General Information of the Compound
Compound ID
CP0470601
Compound Name
(1R,5R,9S)-5-(3-hydroxyphenyl)-2-[2-[4-(trifluoromethyl)phenyl]ethyl]-2-azabicyclo[3.3.1]nonan-9-ol;hydrochloride
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Structure
Formula
C23H27ClF3NO2
Molecular Weight
441.921
Canonical SMILES
Cl.O[C@@H]1[C@H]2CCC[C@@]1(CCN2CCc1ccc(cc1)C(F)(F)F)c1cccc(O)c1
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InChI
InChI=1S/C23H26F3NO2.ClH/c24-23(25,26)17-8-6-16(7-9-17)10-13-27-14-12-22(11-2-5-20(27)21(22)29)18-3-1-4-19(28)15-18;/h1,3-4,6-9,15,20-21,28-29H,2,5,10-14H2;1H/t20-,21-,22-;/m1./s1
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InChIKey
AKBZSAUQISOIGO-AFYLVLOISA-N
Physicochemical Property
logP
4.9324
Rotatable Bonds
4
Heavy Atom Count
30
Polar Areas
43.7
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137657690
ChEMBL ID
CHEMBL4102551
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01526, Delta-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6 Rattus norvegicus (Rat)  1
1
EC50 = 901 nM
   TI
   LI
   LO
   TS
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 761 nM
   TI
   LI
   LO
   TS
Protein ID: PT01549, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6 Rattus norvegicus (Rat)  1
1
EC50 = 19 nM
   TI
   LI
   LO
   TS