General Information of the Compound
Compound ID
CP0471250
Compound Name
2-{2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3-hydroxy-propionylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-3-hydroxy-butyric acid
    Show/Hide
Synonyms
DSLET
DSTLE
Dislet
[D-Ser2, Leu5, Thr6]-enkephalin
    Show/Hide
Structure
Formula
C33H46N6O10
Molecular Weight
686.763
Canonical SMILES
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
    Show/Hide
InChI
InChI=1S/C33H46N6O10/c1-18(2)13-24(32(47)39-28(19(3)41)33(48)49)37-31(46)25(15-20-7-5-4-6-8-20)36-27(43)16-35-30(45)26(17-40)38-29(44)23(34)14-21-9-11-22(42)12-10-21/h4-12,18-19,23-26,28,40-42H,13-17,34H2,1-3H3,(H,35,45)(H,36,43)(H,37,46)(H,38,44)(H,39,47)(H,48,49)/t19-,23+,24+,25+,26-,28+/m1/s1
    Show/Hide
InChIKey
PKSODCLCMBUCPW-LVNBQDLPSA-N
CAS
75644-90-5
Physicochemical Property
logP
-1.9361
Rotatable Bonds
19
Heavy Atom Count
49
Polar Areas
269.51
Hydrogen Bond Donor Count
10
Hydrogen Bond Acceptor Count
10
Complexity
49

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 107847
SID: 15484131
ChEMBL ID
CHEMBL124283
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01526, Delta-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6 Rattus norvegicus (Rat)  1
1
Activity = 93 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( DSLET )
Drug Name DSLET
Target(s)
Opioid receptor delta (OPRD1)
Agonist
Opioid receptor mu (MOP)
Agonist