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide Show/Hide	C49H66N10O10S2	3
1	IC50 = 0.77 nM
2	Ki = 6.8 nM
3	Ki = 67.6 nM
CP0051091 Compound Info	(2S)-6-amino-N-benzyl-2-[(4R)-3-oxo-4-[(phenylacetyl)amino]-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]hexanamide Show/Hide	C33H37N5O3	1
1	IC50 = 1.2 nM
CP0508415 Compound Info	US8742110, 5-10 Show/Hide	C26H30N2O5	1
1	IC50 = 1.536 nM
CP0050675 Compound Info	(4R,7R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37-{2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]propanamido]-3-carbamoylpropanamido]-3-hydroxypropanamido]-3-carbamoylpropanoyl]pyrrolidin-2-yl]formamido}propanamido]-4-(methylsulfanyl)butanamido]propanoyl]pyrrolidin-2-yl]formamido}-5-carbamimidamidopentanamido]-4-carboxybutanamido]-5-carbamimidamidopentanamido]hexanamido]propanamido]a Show/Hide	C137H207N41O39S3	3
1	IC50 = 2.1 nM
2	IC50 = 2.4 nM
3	IC50 = 2.9 nM
CP0038580 Compound Info	(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37-[[2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-carboxybutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]propanoyl]amino]acetyl]amino]-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-10,16-bis[(1S)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-2-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecazacyclooctatriacontane-4-carboxylic acid Show/Hide	C137H207N41O39S3	3
1	IC50 = 2.4 nM
2	IC50 = 2.9 nM
3	IC50 = 3.9 nM
CP0042009 Compound Info	(4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-19-((R)-2-amino-3-phenylpropanamido)-10-(4-aminobutyl)-16-benzyl-7-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide Show/Hide	C49H65N11O10S2	2
1	IC50 = 2.7 nM
2	IC50 = 5.1 nM
CP0046225 Compound Info	(4R,7S,10S,13S,16S,19S,22S,25R)-25-amino-13-(4-aminobutyl)-7,19,22-tribenzyl-10-[(1R)-1-hydroxyethyl]-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacosane-4-carboxylic acid Show/Hide	C54H66N10O10S2	1
1	IC50 = 14 nM
CP0036365 Compound Info	H-c(Cys3-Phe6-Phe7-DTrp8-Lys9-Thr10-Phe11-Cys14)-OH Show/Hide	C54H66N10O10S2	1
1	IC50 = 46 nM
CP0686283 Compound Info	PTR-3046 Show/Hide	C59H77N11O10	1
1	IC50 = 67 nM
CP0151093 Compound Info	(3S,6S,9S,12R,15S,18S)-9-(4-Amino-butyl)-3-benzyl-15-(4-hydroxy-benzyl)-12-(1H-indol-3-ylmethyl)-6-isopropyl-1,18-dimethyl-1,4,7,10,13,16hexaaza-cyclooctadecane-2,5,8,11,14,17-hexaone Show/Hide	C44H56N8O7	1
1	IC50 = 81 nM
CP0278709 Compound Info	(1R,9R)-5-(4-Amino-butyl)-2-(1H-indol-3-ylmethyl)-7-naphthalen-1-ylmethyl-[1,4,7]thiadiazonane-3,6-dione Show/Hide	C30H34N4O2S	1
1	IC50 = 87 nM
CP0651917 Compound Info	5-((1R,3R)-1-(1-ethyl-1H-pyrazol-4-yl)-3-(4-(5-fluoropyridin-2-yl)-1H-imidazol-2-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-3-methyl-1,3,4-oxadiazol-2(3H)-one Show/Hide	C27H24FN9O2	1
1	IC50 = 1530 nM
CP0198320 Compound Info	3-[4-(4-Amino-butyl)-5-quinolin-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl]-1-(7-methyl-1H-indol-3-yl)-propan-1-one Show/Hide	C27H28N6OS	1
1	Ki = 0.38 nM
CP0152283 Compound Info	4-{3-[2-(6-Fluoro-1H-indol-3-yl)-ethylsulfanyl]-5-quinolin-2-yl-[1,2,4]triazol-4-yl}-butylamine Show/Hide	C25H25FN6S	1
1	Ki = 1.7 nM
CP0050325 Compound Info	4-{3-[2-(7-Methyl-1H-indol-3-yl)-ethylsulfanyl]-5-quinolin-2-yl-[1,2,4]triazol-4-yl}-butylamine Show/Hide	C26H28N6S	1
1	Ki = 2.1 nM
CP0255232 Compound Info	4-{3-[2-(5-Chloro-1H-indol-3-yl)-ethylsulfanyl]-5-quinolin-2-yl-[1,2,4]triazol-4-yl}-butylamine Show/Hide	C25H25ClN6S	1
1	Ki = 2.3 nM
CP0142929 Compound Info	N-[1-[(4-chloro-3-ethoxyphenyl)methyl]piperidin-4-yl]-5-methylpyridine-3-carboxamide Show/Hide	C21H26ClN3O2	1
1	Ki = 20 nM
CP0136960 Compound Info	(4R,7S,10S,13R,16S,19S)-10-(4-aminobutyl)-19-[[(2S)-2-amino-3-(4-chlorophenyl)propanoyl]amino]-N-[(2S)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide Show/Hide	C58H68ClN11O10S2	1
1	Ki = 48 nM

Clinical Information about the Protein

Target 1 ( Somatostatin receptor type 5 (SSTR5) )

Target Type	Successful Target
Disease	1 Target-related Disease				1
1	Cushing disease [ICD-11: 5A70]
Approved Drug(s)	1 Approved Drug				1
1	Pasireotide	Drug Info	Approved	Cushing disease

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han