Compound ID |
Compound Name |
Compound Formula |
CP0168442
|
CAS_111555-58-9
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|
C26H25NO4
|
1
|
1 |
Activity = 0.037 nM
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|
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CP0167293
|
7-Benzylidenenaltrexone
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C27H27NO4
|
1
|
1 |
Activity = 0.079 nM
|
|
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CP0040319
|
4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-hydroxyphenyl)methyl)-N,N-diethylbenzamide
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C27H37N3O2
|
1
|
1 |
Activity = 0.45 nM
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|
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CP0072629
|
2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(1S,2R,6S,14R,15R,16R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-2-propanol
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C26H35NO4
|
1
|
1 |
Activity = 1.6 nM
|
|
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CP0041235
|
22-methyl-(2S,13R)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15(25),16,18-heptaene-2,16-diol(HCl0.5H2O) (Oxymorphindole, OMI)
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|
C23H22N2O3
|
1
|
1 |
Activity = 6.5 nM
|
|
|
CP0096567
|
7-(2'-spiroindanyl)oxymorphone
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C25H25NO4
|
1
|
1 |
Activity = 8.4 nM
|
|
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CP0053097
|
2-[2-(2-{2-[2-Diallylamino-3-(4-hydroxy-phenyl)-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid
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|
C38H53N5O7
|
1
|
1 |
Activity = 37 nM
|
|
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CP0369775
|
ETORPHINE
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|
C25H33NO4
|
1
|
1 |
Activity = 40 nM
|
|
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CP0041255
|
(+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide
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|
C28H39N3O2
|
2
|
1 |
Activity = 60 nM
|
|
|
2 |
EC50 = 166 nM
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|
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CP0042565
|
(S)-3-((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-N-{(S)-1-[(S)-1-(carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propyl}-succinamic acid
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|
C37H52N8O10
|
1
|
1 |
Activity = 81 nM
|
|
|
CP0471250
|
2-{2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3-hydroxy-propionylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-3-hydroxy-butyric acid
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|
C33H46N6O10
|
1
|
1 |
Activity = 93 nM
|
|
|
CP0895221
|
Tyr-c[D-Pen-Gly-Phe-(pCl)-D-Pen]
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|
C30H38ClN5O7S2
|
1
|
1 |
Activity = 135 nM
|
|
|
CP0038418
|
13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triaza-cyclotetradecane-4-carboxylic acid
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|
C30H39N5O7S2
|
1
|
1 |
Activity = 487 nM
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|
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CP0447074
|
(2S)-2-amino-N-[(4R)-1-(cyclopropanecarbonyl)-6-(quinolin-3-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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|
C36H37F3N4O5
|
2
|
1 |
EC50 = 0.71 nM
|
|
|
2 |
Ki = 0.08 nM
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|
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CP0447075
|
(2S)-N-[(4R)-1-acetyl-6-(1-benzofuran-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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|
C33H34F3N3O6
|
2
|
1 |
EC50 = 1.6 nM
|
|
|
2 |
Ki = 0.73 nM
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|
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CP0452046
|
(2S)-2-amino-N-[(4R)-1-(cyclopropanecarbonyl)-6-(naphthalen-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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|
C37H38F3N3O5
|
2
|
1 |
EC50 = 1.9 nM
|
|
|
2 |
Ki = 0.37 nM
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|
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CP0447077
|
