Brief Information of the Cell Line and Protein
Cell Line ID: CL000049 , C6
Synonyms
C-6
C 6
RGC-6
RGC6
RGc6
Category Cancer cell line
Organism
Rattus norvegicus (Rat)
Cellosaurus ID
CVCL_0194
Protein ID: PT01526 , Delta-type opioid receptor
Gene Name OPRD1
Organism Rattus norvegicus, Rat
Protein Classification Membrane receptor
Uniprot ID P33533
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000049  Protein ID: PT01526
 
Compound ID Compound Name Compound Formula
CP0168442
CAS_111555-58-9
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C26H25NO4
 1
1
Activity = 0.037 nM
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CP0167293
7-Benzylidenenaltrexone
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C27H27NO4
 1
1
Activity = 0.079 nM
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CP0040319
4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-hydroxyphenyl)methyl)-N,N-diethylbenzamide
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C27H37N3O2
 1
1
Activity = 0.45 nM
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CP0072629
2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(1S,2R,6S,14R,15R,16R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-2-propanol
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C26H35NO4
 1
1
Activity = 1.6 nM
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CP0041235
22-methyl-(2S,13R)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15(25),16,18-heptaene-2,16-diol(HCl0.5H2O) (Oxymorphindole, OMI)
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C23H22N2O3
 1
1
Activity = 6.5 nM
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CP0096567
7-(2'-spiroindanyl)oxymorphone
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C25H25NO4
 1
1
Activity = 8.4 nM
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CP0053097
2-[2-(2-{2-[2-Diallylamino-3-(4-hydroxy-phenyl)-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid
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C38H53N5O7
 1
1
Activity = 37 nM
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CP0369775
ETORPHINE
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C25H33NO4
 1
1
Activity = 40 nM
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CP0041255
(+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide
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C28H39N3O2
 2
1
Activity = 60 nM
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2
EC50 = 166 nM
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CP0042565
(S)-3-((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-N-{(S)-1-[(S)-1-(carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propyl}-succinamic acid
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C37H52N8O10
 1
1
Activity = 81 nM
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CP0471250
2-{2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3-hydroxy-propionylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-3-hydroxy-butyric acid
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C33H46N6O10
 1
1
Activity = 93 nM
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CP0895221
Tyr-c[D-Pen-Gly-Phe-(pCl)-D-Pen]
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C30H38ClN5O7S2
 1
1
Activity = 135 nM
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CP0038418
13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triaza-cyclotetradecane-4-carboxylic acid
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C30H39N5O7S2
 1
1
Activity = 487 nM
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CP0447074
(2S)-2-amino-N-[(4R)-1-(cyclopropanecarbonyl)-6-(quinolin-3-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C36H37F3N4O5
 2
1
EC50 = 0.71 nM
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2
Ki = 0.08 nM
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CP0447075
