| Compound ID |
Compound Name |
Compound Formula |
|
CP0002050
|
US9777008, Compound 233
Show/Hide
|
C29H33N7O2
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0003301
|
US9745291, Compound 101
Show/Hide
|
C25H31N3O4
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0003839
|
US9745291, Compound 269
Show/Hide
|
C23H25N3O3
|
2
|
| 1 |
EC50 < 100 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
|
CP0003846
|
US10307413, Compound 1
Show/Hide
|
C24H25N3O2
|
2
|
| 1 |
EC50 < 100 nM
|
|
|
| 2 |
IC50 = 37 nM
|
|
|
|
CP0003847
|
US10307413, Compound 9
Show/Hide
|
C24H25N3O2
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0006308
|
2-(2-(2-((3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)amino)pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-morpholinoethanone
Show/Hide
|
C29H33N7O3
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0006311
|
US10307413, Compound 20
Show/Hide
|
C24H25N3O2
|
2
|
| 1 |
EC50 < 100 nM
|
|
|
| 2 |
IC50 = 32 nM
|
|
|
|
CP0006571
|
1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-4-(3-morpholinophenyl)piperazin-2-one
Show/Hide
|
C26H34N4O3
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0006588
|
US9777008, Compound 255
Show/Hide
|
C28H33N7O
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0006605
|
US9777008, Compound 246
Show/Hide
|
C30H35N7O2
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0006829
|
US9745291, Compound 38
Show/Hide
|
C22H29N3O3
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0007009
|
US9745291, Compound 81
Show/Hide
|
C23H29N3O4
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0007010
|
US9745291, Compound 109
Show/Hide
|
C22H29N3O5S
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0007091
|
US9745291, Compound 6
Show/Hide
|
C23H25N3O3
|
2
|
| 1 |
EC50 < 100 nM
|
|
|
| 2 |
IC50 = 36 nM
|
|
|
|
CP0007096
|
US9745291, Compound 82
Show/Hide
|
C22H26N4O3
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0007201
|
US10307413, Compound 8
Show/Hide
|
C24H25N3O2
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0007542
|
US10307413, Compound 13
Show/Hide
|
C24H25N3O2
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0007543
|
US10307413, Compound 16
Show/Hide
|
C24H31N3O3
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0007548
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((4-(3-methyl-3H-imidazo[4,5-b]pyridin-5-yl)pyridin-2-yl)amino)propan-2-ol
Show/Hide
|
C24H26N6O
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0010207
|
US9745291, Compound 77
Show/Hide
|
C24H31N3O4
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0010208
|
US9745291, Compound 92
Show/Hide
|
C22H24N4O3
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0010213
|
US9745291, Compound 107
Show/Hide
|
C24H32N4O5S
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0010451
|
US9777008, Compound 199
Show/Hide
|
C25H27N5O
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0010458
|
US9777008, Compound 247
Show/Hide
|
C30H36N8O2
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0010563
|
US9745291, Compound 37
Show/Hide
|
C21H26N2O5S
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0010570
|
US9745291, Compound 75
Show/Hide
|
C25H33N3O4
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0010573
|
US9745291, Compound 102
Show/Hide
|
C24H31N3O5S
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0010795
|
US9745291, Compound 100
Show/Hide
|
C22H26N2O5
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0010796
|
US9745291, Compound 111
Show/Hide
|
C24H31N3O6S
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0010798
|
US10307413, Compound 3
Show/Hide
|
C19H22N2O2
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0010865
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((4-(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl)pyridin-2-yl)amino)propan-2-ol
Show/Hide
|
C24H26N6O
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0012001
|
US10307413, Compound 2
Show/Hide
|
C23H26N4O2
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0012864
|
US9745291, Compound 93
Show/Hide
|
C25H33N3O4
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0013929
|
US9745291, Compound 39
Show/Hide
|
C24H27N3O3
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0013933
|
US9745291, Compound 73
Show/Hide
|
C24H27N3O3
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0013935
|
US9745291, Compound 98
Show/Hide
|
C24H27N3O4
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0013942
|
US9777008, Compound 256
Show/Hide
|
C30H35N7O2
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0014276
|
US10307413, Compound 41
Show/Hide
|
C27H37N3O3
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0014293
|
US9745291, Compound 110
Show/Hide
|
C24H31N3O5S
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0014987
|
US10307413, Compound 40
Show/Hide
|
C25H33N3O3
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0636066
|
2-(2-(1H-pyrazol-3-yl)phenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide
Show/Hide
|
C23H26N4O3
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0637179
|
(R)-2-(2-(1H-pyrazol-3-yl)phenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide
Show/Hide
|
C23H26N4O3
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
|
CP0002032
|
US10307413, Compound 26
Show/Hide
|
C21H25N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0002033
|
US10307413, Compound 36
Show/Hide
|
C24H32N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0002042
|
US9777008, Compound 47
Show/Hide
|
C23H30N2O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0002043
|
US9777008, Compound 53
Show/Hide
|
C25H35N3O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0002046
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4-methylpyridin-3-yl)phenoxy)propan-2-ol
Show/Hide
|
C24H26N2O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003051
|
US9745291, Compound 1
Show/Hide