(2S)-2-amino-N-[(4R)-6-(1-benzofuran-2-ylmethyl)-1-(cyclopropanecarbonyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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|
C35H36F3N3O6
|
2
|
1 |
EC50 = 3.7 nM
|
|
|
2 |
Ki = 0.26 nM
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|
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CP0407775
|
(2S)-2-amino-N-[(4R)-6-benzyl-1-(cyclobutanecarbonyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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|
C32H37N3O3
|
2
|
1 |
EC50 = 5.1 nM
|
|
|
2 |
Ki = 0.15 nM
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|
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CP0451769
|
(2S)-N-[(4R)-1-acetyl-6-(quinolin-3-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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|
C34H35F3N4O5
|
2
|
1 |
EC50 = 5.8 nM
|
|
|
2 |
Ki = 0.2 nM
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|
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CP0382450
|
(2S)-2-amino-N-[(4R)-6-benzyl-1-butanoyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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|
C31H37N3O3
|
2
|
1 |
EC50 = 8.1 nM
|
|
|
2 |
Ki = 1 nM
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|
|
CP0429424
|
(2S)-2-amino-N-[(4R)-6-benzyl-1-(cyclopropanecarbonyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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|
C31H35N3O3
|
2
|
1 |
EC50 = 10 nM
|
|
|
2 |
Ki = 0.35 nM
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|
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CP0468797
|
(2S)-2-amino-N-[(4R)-6-benzyl-1-methylsulfonyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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|
C30H34F3N3O6S
|
2
|
1 |
EC50 = 12 nM
|
|
|
2 |
Ki = 0.41 nM
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|
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CP0385113
|
(2S)-N-[(4R)-1-acetyl-6-(cyclohexylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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|
C29H39N3O3
|
2
|
1 |
EC50 = 14 nM
|
|
|
2 |
Ki = 0.32 nM
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|
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CP0420051
|
methyl (4R)-4-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-6-benzyl-3,4-dihydro-2H-quinoline-1-carboxylate
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|
C29H33N3O4
|
2
|
1 |
EC50 = 14 nM
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|
|
2 |
Ki = 0.51 nM
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CP0429428
|
ethyl 2-[(4R)-4-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-6-benzyl-3,4-dihydro-2H-quinolin-1-yl]acetate
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|
C31H37N3O4
|
2
|
1 |
EC50 = 15 nM
|
|
|
2 |
Ki = 0.58 nM
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CP0419399
|
(2S)-2-amino-N-[(4R)-6-benzyl-1-(2-methylpropanoyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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|
C31H37N3O3
|
2
|
1 |
EC50 = 25 nM
|
|
|
2 |
Ki = 0.53 nM
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CP0420050
|
(2S)-2-amino-N-[(4R)-6-benzyl-1-propanoyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
Show/Hide
|
C30H35N3O3
|
2
|
1 |
EC50 = 32 nM
|
|
|
2 |
Ki = 1.1 nM
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|
|
CP0458891
|
(5R,8S,11S,14S)-14-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-11-benzyl-8-(naphthalen-2-ylmethyl)-7,10,13-trioxo-1,3-dithia-6,9,12-triazacyclopentadecane-5-carboxamide
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|
C38H42N6O6S2
|
3
|
1 |
EC50 = 36 nM
|
|
|
2 |
Ki = 0.48 nM
|
|
|
3 |
Ki = 2.1 nM
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CP0420240
|
(2S)-2-amino-N-[(4R)-6-benzyl-1-(2-methoxyacetyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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|
C30H35N3O4
|
2
|
1 |
EC50 = 67 nM
|
|
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2 |
Ki = 2.1 nM
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CP0385120
|
(2S)-N-[(4R)-1-acetyl-6-benzyl-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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|
C29H33N3O3
|
2
|
1 |
EC50 = 68 nM
|
|
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2 |
Ki = 1.8 nM
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CP0385126