(2S)-N-[(4R)-1-acetyl-6-(1-benzofuran-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C33H34F3N3O6
 2
1
EC50 = 1.6 nM
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2
Ki = 0.73 nM
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CP0452046
(2S)-2-amino-N-[(4R)-1-(cyclopropanecarbonyl)-6-(naphthalen-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C37H38F3N3O5
 2
1
EC50 = 1.9 nM
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2
Ki = 0.37 nM
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CP0447077
(2S)-2-amino-N-[(4R)-6-(1-benzofuran-2-ylmethyl)-1-(cyclopropanecarbonyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C35H36F3N3O6
 2
1
EC50 = 3.7 nM
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2
Ki = 0.26 nM
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CP0407775
(2S)-2-amino-N-[(4R)-6-benzyl-1-(cyclobutanecarbonyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C32H37N3O3
 2
1
EC50 = 5.1 nM
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2
Ki = 0.15 nM
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CP0451769
(2S)-N-[(4R)-1-acetyl-6-(quinolin-3-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C34H35F3N4O5
 2
1
EC50 = 5.8 nM
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2
Ki = 0.2 nM
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CP0382450
(2S)-2-amino-N-[(4R)-6-benzyl-1-butanoyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C31H37N3O3
 2
1
EC50 = 8.1 nM
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2
Ki = 1 nM
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CP0429424
(2S)-2-amino-N-[(4R)-6-benzyl-1-(cyclopropanecarbonyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C31H35N3O3
 2
1
EC50 = 10 nM
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2
Ki = 0.35 nM
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CP0468797
(2S)-2-amino-N-[(4R)-6-benzyl-1-methylsulfonyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C30H34F3N3O6S
 2
1
EC50 = 12 nM
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2
Ki = 0.41 nM
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CP0385113
(2S)-N-[(4R)-1-acetyl-6-(cyclohexylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C29H39N3O3
 2
1
EC50 = 14 nM
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2
Ki = 0.32 nM
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CP0420051
methyl (4R)-4-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-6-benzyl-3,4-dihydro-2H-quinoline-1-carboxylate
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C29H33N3O4
 2
1
EC50 = 14 nM
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2
Ki = 0.51 nM
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CP0429428
ethyl 2-[(4R)-4-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-6-benzyl-3,4-dihydro-2H-quinolin-1-yl]acetate
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C31H37N3O4
 2
1
EC50 = 15 nM
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2
Ki = 0.58 nM
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CP0419399
(2S)-2-amino-N-[(4R)-6-benzyl-1-(2-methylpropanoyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C31H37N3O3
 2
1
EC50 = 25 nM
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2
Ki = 0.53 nM
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CP0420050
(2S)-2-amino-N-[(4R)-6-benzyl-1-propanoyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C30H35N3O3
 2
1
EC50 = 32 nM
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2
Ki = 1.1 nM
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CP0458891
(5R,8S,11S,14S)-14-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-11-benzyl-8-(naphthalen-2-ylmethyl)-7,10,13-trioxo-1,3-dithia-6,9,12-triazacyclopentadecane-5-carboxamide
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C38H42N6O6S2
 3
1
EC50 = 36 nM
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2
Ki = 0.48 nM
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3
Ki = 2.1 nM