|
C20H24N2O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003052
|
US9745291, Compound 8
Show/Hide
|
C21H23N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003053
|
US9745291, Compound 20
Show/Hide
|
C21H26N2O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003055
|
US9745291, Compound 54
Show/Hide
|
C24H28N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003056
|
US9745291, Compound 65
Show/Hide
|
C20H25N3O5S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003281
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-(tetrahydro-2H-pyran-4-yl)-1H-benzo[d]imidazol-6-yl)phenoxy)propan-2-ol
Show/Hide
|
C30H33N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003284
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-yl)phenoxy)propan-2-ol
Show/Hide
|
C26H27N3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003285
|
US10307413, Compound 48
Show/Hide
|
C24H30N2O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003300
|
US9745291, Compound 79
Show/Hide
|
C24H32N4O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003303
|
US10307413, Compound 14
Show/Hide
|
C23H29N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003820
|
US9745291, Compound 64
Show/Hide
|
C24H30N2O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003841
|
US9745291, Compound 80
Show/Hide
|
C23H27N3O5
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003842
|
US9745291, Compound 86
Show/Hide
|
C26H35N3O5
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003845
|
US9745291, Compound 119
Show/Hide
|
C23H29N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003848
|
1-(3,4-Dihydroisoquinolin-2(1H)-yl)-3-((4-(1-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)propan-2-ol
Show/Hide
|
C24H26N6O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003859
|
US9777008, Compound 205
Show/Hide
|
C24H26N6O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003862
|
US9777008, Compound 269
Show/Hide
|
C28H29N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003863
|
N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-N-(3-(1-methyl-1H-benzo[d]imidazol-6-yl)phenyl)acetamide
Show/Hide
|
C28H30N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003866
|
N-(2-hydroxy-3-(isoindolin-2-yl)propyl)-2-(2-(methylsulfonyl)phenoxy)acetamide
Show/Hide
|
C20H24N2O5S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0003870
|
US10307413, Compound 43
Show/Hide
|
C24H31N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0004036
|
1-(3,4-Dihydroisoquinolin-2(1H)-yl)-3-((4-(1-methyl-1H-benzo[d]imidazol-6-yl)pyridin-2-yl)amino)propan-2-ol
Show/Hide
|
C25H27N5O
|
2
|
| 1 |
EC50 = 101 nM
|
|
|
| 2 |
IC50 = 180 nM
|
|
|
|
CP0005521
|
US9777008, Compound 275
Show/Hide
|
C25H27N5O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006309
|
US9777008, Compound 240
Show/Hide
|
C28H32N6O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006310
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-methyl-1H-pyrazolo[4,3-c]pyridin-6-yl)phenoxy)propan-2-ol
Show/Hide
|
C25H26N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006338
|
US10307413, Compound 38
Show/Hide
|
C24H31N3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006566
|
1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-4-(5-morpholinopyridin-3-yl)piperazin-2-one
Show/Hide
|
C25H33N5O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006570
|
US10307413, Compound 23
Show/Hide
|
C21H25N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006583
|
US9777008, Compound 191
Show/Hide
|
C24H25N5O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006584
|
US9777008, Compound 221
Show/Hide
|
C31H36N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006585
|
US9777008, Compound 224
Show/Hide
|
C24H26N6O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006587
|
US9777008, Compound 252
Show/Hide
|
C30H36N6O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006592
|
US10118918, Compound 7
Show/Hide
|
C22H24N4O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006594
|
US9745291, Compound 7
Show/Hide
|
C20H23FN2O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006597
|
US9745291, Compound 91
Show/Hide
|
C23H29N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006616
|
US10307413, Compound 30
Show/Hide
|
C25H34N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006830
|
US9745291, Compound 49
Show/Hide
|
C24H31N3O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006831
|
US9745291, Compound 88
Show/Hide
|
C24H33N3O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006834
|
US9745291, Compound 149
Show/Hide
|
C24H31N3O6S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006842
|
US9777008, Compound 254
Show/Hide
|
C26H29N7O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006843
|
US9777008, Compound 263
Show/Hide
|
C31H34N4O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0006846
|
N-(2-hydroxy-3-(isoindolin-2-yl)propyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide
Show/Hide
|
C23H25N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007093
|
US10307413, Compound 45
Show/Hide
|
C23H29N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007094
|
US9745291, Compound 42
Show/Hide
|
C21H27N3O5S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007095
|
US10150758, Compound 9
Show/Hide
|
C22H26ClN3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007097
|
US9745291, Compound 84
Show/Hide
|
C25H34N4O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007098
|
US9745291, Compound 99
Show/Hide
|
C24H31N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007100
|
US9745291, Compound 142
Show/Hide
|
C22H29N3O5S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007104
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-(1-methylazetidin-3-yl)-1H-benzo[d]imidazol-6-yl)phenoxy)propan-2-ol
Show/Hide
|
C29H32N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007109
|
