4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one

(2R,3R,4S,5R)-2-(4-amino-5-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3,4-diol

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(2-pyrrolidin-1-yl-7-quinolyl)oxymethyl]tetrahydrofuran-3,4-diol

(1R,2S,3R,5S)-3-(4-amino-5-cyclohexyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-[2-(methylamino)-7-quinolyl]ethyl]cyclopentane-1,2-diol

(2R,3R,4S,5R)-2-(4-amino-5-cyclopentyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-[2-(methylamino)-7-quinolyl]ethyl]tetrahydrofuran-3,4-diol

(1R,2S,3R,5S)-3-(4-amino-5-cyclopentyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-[2-(ethylamino)-7-quinolyl]ethyl]cyclopentane-1,2-diol

(2R,3R,4S,5R)-5-(4-amino-5-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(2R,3R,4S,5R)-5-[4-amino-5-(1-methylimidazol-4-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-2-[[2-(ethylamino)-7-quinolyl]oxymethyl]-4-fluoro-tetrahydrofuran-3-ol

(2R,3R,4S,5R)-5-[4-amino-5-(1-methylimidazol-4-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-4-fluoro-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(2R,3R,4S,5R)-2-(4-amino-5-bromo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3,4-diol

(2R,3R,4S,5R)-5-[4-amino-5-(3-methylpyrazol-1-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-2-[[2-(azetidin-1-yl)-7-quinolyl]oxymethyl]-4-fluoro-tetrahydrofuran-3-ol

(2R,3S,5R)-5-(4-amino-5-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(1R,2S,3R,5S)-3-(4-amino-5-methyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-[2-(methylamino)-7-quinolyl]ethyl]cyclopentane-1,2-diol

(2R,3R,4S,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(1R,2S,3R,5S)-3-[4-amino-5-(hydroxymethyl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-[2-[2-(methylamino)-7-quinolyl]ethyl]cyclopentane-1,2-diol

(2R,3R,4S,5R)-5-(4-amino-5-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-2-[[2-(ethylamino)-7-quinolyl]oxymethyl]-4-fluoro-tetrahydrofuran-3-ol

(2R,3R,4S,5R)-2-(4-amino-5-cyclohexyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3,4-diol

(2R,3R,4S,5R)-2-[4-amino-5-(cyclopentylmethyl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3,4-diol

(2R,3S,5R)-5-(4-amino-5-cyclopentyl-pyrrolo[2,3-d]pyrimidin-7-yl)-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(2R,3R,4S,5R)-5-[4-amino-5-(1H-pyrazol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-4-fluoro-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(1S,2S,4R)-4-[4-amino-5-(1-methylpyrazol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-2-[2-[2-(azetidin-1-yl)-7-quinolyl]ethyl]cyclopentanol

(1S,2R,4R)-4-[4-amino-5-(1-methylpyrazol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-2-[[2-(azetidin-1-yl)-7-quinolyl]oxymethyl]cyclopentanol

(2R,3R,4S,5R)-5-[4-amino-5-[(2R)-tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidin-7-yl]-4-fluoro-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(2R,3R,4S,5R)-2-(4-amino-5-cyclopentyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[[2-(dimethylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3,4-diol

1-[7-[[(2R,3R,4S,5R)-5-[4-amino-5-(1-methylpyrazol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-4-fluoro-3-hydroxy-tetrahydrofuran-2-yl]methoxy]-2-quinolyl]azetidin-3-ol

(2R,3R,4S,5R)-5-(4-amino-5-cyclopentyl-pyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(2R,3R,4S,5R)-5-[4-amino-5-(cyclopropylmethyl)pyrrolo[2,3-d]pyrimidin-7-yl]-4-fluoro-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(2R,3R,4S,5R)-5-(4-amino-5-bromo-pyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(1R,2S,3R,5S)-3-(4-amino-5-cyclopentyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-[2-(methylamino)-7-quinolyl]ethyl]cyclopentane-1,2-diol

(2R,3R,4S,5R)-5-[4-amino-5-(2-pyridyl)pyrrolo[2,3-d]pyrimidin-7-yl]-4-fluoro-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(2R,3R,4S,5R)-5-(4-amino-5-cyclopropyl-pyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(2R,3S,5R)-5-[4-amino-5-(1-methylpyrazol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-2-[[2-(cyclopropylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

