General Information of the Protein
Protein ID
PT01526
Protein Name
Delta-type opioid receptor
Secondarily
Protein Name
Opioid receptor A
Gene Name
OPRD1
Secondarily
Gene Name
Ror-a
Sequence
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Opioid receptor
Function
G-protein coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
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Uniprot ID
P33533
Ensembl ID
ENSG00000116329
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000047 , 108CC15
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0383819
 Compound Info 
(S,3S,3'S)-N,N'-(ethane-1,2-diyl)bis(2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide)
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C44H52N6O6
  1
1
Kd = 0.912 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0390966
 Compound Info 
(S,3S,3'S)-N,N'-(hex-3-ene-1,6-diyl)bis(2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide)
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C48H58N6O6
  1
1
Kd = 1.148 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0390493
 Compound Info 
(S,S,3S,3'S,3''S)-N,N',N''-(2,2',2''-nitrilotris(ethane-2,1-diyl))tris(2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide)
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C69H84N10O9
  1
1
Kd = 2.291 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0087279
 Compound Info 
(S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
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C21H24N2O4
  1
1
Kd = 3.311 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0400425
 Compound Info 
(2S,2'S)-N,N'-((4S,4'S)-2,2'-(2,2'-(ethane-1,2-diylbis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepine-4,2-diyl))bis(2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide)
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C48H58N8O8
  1
1
Kd = 18.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0496996
 Compound Info 
(2S,2'S,2''S)-N,N',N''-((4S,4'S,4''S)-2,2',2''-(2,2',2''-(2,2',2''-nitrilotris(ethane-2,1-diyl)tris(azanediyl))tris(2-oxoethane-2,1-diyl))tris(3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepine-4,2-diyl))tris(2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanamide)
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C75H93N13O12
  1
1
Kd = 22.91 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000051 , BHK-21
 Cell Line Info 
Cell Line ID: CL000049 , C6
 Cell Line Info 
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Cell Line ID: CL001020 , EE-HEK293
 Cell Line Info 
Cell Line ID: CL000033 , GH3
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0000305
 Compound Info 
(-)-(etorphine)
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C17H19NO3
  2
1 Activity = 1220 nM
2 Ki = 684 nM
CP0040319
 Compound Info 
4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-hydroxyphenyl)methyl)-N,N-diethylbenzamide
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C27H37N3O2
  1
1 IC50 = 0.31 nM
CP0042565
 Compound Info 
(S)-3-((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-N-{(S)-1-[(S)-1-(carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propyl}-succinamic acid
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C37H52N8O10
  2
1 IC50 = 0.6 nM
2 Ki = 0.15 nM
CP0041255
 Compound Info 
(+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide
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C28H39N3O2
  2
1 IC50 = 1.06 nM
2 Ki = 1.57 nM
CP0038418
 Compound Info 
13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triaza-cyclotetradecane-4-carboxylic acid
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C30H39N5O7S2
  4
1 IC50 = 1.6 nM
2 IC50 = 5.83 nM
3 IC50 = 8.5 nM
4 Ki = 2.72 nM
CP0050068
 Compound Info 
(1S,2S,13R,21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol
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C26H26N2O3
  3
1 Ki = 0.062 nM
2 Ki = 0.22 nM
3 Ki = 0.41 nM
CP0167293
 Compound Info 
7-Benzylidenenaltrexone
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C27H27NO4
  1
1 Ki = 0.1 nM
CP0268775
 Compound Info 
(S)-4-((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-4-{(1S,2S)-1-[(1S,2S)-1-(carbamoylmethyl-carbamoyl)-2-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-butyric acid
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C40H58N8O10
  1
1 Ki = 0.535 nM
CP0088373
 Compound Info 
(S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid
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C28H37N5O7
  2
1 Ki = 1.5 nM
2 Ki = 2.53 nM
CP0043301
 Compound Info 
(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]-N-methylacetamido}-N-(2-hydroxyethyl)-3-phenylpropanamide
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C26H35N5O6
  1
1 Ki = 2670 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT00642 Opioid receptor, delta 1b Danio rerio, Zebrafish, Brachydanio rerio
 Protein Info