(R)No FitNNo Fit((S)-2-hydroxy-3-(isoindolin-2-yl)propyl)-2-(quinolin-8-yloxy)propanamide
Show/Hide
|
C23H25N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007196
|
US10307413, Compound 29
Show/Hide
|
C24H32N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007200
|
US10307413, Compound 37
Show/Hide
|
C23H29N3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007204
|
US10307413, Compound 21
Show/Hide
|
C19H23N3O4S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007205
|
1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-4-(quinolin-8-yl)piperazin-2-one
Show/Hide
|
C25H28N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007206
|
4-(4-chlorophenyl)-1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)piperazin-2-one
Show/Hide
|
C22H26ClN3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007263
|
US9745291, Compound 16
Show/Hide
|
C20H23FN2O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007266
|
US9777008, Compound 222
Show/Hide
|
C30H33N5O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007272
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl)phenoxy)propan-2-ol
Show/Hide
|
C25H26N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007516
|
US9745291, Compound 44
Show/Hide
|
C23H25N3O3
|
2
|
| 1 |
EC50 = 101 nM
|
|
|
| 2 |
IC50 = 327 nM
|
|
|
|
CP0007532
|
US10307413, Compound 24
Show/Hide
|
C20H25N3O4S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007533
|
US9745291, Compound 29
Show/Hide
|
C21H25N3O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007535
|
US9745291, Compound 76
Show/Hide
|
C24H27N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0007549
|
US9777008, Compound 244
Show/Hide
|
C31H36N6O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0009303
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-methyl-1H-benzo[d]imidazol-6-yl)phenoxy)propan-2-ol
Show/Hide
|
C26H27N3O2
|
2
|
| 1 |
EC50 = 101 nM
|
|
|
| 2 |
IC50 = 435 nM
|
|
|
|
CP0010198
|
US9745291, Compound 11
Show/Hide
|
C21H23N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010199
|
US9745291, Compound 15
Show/Hide
|
C21H26N2O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010200
|
US9745291, Compound 17
Show/Hide
|
C21H23N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010202
|
US9745291, Compound 27
Show/Hide
|
C22H29N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010203
|
US9745291, Compound 46
Show/Hide
|
C22H26N4O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010206
|
US9745291, Compound 74
Show/Hide
|
C24H27N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010209
|
US9745291, Compound 94
Show/Hide
|
C28H34N4O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010210
|
US9745291, Compound 95
Show/Hide
|
C25H31N5O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010211
|
US9745291, Compound 103
Show/Hide
|
C25H33N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010212
|
US9745291, Compound 105
Show/Hide
|
C25H30N4O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010214
|
US9745291, Compound 112
Show/Hide
|
C22H27N3O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010215
|
US9745291, Compound 123
Show/Hide
|
C21H27N3O5S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010453
|
US9777008, Compound 207
Show/Hide
|
C24H26N6O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010460
|
US9777008, Compound 265
Show/Hide
|
C27H29N5O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010465
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(quinolin-8-yl)phenoxy)propan-2-ol
Show/Hide
|
C27H26N2O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010478
|
US10307413, Compound 15
Show/Hide
|
C25H33N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010558
|
US9745291, Compound 12
Show/Hide
|
C21H26N2O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010560
|
US9745291, Compound 19
Show/Hide
|
C21H26N2O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010561
|
US9745291, Compound 28
Show/Hide
|
C21H27N3O5S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010562
|
US9745291, Compound 30
Show/Hide
|
C22H26N4O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010564
|
US9745291, Compound 40
Show/Hide
|
C26H34N2O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010565
|
US9745291, Compound 47
Show/Hide
|
C21H26N2O5S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010568
|
US9745291, Compound 66
Show/Hide
|
C24H26N2O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010569
|
US9745291, Compound 71
Show/Hide
|
C27H35N5O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010572
|
US9745291, Compound 97
Show/Hide
|
C24H27N3O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010576
|
US9745291, Compound 146
Show/Hide
|
C24H29N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010577
|
US10307413, Compound 5
Show/Hide
|
C19H23N3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010583
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-(pyrrolidin-3-yl)-1H-benzo[d]imidazol-6-yl)phenoxy)propan-2-ol
Show/Hide
|
C29H32N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010585
|
US9777008, Compound 220
Show/Hide
|
C30H34N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010586
|
US9777008, Compound 243
Show/Hide
|
C31H35N5O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010771
|
US9777008, Compound 236
Show/Hide
|
C25H27N5O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010773
|
US10307413, Compound 28
Show/Hide
|
C23H31N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010774
|
US10307413, Compound 34
Show/Hide
|
C24H31N3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010776
|
US10307413, Compound 47
Show/Hide
|
C26H35N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010777
|
1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)indolin-2-one
Show/Hide
|
C20H22N2O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010779
|
1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-4-(p-tolyl)piperazin-2-one
