General Information of the Cell Line
Cell Line ID
CL000333
Cell Line Name
GTM-3
Synonyms
GTM3
Glaucomatous Trabecular Meshwork-3
HTM-3
Human Trabecular Meshwork-3
Category
Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_5G33
Tissue Information
Eye
Disease
Glaucoma (NCIt: C26782)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01184, Rho-associated protein kinase 1
Compound ID Compound Name Compound Formula
CP0333734
(+/-)-4-(5-(1-aminobutyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C17H20N4S
 1
1
EC50 = 600 nM
   TI
   LI
   LO
   TS
CP0060392
(R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide
   Show/Hide
C16H16N4O
 1
1
EC50 = 790 nM
   TI
   LI
   LO
   TS
CP0293496
(+/-)-3-(amino(2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thiophen-5-yl)methyl)phenol
   Show/Hide
C20H18N4OS
 1
1
EC50 = 900 nM
   TI
   LI
   LO
   TS
CP0095525
3-(2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thiophen-5-ylamino)phenol
   Show/Hide
C19H16N4OS
 1
1
EC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0038863
(+/-)-4-(5-(amino(phenyl)methyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C20H18N4S
 1
1
EC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0146228
(+/-)-4-(5-(1-amino-3-methylbutyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C18H22N4S
 1
1
EC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0191216
(+/-)-4-(5-(1-aminopropyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C16H18N4S
 1
1
EC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0105393
(+/-)--4-(5-(amino(m-tolyl)methyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C21H20N4S
 1
1
EC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0317856
(+/-)-4-(5-(1-amino-2-methylpropyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C17H20N4S
 1
1
EC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0114870
(+/-)--4-(5-(amino(4-methoxyphenyl)methyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C21H20N4OS
 1
1
EC50 = 2600 nM
   TI
   LI
   LO
   TS
CP0146224
(+/-)--4-(5-(amino(3-chlorophenyl)methyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C20H17ClN4S
 1
1
EC50 = 2700 nM
   TI
   LI
   LO
   TS
CP0105390
3-((2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thiophen-5-yl)methyl)phenol
   Show/Hide
C20H17N3OS
 1
1
EC50 = 2900 nM
   TI
   LI
   LO
   TS
CP0095526
(+/-)-4-(5-(amino(3-methoxyphenyl)methyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C21H20N4OS
 1
1
EC50 = 3600 nM
   TI
   LI
   LO
   TS
CP0146227
(+/-)-4-(5-(1-aminoethyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C15H16N4S
 1
1
EC50 = 4200 nM
   TI
   LI
   LO
   TS
CP0038854
4-(3-methyl-5-phenylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C19H15N3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0093642
4-(5-(3-methoxybenzyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C21H19N3OS
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0095519
4-(3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C13H11N3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0095524
3-((2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thiophen-5-yl)methyl)benzoic acid
   Show/Hide
C21H17N3O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0146220
4-(5-(4-methoxybenzyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C21H19N3OS
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0146221
4-(3-methyl-5-(3-(trifluoromethyl)benzyl)benzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C21H16F3N3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0258963
4-(5-benzyl-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C20H17N3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0293498
4-(5-(aminomethyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C14H14N4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0299314
4-(5-(2-methoxybenzyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
   Show/Hide
C21H19N3OS
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0333731
methyl 3-[[2-(2-aminopyrimidin-4-yl)-3-methyl-1-benzothiophen-5-yl]methyl]benzoate
   Show/Hide
C22H19N3O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0333732
3-(2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thiophen-5-yloxy)phenol
   Show/Hide
C19H15N3O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Eye)
Cell Line Name Organism Disease
CHRF Homo sapiens (Human) Childhood acute megakaryoblastic leukemia
Y-79 Homo sapiens (Human) Retinoblastoma
HCE-T Homo sapiens (Human) -
MIO-M1 Homo sapiens (Human) -
RGC-5 Mus musculus (Mouse) -
661W Mus musculus (Mouse) -
FG-9307 Paralichthys olivaceus (Bastard halibut) -