General Information of the Compound
Compound ID
CP0961089
Compound Name
(S)-7-(5-(((2-(azetidin-1-yl)quinolin-7-yl)oxy)methyl)pyridin-3-yl)-5-(tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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Structure
Formula
C28H27N7O2
Molecular Weight
493.571
Canonical SMILES
Nc1ncnc2c1c([C@@H]1CCCO1)cn2-c1cncc(COc2ccc3ccc(N4CCC4)nc3c2)c1
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InChI
InChI=1S/C28H27N7O2/c29-27-26-22(24-3-1-10-36-24)15-35(28(26)32-17-31-27)20-11-18(13-30-14-20)16-37-21-6-4-19-5-7-25(33-23(19)12-21)34-8-2-9-34/h4-7,11-15,17,24H,1-3,8-10,16H2,(H2,29,31,32)/t24-/m0/s1
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InChIKey
RNODSVXHVZCKSE-DEOSSOPVSA-N
Physicochemical Property
logP
4.5865
Rotatable Bonds
6
Heavy Atom Count
37
Polar Areas
104.21
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156304160
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05070, N6-adenosine-methyltransferase catalytic subunit
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000071 MOLM-13 Homo sapiens (Human)  1
1
IC50 < 1000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 < 10 nM