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4R)-6-(naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]propanamide
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|
C31H33N3O2
|
2
|
1 |
EC50 = 69 nM
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|
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2 |
Ki = 6 nM
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CP0382568
|
(2S)-2-amino-N-[(4R)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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|
C27H31N3O2
|
2
|
1 |
EC50 = 110 nM
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|
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2 |
Ki = 9.4 nM
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CP0888239
|
(S)-2-amino-N-((R)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl)-3-(4-hydroxy-2,6-dimethylphenyl)propanamide 2,2,2-trifluoroacetate
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|
C29H32F3N3O4
|
2
|
1 |
EC50 = 110 nM
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|
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2 |
Ki = 9.4 nM
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CP0521687
|
(1S,5S,9R)-5-(3-hydroxyphenyl)-2-[(E)-3-phenylprop-2-enyl]-2-azabicyclo[3.3.1]nonan-9-ol;oxalic acid
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|
C25H29NO6
|
1
|
1 |
EC50 = 253 nM
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|
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CP0446710
|
(2S)-2-amino-N-[(4R)-1-(2-amino-2-oxoethyl)-6-benzyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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|
C29H34N4O3
|
2
|
1 |
EC50 = 270 nM
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2 |
Ki = 2 nM
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CP0216238
|
(4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
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|
C30H39N5O7S2
|
1
|
1 |
EC50 = 368 nM
|
|
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CP0409019
|
(1R,5R,9S)-5-(3-hydroxyphenyl)-2-[2-(4-nitrophenyl)ethyl]-2-azabicyclo[3.3.1]nonan-9-ol;oxalic acid
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|
C24H28N2O8
|
1
|
1 |
EC50 = 630 nM
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CP0470601
|
(1R,5R,9S)-5-(3-hydroxyphenyl)-2-[2-[4-(trifluoromethyl)phenyl]ethyl]-2-azabicyclo[3.3.1]nonan-9-ol;hydrochloride
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|
C23H27ClF3NO2
|
1
|
1 |
EC50 = 901 nM
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|
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CP0372433
|
(1R,5R,9S)-(-)-9-hydroxy-5-(3-hydroxyphenyl-2-phenylethyl-2-azabicyclo[3.3.1]nonane
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|
C22H27NO2
|
1
|
1 |
EC50 = 1084 nM
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|
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CP0404433
|
(2S)-2-amino-N-[(4R)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,5-dimethylphenyl)propanamide
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|
C27H31N3O2
|
2
|
1 |
EC50 = 5900 nM
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|
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2 |
Ki = 390 nM
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CP0846973
|
10-hydroxy-17-(3-phenylpropoxy)-4-tetrahydro-2-furanylmethyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-one
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|
C30H35NO5
|
1
|
1 |
Ki = 0.09 nM
|
|
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CP0472984
|
(2S)-2-amino-N-[(4R)-1-(cyclopropanecarbonyl)-6-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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|
C35H38F3N3O7
|
1
|
1 |
Ki = 0.19 nM
|
|
|
CP0050068
|
(1S,2S,13R,21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol
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|
C26H26N2O3
|
1
|
1 |
Ki = 0.2 nM
|
|
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CP0429383
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4R)-6-(naphthalen-2-ylmethyl)-1-propanoyl-3,4-dihydro-2H-quinolin-4-yl]propanamide
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|
C34H37N3O3
|
1
|
1 |
Ki = 0.21 nM
|
|
|
CP0472987
|
(2S)-2-amino-N-[(4R)-1-benzoyl-6-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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|