Show/Hide
|
C23H29N3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010797
|
US9745291, Compound 117
Show/Hide
|
C25H33N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010800
|
US9777008, Compound 226
Show/Hide
|
C25H27N5O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010802
|
US9745291, Compound 21
Show/Hide
|
C22H27N3O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010803
|
US9745291, Compound 48
Show/Hide
|
C27H32N4O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010866
|
US9777008, Compound 250
Show/Hide
|
C29H34N6O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010867
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((4-(1-(tetrahydro-2H-pyran-4-yl)-1H-benzo[d]imidazol-6-yl)pyridin-2-yl)amino)propan-2-ol
Show/Hide
|
C29H33N5O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0010874
|
2-(2-(1H-pyrazol-3-yl)phenoxy)-N-(2-hydroxy-3-(isoindolin-2-yl)propyl)acetamide
Show/Hide
|
C23H29N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0011717
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((3-(1-methyl-1H-benzo[d]imidazol-6-yl)phenyl)amino)propan-2-ol
Show/Hide
|
C26H28N4O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0011925
|
US9777008, Compound 259
Show/Hide
|
C23H26N4O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0011930
|
US9745291, Compound 31
Show/Hide
|
C22H27N3O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0011938
|
US9777008, Compound 169
Show/Hide
|
C26H28N2O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0011941
|
US9777008, Compound 219
Show/Hide
|
C30H34N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0011945
|
US9745291, Compound 90
Show/Hide
|
C26H34N4O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0011999
|
US9745291, Compound 108
Show/Hide
|
C25H34N4O5S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0012000
|
US9745291, Compound 130
Show/Hide
|
C26H35N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0012002
|
US9745291, Compound 26
Show/Hide
|
C21H26N2O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0012835
|
US9777008, Compound 270
Show/Hide
|
C32H37N5O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0012840
|
US10150758, Compound 29
Show/Hide
|
C24H32N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0012841
|
4-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
Show/Hide
|
C20H22N2O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0012849
|
US9777008, Compound 174
Show/Hide
|
C26H27N3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0012852
|
US10307413, Compound 22
Show/Hide
|
C20H23N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0012853
|
US10307413, Compound 32
Show/Hide
|
C19H23N3O4S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0012855
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-methyl-1H-benzo[d]imidazol-5-yl)phenoxy)propan-2-ol
Show/Hide
|
C26H27N3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0012862
|
US9745291, Compound 78
Show/Hide
|
C24H31N3O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0012863
|
US9745291, Compound 83
Show/Hide
|
C25H31N3O5
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0012868
|
US10307413, Compound 17
Show/Hide
|
C18H21N3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013458
|
US10307413, Compound 19
Show/Hide
|
C24H25N3O2
|
2
|
| 1 |
EC50 = 101 nM
|
|
|
| 2 |
IC50 = 406 nM
|
|
|
|
CP0013525
|
US9745291, Compound 23
Show/Hide
|
C22H26N4O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013527
|
US9745291, Compound 35
Show/Hide
|
C22H29N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013528
|
US9745291, Compound 43
Show/Hide
|
C25H29N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013566
|
US10150758, Compound 6
Show/Hide
|
C22H26FN3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013570
|
US9777008, Compound 49
Show/Hide
|
C25H34N2O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013573
|
US9777008, Compound 249
Show/Hide
|
C32H36N4O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013920
|
US9777008, Compound 81
Show/Hide
|
C28H31N3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013924
|
US9745291, Compound 32
Show/Hide
|
C20H24N2O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013927
|
US9745291, Compound 36
Show/Hide
|
C22H27N3O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013930
|
US9745291, Compound 53
Show/Hide
|
C21H27N3O5S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013932
|
US9745291, Compound 70
Show/Hide
|
C26H33N5O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013934
|
US9745291, Compound 96
Show/Hide
|
C26H33N5O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013937
|
US9745291, Compound 106
Show/Hide
|
C25H34N4O5S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013939
|
US9777008, Compound 237
Show/Hide
|
C25H27N5O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013940
|
US10307413, Compound 18
Show/Hide
|
C18H21N3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013941
|
US9777008, Compound 245
Show/Hide
|
C26H29N7O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013943
|
US9777008, Compound 261
Show/Hide
|
C25H27N5O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013947
|
(S)No FitN-(2-hydroxy-3-(isoindolin-2-yl)propyl)-2-phenoxyacetamide
Show/Hide
|
C22H23N3O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0013948
|
2-(2-(N,N-dimethylsulfamoyl)phenoxy)-N-(2-hydroxy-3-(isoindolin-2-yl)propyl)acetamide
Show/Hide
|
C21H27N3O5S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0014280
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((6-(1-methyl-1H-benzo[d]imidazol-6-yl)pyrazin-2-yl)amino)propan-2-ol
Show/Hide
|
C24H26N6O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0014283
|
US9745291, Compound 34
Show/Hide
|
C21H25N3O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0014289
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(3-methyl-3H-imidazo[4,5-b]pyridin-5-yl)phenoxy)propan-2-ol
