Brief Information of the Compound and Protein
Compound Name
4-(aminomethyl)-6-(1-methyl-5-phenyl-1H- pyrazol-4-yl)phthalazin-1(2H)-one
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PubChem ID
CID: 156151538
Canonical SMILES
Cn1ncc(c1-c1ccccc1)-c1ccc2c(c1)c(CN)n[nH]c2=O
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Compound Formula C19H17N5O
Compound Structure
Protein Name
Protein arginine N-methyltransferase 5
Protein Classification
Epigenetic regulator
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Writer
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Protein methyltransferase
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Protein arginine methyltransferase
Uniprot ID
O14744
Gene Name
PRMT5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  2
1
IC50 = 2470 nM
   TI
   LI
   LO
   TS
2
IC50 = 9810 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3000 nM