C38H38F3N3O7
|
1
|
1 |
Ki = 0.22 nM
|
|
|
CP0385129
|
(2S)-N-[(4R)-1-acetyl-6-(naphthalen-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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|
C33H35N3O3
|
1
|
1 |
Ki = 0.23 nM
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|
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CP0429425
|
(2S)-2-amino-N-[(4R)-1-benzoyl-6-benzyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
Show/Hide
|
C34H35N3O3
|
1
|
1 |
Ki = 0.24 nM
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|
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CP0380849
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(R)-hydroxy(phenyl)methyl]-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
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|
C31H37NO4
|
1
|
1 |
Ki = 0.25 nM
|
|
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CP0499509
|
US10231963, Table B.13
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|
C28H31NO4
|
1
|
1 |
Ki = 0.26 nM
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|
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CP0378305
|
(1R,13S,14R)-24-(cyclopropylmethyl)-20-methoxy-4,24-diazahexacyclo[12.7.3.0^{1,13}.0^{3,11}.0^{5,10}.0^{16,21}]tetracosa-3(11),5(10),6,8,16,18,20-heptaene-13,19-diol
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|
C27H30N2O3
|
1
|
1 |
Ki = 0.4 nM
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CP0848722
|
(1'R,5alpha,6R,7R,14alpha)-1'-(3-methylphenyl)-1'-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-7beta-methyl 17-cyclopropylmethyl-6,14-etheno-morphinan-7-yl)-methan-1'-ol
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|
C32H37NO4
|
1
|
1 |
Ki = 0.4 nM
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|
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CP0382583
|
(2S)-N-[(4R)-1-acetyl-6-(2,3-dihydro-1H-inden-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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|
C32H37N3O3
|
1
|
1 |
Ki = 0.44 nM
|
|
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CP0847461
|
4-cyclobutylmethyl-10-hydroxy-17-(3-phenylpropoxy)-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-one
Show/Hide
|
C30H35NO4
|
1
|
1 |
Ki = 0.46 nM
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|
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CP0472986
|
(2S)-2-amino-N-[(4R)-1-benzoyl-6-(naphthalen-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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|
C40H38F3N3O5
|
1
|
1 |
Ki = 0.46 nM
|
|
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CP0414678
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(R)-(4-fluorophenyl)-hydroxymethyl]-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
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|
C31H36FNO4
|
1
|
1 |
Ki = 0.47 nM
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|
|
CP0437789
|
14-O-phenylpropylnaltrexone
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|
C29H33NO4
|
1
|
1 |
Ki = 0.48 nM
|
|
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CP0072627
|
BUPRENORPHINE
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|
C29H41NO4
|
1
|
1 |
Ki = 0.48 nM
|
|
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CP0850661
|
(1'R,5alpha,6R,7R,14alpha)-1'-phenyl-1'-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-7beta-methyl 17-cyclopropylmethyl-6,14-ethenomorphinan-7-yl)-methan-1'-ol
Show/Hide
|
C31H35NO4
|
1
|
1 |
Ki = 0.48 nM
|
|
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CP0451771
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(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4R)-1-methylsulfonyl-6-(quinolin-3-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]propanamide;2,2,2-trifluoroacetic acid
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|
C33H35F3N4O6S
|
1
|
1 |
Ki = 0.64 nM
|
|
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CP0451779
|
(2S)-2-amino-N-[(4R)-6-(1-benzofuran-2-ylmethyl)-1-benzoyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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|
C38H36F3N3O6
|
1
|
1 |
Ki = 0.64 nM
|
|
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CP0430968
|
(2S)-2-amino-N-[(4R)-1-benzoyl-6-(quinolin-3-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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|