Show/Hide
|
C25H26N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0014290
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(2-methyl-2H-pyrazolo[3,4-b]pyridin-6-yl)phenoxy)propan-2-ol
Show/Hide
|
C25H26N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0014294
|
US9745291, Compound 113
Show/Hide
|
C23H29N3O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0014296
|
US9777008, Compound 241
Show/Hide
|
C29H34N6O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0014297
|
US9777008, Compound 242
Show/Hide
|
C31H36N6O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0014298
|
US9777008, Compound 253
Show/Hide
|
C29H33N5O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0014299
|
(R)-1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(quinolin-8-yl)phenoxy)propan-2-ol
Show/Hide
|
C27H26N2O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0014302
|
US10307413, Compound 35
Show/Hide
|
C23H30N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0014410
|
US9745291, Compound 22
Show/Hide
|
C21H26N2O4
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0014413
|
US10307413, Compound 31
Show/Hide
|
C20H25N3O4S
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0633916
|
1-(3-(1H-benzo[d]imidazol-4-yl)phenylamino)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
Show/Hide
|
C25H26N4O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0635768
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(5-(1-methyl-1H-benzo[d]imidazol-5-yl)-1H-pyrazol-3-ylamino)propan-2-ol
Show/Hide
|
C23H26N6O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0636068
|
(S)-1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-4-(phenylamino)pyridin-2(1H)-one
Show/Hide
|
C23H25N3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0636090
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(5-(1-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrazol-3-ylamino)propan-2-ol
Show/Hide
|
C23H26N6O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0637180
|
N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-(1H-pyrazol-3-yl)benzamide
Show/Hide
|
C22H24N4O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0637409
|
1-(3-(1H-benzo[d]imidazol-4-yl)phenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
Show/Hide
|
C25H25N3O2
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0638348
|
(S)-2-(2-(1H-pyrazol-3-yl)phenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide
Show/Hide
|
C23H26N4O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0002034
|
US10307413, Compound 42
Show/Hide
|
C23H29N3O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0002035
|
US10150758, Compound 20
Show/Hide
|
C23H29N3O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0002040
|
1-([1, 1′-biphenyl]-3-yloxy)-3-(3, 4-dihydroisoquinolin-2(1H)-yl) propan-2-ol
Show/Hide
|
C24H25NO2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0002044
|
US9777008, Compound 92
Show/Hide
|
C24H24ClNO2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0002048
|
US9777008, Compound 162
Show/Hide
|
C23H26N4O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0002049
|
US9777008, Compound 185
Show/Hide
|
C29H32N2O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0003282
|
(3′-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropoxy)-[1,1′-biphenyl]-3-yl)(morpholino)methanone
Show/Hide
|
C29H32N2O4
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0003822
|
US9745291, Compound 127
Show/Hide
|
C21H28N4O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0003844
|
US9745291, Compound 114
Show/Hide
|
C22H28N2O5S
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0003849
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(2-(dimethylamino)pyrimidin-5-yl)phenoxy)propan-2-ol
Show/Hide
|
C24H28N4O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0003850
|
US9777008, Compound 136
Show/Hide
|
C24H26N4O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0003873
|
1-((3-((cyclopentylamino)methyl)phenyl)amino)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
Show/Hide
|
C24H33N3O
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0006304
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(quinolin-3-yl)phenoxy)propan-2-ol
Show/Hide
|
C27H26N2O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0006305
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-phenyl-1H-benzo[d]imidazol-6-yl)phenoxy)propan-2-ol
Show/Hide
|
C31H29N3O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0006307
|
US9777008, Compound 163
Show/Hide
|
C24H25N3O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0006313
|
US9777008, Compound 147
Show/Hide
|
C27H28N2O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0006559
|
US9777008, Compound 94
Show/Hide
|
C25H24N2O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0006564
|
US10307413, Compound 25
Show/Hide
|
C20H23N3O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0006600
|
US9777008, Compound 154
Show/Hide
|
C24H24FNO2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0006601
|
US9777008, Compound 183
Show/Hide
|
C23H26N4O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0006604
|
US9777008, Compound 201
Show/Hide
|
C27H30FNO3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0006610
|
US9777008, Compound 116
Show/Hide
|
C25H35N3O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0006618
|
1-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)phenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
Show/Hide
|
C26H27NO4
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0006619
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((2′-phenoxy-[1,1′-biphenyl]-3-yl)oxy)propan-2-ol
Show/Hide
|
C30H29NO3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0006840
|
US9777008, Compound 93
Show/Hide
|
C25H24N2O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0006847
|
