| Compound ID |
Compound Name |
Compound Formula |
|
CP0093295
|
(S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; hydrochloride
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|
C23H23N3O5
|
3
|
| 1 |
EC50 = 12 nM
|
|
|
| 2 |
IC50 = 60 nM
|
|
|
| 3 |
IC50 > 3000 nM
|
|
|
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CP0849235
|
Rac-3-((3aSR,6SR,6aSR,12aRS,13aSR,13bRS)-6-(4-bromophenyl)-12a-methyl-1,3,7,12-tetraoxo-3a,4,6a,7,12,12a,13,13a-octahydro-1H-anthra[2,3-e]isoindol-2(3H,6H,13bH)-yl)propanoic acid
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|
C30H26BrNO6
|
1
|
| 1 |
EC50 = 1400 nM
|
|
|
|
CP0849525
|
Rac-(3aSR,6SR,6aSR,12aRS,13aSR,13bRS)-12a-methyl-6-(4'-(trifluoromethyl)phenyl-3a,4,6,6a,13,13a-hexahydro-1H-anthra[2,3-e]isoindole-1,3,7,12(2H,12aH,13bH)-tetraone
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|
C28H22F3NO4
|
1
|
| 1 |
EC50 = 2300 nM
|
|
|
|
CP0926433
|
Rac-3-((3aS,6S,6aS,12aR,13aS,13bR)-6-(4-fluorophenyl)-12a-methyl-1,3,7,12-tetraoxo-3a,4,6a,7,12,12a,13,13a-octahydro-1H-anthra[2,3-e]isoindol-2(3H,6H,13bH)-yl)propanoic acid
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|
C30H26FNO6
|
1
|
| 1 |
EC50 = 4100 nM
|
|
|
|
CP0893296
|
Rac-(3aSR,6SR,6aSR,12aRS,13aSR,13bRS)-8-methoxy-12a-methyl-6-(4-(trifluoromethyl)phenyl)-3a,4,6,6a,13,13a-hexahydro-1H-anthra[2,3-e]isoindole-1,3,7,12(2H,12aH,13bH)-tetraone
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|
C29H24F3NO5
|
1
|
| 1 |
EC50 = 6700 nM
|
|
|
|
CP0962209
|
Rac-(3aSR,6SR,6aSR,13aSR,13bRS)-11-hydroxy-6a-methyl-6-(4-(trifluoromethyl)phenyl)-3a,4,6,6a,13,13a-hexahydro-1H-anthra[2,3-e]isoindole-1,3,7,12(2H,12aH,13bH)-tetraone
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|
C28H22F3NO5
|
1
|
| 1 |
EC50 = 6700 nM
|
|
|
|
CP0967690
|
Rac-(3aSR,6SR,6aSR,12aRS,13aSR,13bRS)-6a,12a-dimethyl-6-(4-(trifluoromethyl)phenyl)-3a,4,6,6a,13,13a-hexahydro-1H-anthra[2,3-e]isoindole-1,3,7,12(2H,12aH,13bH)-tetraone
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|
C29H24F3NO4
|
1
|
| 1 |
EC50 = 7800 nM
|
|
|
|
CP0957928
|
Rac-3-((3aSR,6SR,6aSR,12aRS,13aSR,13bRS)-6-(4-bromophenyl)-8-methoxy-12a-methyl-1,3,7,12-tetraoxo-3a,4,6a,7,12,12a,13,13a-octahydro-1H-anthra[2,3-e]isoindol-2(3H,6H,13bH)-yl)propanoic acid
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|
C31H28BrNO7
|
1
|
| 1 |
EC50 = 15500 nM
|
|
|
|
CP0473514
|
2-chloro-N-(6-(4-hydroxy-6-(trifluoromethyl)pyrimidin-2-yl)pyridin-3-yl)acetamide
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|
C12H8ClF3N4O2
|
2
|
| 1 |
IC50 = 800 nM
|
|
|
| 2 |
IC50 = 8000 nM
|
|
|
|
CP0386110
|
2-chloro-N-(6-(4-chloro-6-(trifluoromethyl)pyrimidin-2-yl)pyridin-3-yl)acetamide
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|
C12H7Cl2F3N4O
|
2
|
| 1 |
IC50 = 1400 nM
|
|
|
| 2 |
IC50 = 10000 nM
|
|
|
|
CP0382925
|
2-chloro-N-(6-(4-(chloromethyl)-6-hydroxypyrimidin-2-yl)pyridin-3-yl)acetamide
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|
C12H10Cl2N4O2
|
2
|
| 1 |
IC50 = 1500 nM
|
|
|
| 2 |
IC50 = 5500 nM
|
|
|
|
CP0428283
|
2-chloro-N-[6-(5-chloro-4-methyl-6-prop-2-enoxypyrimidin-2-yl)pyridin-3-yl]acetamide
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|
C15H14Cl2N4O2
|
2
|
| 1 |
IC50 = 1500 nM
|
|
|
| 2 |
IC50 = 8000 nM
|
|
|
|
CP0481249
|
2-chloro-N-(6-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-yl)pyridin-3-yl)acetamide
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|
C14H15ClN4O2
|
2
|
| 1 |
IC50 = 1500 nM
|
|
|
| 2 |
IC50 = 5500 nM
|
|
|
|
CP0499868
|
2-chloro-N-[6-(5-ethyl-4-methyl-6-prop-2-enoxypyrimidin-2-yl)pyridin-3-yl]acetamide
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|
C17H19ClN4O2
|
2
|
| 1 |
IC50 = 1800 nM
|
|
|
| 2 |
IC50 = 22000 nM
|
|
|
|
CP0382926
|
2-chloro-N-(6-(5-fluoro-4-hydroxy-6-methylpyrimidin-2-yl)pyridin-3-yl)acetamide
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|
C12H10ClFN4O2
|
2
|
| 1 |