C39H37F3N4O5
|
1
|
1 |
Ki = 0.74 nM
|
|
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CP0420052
|
(2S)-2-amino-N-[(4R)-1-butanoyl-6-(naphthalen-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
Show/Hide
|
C35H39N3O3
|
1
|
1 |
Ki = 0.8 nM
|
|
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CP0472985
|
(2S)-N-[(4R)-1-acetyl-6-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C33H36F3N3O7
|
1
|
1 |
Ki = 0.83 nM
|
|
|
CP0382584
|
(2S)-N-[(4R)-1-acetyl-6-(2,3-dihydro-1H-inden-1-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
Show/Hide
|
C32H37N3O3
|
1
|
1 |
Ki = 0.84 nM
|
|
|
CP0430965
|
(2S)-2-amino-N-[(4R)-1-(cyclopropanecarbonyl)-6-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C36H41F3N4O5
|
1
|
1 |
Ki = 0.88 nM
|
|
|
CP0430966
|
(2S)-N-[(4R)-1-acetyl-6-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C34H39F3N4O5
|
1
|
1 |
Ki = 0.89 nM
|
|
|
CP0893297
|
oxymorphindole hydrochloride
Show/Hide
|
C23H23ClN2O3
|
1
|
1 |
Ki = 0.9 nM
|
|
|
CP0910158
|
10-hydroxy-17-(3-phenylpropoxy)-4-propyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-one
Show/Hide
|
C28H33NO4
|
1
|
1 |
Ki = 0.93 nM
|
|
|
CP0475259
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4R)-1-methylsulfonyl-6-(naphthalen-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C34H36F3N3O6S
|
1
|
1 |
Ki = 0.95 nM
|
|
|
CP0430970
|
(2S)-2-amino-N-[(4R)-6-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-1-methylsulfonyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C33H39F3N4O6S
|
1
|
1 |
Ki = 0.98 nM
|
|
|
CP0382350
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(1R)-1-hydroxy-1-pyridin-4-ylethyl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C30H36N2O4
|
1
|
1 |
Ki = 0.99 nM
|
|
|
CP0413167
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(1S)-1-hydroxy-1-thiophen-2-ylethyl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C29H35NO4S
|
1
|
1 |
Ki = 1 nM
|
|
|
CP0429384
|
methyl (4R)-4-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-6-(naphthalen-2-ylmethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
Show/Hide
|
C33H35N3O4
|
1
|
1 |
Ki = 1 nM
|
|
|
CP0489973
|
(2S)-2-amino-N-[(4R)-6-(1-benzofuran-2-ylmethyl)-1-methylsulfonyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C32H34F3N3O7S
|
1
|
1 |
Ki = 1 nM
|
|
|
CP0869549
|
10-hydroxy-4-phenethyl-17-(3-phenylpropoxy)-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-one
Show/Hide
|
C33H35NO4
|
1
|
1 |
Ki = 1.25 nM
|
|
|
CP0385133
|
(2S)-N-[(4R)-1-acetyl-6-(naphthalen-1-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
Show/Hide
|
C33H35N3O3
|
1
|
1 |
Ki = 1.3 nM
|
|
|
CP0447297
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4R)-6-(quinolin-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C32H33F3N4O4
|
1
|
1 |
Ki = 1.5 nM
|
|
|
CP0482858
|
(2S)-2-amino-N-[(4R)-6-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-1-methylsulfonyl-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C32H36F3N3O8S
|
1
|
1 |
Ki = 1.5 nM
|
|
|
CP0045401
|
(5R,8S,11S,14S)-14-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-8,11-dibenzyl-7,10,13-trioxo-1,3-dithia-6,9,12-triazacyclopentadecane-5-carboxamide
Show/Hide
|
C34H40N6O6S2
|
1
|
1 |
Ki = 1.8 nM
|
|
|
CP0451768
|
(2S)-2-amino-N-[(4R)-6-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C32H37F3N4O4
|
1
|
1 |
Ki = 3.1 nM
|
|
|
CP0385128
|
(2S)-2-amino-N-[(4R)-6-(cyclohexylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
Show/Hide
|
C27H37N3O2
|
1
|
1 |
Ki = 3.4 nM
|
|
|
CP0385122
|
(2S)-2-amino-N-[(1R)-7-benzyl-1,2,3,4-tetrahydronaphthalen-1-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
Show/Hide
|
C28H32N2O2
|
1
|
1 |
Ki = 4 nM
|
|
|
CP0482883
|
(2S)-2-amino-N-[(4R)-1-benzoyl-6-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-3,4-dihydro-2H-quinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C39H41F3N4O5
|
1
|
1 |
Ki = 4 nM
|
|
|
CP0385221
|
(2S)-2-amino-N-[(4R)-6-(2,3-dihydro-1H-inden-2-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
Show/Hide
|
C30H35N3O2
|
1
|
1 |
Ki = 4.1 nM
|
|
|
CP0378307
|
(1R,13S,14R)-20-methoxy-24-methyl-4,24-diazahexacyclo[12.7.3.0^{1,13}.0^{3,11}.0^{5,10}.0^{16,21}]tetracosa-3(11),5(10),6,8,16,18,20-heptaene-13,19-diol
Show/Hide
|
C24H26N2O3
|
1
|
1 |
Ki = 4.5 nM
|
|
|
CP0385127