N-(2-hydroxy-3-(isoindolin-2-yl)propyl)-3-(pyridin-2-yl)benzamide
Show/Hide
|
C23H23N3O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007008
|
US9745291, Compound 69
Show/Hide
|
C22H27N5O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007011
|
US9745291, Compound 124
Show/Hide
|
C22H25N3O5
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007015
|
US9777008, Compound 149
Show/Hide
|
C28H34N4O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007016
|
US9777008, Compound 164
Show/Hide
|
C23H24N4O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007101
|
1-((5′-chloro-2′-methoxy-[1,1′-biphenyl]-3-yl)oxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
Show/Hide
|
C25H26ClNO3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007102
|
US9777008, Compound 188
Show/Hide
|
C25H24N2O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007105
|
(S)-1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(quinolin-8-yl)phenoxy)propan-2-ol
Show/Hide
|
C27H26N2O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007208
|
US9777008, Compound 95
Show/Hide
|
C24H25NO3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007209
|
US9777008, Compound 111
Show/Hide
|
C26H26N2O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007210
|
US9777008, Compound 139
Show/Hide
|
C23H23FN2O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007214
|
US9777008, Compound 173
Show/Hide
|
C26H27N3O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007215
|
US9777008, Compound 186
Show/Hide
|
C26H28N2O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007264
|
US9777008, Compound 170
Show/Hide
|
C26H25NO2S
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007265
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1,3-dimethyl-1H-indol-6-yl)phenoxy)propan-2-ol
Show/Hide
|
C28H30N2O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007267
|
US9777008, Compound 276
Show/Hide
|
C25H27N5O
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007271
|
US9777008, Compound 130
Show/Hide
|
C25H27NO4S
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007274
|
US9777008, Compound 182
Show/Hide
|
C25H27N3O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007401
|
1-(3,4-Dihydroisoquinolin-2(1H)-yl)-3-((6-(1-methyl-1H-benzo[d]imidazol-6-yl)pyridin-2-yl)amino)propan-2-ol
Show/Hide
|
C25H27N5O
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007402
|
US9777008, Compound 148
Show/Hide
|
C26H26N2O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007536
|
US9745291, Compound 89
Show/Hide
|
C24H33N3O4
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007537
|
US9745291, Compound 118
Show/Hide
|
C22H26N4O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0007546
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((4′-methoxy-[1,1′-biphenyl]-3-yl)oxy)propan-2-ol
Show/Hide
|
C25H27NO3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010204
|
US9745291, Compound 60
Show/Hide
|
C23H25N3O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010217
|
US9745291, Compound 134
Show/Hide
|
C26H35N3O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010220
|
US10307413, Compound 11
Show/Hide
|
C19H22N2O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010257
|
US9777008, Compound 132
Show/Hide
|
C25H24F3NO2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010258
|
N-(3-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropoxy)phenyl)pyrimidine-5-carboxamide
Show/Hide
|
C23H24N4O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010455
|
US9777008, Compound 217
Show/Hide
|
C25H27N5O
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010459
|
US9777008, Compound 264
Show/Hide
|
C31H34N4O4
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010467
|
US9777008, Compound 67
Show/Hide
|
C26H27NO3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010469
|
US9777008, Compound 90
Show/Hide
|
C26H29NO3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010470
|
US9777008, Compound 151
Show/Hide
|
C26H30N2O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010471
|
6-(3-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropoxy)phenyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
Show/Hide
|
C26H26N2O4
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010472
|
US9777008, Compound 172
Show/Hide
|
C25H24N2O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010559
|
US9745291, Compound 18
Show/Hide
|
C20H25N3O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010571
|
US9745291, Compound 85
Show/Hide
|
C25H34N4O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010574
|
US9745291, Compound 120
Show/Hide
|
C24H31N3O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010578
|
US10307413, Compound 12
Show/Hide
|
C24H25N3O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010582
|
US9777008, Compound 131
Show/Hide
|
C25H27NO4S
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010778
|
4-(3-chlorophenyl)-1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)piperazin-2-one
Show/Hide
|
C22H26ClN3O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010790
|
US9777008, Compound 74
Show/Hide
|
C25H27NO3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010868
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(3-methylimidazo[1,5-a]pyridin-6-yl)phenoxy)propan-2-ol
Show/Hide
|
C26H27N3O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0010875
|
US10118918, Compound 11
Show/Hide
|
C23H29N3O4
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0011308
|
US9777008, Compound 129
Show/Hide
|
C25H28N2O4S
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0011714
|
US10307413, Compound 39
Show/Hide
|
C22H29N3O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0011716
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((3′-(hydroxymethyl)-[1,1′-biphenyl]-3-yl)oxy)propan-2-ol
Show/Hide
|
C25H27NO3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0011927
|
1-(3-(dibenzo[b,d]furan-4-yl)phenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
Show/Hide
|
C30H27NO3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0011933
|
US9777008, Compound 108
Show/Hide
|
C26H27N3O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0011935
|
US9777008, Compound 138
Show/Hide
|
C25H26FNO2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0011936
|
US9777008, Compound 160
Show/Hide
|
C23H26N4O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0011937
|
US9777008, Compound 161
Show/Hide
|
C23H24N4O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0011940
|
1-(3-(1-(azetidin-3-yl)-1H-benzo[d]imidazol-6-yl)phenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
Show/Hide
|
C28H30N4O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0012003
|
US9777008, Compound 262
Show/Hide
|
C28H30N4O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0012845
|
(4-((5-(4-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropoxy)phenyl)-1H-pyrazol-1-yl)methyl)phenyl)(pyrrolidin-1-yl)methanone
Show/Hide
|
C33H36N4O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0012846
|
US9777008, Compound 63
Show/Hide
|
C25H27NO4S
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0012848
|
1-(3-(1-benzyl-1H-benzo[d]imidazol-6-yl)phenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
Show/Hide
|
C32H31N3O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0012865
|
US9745291, Compound 116
Show/Hide
|
C24H31N3O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0012866
|
US9745291, Compound 122
Show/Hide
|
C26H34N4O6S
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0012867
|
US9745291, Compound 138
Show/Hide
|
C24H28N4O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0013571
|
1-((2′-chloro-5′-(trifluoromethyl)-[1,1′-biphenyl]-3-yl)oxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
Show/Hide
|
C25H23ClF3NO2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0013572
|
US9777008, Compound 88
Show/Hide
|
C25H26ClNO3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0013921
|
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-6-yl)phenoxy)propan-2-ol
Show/Hide
|
C33H33N3O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0013925
|
US9777008, Compound 137
Show/Hide
|
C26H27NO3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0013936
|
US9745291, Compound 104
Show/Hide
|
C25H30N4O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0013950
|
N-(2-hydroxy-3-(isoindolin-2-yl)propyl)-2-(quinolin-8-yloxy)acetamide
Show/Hide
|
C22H23N3O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0014285
|
US9777008, Compound 150
Show/Hide
|
C29H35NO3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0014286
|
US9777008, Compound 152
Show/Hide
|
C25H26N2O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0014288
|
US9777008, Compound 171
Show/Hide
|
C25H26N2O3
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0634822
|
1-(3-(1H-indazol-5-yl)phenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
Show/Hide
|
C25H25N3O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0635908
|
1-(3-(1H-indazol-6-yl)phenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
Show/Hide
|
C25H25N3O2
|
1
|
| 1 |
EC50 = 1001 nM
|
|
|
|
CP0636067
|
N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-(3-oxo-3,4-dihydroquinoxalin-5-yloxy)acetamide
Show/Hide
|
C22H24N4O4
|
1
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| 1 |
EC50 = 1001 nM
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CP0636250
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2-(2-(1H-imidazol-2-yl)phenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide
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C23H26N4O3
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1
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| 1 |
EC50 = 1001 nM
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CP0637383
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1-(3-(1H-benzo[d]imidazol-6-yl)phenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
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C25H25N3O2
|
1
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| 1 |
EC50 = 1001 nM
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CP0637836
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1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(3-methyl-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)phenoxy)propan-2-ol
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C25H30N4O2
|
1
|
| 1 |
EC50 = 1001 nM
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CP0638743
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1-(3-(1H-benzo[d][1,2,3]triazol-6-yl)phenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
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C24H24N4O2
|
1
|
| 1 |
EC50 = 1001 nM
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|
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CP0003854
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US9777008, Compound 166
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C25H24N2O3
|
1
|
| 1 |
EC50 = 10001 nM
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CP0003874
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1-(3-(benzo[d][1,3]dioxol-5-yl)phenoxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
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C25H25NO4
|
1
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| 1 |
EC50 = 10001 nM
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|
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CP0005518
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US9777008, Compound 200
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C25H23ClF3NO3
|
1
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| 1 |
EC50 = 10001 nM
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|
|
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CP0007273