N1-(7-((5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-2-isopropylquinazolin-4-yl)-N2,N2-dimethylethane-1,2-diamine

7-((5-(4-amino-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-2-ethyl-N-(2-methoxyethyl)-1,5-naphthyridin-4-amine

7-((5-(4-amino-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-ethylquinolin-2-amine

7-(5-(((2-isopropyl-4-(piperazin-1-yl)quinolin-7-yl)oxy)methyl)pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

7-(5-(((2-ethyl-4-morpholinoquinolin-7-yl)oxy)methyl)pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

7-((5-(4-amino-5-(cyclopropylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methylquinolin-2-amine

7-((5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methylquinolin-2-amine

N1-(7-((5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-2-cyclobutylquinolin-4-yl)-N2,N2-dimethylethane-1,2-diamine

(R)-7-((5-(4-amino-5-(tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methylquinolin-2-amine

7-((5-(4-amino-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-cyclopropyl-2-ethyl-N-methylquinolin-4-amine

7-((5-(4-amino-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-(cyclopropylmethyl)-2-ethyl-N-methylquinolin-4-amine

7-(5-(2-(2-(azetidin-1-yl)quinolin-7-yl)ethyl)pyridin-3-yl)-5-(tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

7-((5-(4-amino-5-cyclopentyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methylquinolin-2-amine

N1-(7-(2-(5-(4-amino-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)ethyl)-2-ethylquinolin-4-yl)-N1,N2,N2-trimethylethane-1,2-diamine

7-((5-(4-amino-5-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-2-ethylquinolin-4-amine

7-((5-(4-amino-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-ethylquinolin-2-amine

7-((5-(4-amino-5-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methylquinolin-2-amine

7-((6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrazin-2-yl)methoxy)-N-methylquinolin-2-amine

7-((5-(4-amino-6-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methylquinolin-2-amine

7-((5-(4-amino-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-2-ethyl-N-methylquinolin-4-amine

7-((6-(4-amino-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrazin-2-yl)methoxy)-N-methylquinolin-2-amine

7-(2-(5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)ethyl)-N-methylquinolin-2-amine

7-((5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-2-ethyl-N-(2-methoxyethyl)quinolin-4-amine

7-((5-(4-amino-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methylquinolin-2-amine

7-(2-(6-(4-amino-5-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrazin-2-yl)ethyl)-N-methylquinolin-2-amine

7-(5-(((2-ethyl-4-(piperazin-1-yl)quinolin-7-yl)oxy)methyl)pyridin-3-yl)-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

N1-(7-(2-(5-(4-amino-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)ethyl)-2-ethyl-5-fluoroquinolin-4-yl)-N2,N2-dimethylethane-1,2-diamine

7-((5-(4-amino-5-(5-methylfuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methylquinolin-2-amine

7-((5-(4-amino-5-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methylquinolin-2-amine 2,2,2-trifluoroacetate

(2R,3R,4S,5R)-5-[4-amino-5-(1-methylpyrazol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-2-[[2-ethyl-4-(methylamino)-7-quinolyl]oxymethyl]-4-fluoro-tetrahydrofuran-3-ol

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[[2-(dimethylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3,4-diol

(1R,2S,3R,5S)-3-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-[2-(dimethylamino)-7-quinolyl]ethyl]cyclopentane-1,2-diol

(1R,2S,3R,5S)-3-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(2-pyridyl)ethyl]cyclopentane-1,2-diol

7-((6-(4-amino-5-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrazin-2-yl)methoxy)-N-methylquinolin-2-amine

7-(5-(((2-(azetidin-1-yl)quinolin-7-yl)oxy)methyl)pyridin-3-yl)-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine

7-((5-(4-amino-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-2-ethylquinolin-4-amine

7-((5-(4-amino-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methylquinolin-2-amine

7-((5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-2-ethylquinolin-4-amine

N1-(7-((5-(4-amino-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-2-ethyl-5-fluoroquinolin-4-yl)-N2,N2-dimethylethane-1,2-diamine

6-(3-(4-amino-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)-N-methylquinolin-2-amine

(3-(4-amino-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(((2-(methylamino)quinolin-7-yl)oxy)methyl)phenyl)methanol

7-((5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methyl-4-(3-morpholinopropyl)quinolin-2-amine

