General Information of the Compound
Compound ID
CP0412224
Compound Name
(2S)-2-amino-N-[(5-benzyl-2-methoxyphenyl)methyl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide;2,2,2-trifluoroacetic acid
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Structure
Formula
C28H31F3N2O5
Molecular Weight
532.559
Canonical SMILES
OC(=O)C(F)(F)F.COc1ccc(Cc2ccccc2)cc1CNC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C
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InChI
InChI=1S/C26H30N2O3.C2HF3O2/c1-17-11-22(29)12-18(2)23(17)15-24(27)26(30)28-16-21-14-20(9-10-25(21)31-3)13-19-7-5-4-6-8-19;3-2(4,5)1(6)7/h4-12,14,24,29H,13,15-16,27H2,1-3H3,(H,28,30);(H,6,7)/t24-;/m0./s1
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InChIKey
CZAPISOUPRDNGI-JIDHJSLPSA-N
Physicochemical Property
logP
4.42794
Rotatable Bonds
8
Heavy Atom Count
38
Polar Areas
121.88
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
5
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155530441
ChEMBL ID
CHEMBL4464497
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01526, Delta-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6 Rattus norvegicus (Rat)  1
1
Ki = 21.5 nM
   TI
   LI
   LO
   TS
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 610 nM
   TI
   LI
   LO
   TS
Protein ID: PT01549, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6 Rattus norvegicus (Rat)  2
1
EC50 = 264 nM
   TI
   LI
   LO
   TS
2
Ki = 3.58 nM
   TI
   LI
   LO
   TS