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CP0420240
(2S)-2-amino-N-[(4R)-6-benzyl-1-(2-methoxyacetyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C30H35N3O4
 2
1
EC50 = 67 nM
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2
Ki = 2.1 nM
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CP0385120
(2S)-N-[(4R)-1-acetyl-6-benzyl-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C29H33N3O3
 2
1
EC50 = 68 nM
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2
Ki = 1.8 nM
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CP0385126
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4R)-6-(naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]propanamide
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C31H33N3O2
 2
1
EC50 = 69 nM
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2
Ki = 6 nM
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CP0382568
(2S)-2-amino-N-[(4R)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C27H31N3O2
 2
1
EC50 = 110 nM
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2
Ki = 9.4 nM
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CP0888239
(S)-2-amino-N-((R)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl)-3-(4-hydroxy-2,6-dimethylphenyl)propanamide 2,2,2-trifluoroacetate
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C29H32F3N3O4
 2
1
EC50 = 110 nM
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2
Ki = 9.4 nM
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CP0521687
(1S,5S,9R)-5-(3-hydroxyphenyl)-2-[(E)-3-phenylprop-2-enyl]-2-azabicyclo[3.3.1]nonan-9-ol;oxalic acid
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C25H29NO6
 1
1
EC50 = 253 nM
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CP0446710
(2S)-2-amino-N-[(4R)-1-(2-amino-2-oxoethyl)-6-benzyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C29H34N4O3
 2
1
EC50 = 270 nM
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2
Ki = 2 nM
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CP0216238
(4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
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C30H39N5O7S2
 1
1
EC50 = 368 nM
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CP0409019
(1R,5R,9S)-5-(3-hydroxyphenyl)-2-[2-(4-nitrophenyl)ethyl]-2-azabicyclo[3.3.1]nonan-9-ol;oxalic acid
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C24H28N2O8
 1
1
EC50 = 630 nM
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CP0470601
(1R,5R,9S)-5-(3-hydroxyphenyl)-2-[2-[4-(trifluoromethyl)phenyl]ethyl]-2-azabicyclo[3.3.1]nonan-9-ol;hydrochloride
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C23H27ClF3NO2
 1
1
EC50 = 901 nM
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CP0372433
(1R,5R,9S)-(-)-9-hydroxy-5-(3-hydroxyphenyl-2-phenylethyl-2-azabicyclo[3.3.1]nonane
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C22H27NO2
 1
1
EC50 = 1084 nM
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CP0404433
(2S)-2-amino-N-[(4R)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,5-dimethylphenyl)propanamide
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C27H31N3O2
 2
1
EC50 = 5900 nM
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2
Ki = 390 nM
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CP0846973
10-hydroxy-17-(3-phenylpropoxy)-4-tetrahydro-2-furanylmethyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-one
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C30H35NO5
 1
1
Ki = 0.09 nM
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CP0472984
(2S)-2-amino-N-[(4R)-1-(cyclopropanecarbonyl)-6-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C35H38F3N3O7
 1
1
Ki = 0.19 nM
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CP0050068
(1S,2S,13R,21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol
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C26H26N2O3
 1
1
Ki = 0.2 nM