IC50 = 2000 nM
|
|
|
| 2 |
IC50 = 6000 nM
|
|
|
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CP0499864
|
2-chloro-N-[6-[4-prop-2-enoxy-6-(trifluoromethyl)pyrimidin-2-yl]pyridin-3-yl]acetamide
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|
C15H12ClF3N4O2
|
2
|
| 1 |
IC50 = 2000 nM
|
|
|
| 2 |
IC50 = 30000 nM
|
|
|
|
CP0388210
|
2-chloro-N-(6-(4-methoxy-6-(trifluoromethyl)pyrimidin-2-yl)pyridin-3-yl)acetamide
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|
C13H10ClF3N4O2
|
2
|
| 1 |
IC50 = 3500 nM
|
|
|
| 2 |
IC50 = 15000 nM
|
|
|
|
CP0382924
|
N-[6-(5-benzyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)pyridin-3-yl]-2-chloroacetamide
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|
C19H17ClN4O2
|
2
|
| 1 |
IC50 = 4000 nM
|
|
|
| 2 |
IC50 = 10000 nM
|
|
|
|
CP0400148
|
2-chloro-N-(6-(5-chloro-4-hydroxy-6-methylpyrimidin-2-yl)pyridin-3-yl)acetamide
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|
C12H10Cl2N4O2
|
1
|
| 1 |
IC50 = 5500 nM
|
|
|
|
CP0386127
|
2-(5-aminopyridin-2-yl)-6-(chloromethyl)pyrimidin-4-ol
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|
C10H9ClN4O
|
2
|
| 1 |
IC50 = 6000 nM
|
|
|
| 2 |
IC50 = 22000 nM
|
|
|
|
CP0379327
|
2-chloro-N-(6-(4-ethoxy-6-(trifluoromethyl)pyrimidin-2-yl)pyridin-3-yl)acetamide
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|
C14H12ClF3N4O2
|
1
|
| 1 |
IC50 = 8000 nM
|
|
|
|
CP0373648
|
2-(5-aminopyridin-2-yl)-5-ethyl-6-methylpyrimidin-4-ol
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|
C12H14N4O
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0373649
|
2-(5-aminopyridin-2-yl)-5-benzyl-6-methylpyrimidin-4-ol
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|
C17H16N4O
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0377229
|
2-(5-aminopyridin-2-yl)-6-(trifluoromethyl)pyrimidin-4-ol
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|
C10H7F3N4O
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0377230
|
2-(5-aminopyridin-2-yl)-5-chloro-6-methylpyrimidin-4-ol
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|
C10H9ClN4O
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0377252
|
2-chloro-2,2-difluoro-N-(6-(4-hydroxy-6-(trifluoromethyl)pyrimidin-2-yl)pyridin-3-yl)acetamide
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|
C12H6ClF5N4O2
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0379326
|
6-(4-(allyloxy)-5-chloro-6-methylpyrimidin-2-yl)pyridin-3-amine
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|
C13H13ClN4O
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0382927
|
2-chloro-N-(6-(4-hydroxy-5,6-dimethylpyrimidin-2-yl)pyridin-3-yl)acetamide
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|
C13H13ClN4O2
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0386078
|
2-(5-aminopyridin-2-yl)-5,6-dimethylpyrimidin-4-ol
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|
C11H12N4O
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0386081
|
6-(4-ethoxy-6-(trifluoromethyl)pyrimidin-2-yl)pyridin-3-amine
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|
C12H11F3N4O
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0400150
|
6-(4-(allyloxy)-6-(trifluoromethyl)pyrimidin-2-yl)pyridin-3-amine
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|
C13H11F3N4O
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0400151
|
6-(4-methoxy-6-(trifluoromethyl)pyrimidin-2-yl)pyridin-3-amine
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|
C11H9F3N4O
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0425829
|
6-(4-(allyloxy)-5-ethyl-6-methylpyrimidin-2-yl)pyridin-3-amine
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|
C15H18N4O
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0473513
|
2-(5-aminopyridin-2-yl)-5-fluoro-6-methylpyrimidin-4-ol
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|
C10H9FN4O
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
