Brief Information of the Compound and Protein
Compound Name
2-[4-[4-(aminomethyl)-8-ethoxy-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-1-benzothiophene-3-carbonitrile
    Show/Hide
PubChem ID
CID: 165403848
Canonical SMILES
CCOc1cc(cc2c(CN)n[nH]c(=O)c12)-c1cnn(C)c1-c1sc2ccccc2c1C#N
    Show/Hide
Compound Formula C24H20N6O2S
Compound Structure
Protein Name
Protein arginine N-methyltransferase 5
Protein Classification
Epigenetic regulator
>
Writer
>
Protein methyltransferase
>
Protein arginine methyltransferase
Uniprot ID
O14744
Gene Name
PRMT5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  2
1
IC50 = 112 nM
   TI
   LI
   LO
   TS
2
IC50 = 618 nM
   TI
   LI
   LO
   TS