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CP0429383
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4R)-6-(naphthalen-2-ylmethyl)-1-propanoyl-3,4-dihydro-2H-quinolin-4-yl]propanamide
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C34H37N3O3
 1
1
Ki = 0.21 nM
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CP0472987
(2S)-2-amino-N-[(4R)-1-benzoyl-6-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C38H38F3N3O7
 1
1
Ki = 0.22 nM
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CP0385129
(2S)-N-[(4R)-1-acetyl-6-(naphthalen-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C33H35N3O3
 1
1
Ki = 0.23 nM
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CP0429425
(2S)-2-amino-N-[(4R)-1-benzoyl-6-benzyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C34H35N3O3
 1
1
Ki = 0.24 nM
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CP0380849
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(R)-hydroxy(phenyl)methyl]-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
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C31H37NO4
 1
1
Ki = 0.25 nM
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CP0499509
US10231963, Table B.13
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C28H31NO4
 1
1
Ki = 0.26 nM
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CP0378305
(1R,13S,14R)-24-(cyclopropylmethyl)-20-methoxy-4,24-diazahexacyclo[12.7.3.0^{1,13}.0^{3,11}.0^{5,10}.0^{16,21}]tetracosa-3(11),5(10),6,8,16,18,20-heptaene-13,19-diol
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C27H30N2O3
 1
1
Ki = 0.4 nM
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CP0848722
(1'R,5alpha,6R,7R,14alpha)-1'-(3-methylphenyl)-1'-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-7beta-methyl 17-cyclopropylmethyl-6,14-etheno-morphinan-7-yl)-methan-1'-ol
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C32H37NO4
 1
1
Ki = 0.4 nM
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CP0382583
(2S)-N-[(4R)-1-acetyl-6-(2,3-dihydro-1H-inden-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C32H37N3O3
 1
1
Ki = 0.44 nM
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CP0847461
4-cyclobutylmethyl-10-hydroxy-17-(3-phenylpropoxy)-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-one
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C30H35NO4
 1
1
Ki = 0.46 nM
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CP0472986
(2S)-2-amino-N-[(4R)-1-benzoyl-6-(naphthalen-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C40H38F3N3O5
 1
1
Ki = 0.46 nM
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CP0414678
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(R)-(4-fluorophenyl)-hydroxymethyl]-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
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C31H36FNO4
 1
1
Ki = 0.47 nM
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CP0437789
14-O-phenylpropylnaltrexone
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C29H33NO4
 1
1
Ki = 0.48 nM
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CP0072627
BUPRENORPHINE
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C29H41NO4
 1
1
Ki = 0.48 nM
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CP0850661
(1'R,5alpha,6R,7R,14alpha)-1'-phenyl-1'-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-7beta-methyl 17-cyclopropylmethyl-6,14-ethenomorphinan-7-yl)-methan-1'-ol
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C31H35NO4
 1
1
Ki = 0.48 nM
   TI
   LI
   LO
   TS
CP0451771
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4R)-1-methylsulfonyl-6-(quinolin-3-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C33H35F3N4O6S
 1
1
Ki = 0.64 nM
   TI
   LI
   LO
   TS
CP0451779
(2S)-2-amino-N-[(4R)-6-(1-benzofuran-2-ylmethyl)-1-benzoyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C38H36F3N3O6
 1
1
Ki = 0.64 nM
   TI
   LI
   LO
   TS
CP0430968
