| Compound ID |
Compound Name |
Compound Formula |
|
CP0534196
|
2-[(2S)-4-[7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
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C33H39N7O2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
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CP0535104
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2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
Show/Hide
|
C32H36ClN7O2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
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CP0473024
|
2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-[(E)-4-fluorobut-2-enoyl]piperazin-2-yl]acetonitrile
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|
C33H37ClFN7O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
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CP0534195
|
2-[(2S)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[8-(trifluoromethyl)naphthalen-1-yl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
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C33H36F3N7O2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
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CP0535103
|
2-[(2S)-4-[7-(8-ethylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
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|
C34H41N7O2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
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CP0570224
|
2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-[(E)-4-methoxybut-2-enoyl]piperazin-2-yl]acetonitrile
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|
C34H40ClN7O3
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
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CP0460810
|
2-[(2S)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
Show/Hide
|
C32H37N7O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0552434
|
7-(2-amino-3,5-dichloro-6-fluorophenyl)-6-chloro-4-[(3S)-3-(cyanomethyl)-4-prop-2-enoylpiperazin-1-yl]-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-2-oxo-1,8-naphthyridine-3-carbonitrile
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|
C33H28Cl3FN8O2
|
1
|
| 1 |
IC50 = 12.25 nM
|
|
|
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CP0015072
|
Adagrasib
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|
C32H35ClFN7O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
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CP0473021
|
2-[4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
Show/Hide
|
C32H37N7O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
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CP0444489
|
7-(2-amino-3,5-dichloro-6-fluorophenyl)-6-chloro-4-[3-(cyanomethyl)-4-prop-2-enoylpiperazin-1-yl]-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-2-oxo-1,8-naphthyridine-3-carbonitrile
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|
C33H28Cl3FN8O2
|
1
|
| 1 |
IC50 = 14.92 nM
|
|
|
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CP0444490
|
7-(2-amino-3,5-dichloro-6-fluorophenyl)-6-chloro-1-[4,6-di(propan-2-yl)pyrimidin-5-yl]-2-oxo-4-(4-prop-2-enoylpiperazin-1-yl)-1,8-naphthyridine-3-carbonitrile
Show/Hide
|
C32H30Cl3FN8O2
|
1
|
| 1 |
IC50 = 18.51 nM
|
|
|
|
CP0570618
|
7-(2-amino-6-fluorophenyl)-6-chloro-1-[4,6-di(propan-2-yl)pyrimidin-5-yl]-2-oxo-4-(4-prop-2-enoylpiperazin-1-yl)-1,8-naphthyridine-3-carbonitrile
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|
C32H32ClFN8O2
|
1
|
| 1 |
IC50 = 20.1 nM
|
|
|
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CP0416375
|
2-[(2S)-4-[7-(8-methoxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
Show/Hide
|
C33H39N7O3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
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CP0533768
|
7-(2-amino-3,5-dichloro-6-fluorophenyl)-6-chloro-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-oxo-1,8-naphthyridine-3-carbonitrile
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|
C32H29Cl3FN7O2
|
1
|
| 1 |
IC50 = 28.8 nM
|
|
|
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CP0563420
|
6-chloro-7-(2-fluorophenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-2-oxo-4-(4-prop-2-enoylpiperazin-1-yl)-1,8-naphthyridine-3-carbonitrile
Show/Hide
|
C31H28ClFN6O2
|
1
|
| 1 |
IC50 = 29.9 nM
|
|
|
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CP0232483
|
6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one
Show/Hide
|
C30H30F2N6O3
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
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CP0533767
|
7-(2-amino-3,5-dichloro-6-fluorophenyl)-6-chloro-4-[(3S,5R)-3,5-dimethyl-4-prop-2-enoylpiperazin-1-yl]-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-2-oxo-1,8-naphthyridine-3-carbonitrile
Show/Hide
|
C33H31Cl3FN7O2
|
1
|
| 1 |
IC50 = 38.11 nM
|
|
|
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CP0559840
|
8-[4-[(3S)-3-(cyanomethyl)-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]naphthalene-1-carbonitrile
Show/Hide
|
C33H36N8O2
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
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CP0349547
|
1-[4-[7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
|
C30H36N6O3
|
2
|
| 1 |
IC50 = 70 nM
|
|
|
| 2 |
IC50 = 142 nM
|
|
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CP0211364
|
1-[4-[(6R,7R)-7-(5-chloro-6-methyl-1H-indazol-4-yl)-2-[3-(dimethylamino)azetidin-1-yl]-6-methyl-5,6,7,8-tetrahydroquinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
|
C29H37ClN8O
|
1
|
| 1 |
IC50 = 116 nM
|
|
|
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CP0356252
|
1-[4-[(6R,7R)-6-methyl-7-(5-methyl-1H-indazol-4-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
|
C30H39N7O2
|
1
|
| 1 |
IC50 = 129 nM
|
|
|
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CP0945004
|
(S)-1-(4-(7-(5,6-Dimethyl-1H-indazol-4-yl)-2-((1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-1-yl)prop-2-en-1-one
Show/Hide
|
C29H38N8O2
|
1
|
| 1 |
IC50 = 254 nM
|
|
|
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CP0903575
|
(S)-1-(4-(2-((1-Methylpyrrolidin-2-yl)methoxy)-7-(5-(trifluoromethyl)-1H-indazol-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-1-yl)prop-2-en-1-one
Show/Hide
|
C28H33F3N8O2
|
1
|
| 1 |
IC50 = 351 nM
|
|
|
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CP0230698
|
1-[4-[(6R,7R)-7-(5-chloro-1H-indazol-4-yl)-2-[3-(dimethylamino)azetidin-1-yl]-6-methyl-5,6,7,8-tetrahydroquinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
|
C28H35ClN8O
|
1
|
| 1 |
IC50 = 395 nM
|
|
|
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CP0469455
|
1-[4-[(6R,7R)-2-[3-(dimethylamino)propoxy]-6-methyl-7-(5-methyl-1H-indazol-4-yl)-5,6,7,8-tetrahydroquinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
|
C29H39N7O2
|
1
|
| 1 |
IC50 = 468 nM
|
|
|
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CP0349546
