Brief Information of the Compound and Protein
Compound Name
2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H- pyrazol-5-yl)-6-ethylbenzonitrile
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PubChem ID
CID: 156151719
Canonical SMILES
CCc1cccc(-c2c(cnn2C)-c2ccc3c(c2)c(CN)n[nH]c3=O)c1C#N
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Compound Formula C22H20N6O
Compound Structure
Protein Name
Protein arginine N-methyltransferase 5
Protein Classification
Epigenetic regulator
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Writer
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Protein methyltransferase
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Protein arginine methyltransferase
Uniprot ID
O14744
Gene Name
PRMT5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  2
1
IC50 = 79 nM
   TI
   LI
   LO
   TS
2
IC50 = 3210 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2000 nM