N-[(3-methoxyphenyl)methyl]-6-pyridin-3-ylimidazo[1,2-b]pyridazine-3-sulfonamide

(R,S)-Rolipram

1-[6-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]sulfonyl-4-phenylpiperidine-4-carbonitrile

4-(4-Bromo-6,7-dihydroxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid ethyl ester

4-(6,7-Dihydroxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid ethyl ester

4-(6,7-Dimethoxy-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(2,4-Dioxo-1-propyl-1,4-dihydro-2H-pteridin-3-yl)-butyric acid ethyl ester

4-(6-Amino-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

6-[6-amino-5-(trifluoromethyl)pyridin-3-yl]imidazo[1,2-b]pyridazine-3-sulfonamide

6-(5-fluoropyridin-3-yl)-N-(oxolan-2-ylmethyl)imidazo[1,2-b]pyridazine-3-sulfonamide

N-(oxolan-2-ylmethyl)-6-pyridin-3-ylimidazo[1,2-b]pyridazine-3-sulfonamide

6-(4-methoxyphenyl)-N-(oxolan-2-ylmethyl)imidazo[1,2-b]pyridazine-3-sulfonamide

4-(4-Cyano-6,7-dimethoxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid ethyl ester

4-(6,7-Dimethoxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid ethyl ester

4-(7-Amino-4-oxo-1,4-dihydro-2H-quinazolin-3-yl)-butyric acid ethyl ester

4-(1-Oxo-1H-isoquinolin-2-yl)-butyric acid ethyl ester

5-(6,7-Dimethoxy-4-oxo-4H-quinazolin-3-yl)-pentanoic acid ethyl ester

6-(5-fluoropyridin-3-yl)-N-[(3-methoxyphenyl)methyl]imidazo[1,2-b]pyridazine-3-sulfonamide

6-(6-methoxypyridin-3-yl)-N-(oxolan-2-ylmethyl)imidazo[1,2-b]pyridazine-3-sulfonamide

4-phenyl-1-(6-pyridin-3-ylimidazo[1,2-b]pyridazin-3-yl)sulfonylpiperidine-4-carbonitrile

1-[6-(4-methylsulfonylphenyl)imidazo[1,2-b]pyridazin-3-yl]sulfonyl-4-phenylpiperidine-4-carbonitrile

4-(6,7-Diacetoxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid ethyl ester

3-(6,7-Dimethoxy-4-oxo-4H-quinazolin-3-yl)-propionic acid ethyl ester

4-(7-Amino-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

3-(4-ethylpiperazin-1-yl)sulfonyl-6-[5-(trifluoromethyl)pyridin-3-yl]imidazo[1,2-b]pyridazine

4-(6-Amino-4-oxo-1,4-dihydro-2H-quinazolin-3-yl)-butyric acid ethyl ester

4-(6,7-Dimethoxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid 2-morpholin-4-yl-ethyl ester hydrochloride

4-(6,7-Dimethoxy-5-nitro-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(6,7-Bis-ethoxycarbonyloxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid ethyl ester

5-[3-(4-pyridin-2-ylpiperazin-1-yl)sulfonylimidazo[1,2-b]pyridazin-6-yl]-3-(trifluoromethyl)pyridin-2-amine

6-pyridin-3-yl-3-(4-pyridin-2-ylpiperazin-1-yl)sulfonylimidazo[1,2-b]pyridazine

3-(4-pyridin-2-ylpiperazin-1-yl)sulfonyl-6-[5-(trifluoromethyl)pyridin-3-yl]imidazo[1,2-b]pyridazine

6-(4-methylsulfonylphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)sulfonylimidazo[1,2-b]pyridazine

3-(4-benzylpiperazin-1-yl)sulfonyl-6-(4-methylsulfonylphenyl)imidazo[1,2-b]pyridazine

4-(4-Aminomethyl-6,7-dimethoxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid ethyl ester

4-(2-Azido-6,7-dimethoxy-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(4-Acetyl-6,7-dimethoxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid ethyl ester

4-(5-Amino-6,7-dimethoxy-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

3-(4-ethylpiperazin-1-yl)sulfonyl-6-pyridin-3-ylimidazo[1,2-b]pyridazine

3-(4-ethylpiperazin-1-yl)sulfonyl-6-(4-methylsulfonylphenyl)imidazo[1,2-b]pyridazine

3-(4-benzylpiperazin-1-yl)sulfonyl-6-pyridin-3-ylimidazo[1,2-b]pyridazine

4-(4-Fluoro-6,7-dimethoxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid ethyl ester

4-(5-Amino-6,7-dimethoxy-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester hydrochloride

3-(4-ethylpiperazin-1-yl)sulfonyl-6-(6-methoxypyridin-3-yl)imidazo[1,2-b]pyridazine

3-(4-ethylpiperazin-1-yl)sulfonyl-6-(4-methoxyphenyl)imidazo[1,2-b]pyridazine

4-phenyl-1-[6-[5-(trifluoromethyl)pyridin-3-yl]imidazo[1,2-b]pyridazin-3-yl]sulfonylpiperidine-4-carbonitrile

5-(6,7-Dimethoxy-1-oxo-1H-isoquinolin-2-yl)-pentanoic acid ethyl ester

4-(5-Chloro-6,7-dimethoxy-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-[2-(4-Bromo-phenylamino)-6,7-dimethoxy-quinazolin-4-yloxy]-butyric acid ethyl ester