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(1R)-7-(naphthalen-1-ylmethyl)-1,2,3,4-tetrahydronaphthalen-1-yl]propanamide
Show/Hide
|
C32H34N2O2
|
1
|
1 |
Ki = 5 nM
|
|
|
CP0451766
|
(2S)-2-amino-N-[(4R)-6-(1-benzofuran-2-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C31H32F3N3O5
|
1
|
1 |
Ki = 5 nM
|
|
|
CP0447314
|
(5R,8S,11S,14S)-14-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-11-benzyl-8-(naphthalen-1-ylmethyl)-7,10,13-trioxo-1,3-dithia-6,9,12-triazacyclopentadecane-5-carboxamide
Show/Hide
|
C38H42N6O6S2
|
1
|
1 |
Ki = 5.2 nM
|
|
|
CP0412205
|
(2S)-2-amino-N-[(5-benzyl-2-propoxyphenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C30H35F3N2O5
|
1
|
1 |
Ki = 5.3 nM
|
|
|
CP0871267
|
10-methoxy-4-phenethyl-17-(3-phenylpropoxy)-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-one
Show/Hide
|
C34H37NO4
|
1
|
1 |
Ki = 5.4 nM
|
|
|
CP0447294
|
(2S)-2-amino-N-[(4R)-6-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C31H34F3N3O6
|
1
|
1 |
Ki = 5.5 nM
|
|
|
CP0870134
|
10-methoxy-17-(3-phenylpropoxy)-4-tetrahydro-2-furanylmethyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-one
Show/Hide
|
C31H37NO5
|
1
|
1 |
Ki = 6.2 nM
|
|
|
CP0432506
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-(4-phenylbutyl)piperazin-1-yl]propan-1-one
Show/Hide
|
C25H35N3O2
|
1
|
1 |
Ki = 6.6 nM
|
|
|
CP0457352
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-(3-naphthalen-1-ylpropyl)piperazin-1-yl]propan-1-one
Show/Hide
|
C28H35N3O2
|
1
|
1 |
Ki = 6.6 nM
|
|
|
CP0385130
|
(2S)-2-amino-N-[(4R)-6-(2,3-dihydro-1H-inden-1-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
Show/Hide
|
C30H35N3O2
|
1
|
1 |
Ki = 6.8 nM
|
|
|
CP0383080
|
(2S)-2-amino-N-[(1R)-1-(5-benzyl-2-methoxyphenyl)ethyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C29H33F3N2O5
|
1
|
1 |
Ki = 6.8 nM
|
|
|
CP0432505
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-(5-phenylpentyl)piperazin-1-yl]propan-1-one
Show/Hide
|
C26H37N3O2
|
1
|
1 |
Ki = 6.9 nM
|
|
|
CP0458898
|
(4R,7S,10S,13S)-13-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-10-benzyl-7-(naphthalen-1-ylmethyl)-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxamide
Show/Hide
|
C37H40N6O6S2
|
1
|
1 |
Ki = 7.1 nM
|
|
|
CP0416998
|
(2S)-2-amino-N-[[5-benzyl-2-(trifluoromethoxy)phenyl]methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C28H28F6N2O5
|
1
|
1 |
Ki = 7.3 nM
|
|
|
CP0443502
|
(2S)-2-amino-1-(4-benzylpiperidin-1-yl)-3-(4-hydroxy-2,6-dimethylphenyl)propan-1-one
Show/Hide
|
C23H30N2O2
|
1
|
1 |
Ki = 7.8 nM
|
|
|
CP0410855
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4R)-6-(2-phenylethyl)-1,2,3,4-tetrahydroquinolin-4-yl]propanamide
Show/Hide
|
C28H33N3O2
|
1
|
1 |
Ki = 8.9 nM
|
|
|
CP0385121
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4R)-6-(naphthalen-2-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]propanamide
Show/Hide
|
C31H33N3O2
|
1
|
1 |
Ki = 10 nM
|
|
|
CP0470384
|
(4R,7S,10S,13S)-13-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-10-benzyl-7-(naphthalen-2-ylmethyl)-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxamide
Show/Hide
|
C37H40N6O6S2
|
1
|
1 |
Ki = 11 nM
|
|
|
CP0432508
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-[(E)-3-naphthalen-1-ylprop-2-enyl]piperazin-1-yl]propan-1-one
Show/Hide
|
C28H33N3O2
|
1
|
1 |
Ki = 11 nM
|
|
|
CP0457353
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-(3-phenylpropyl)piperidin-1-yl]propan-1-one
Show/Hide
|
C25H34N2O2
|
1
|
1 |
Ki = 12 nM
|
|
|
CP0428399
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(1R)-7-(naphthalen-2-ylmethyl)-1,2,3,4-tetrahydronaphthalen-1-yl]propanamide
Show/Hide
|
C32H34N2O2
|
1
|
1 |
Ki = 12 nM
|
|
|
CP0402366
|
(2S)-2-amino-N-[[5-benzyl-2-(cyclopropylmethoxy)phenyl]methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C31H35F3N2O5
|
1
|
1 |
Ki = 13.9 nM
|
|
|
CP0379925
|
(2S)-2-amino-1-(4-benzyl-3,4-dihydro-2H-quinolin-1-yl)-3-(4-hydroxy-2,6-dimethylphenyl)propan-1-one
Show/Hide
|
C27H30N2O2
|
1
|
1 |
Ki = 14 nM
|
|
|
CP0385125
|
(2S)-2-amino-N-[(1R)-7-(cyclohexylmethyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
Show/Hide
|
C28H38N2O2
|
1
|
1 |
Ki = 14 nM
|
|
|
CP0416997
|
(2S)-2-amino-N-[(3-benzylphenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C27H29F3N2O4
|
1
|
1 |
Ki = 14.7 nM
|
|
|
CP0452452
|