7-((5-(4-amino-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methylquinolin-2-amine

(3-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(((2-(methylamino)quinolin-7-yl)oxy)methyl)phenyl)methanol

7-((5-(4-amino-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-2-ethyl-N,N-dimethylquinolin-4-amine

7-((5-(4-amino-5-(1-methyl-1H-pyrazol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methylquinolin-2-amine

7-((5-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methylquinolin-2-amine

(2R,3R,4S,5R)-5-[4-amino-5-(4-methyl-1,3-oxazol-2-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-2-[[2-(azetidin-1-yl)quinolin-7-yl]oxymethyl]-4-fluorooxolan-3-ol

(2R,3R,4S,5R)-5-[4-amino-5-[(2S)-oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-7-yl]-2-[[2-(azetidin-1-yl)quinolin-7-yl]oxymethyl]-4-fluorooxolan-3-ol

(2R,3R,4S,5R)-2-(4-amino-5-cyclopentylpyrrolo[2,3-d]pyrimidin-7-yl)-5-[[2-(ethylamino)quinolin-7-yl]oxymethyl]oxolane-3,4-diol

(2R,3R,4S,5R)-2-[4-amino-5-(1-methylpyrazol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-[[2-(methylamino)quinolin-7-yl]oxymethyl]oxolane-3,4-diol

(2R,3R,4S,5R)-5-(4-amino-5-pyrazol-1-ylpyrrolo[2,3-d]pyrimidin-7-yl)-2-[[2-(azetidin-1-yl)quinolin-7-yl]oxymethyl]-4-fluorooxolan-3-ol

(2R,3R,4S,5R)-5-[4-amino-5-(5-methylfuran-2-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-4-fluoro-2-[[2-(methylamino)quinolin-7-yl]oxymethyl]oxolan-3-ol

(2R,3R,4S,5R)-5-(4-amino-5-oxazol-2-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(2R,3R,4S,5R)-2-(4-amino-5-cyclopentyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3,4-diol

(2R,3S,5R)-5-(4-amino-5-pyrazol-1-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-2-[[2-(azetidin-1-yl)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(2R,3R,4S,5R)-5-[4-amino-5-(1-methylpyrazol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-4-fluoro-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(2R,3R,4S,5R)-5-[4-amino-5-(1-methylpyrazol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-2-[[2-(cyclobutylamino)-7-quinolyl]oxymethyl]-4-fluoro-tetrahydrofuran-3-ol

(2R,3R,4S,5R)-5-[4-amino-5-(1-methylpyrazol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-2-[[2-(azetidin-1-yl)-7-quinolyl]oxymethyl]-4-fluoro-tetrahydrofuran-3-ol

(2R,3R,4S,5R)-5-[4-amino-5-[(2R)-tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidin-7-yl]-2-[[2-(azetidin-1-yl)-7-quinolyl]oxymethyl]-4-fluoro-tetrahydrofuran-3-ol

(2R,3S,5R)-5-[4-amino-5-(1-methylpyrazol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-2-[[2-(azetidin-1-yl)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

(2R,3R,4S,5R)-5-[4-amino-5-[(2S)-tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidin-7-yl]-4-fluoro-2-[[2-(methylamino)-7-quinolyl]oxymethyl]tetrahydrofuran-3-ol

7-(2-(5-(4-amino-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)ethyl)-N-ethylquinolin-2-amine

7-(2-(5-(4-amino-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)ethyl)-2-ethyl-N-(2-methoxyethyl)-N-methylquinolin-4-amine

(S)-7-(5-(((2-(azetidin-1-yl)quinolin-7-yl)oxy)methyl)pyridin-3-yl)-5-(tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

7-(5-(2-(2-(azetidin-1-yl)quinolin-7-yl)ethyl)pyridin-3-yl)-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

(S)-7-((5-(4-amino-5-(tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)methoxy)-N-methylquinolin-2-amine

7-(2-(5-(4-amino-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)ethyl)-N-methylquinolin-2-amine

7-(2-(5-(4-amino-5-(1-methyl-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyridin-3-yl)ethyl)-2-ethyl-N-(2-methoxyethyl)quinolin-4-amine

7-(5-(((2-(azetidin-1-yl)quinolin-7-yl)oxy)methyl)pyridin-3-yl)-5-(1-(2-methoxyethyl)-1H-pyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine