| Compound ID |
Compound Name |
Compound Formula |
|
CP0968964
|
(R)-2-(4-(4-(aminomethyl)-1-oxo-8-(tetrahydrofuran-2-yl)-1,2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)benzo[b]thiophene-3-carbonitrile
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|
C26H22N6O2S
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 174 nM
|
|
|
|
CP0532845
|
2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H- pyrazol-5-yl)benzo[b]thiophene-3- carbonitrile
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|
C22H16N6OS
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 > 1000 nM
|
|
|
|
CP0576038
|
2-[4-[4-(aminomethyl)-8-(methoxymethyl)-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-1-benzothiophene-3-carbonitrile
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|
C24H20N6O2S
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 267 nM
|
|
|
|
CP0537549
|
2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H- pyrazol-5-yl)-4-chloro-6- cyclopropoxybenzonitrile
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|
C23H19ClN6O2
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
IC50 = 834 nM
|
|
|
|
CP0033993
|
US11479551, Example 16-7
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|
C23H18ClFN6O2
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
IC50 = 653 nM
|
|
|
|
CP0579160
|
2-[4-[4-(aminomethyl)-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-6-cyclopropyloxy-4-methylbenzonitrile
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|
C24H22N6O2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0019668
|
US10307413, Compound 208
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|
C24H32N6O3
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 12 nM
|
|
|
|
CP0567391
|
2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H- pyrazol-5-yl)-1-naphthonitrile
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|
C24H18N6O
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 1210 nM
|
|
|
|
CP0571094
|
2-[4-[4-(aminomethyl)-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-3-chloro-6-cyclopropyloxybenzonitrile
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|
C23H19ClN6O2
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 > 1000 nM
|
|
|
|
CP0550406
|
2-[4-[4-(aminomethyl)-8-methyl-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-1-benzothiophene-3-carbonitrile
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|
C23H18N6OS
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 > 1000 nM
|
|
|
|
CP0567706
|
2-[4-[4-(aminomethyl)-8-chloro-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-1-benzothiophene-3-carbonitrile
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|
C22H15ClN6OS
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 > 1000 nM
|
|
|
|
CP0564437
|
2-[4-[4-(aminomethyl)-8-(difluoromethyl)-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-1-benzothiophene-3-carbonitrile
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|
C23H16F2N6OS
|
2
|
| 1 |
IC50 = 25 nM
|
|
|
| 2 |
IC50 = 759 nM
|
|
|
|
CP0527986
|
2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H- pyrazol-5-yl)-6-cyclopropoxybenzonitrile
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|
C23H20N6O2
|
2
|
| 1 |
IC50 = 34 nM
|
|
|
| 2 |
IC50 = 6550 nM
|
|
|
|
CP0488633
|
2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H- pyrazol-5-yl)-6-methoxybenzonitrile
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|
C21H18N6O2
|
2
|
| 1 |
IC50 = 62 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0567390
|
2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H- pyrazol-5-yl)-6-chlorobenzonitrile
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|
C20H15ClN6O
|
2
|
| 1 |
IC50 = 62 nM
|
|
|
| 2 |
IC50 = 8811 nM
|
|
|
|
CP0575516
|
2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H- pyrazol-5-yl)-6-ethylbenzonitrile
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|
C22H20N6O
|
2
|
| 1 |
IC50 = 79 nM
|
|
|
| 2 |
IC50 = 3210 nM
|
|
|
|
CP0542854
|
2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H- pyrazol-5-yl)-6-methylbenzonitrile
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|
C21H18N6O
|
2
|
| 1 |
IC50 = 101 nM
|
|
|
| 2 |
IC50 = 8830 nM
|
|
|
|
CP0579147
|
2-[4-[4-(aminomethyl)-8-ethoxy-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-1-benzothiophene-3-carbonitrile
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|
C24H20N6O2S
|
2
|
| 1 |
IC50 = 112 nM
|
|
|
| 2 |
IC50 = 618 nM
|
|
|
|
CP0562030
|
3-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H- pyrazol-5-yl)-2-naphthonitrile
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|
C24H18N6O
|
1
|
| 1 |
IC50 = 118 nM
|
|
|
|
CP0550405
|
2-[4-[4-(aminomethyl)-8-hydroxy-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-1-benzothiophene-3-carbonitrile
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|
C22H16N6O2S
|
2
|
| 1 |
IC50 = 262 nM
|
|
|
| 2 |
IC50 > 1000 nM
|
|
|
|
CP0574592
|
2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H- pyrazol-5-yl)-3-fluorobenzonitrile
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|
C20H15FN6O
|
2
|
| 1 |
IC50 = 322 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0964187
|
(S)-2-(4-(4-(aminomethyl)-1-oxo-8-(tetrahydrofuran-2-yl)-1,2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)benzo[b]thiophene-3-carbonitrile
Show/Hide
|
C26H22N6O2S
|
2
|
| 1 |
IC50 = 390 nM
|
|
|
| 2 |
IC50 > 1000 nM
|
|
|
|
CP0579159
|
2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H- pyrazol-5-yl)benzonitrile
Show/Hide
|
C20H16N6O
|
2
|
| 1 |
IC50 = 826 nM
|
|
|
| 2 |
IC50 = 3165 nM
|
|
|
|
CP0527985
|
4-(aminomethyl)-6-(1-methyl-5-phenyl-1H- pyrazol-4-yl)phthalazin-1(2H)-one
Show/Hide
|
C19H17N5O
|
2
|
| 1 |
IC50 = 2470 nM
|
|
|
| 2 |
IC50 = 9810 nM
|
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|