(5R,8S,11S,14S)-14-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-8-benzyl-11-(naphthalen-2-ylmethyl)-7,10,13-trioxo-1,3-dithia-6,9,12-triazacyclopentadecane-5-carboxamide
Show/Hide
|
C38H42N6O6S2
|
1
|
1 |
Ki = 15 nM
|
|
|
CP0371759
|
(1R,13S,14R)-24-(cyclopropylmethyl)-19,20-dimethoxy-4,24-diazahexacyclo[12.7.3.0^{1,13}.0^{3,11}.0^{5,10}.0^{16,21}]tetracosa-3(11),5(10),6,8,16,18,20-heptaen-13-ol
Show/Hide
|
C28H32N2O3
|
1
|
1 |
Ki = 19 nM
|
|
|
CP0457351
|
(2S)-2-amino-1-[4-(3,3-diphenylpropyl)piperazin-1-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propan-1-one
Show/Hide
|
C30H37N3O2
|
1
|
1 |
Ki = 21 nM
|
|
|
CP0412224
|
(2S)-2-amino-N-[(5-benzyl-2-methoxyphenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C28H31F3N2O5
|
1
|
1 |
Ki = 21.5 nM
|
|
|
CP0396057
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-[(E)-4-phenylbut-2-enyl]piperazin-1-yl]propan-1-one
Show/Hide
|
C25H33N3O2
|
1
|
1 |
Ki = 23 nM
|
|
|
CP0849802
|
(S)-1-((5-Benzyl-2-ethoxybenzyl)amino)-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropan-2-aminium Trifluoroacetate
Show/Hide
|
C29H33F3N2O5
|
1
|
1 |
Ki = 23.8 nM
|
|
|
CP0421079
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-[(Z)-4-phenylbut-2-enyl]piperazin-1-yl]propan-1-one
Show/Hide
|
C25H33N3O2
|
1
|
1 |
Ki = 28 nM
|
|
|
CP0402374
|
(2S)-2-amino-N-[(5-benzyl-2-methylphenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C28H31F3N2O4
|
1
|
1 |
Ki = 33.9 nM
|
|
|
CP0418175
|
(5R,8S,11S,14S)-14-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-8-benzyl-11-(naphthalen-1-ylmethyl)-7,10,13-trioxo-1,3-dithia-6,9,12-triazacyclopentadecane-5-carboxamide
Show/Hide
|
C38H42N6O6S2
|
1
|
1 |
Ki = 34 nM
|
|
|
CP0452451
|
(4R,7S,10S,13S)-13-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-7-benzyl-10-(naphthalen-1-ylmethyl)-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxamide
Show/Hide
|
C37H40N6O6S2
|
1
|
1 |
Ki = 34 nM
|
|
|
CP0379924
|
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-[4-(3-phenylpropyl)piperazin-1-yl]propan-1-one
Show/Hide
|
C24H33N3O2
|
1
|
1 |
Ki = 36 nM
|
|
|
CP0392519
|
(2S)-2-amino-N-[(4R)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl]-3-(2,6-dichloro-4-hydroxyphenyl)propanamide
Show/Hide
|
C25H25Cl2N3O2
|
1
|
1 |
Ki = 37 nM
|
|
|
CP0416992
|
(2S)-2-amino-N-[(5-benzyl-2-chlorophenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C27H28ClF3N2O4
|
1
|
1 |
Ki = 38.1 nM
|
|
|
CP0126886
|
(4R,4aS,7aR,12bR)-9-hydroxy-4a-methoxy-3,7a-dimethyl-1,2,4,5,6,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Show/Hide
|
C19H23NO4
|
1
|
1 |
Ki = 40.9 nM
|
|
|
CP0453799
|
(1R,13S,14R)-19,20-dimethoxy-24-methyl-4,24-diazahexacyclo[12.7.3.0^{1,13}.0^{3,11}.0^{5,10}.0^{16,21}]tetracosa-3(11),5(10),6,8,16,18,20-heptaen-13-ol
Show/Hide
|
C25H28N2O3
|
1
|
1 |
Ki = 41 nM
|
|
|
CP0400891
|
(2S)-2-amino-N-[(4R)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2-methylphenyl)propanamide
Show/Hide
|
C26H29N3O2
|
1
|
1 |
Ki = 42 nM
|
|
|
CP0412223
|
(2S)-2-amino-N-[(1R)-1-(3-benzylphenyl)ethyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
Show/Hide
|
C28H31F3N2O4
|
1
|
1 |
Ki = 46 nM
|
|
|
CP0470368
|
(4R,7S,10S,13S)-13-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-7-benzyl-10-(naphthalen-2-ylmethyl)-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxamide
Show/Hide
|
C37H40N6O6S2
|
1
|
1 |
Ki = 55 nM
|
|
|
CP0459878
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(2S)-2-amino-N-[(4S)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C27H31N3O2
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1
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1 |
Ki = 56 nM
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CP0468852
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(2S)-2-amino-N-[(1R)-1-(3-benzylphenyl)propyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C29H33F3N2O4
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1
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1 |
Ki = 61 nM
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CP0412222
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(2S)-2-amino-N-[[5-benzyl-2-(ethylamino)phenyl]methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C29H34F3N3O4
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1
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1 |
Ki = 63.8 nM
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CP0448772
