| Compound ID |
Compound Name |
Compound Formula |
|
CP0692982
|
[(1R,2R,4R,5S)-5-(3-Methyl-6-oxo-1,2,7-triaza-2,7-dihydroinden-4-yl)-2-norbornanyl]acetonitrile
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|
C16H18N4O
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0002393
|
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
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|
C16H20N6O
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0701646
|
rac-3-Methyl-4-[trans-4-[2-oxo-2-(3-phenylpyrrolidin-1-yl)-ethyl]cyclohexyl]-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
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|
C25H30N4O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0812653
|
4-[trans-4-[2-(4,4-Dimethyl-1-piperidyl)-2-oxo-ethyl]-cyclohexyl]-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
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|
C22H32N4O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0640933
|
ABROCITINIB
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|
C14H21N5O2S
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0712228
|
4-[trans-4-[2-(3-Benzylazetidin-1-yl)-2-oxo-ethyl]-cyclohexyl]-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
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|
C25H30N4O2
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0701645
|
[trans-4-(3-Methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]-pyridin-4-yl)cyclohexyl] (1S)-2,2-difluorocyclopropanecarboxylate
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|
C17H19F2N3O3
|
1
|
| 1 |
IC50 = 420 nM
|
|
|
|
CP0692981
|
[(1S,2S,4S,5R)-5-(3-Methyl-6-oxo-1,2,7-triaza-2,7-dihydroinden-4-yl)-2-norbornanyl]acetonitrile
Show/Hide
|
C16H18N4O
|
1
|
| 1 |
IC50 = 770 nM
|
|
|
|
CP0701648
|
rac-3-Methyl-4-[(1R*,2S*,4S*)-norbornan-2-yl]-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
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|
C14H17N3O
|
1
|
| 1 |
IC50 = 850 nM
|
|
|
|
CP0701641
|
rac-4-(2-Bicyclo[2.2.2]octanyl)-3-methyl-2,7-dihydropyrazolo-[3,4-b]pyridin-6-one
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|
C15H19N3O
|
1
|
| 1 |
IC50 = 890 nM
|
|
|
|
CP0701647
|
rac-3-Methyl-4-[(1R*,2R*,4S*)-norbornan-2-yl]-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
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|
C14H17N3O
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0692984
|
2-[trans-4-(3-Methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]-pyridin-4-yl)cyclohexyl]acetonitrile
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|
C15H18N4O
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0693222
|
3-[trans-4-(3-Methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]-pyridin-4-yl)cyclohexyl]propanenitrile
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|
C16H20N4O
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0768026
|
[(1S,2R,4S,5R)-5-(3-Methyl-6-oxo-1,2,7-triaza-2,7-dihydroinden-4-yl)-2-norbornanyl]acetonitrile
Show/Hide
|
C16H18N4O
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0692983
|
rac-3-Methyl-4-[(1S*,2R*)-2-methylcyclohexyl]-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
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|
C14H19N3O
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0692980
|
(1S)-2,2-Difluoro-N-[trans-4-(3-methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]-cyclopropanecarboxamide
Show/Hide
|
C17H20F2N4O2
|
1
|
| 1 |
IC50 = 1700 nM
|
|
|
|
CP0162853
|
4-cyclohexyl-3-cyclopropyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
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|
C15H19N3O
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0207734
|
4-cyclohexyl-3-ethyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
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|
C14H19N3O
|
1
|
| 1 |
IC50 = 2500 nM
|
|
|
|
CP0701643
|
[(1R,2S,4R,5S)-5-(3-Methyl-6-oxo-1,2,7-triaza-2,7-dihydroinden-4-yl)-2-norbornanyl]acetonitrile
Show/Hide
|
C16H18N4O
|
1
|
| 1 |
IC50 = 2700 nM
|
|
|
|
CP0812651
|
1-Cyclobutyl-N-[trans-4-(3-methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]-methanesulfonamide
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|
C18H26N4O3S
|
1
|
| 1 |
IC50 = 3200 nM
|
|
|
|
CP0124474
|
4-(cyclobutylmethyl)-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
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|
C12H15N3O
|
1
|
| 1 |
IC50 = 3400 nM
|
|
|
|
CP0330677
|
4-cyclohexyl-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
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|
C13H17N3O
|
1
|
| 1 |
IC50 = 3700 nM
|
|
|
|
CP0207730
|
4-cyclopentyl-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
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|
C12H15N3O
|
1
|
| 1 |
IC50 = 4300 nM
|
|
|
|
CP0162855
|
4-cyclohexyl-5-(hydroxymethyl)-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
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|
C14H19N3O2
|
1
|
| 1 |
IC50 = 4800 nM
|
|
|
|
CP0356130
|
4-cyclohexyl-5-(2-hydroxyethyl)-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
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|
C15H21N3O2
|
1
|
| 1 |
IC50 = 8500 nM
|
|
|
|
CP0701644
|
N-[trans-4-(3-Methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]-pyridin-4-yl)cyclohexyl]cyclopentanecarboxamide
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|
C19H26N4O2
|
1
|
| 1 |
IC50 = 9100 nM
|
|
|
|
CP0735624
|
N-[trans-4-(3-Methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]-pyridin-4-yl)cyclohexyl]cyclopropanecarboxamide
Show/Hide
|
C17H22N4O2
|
1
|
| 1 |
IC50 > 14000 nM
|
|
|
|
CP0812652
|
rac-1-[2-[trans-4-(3-Methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]-pyridin-4-yl)cyclohexyl]acetyl]pyrrolidine-3-carbonitrile
Show/Hide
|
C20H25N5O2
|
1
|
| 1 |
IC50 = 14000 nM
|
|
|
|
CP0330676
|
4-cyclohexyl-3-methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]pyridine-5-carbonitrile
Show/Hide
|
C14H16N4O
|
1
|
| 1 |
IC50 = 20000 nM
|
|
|
|
CP0812656
|
4-(4-trans-Hydroxycyclohexyl)-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C13H17N3O2
|
1
|
| 1 |
IC50 = 20000 nM
|
|
|
|
CP0701642
|
1-[2-[trans-4-(3-Methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]-pyridin-4-yl)cyclohexyl]acetyl]azetidine-3-carbonitrile
Show/Hide
|
C19H23N5O2
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0692985
|
4-(4-trans-Aminocyclohexyl)-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C13H18N4O
|
1
|
| 1 |
IC50 > 40000 nM
|
|
|
|
CP0712223
|
N-Cyclopropyl-trans-4-(3-methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexanecarboxamide
Show/Hide
|
C17H22N4O2
|
1
|
| 1 |
IC50 > 40000 nM
|
|
|
|
CP0768025
|
(1R)-2,2-Difluoro-N-[trans-4-(3-methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]-cyclopropanecarboxamide
Show/Hide
|
C17H20F2N4O2
|
1
|
| 1 |
IC50 > 40000 nM
|
|
|
|
CP0207733
|
4-cyclohexyl-1,7-dihydropyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C12H15N3O
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0330675
|
3-methyl-4-phenyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C13H11N3O
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