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1-[4-[2-[(2S)-1-(dimethylamino)propan-2-yl]oxy-7-(3-hydroxynaphthalen-1-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
|
C29H36N6O3
|
1
|
| 1 |
IC50 = 540 nM
|
|
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CP0508163
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1-[4-[(6R,7R)-6-methyl-7-(5-methyl-1H-indazol-4-yl)-5,6,7,8-tetrahydroquinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
|
C24H28N6O
|
1
|
| 1 |
IC50 = 780 nM
|
|
|
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CP0520941
|
2-[(2R)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
Show/Hide
|
C32H37N7O2
|
1
|
| 1 |
IC50 = 1020 nM
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CP0903594
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(S)-1-(4-(7-(5-Ethyl-1H-indazol-4-yl)-2-((1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-1-yl)prop-2-en-1-one
Show/Hide
|
C29H38N8O2
|
1
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| 1 |
IC50 = 1080 nM
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CP0953363
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(S)-1-(4-(7-(5-Isopropyl-1H-indazol-4-yl)-2-((1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-1-yl)prop-2-en-1-one
Show/Hide
|
C30H40N8O2
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1
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| 1 |
IC50 = 1180 nM
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CP0306601
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1-[4-[2-[3-(dimethylamino)propoxy]-7-(3-hydroxynaphthalen-1-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
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C29H36N6O3
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1
|
| 1 |
IC50 = 1500 nM
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CP0903593
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(S)-1-(4-(7-(5-Methyl-1H-indazol-4-yl)-2-((1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-1-yl)prop-2-en-1-one
Show/Hide
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C28H36N8O2
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1
|
| 1 |
IC50 = 1500 nM
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CP0147091
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1-[4-[2-[2-(dimethylamino)ethoxy]-7-(3-hydroxynaphthalen-1-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
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C28H34N6O3
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1
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| 1 |
IC50 = 1900 nM
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CP0473101
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2-[1-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-4-prop-2-enoylpiperazin-2-yl]acetonitrile
Show/Hide
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C32H37N7O2
|
1
|
| 1 |
IC50 = 3320 nM
|
|
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CP0570223
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1-[4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
|
C30H36N6O2
|
1
|
| 1 |
IC50 = 4400 nM
|
|
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CP0460809
|
1-[3-(hydroxymethyl)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
|
C31H38N6O3
|
1
|
| 1 |
IC50 = 4530 nM
|
|
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CP0517563
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1-[2-(hydroxymethyl)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
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C31H38N6O3
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1
|
| 1 |
IC50 = 4630 nM
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CP0559839
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1-[3-(2-hydroxyethyl)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
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C32H40N6O3
|
1
|
| 1 |
IC50 = 4840 nM
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CP0141410
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1-[4-[7-(3-hydroxynaphthalen-1-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
|
C24H25N5O2
|
1
|
| 1 |
IC50 = 7600 nM
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|
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CP0127618
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1-[4-[7-(7-hydroxynaphthalen-1-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
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C24H25N5O2
|
1
|
| 1 |
IC50 > 16000 nM
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|
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CP0178858
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1-[4-(7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl)piperazin-1-yl]prop-2-en-1-one
Show/Hide
|
C24H25N5O
|
1
|
| 1 |
IC50 > 16000 nM
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|
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CP0188599
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1-[4-[7-(5-methyl-1H-indazol-4-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
|
C22H25N7O
|
1
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| 1 |
IC50 > 16000 nM
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CP0306600
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1-[4-[7-(2-fluoro-6-hydroxyphenyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
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C20H22FN5O2
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1
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| 1 |
IC50 > 16000 nM
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|
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CP0417487
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1-[4-[7-(2-fluoro-5-hydroxyphenyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
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C20H22FN5O2
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1
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| 1 |
IC50 > 16000 nM
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CP0473023
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2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-methoxyprop-2-enoyl)piperazin-2-yl]acetonitrile
Show/Hide
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C33H38ClN7O3
|
1
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| 1 |
IC50 > 5000 nM
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CP0524392
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1-[2-(2-hydroxyethyl)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
Show/Hide
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C32H40N6O3
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1
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| 1 |
IC50 > 5000 nM
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