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(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4S)-6-(naphthalen-2-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]propanamide
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C31H33N3O2
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1
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1 |
Ki = 66 nM
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CP0419423
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2-[(4R)-4-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-6-benzyl-3,4-dihydro-2H-quinolin-1-yl]acetic acid
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C29H33N3O4
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1
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1 |
Ki = 67 nM
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CP0416993
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(2S)-2-amino-N-[(5-benzyl-2-phenylmethoxyphenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C34H35F3N2O5
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1
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1 |
Ki = 70.4 nM
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CP0412199
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(2S)-2-amino-N-[[5-benzyl-2-(propanoylamino)phenyl]methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C30H34F3N3O5
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1
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1 |
Ki = 108 nM
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CP0410856
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(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(4S)-6-(2-phenylethyl)-1,2,3,4-tetrahydroquinolin-4-yl]propanamide
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C28H33N3O2
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1
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1 |
Ki = 120 nM
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CP0000305
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(-)-(etorphine)
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C17H19NO3
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2
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1 |
Ki = 171 nM
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2 |
Ki = 217 nM
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CP0412225
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(2S)-2-amino-N-[(5-benzyl-2-hydroxyphenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C27H29F3N2O5
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1
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1 |
Ki = 175 nM
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CP0410857
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(2S)-2-amino-N-[(4S)-6-(2,3-dihydro-1H-inden-2-ylmethyl)-1,2,3,4-tetrahydroquinolin-4-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
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C30H35N3O2
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1
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1 |
Ki = 180 nM
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CP0484176
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(2S)-N-[(2-acetamido-5-benzylphenyl)methyl]-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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C29H32F3N3O5
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1
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1 |
Ki = 387 nM
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CP0392521
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(2S)-2-amino-N-[(4R)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl]-3-(2,6-dimethylphenyl)propanamide
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C27H31N3O
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1
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1 |
Ki = 660 nM
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CP0456604
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(2S)-2-amino-N-[(4R)-6-benzyl-1,2,3,4-tetrahydroquinolin-4-yl]-3-(8-hydroxynaphthalen-2-yl)propanamide
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C29H29N3O2
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1
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1 |
Ki = 1600 nM
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