(2S)-2-amino-N-[(4R)-1-benzoyl-6-(quinolin-3-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C39H37F3N4O5
 1
1
Ki = 0.74 nM
   TI
   LI
   LO
   TS
CP0420052
(2S)-2-amino-N-[(4R)-1-butanoyl-6-(naphthalen-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
   Show/Hide
C35H39N3O3
 1
1
Ki = 0.8 nM
   TI
   LI
   LO
   TS
CP0472985
(2S)-N-[(4R)-1-acetyl-6-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C33H36F3N3O7
 1
1
Ki = 0.83 nM
   TI
   LI
   LO
   TS
CP0382584
(2S)-N-[(4R)-1-acetyl-6-(2,3-dihydro-1H-inden-1-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
   Show/Hide
C32H37N3O3
 1
1
Ki = 0.84 nM
   TI
   LI
   LO
   TS
CP0430965
(2S)-2-amino-N-[(4R)-1-(cyclopropanecarbonyl)-6-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C36H41F3N4O5
 1
1
Ki = 0.88 nM
   TI
   LI
   LO
   TS
CP0430966
(2S)-N-[(4R)-1-acetyl-6-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C34H39F3N4O5
 1
1
Ki = 0.89 nM
   TI
   LI
   LO
   TS
CP0893297
oxymorphindole hydrochloride
   Show/Hide
C23H23ClN2O3
 1
1
Ki = 0.9 nM
   TI
   LI
   LO
   TS
CP0910158
10-hydroxy-17-(3-phenylpropoxy)-4-propyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-one
   Show/Hide
C28H33NO4
 1
1
Ki = 0.93 nM
   TI
   LI
   LO
   TS
CP0475259
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4R)-1-methylsulfonyl-6-(naphthalen-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C34H36F3N3O6S
 1
1
Ki = 0.95 nM
   TI
   LI
   LO
   TS
CP0430970
(2S)-2-amino-N-[(4R)-6-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-1-methylsulfonyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C33H39F3N4O6S
 1
1
Ki = 0.98 nM
   TI
   LI
   LO
   TS
CP0382350
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(1R)-1-hydroxy-1-pyridin-4-ylethyl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
   Show/Hide
C30H36N2O4
 1
1
Ki = 0.99 nM
   TI
   LI
   LO
   TS
CP0413167
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(1S)-1-hydroxy-1-thiophen-2-ylethyl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
   Show/Hide
C29H35NO4S
 1
1
Ki = 1 nM
   TI
   LI
   LO
   TS
CP0429384
methyl (4R)-4-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-6-(naphthalen-2-ylmethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
   Show/Hide
C33H35N3O4
 1
1
Ki = 1 nM
   TI
   LI
   LO
   TS
CP0489973
(2S)-2-amino-N-[(4R)-6-(1-benzofuran-2-ylmethyl)-1-methylsulfonyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C32H34F3N3O7S
 1
1
Ki = 1 nM
   TI
   LI
   LO
   TS
CP0869549
10-hydroxy-4-phenethyl-17-(3-phenylpropoxy)-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-one
   Show/Hide
C33H35NO4
 1
1
Ki = 1.25 nM
   TI
   LI
   LO
   TS
CP0385133
(2S)-N-[(4R)-1-acetyl-6-(naphthalen-1-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
   Show/Hide
C33H35N3O3
 1
1
Ki = 1.3 nM
   TI
   LI
   LO
   TS
CP0447297
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4R)-6-(quinolin-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C32H33F3N4O4
 1
1
Ki = 1.5 nM
   TI
   LI
   LO
   TS
CP0482858
(2S)-2-amino-N-[(4R)-6-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-1-methylsulfonyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C32H36F3N3O8S
 1
1
Ki = 1.5 nM
   TI
   LI
   LO
   TS
CP0045401
(5R,8S,11S,14S)-14-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-8,11-dibenzyl-7,10,13-trioxo-1,3-dithia-6,9,12-triazacyclopentadecane-5-carboxamide
   Show/Hide
C34H40N6O6S2
 1
1
Ki = 1.8 nM
   TI
   LI
   LO
   TS
CP0451768
(2S)-2-amino-N-[(4R)-6-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C32H37F3N4O4
 1
1
Ki = 3.1 nM
   TI
   LI
   LO
   TS
CP0385128
(2S)-2-amino-N-[(4R)-6-(cyclohexylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
   Show/Hide
C27H37N3O2
 1
1
Ki = 3.4 nM
   TI
   LI
   LO
   TS
CP0385122
(2S)-2-amino-N-[(1R)-7-benzyl-1,2,3,4-tetrahydronaphthalen-1-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
   Show/Hide