4-(6,7-Dimethoxy-2-phenylamino-quinazolin-4-yloxy)-butyric acid ethyl ester

4-(6-Nitro-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(6-Bromo-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(7-Chloro-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(2-Amino-6,7-dimethoxy-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(7-Nitro-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(2-Dimethylamino-6,7-dimethoxy-quinazolin-4-yloxy)-butyric acid ethyl ester

4-(5-Chloro-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(6,7-Difluoro-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(6-Chloro-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(6,7-Dimethoxy-4-oxo-2-phenylamino-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(5-Azido-6,7-dimethoxy-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(7-Fluoro-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(4-Oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(6-Fluoro-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

1-(6-chloroimidazo[1,2-b]pyridazin-3-yl)sulfonyl-4-phenylpiperidine-4-carbonitrile

6-chloroimidazo[1,2-b]pyridazine-3-sulfonamide

N-[(3-methoxyphenyl)methyl]-6-(4-methylsulfonylphenyl)imidazo[1,2-b]pyridazine-3-sulfonamide

6-(5-fluoropyridin-3-yl)-3-(4-pyridin-2-ylpiperazin-1-yl)sulfonylimidazo[1,2-b]pyridazine

3-(4-benzylpiperazin-1-yl)sulfonyl-6-chloroimidazo[1,2-b]pyridazine

6-chloro-N-(oxolan-2-ylmethyl)imidazo[1,2-b]pyridazine-3-sulfonamide

6-chloro-N-[(3-methoxyphenyl)methyl]imidazo[1,2-b]pyridazine-3-sulfonamide

6-(6-methoxypyridin-3-yl)-3-(4-pyridin-2-ylpiperazin-1-yl)sulfonylimidazo[1,2-b]pyridazine

N-(oxolan-2-ylmethyl)-6-[5-(trifluoromethyl)pyridin-3-yl]imidazo[1,2-b]pyridazine-3-sulfonamide

6-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3-methoxyphenyl)methyl]imidazo[1,2-b]pyridazine-3-sulfonamide

N-[(3-methoxyphenyl)methyl]-6-(6-methoxypyridin-3-yl)imidazo[1,2-b]pyridazine-3-sulfonamide

6-chloro-3-(4-ethylpiperazin-1-yl)sulfonylimidazo[1,2-b]pyridazine

3-(4-ethylpiperazin-1-yl)sulfonyl-6-(5-fluoropyridin-3-yl)imidazo[1,2-b]pyridazine

N-[(3-methoxyphenyl)methyl]-6-[5-(trifluoromethyl)pyridin-3-yl]imidazo[1,2-b]pyridazine-3-sulfonamide

6-chloro-3-(4-phenylpiperazin-1-yl)sulfonylimidazo[1,2-b]pyridazine

6-chloro-3-(4-pyridin-2-ylpiperazin-1-yl)sulfonylimidazo[1,2-b]pyridazine

1-[6-(5-fluoropyridin-3-yl)imidazo[1,2-b]pyridazin-3-yl]sulfonyl-4-phenylpiperidine-4-carbonitrile

6-(4-methylsulfonylphenyl)-N-(oxolan-2-ylmethyl)imidazo[1,2-b]pyridazine-3-sulfonamide

3-(4-benzylpiperazin-1-yl)sulfonyl-6-(5-fluoropyridin-3-yl)imidazo[1,2-b]pyridazine

(3-Chloro-phenyl)-(6,7-dimethoxy-isoquinolin-1-yl)-amine

4-(6,7-Dimethoxy-4-nitro-1-oxo-1H-isoquinolin-2-yl)-butyric acid ethyl ester

(4-Chloro-phenyl)-(6,7-dimethoxy-isoquinolin-1-yl)-amine

(3-Bromo-phenyl)-(6,7-dimethoxy-isoquinolin-1-yl)-amine

4-(4-Amino-6,7-dimethoxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid ethyl ester hydrochloride

(4-Bromo-phenyl)-(6,7-dimethoxy-isoquinolin-1-yl)-amine

4-(6,7-Dihydroxy-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(2-Chloro-6,7-dimethoxy-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

3-(6,7-Dimethoxy-1-oxo-1H-isoquinolin-2-yl)-propionic acid ethyl ester

4-[2-(4-Bromo-phenylamino)-6,7-dimethoxy-4-oxo-4H-quinazolin-3-yl]-butyric acid ethyl ester

4-[2-(4-Azido-phenylamino)-6,7-dimethoxy-4-oxo-4H-quinazolin-3-yl]-butyric acid ethyl ester

4-(4-Bromo-6,7-dimethoxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid ethyl ester

2-(6,7-Dimethoxy-isoquinolin-1-ylamino)-ethanol

4-(2-Chloro-6,7-dimethoxy-quinazolin-4-yloxy)-butyric acid ethyl ester

4-(4,5-Difluoro-6,7-dimethoxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid ethyl ester

(6,7-Dimethoxy-isoquinolin-1-yl)-phenyl-amine

4-(4-Bromo-6,7-dimethoxy-1-oxo-1H-isoquinolin-2-yl)-N-methyl-butyramide

4-(6,7-Dimethoxy-1-oxo-1H-isoquinolin-2-yl)-butyric acid

4-(5-Acetylamino-6,7-dimethoxy-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester

4-(6,7-Dimethoxy-1-oxo-1H-isoquinolin-2-yl)-N-methyl-butyramide