General Information of the Compound
Compound ID
CP0571094
Compound Name
2-[4-[4-(aminomethyl)-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-3-chloro-6-cyclopropyloxybenzonitrile
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Structure
Formula
C23H19ClN6O2
Molecular Weight
446.898
Canonical SMILES
Cn1ncc(c1-c1c(Cl)ccc(OC2CC2)c1C#N)-c1ccc2c(c1)c(CN)n[nH]c2=O
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InChI
InChI=1S/C23H19ClN6O2/c1-30-22(21-16(9-25)20(7-6-18(21)24)32-13-3-4-13)17(11-27-30)12-2-5-14-15(8-12)19(10-26)28-29-23(14)31/h2,5-8,11,13H,3-4,10,26H2,1H3,(H,29,31)
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InChIKey
DWTVDEXBMMNFAQ-UHFFFAOYSA-N
Physicochemical Property
logP
3.51558
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
122.61
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156151356
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03087, Protein arginine N-methyltransferase 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  2
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
2
IC50 > 1000 nM
   TI
   LI
   LO
   TS