C28H32N2O2
 1
1
Ki = 4 nM
   TI
   LI
   LO
   TS
CP0482883
(2S)-2-amino-N-[(4R)-1-benzoyl-6-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C39H41F3N4O5
 1
1
Ki = 4 nM
   TI
   LI
   LO
   TS
CP0385221
(2S)-2-amino-N-[(4R)-6-(2,3-dihydro-1H-inden-2-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
   Show/Hide
C30H35N3O2
 1
1
Ki = 4.1 nM
   TI
   LI
   LO
   TS
CP0378307
(1R,13S,14R)-20-methoxy-24-methyl-4,24-diazahexacyclo[12.7.3.0^{1,13}.0^{3,11}.0^{5,10}.0^{16,21}]tetracosa-3(11),5(10),6,8,16,18,20-heptaene-13,19-diol
   Show/Hide
C24H26N2O3
 1
1
Ki = 4.5 nM
   TI
   LI
   LO
   TS
CP0385127
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(1R)-7-(naphthalen-1-ylmethyl)-1,2,3,4-tetrahydronaphthalen-1-yl]propanamide
   Show/Hide
C32H34N2O2
 1
1
Ki = 5 nM
   TI
   LI
   LO
   TS
CP0451766
(2S)-2-amino-N-[(4R)-6-(1-benzofuran-2-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C31H32F3N3O5
 1
1
Ki = 5 nM
   TI
   LI
   LO
   TS
CP0447314
(5R,8S,11S,14S)-14-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-11-benzyl-8-(naphthalen-1-ylmethyl)-7,10,13-trioxo-1,3-dithia-6,9,12-triazacyclopentadecane-5-carboxamide
   Show/Hide
C38H42N6O6S2
 1
1
Ki = 5.2 nM
   TI
   LI
   LO
   TS
CP0412205
(2S)-2-amino-N-[(5-benzyl-2-propoxyphenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C30H35F3N2O5
 1
1
Ki = 5.3 nM
   TI
   LI
   LO
   TS
CP0871267
10-methoxy-4-phenethyl-17-(3-phenylpropoxy)-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-one
   Show/Hide
C34H37NO4
 1
1
Ki = 5.4 nM
   TI
   LI
   LO
   TS
CP0447294
(2S)-2-amino-N-[(4R)-6-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C31H34F3N3O6
 1
1
Ki = 5.5 nM
   TI
   LI
   LO
   TS
CP0870134
10-methoxy-17-(3-phenylpropoxy)-4-tetrahydro-2-furanylmethyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-one
   Show/Hide
C31H37NO5
 1
1
Ki = 6.2 nM
   TI
   LI
   LO
   TS
CP0432506
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-(4-phenylbutyl)piperazin-1-yl]propan-1-one
   Show/Hide
C25H35N3O2
 1
1
Ki = 6.6 nM
   TI
   LI
   LO
   TS
CP0457352
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-(3-naphthalen-1-ylpropyl)piperazin-1-yl]propan-1-one
   Show/Hide
C28H35N3O2
 1
1
Ki = 6.6 nM
   TI
   LI
   LO
   TS
CP0385130
(2S)-2-amino-N-[(4R)-6-(2,3-dihydro-1H-inden-1-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
   Show/Hide
C30H35N3O2
 1
1
Ki = 6.8 nM
   TI
   LI
   LO
   TS
CP0383080
(2S)-2-amino-N-[(1R)-1-(5-benzyl-2-methoxyphenyl)ethyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C29H33F3N2O5
 1
1
Ki = 6.8 nM
   TI
   LI
   LO
   TS
CP0432505
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-(5-phenylpentyl)piperazin-1-yl]propan-1-one
   Show/Hide
C26H37N3O2
 1
1
Ki = 6.9 nM
   TI
   LI
   LO
   TS
CP0458898
(4R,7S,10S,13S)-13-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-10-benzyl-7-(naphthalen-1-ylmethyl)-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxamide
   Show/Hide
C37H40N6O6S2
 1
1
Ki = 7.1 nM
   TI
   LI
   LO
   TS
CP0416998
(2S)-2-amino-N-[[5-benzyl-2-(trifluoromethoxy)phenyl]methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C28H28F6N2O5
 1
1
Ki = 7.3 nM
   TI
   LI
   LO
   TS
CP0443502
(2S)-2-amino-1-(4-benzylpiperidin-1-yl)-3-(4-hydroxy-2,6-dimethylphenyl)propan-1-one
   Show/Hide
C23H30N2O2
 1
1
Ki = 7.8 nM
   TI
   LI
   LO
   TS
CP0410855
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4R)-6-(2-phenylethyl)-1,2,3,4-tetrahydroquinolin-4-yl]propanamide
   Show/Hide
C28H33N3O2
 1
1
Ki = 8.9 nM
   TI
   LI
   LO
   TS
CP0385121
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4R)-6-(naphthalen-2-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]propanamide
   Show/Hide
C31H33N3O2
 1
1
Ki = 10 nM
   TI
   LI
   LO
   TS
CP0470384
(4R,7S,10S,13S)-13-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-10-benzyl-7-(naphthalen-2-ylmethyl)-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxamide
   Show/Hide
C37H40N6O6S2
 1
1
Ki = 11 nM
   TI
   LI
   LO
   TS
CP0432508
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-[(E)-3-naphthalen-1-ylprop-2-enyl]piperazin-1-yl]propan-1-one
   Show/Hide
C28H33N3O2
 1
1
Ki = 11 nM
   TI
   LI
   LO
   TS
CP0457353
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-(3-phenylpropyl)piperidin-1-yl]propan-1-one
   Show/Hide
C25H34N2O2
 1
1
Ki = 12 nM
   TI
   LI
   LO
   TS
CP0428399
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(1R)-7-(naphthalen-2-ylmethyl)-1,2,3,4-tetrahydronaphthalen-1-yl]propanamide
   Show/Hide
C32H34N2O2
 1
1
Ki = 12 nM
   TI
   LI
   LO
   TS
CP0402366
(2S)-2-amino-N-[[5-benzyl-2-(cyclopropylmethoxy)phenyl]methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C31H35F3N2O5
 1
1
Ki = 13.9 nM
   TI
   LI
   LO
   TS
CP0379925
(2S)-2-amino-1-(4-benzyl-3,4-dihydro-2H-quinolin-1-yl)-3-(4-hydroxy-2,6-dimethylphenyl)propan-1-one
   Show/Hide
C27H30N2O2
 1
1
Ki = 14 nM
   TI
   LI
   LO
   TS
CP0385125
(2S)-2-amino-N-[(1R)-7-(cyclohexylmethyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
   Show/Hide
C28H38N2O2
 1
1
Ki = 14 nM
   TI
   LI
   LO
   TS
CP0416997
(2S)-2-amino-N-[(3-benzylphenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C27H29F3N2O4
 1
1
Ki = 14.7 nM
   TI
   LI
   LO
   TS
CP0452452
(5R,8S,11S,14S)-14-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-8-benzyl-11-(naphthalen-2-ylmethyl)-7,10,13-trioxo-1,3-dithia-6,9,12-triazacyclopentadecane-5-carboxamide
   Show/Hide
C38H42N6O6S2
 1
1
Ki = 15 nM
   TI
   LI
   LO
   TS
CP0371759
(1R,13S,14R)-24-(cyclopropylmethyl)-19,20-dimethoxy-4,24-diazahexacyclo[12.7.3.0^{1,13}.0^{3,11}.0^{5,10}.0^{16,21}]tetracosa-3(11),5(10),6,8,16,18,20-heptaen-13-ol
   Show/Hide
C28H32N2O3
 1
1
Ki = 19 nM
   TI
   LI
   LO
   TS
CP0457351
(2S)-2-amino-1-[4-(3,3-diphenylpropyl)piperazin-1-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propan-1-one
   Show/Hide
C30H37N3O2
 1
1
Ki = 21 nM
   TI
   LI
   LO
   TS
CP0412224
(2S)-2-amino-N-[(5-benzyl-2-methoxyphenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C28H31F3N2O5
 1
1
Ki = 21.5 nM
   TI
   LI
   LO
   TS
CP0396057
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-[(E)-4-phenylbut-2-enyl]piperazin-1-yl]propan-1-one
   Show/Hide
C25H33N3O2
 1
1
Ki = 23 nM
   TI
   LI
   LO
   TS
CP0849802
(S)-1-((5-Benzyl-2-ethoxybenzyl)amino)-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropan-2-aminium Trifluoroacetate
   Show/Hide
C29H33F3N2O5
 1
1
Ki = 23.8 nM
   TI
   LI
   LO
   TS
CP0421079
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-[(Z)-4-phenylbut-2-enyl]piperazin-1-yl]propan-1-one
   Show/Hide
C25H33N3O2
 1
1
Ki = 28 nM
   TI
   LI
   LO
   TS
CP0402374
(2S)-2-amino-N-[(5-benzyl-2-methylphenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C28H31F3N2O4
 1
1
Ki = 33.9 nM
   TI
   LI
   LO
   TS
CP0418175
(5R,8S,11S,14S)-14-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-8-benzyl-11-(naphthalen-1-ylmethyl)-7,10,13-trioxo-1,3-dithia-6,9,12-triazacyclopentadecane-5-carboxamide
   Show/Hide
C38H42N6O6S2
 1
1
Ki = 34 nM
   TI
   LI
   LO
   TS
CP0452451
(4R,7S,10S,13S)-13-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-7-benzyl-10-(naphthalen-1-ylmethyl)-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxamide
   Show/Hide
C37H40N6O6S2
 1
1
Ki = 34 nM
   TI
   LI
   LO
   TS
CP0379924
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-(3-phenylpropyl)piperazin-1-yl]propan-1-one
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C24H33N3O2
 1
1
Ki = 36 nM
   TI
   LI
   LO
   TS
CP0392519
(2S)-2-amino-N-[(4R)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl]-3-(2,6-dichloro-4-hydroxyphenyl)propanamide
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C25H25Cl2N3O2
 1
1
Ki = 37 nM
   TI
   LI
   LO
   TS
CP0416992