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US9777008, Compound 168
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C25H26ClNO3
|
1
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| 1 |
EC50 = 10001 nM
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|
|
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CP0011934
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US9777008, Compound 124
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|
C26H23F6NO2
|
1
|
| 1 |
EC50 = 10001 nM
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|
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CP0012847
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1-((2′,3′-difluoro-[1,1′-biphenyl]-3-yl)amino)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2
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|
C24H23F2NO2
|
1
|
| 1 |
EC50 = 10001 nM
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|
|
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CP0012856
|
US9745291, Compound 9
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|
C21H26N2O3
|
1
|
| 1 |
EC50 = 10001 nM
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|
|
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CP0013923
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US9777008, Compound 127
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C25H23ClF3NO2
|
1
|
| 1 |
EC50 = 10001 nM
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|
|
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CP0003283
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US9777008, Compound 135
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C26H27NO4
|
1
|
| 1 |
EC50 > 20000 nM
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|
|
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CP0003856
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US9777008, Compound 180
Show/Hide
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C25H26N2O4
|
1
|
| 1 |
EC50 > 20000 nM
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|
|
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CP0003872
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US9777008, Compound 32
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C25H34N2O2
|
1
|
| 1 |
EC50 > 20000 nM
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|
|
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CP0007013
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US9777008, Compound 114
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C26H27N3O2
|
1
|
| 1 |
EC50 > 20000 nM
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|
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CP0010793
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US9777008, Compound 80
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C27H29N3O2
|
1
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| 1 |
EC50 > 20000 nM
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|
|
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CP0013917
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US9777008, Compound 110
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C25H26ClNO3
|
1
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| 1 |
EC50 > 20000 nM
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|
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CP0848464
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1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-4-o-tolylpiperazin-2-one
Show/Hide
|
C23H29N3O2
|
1
|
| 1 |
EC50 > 50000 nM
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|
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CP0848465
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(S)-1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-4-phenylpyridin-2(1H)-one
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C23H24N2O2
|
1
|
| 1 |
EC50 > 50000 nM
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|
|
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CP0930216
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1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-4-(2-fluorophenyl)piperazin-2-one
Show/Hide
|
C22H26FN3O2
|
1
|
| 1 |
EC50 > 50000 nM
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|
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CP0944906
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(R)-1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-4-phenylpyridin-2(1H)-one
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|
C23H24N2O2
|
1
|
| 1 |
EC50 > 50000 nM
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|
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CP0635662
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5-(3-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropoxy)phenyl)-1H-benzo[d]imidazol-2(3H)-one
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|
C25H25N3O3
|
1
|
| 1 |
EC50 > 101 nM
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|
|
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CP0015066
|
US10307413, Compound 188
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C22H28N4O2
|
1
|
| 1 |
IC50 = 3 nM
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|
|
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CP0003100
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US10307413, Compound 337
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C20H25N5O3
|
1
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| 1 |
IC50 = 9 nM
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|
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CP0006617
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US10307413, Compound 44
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C24H31N3O3
|
1
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| 1 |
IC50 = 13 nM
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