(2S)-2-amino-N-[(5-benzyl-2-chlorophenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C27H28ClF3N2O4
 1
1
Ki = 38.1 nM
   TI
   LI
   LO
   TS
CP0126886
(4R,4aS,7aR,12bR)-9-hydroxy-4a-methoxy-3,7a-dimethyl-1,2,4,5,6,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
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C19H23NO4
 1
1
Ki = 40.9 nM
   TI
   LI
   LO
   TS
CP0453799
(1R,13S,14R)-19,20-dimethoxy-24-methyl-4,24-diazahexacyclo[12.7.3.0^{1,13}.0^{3,11}.0^{5,10}.0^{16,21}]tetracosa-3(11),5(10),6,8,16,18,20-heptaen-13-ol
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C25H28N2O3
 1
1
Ki = 41 nM
   TI
   LI
   LO
   TS
CP0400891
(2S)-2-amino-N-[(4R)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2-methylphenyl)propanamide
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C26H29N3O2
 1
1
Ki = 42 nM
   TI
   LI
   LO
   TS
CP0412223
(2S)-2-amino-N-[(1R)-1-(3-benzylphenyl)ethyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C28H31F3N2O4
 1
1
Ki = 46 nM
   TI
   LI
   LO
   TS
CP0470368
(4R,7S,10S,13S)-13-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-7-benzyl-10-(naphthalen-2-ylmethyl)-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxamide
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C37H40N6O6S2
 1
1
Ki = 55 nM
   TI
   LI
   LO
   TS
CP0459878
(2S)-2-amino-N-[(4S)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C27H31N3O2
 1
1
Ki = 56 nM
   TI
   LI
   LO
   TS
CP0468852
(2S)-2-amino-N-[(1R)-1-(3-benzylphenyl)propyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C29H33F3N2O4
 1
1
Ki = 61 nM
   TI
   LI
   LO
   TS
CP0412222
(2S)-2-amino-N-[[5-benzyl-2-(ethylamino)phenyl]methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C29H34F3N3O4
 1
1
Ki = 63.8 nM
   TI
   LI
   LO
   TS
CP0448772
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4S)-6-(naphthalen-2-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]propanamide
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C31H33N3O2
 1
1
Ki = 66 nM
   TI
   LI
   LO
   TS
CP0419423
2-[(4R)-4-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-6-benzyl-3,4-dihydro-2H-quinolin-1-yl]acetic acid
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C29H33N3O4
 1
1
Ki = 67 nM
   TI
   LI
   LO
   TS
CP0416993
(2S)-2-amino-N-[(5-benzyl-2-phenylmethoxyphenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C34H35F3N2O5
 1
1
Ki = 70.4 nM
   TI
   LI
   LO
   TS
CP0412199
(2S)-2-amino-N-[[5-benzyl-2-(propanoylamino)phenyl]methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C30H34F3N3O5
 1
1
Ki = 108 nM
   TI
   LI
   LO
   TS
CP0410856
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4S)-6-(2-phenylethyl)-1,2,3,4-tetrahydroquinolin-4-yl]propanamide
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C28H33N3O2
 1
1
Ki = 120 nM
   TI
   LI
   LO
   TS
CP0000305
(-)-(etorphine)
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C17H19NO3
 2
1
Ki = 171 nM
   TI
   LI
   LO
   TS
2
Ki = 217 nM
   TI
   LI
   LO
   TS
CP0412225
(2S)-2-amino-N-[(5-benzyl-2-hydroxyphenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C27H29F3N2O5
 1
1
Ki = 175 nM
   TI
   LI
   LO
   TS
CP0410857
(2S)-2-amino-N-[(4S)-6-(2,3-dihydro-1H-inden-2-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C30H35N3O2
 1
1
Ki = 180 nM
   TI
   LI
   LO
   TS
CP0484176
(2S)-N-[(2-acetamido-5-benzylphenyl)methyl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C29H32F3N3O5
 1
1
Ki = 387 nM
   TI
   LI
   LO
   TS
CP0392521
(2S)-2-amino-N-[(4R)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl]-3-(2,6-dimethylphenyl)propanamide
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C27H31N3O
 1
1
Ki = 660 nM
   TI
   LI
   LO
   TS
CP0456604
(2S)-2-amino-N-[(4R)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl]-3-(8-hydroxynaphthalen-2-yl)propanamide
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C29H29N3O2
 1
1
Ki = 1600 nM
   TI
   LI
   LO
   TS